Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1N2_LEIMA

TriTrypDb:

LmjF.36.1920 , LMJLV39_360025800 , LMJSD75_360025900

Length:

496

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1N2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1N2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.603
CLV_C14_Caspase3-7	268	272	PF00656	0.601
CLV_C14_Caspase3-7	70	74	PF00656	0.656
CLV_NRD_NRD_1	21	23	PF00675	0.672
CLV_NRD_NRD_1	219	221	PF00675	0.590
CLV_NRD_NRD_1	436	438	PF00675	0.493
CLV_PCSK_KEX2_1	145	147	PF00082	0.487
CLV_PCSK_KEX2_1	160	162	PF00082	0.579
CLV_PCSK_KEX2_1	219	221	PF00082	0.533
CLV_PCSK_KEX2_1	435	437	PF00082	0.526
CLV_PCSK_KEX2_1	485	487	PF00082	0.576
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.468
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.557
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.615
CLV_PCSK_PC1ET2_1	485	487	PF00082	0.576
CLV_PCSK_SKI1_1	136	140	PF00082	0.420
CLV_PCSK_SKI1_1	160	164	PF00082	0.593
CLV_PCSK_SKI1_1	172	176	PF00082	0.499
CLV_PCSK_SKI1_1	300	304	PF00082	0.516
CLV_PCSK_SKI1_1	322	326	PF00082	0.561
CLV_PCSK_SKI1_1	414	418	PF00082	0.572
CLV_PCSK_SKI1_1	446	450	PF00082	0.539
DEG_APCC_DBOX_1	246	254	PF00400	0.534
DEG_Nend_UBRbox_2	1	3	PF02207	0.580
DOC_CYCLIN_RxL_1	297	307	PF00134	0.521
DOC_CYCLIN_RxL_1	319	326	PF00134	0.596
DOC_MAPK_gen_1	183	191	PF00069	0.559
DOC_MAPK_gen_1	225	234	PF00069	0.559
DOC_MAPK_RevD_3	132	146	PF00069	0.309
DOC_PP1_RVXF_1	134	140	PF00149	0.378
DOC_PP4_FxxP_1	162	165	PF00568	0.560
DOC_USP7_MATH_1	10	14	PF00917	0.603
DOC_USP7_MATH_1	108	112	PF00917	0.623
DOC_USP7_MATH_1	274	278	PF00917	0.547
DOC_USP7_MATH_1	426	430	PF00917	0.619
DOC_USP7_MATH_1	453	457	PF00917	0.603
DOC_USP7_MATH_1	489	493	PF00917	0.635
DOC_USP7_UBL2_3	472	476	PF12436	0.575
DOC_WW_Pin1_4	328	333	PF00397	0.630
DOC_WW_Pin1_4	422	427	PF00397	0.636
LIG_14-3-3_CanoR_1	154	162	PF00244	0.525
LIG_14-3-3_CanoR_1	177	183	PF00244	0.572
LIG_14-3-3_CanoR_1	22	26	PF00244	0.603
LIG_14-3-3_CanoR_1	319	325	PF00244	0.461
LIG_14-3-3_CanoR_1	420	424	PF00244	0.489
LIG_Actin_WH2_2	7	24	PF00022	0.616
LIG_BRCT_BRCA1_1	276	280	PF00533	0.537
LIG_BRCT_BRCA1_1	385	389	PF00533	0.543
LIG_BRCT_BRCA1_1	50	54	PF00533	0.726
LIG_CaM_IQ_9	348	363	PF13499	0.556
LIG_eIF4E_1	290	296	PF01652	0.581
LIG_FAT_LD_1	175	183	PF03623	0.486
LIG_FHA_1	142	148	PF00498	0.472
LIG_FHA_1	184	190	PF00498	0.562
LIG_FHA_1	48	54	PF00498	0.699
LIG_FHA_2	107	113	PF00498	0.695
LIG_FHA_2	193	199	PF00498	0.496
LIG_FHA_2	249	255	PF00498	0.538
LIG_FHA_2	266	272	PF00498	0.408
LIG_FHA_2	321	327	PF00498	0.491
LIG_FHA_2	37	43	PF00498	0.762
LIG_FHA_2	428	434	PF00498	0.675
LIG_FHA_2	44	50	PF00498	0.621
LIG_Integrin_RGD_1	220	222	PF01839	0.602
LIG_LIR_Apic_2	159	165	PF02991	0.567
LIG_LIR_Apic_2	422	426	PF02991	0.636
LIG_LIR_Gen_1	201	211	PF02991	0.512
LIG_LIR_Gen_1	277	287	PF02991	0.483
LIG_LIR_Gen_1	306	317	PF02991	0.407
LIG_LIR_Gen_1	386	396	PF02991	0.613
LIG_LIR_Gen_1	463	471	PF02991	0.574
LIG_LIR_Nem_3	116	121	PF02991	0.461
LIG_LIR_Nem_3	201	207	PF02991	0.513
LIG_LIR_Nem_3	277	283	PF02991	0.437
LIG_LIR_Nem_3	306	312	PF02991	0.403
LIG_LIR_Nem_3	338	343	PF02991	0.584
LIG_LIR_Nem_3	386	392	PF02991	0.591
LIG_LIR_Nem_3	459	464	PF02991	0.511
LIG_LYPXL_yS_3	273	276	PF13949	0.533
LIG_Pex14_1	461	465	PF04695	0.621
LIG_Pex14_2	280	284	PF04695	0.487
LIG_SH2_CRK	465	469	PF00017	0.584
LIG_SH2_PTP2	423	426	PF00017	0.637
LIG_SH2_STAP1	121	125	PF00017	0.466
LIG_SH2_STAP1	236	240	PF00017	0.547
LIG_SH2_STAP1	465	469	PF00017	0.617
LIG_SH2_STAT5	196	199	PF00017	0.550
LIG_SH2_STAT5	265	268	PF00017	0.527
LIG_SH2_STAT5	290	293	PF00017	0.585
LIG_SH2_STAT5	311	314	PF00017	0.474
LIG_SH2_STAT5	357	360	PF00017	0.528
LIG_SH2_STAT5	423	426	PF00017	0.526
LIG_SH2_STAT6	409	413	PF00017	0.579
LIG_SH3_3	326	332	PF00018	0.634
LIG_SUMO_SIM_par_1	331	336	PF11976	0.607
LIG_SUMO_SIM_par_1	67	73	PF11976	0.551
LIG_TRAF2_1	255	258	PF00917	0.577
LIG_TRAF2_1	286	289	PF00917	0.488
LIG_UBA3_1	178	185	PF00899	0.487
LIG_UBA3_1	53	60	PF00899	0.652
MOD_CK1_1	104	110	PF00069	0.706
MOD_CK1_1	181	187	PF00069	0.575
MOD_CK1_1	192	198	PF00069	0.463
MOD_CK2_1	108	114	PF00069	0.622
MOD_CK2_1	248	254	PF00069	0.534
MOD_CK2_1	283	289	PF00069	0.501
MOD_CK2_1	312	318	PF00069	0.431
MOD_CK2_1	320	326	PF00069	0.428
MOD_CK2_1	339	345	PF00069	0.593
MOD_CK2_1	36	42	PF00069	0.677
MOD_CK2_1	427	433	PF00069	0.620
MOD_CK2_1	43	49	PF00069	0.742
MOD_CK2_1	453	459	PF00069	0.574
MOD_GlcNHglycan	106	109	PF01048	0.692
MOD_GlcNHglycan	191	194	PF01048	0.623
MOD_GlcNHglycan	385	388	PF01048	0.441
MOD_GlcNHglycan	491	494	PF01048	0.612
MOD_GSK3_1	104	111	PF00069	0.643
MOD_GSK3_1	160	167	PF00069	0.502
MOD_GSK3_1	34	41	PF00069	0.762
MOD_GSK3_1	422	429	PF00069	0.538
MOD_GSK3_1	43	50	PF00069	0.685
MOD_GSK3_1	453	460	PF00069	0.523
MOD_GSK3_1	474	481	PF00069	0.598
MOD_NEK2_1	1	6	PF00069	0.687
MOD_NEK2_1	106	111	PF00069	0.658
MOD_NEK2_1	178	183	PF00069	0.500
MOD_NEK2_1	189	194	PF00069	0.486
MOD_NEK2_1	21	26	PF00069	0.620
MOD_NEK2_1	283	288	PF00069	0.521
MOD_NEK2_1	312	317	PF00069	0.411
MOD_NEK2_1	320	325	PF00069	0.417
MOD_NEK2_1	47	52	PF00069	0.677
MOD_PIKK_1	153	159	PF00454	0.542
MOD_PKA_1	160	166	PF00069	0.530
MOD_PKA_2	153	159	PF00069	0.530
MOD_PKA_2	160	166	PF00069	0.460
MOD_PKA_2	21	27	PF00069	0.602
MOD_PKA_2	318	324	PF00069	0.482
MOD_PKA_2	33	39	PF00069	0.447
MOD_PKA_2	419	425	PF00069	0.520
MOD_Plk_1	34	40	PF00069	0.670
MOD_Plk_2-3	164	170	PF00069	0.603
MOD_Plk_2-3	478	484	PF00069	0.614
MOD_Plk_4	192	198	PF00069	0.513
MOD_Plk_4	291	297	PF00069	0.453
MOD_Plk_4	320	326	PF00069	0.539
MOD_Plk_4	419	425	PF00069	0.495
MOD_Plk_4	427	433	PF00069	0.508
MOD_ProDKin_1	328	334	PF00069	0.624
MOD_ProDKin_1	422	428	PF00069	0.638
MOD_SUMO_for_1	475	478	PF00179	0.579
MOD_SUMO_for_1	484	487	PF00179	0.620
MOD_SUMO_rev_2	159	167	PF00179	0.551
MOD_SUMO_rev_2	226	232	PF00179	0.540
MOD_SUMO_rev_2	442	450	PF00179	0.482
MOD_SUMO_rev_2	466	474	PF00179	0.570
MOD_SUMO_rev_2	64	74	PF00179	0.588
TRG_DiLeu_BaEn_2	113	119	PF01217	0.497
TRG_ENDOCYTIC_2	273	276	PF00928	0.464
TRG_ENDOCYTIC_2	311	314	PF00928	0.510
TRG_ENDOCYTIC_2	410	413	PF00928	0.509
TRG_ENDOCYTIC_2	465	468	PF00928	0.591
TRG_ER_diArg_1	218	220	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	300	304	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	356	361	PF00026	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT1	Leptomonas seymouri	61%	97%
A0A0S4ITY0	Bodo saltans	37%	100%
A0A1X0P7R8	Trypanosomatidae	30%	97%
A0A3S7XAS3	Leishmania donovani	92%	100%
A0A422MV92	Trypanosoma rangeli	30%	100%
A4HP57	Leishmania braziliensis	74%	100%
A4IDG3	Leishmania infantum	93%	100%
E9ASW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DKS4	Trypanosoma cruzi	31%	100%