RING-type E3 ubiquitin transferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q1N0_LEIMA

TriTrypDb:

LmjF.36.1930 , LMJLV39_360026000 , LMJSD75_360026100

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	8
GO:0016020	membrane	2	7
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4Q1N0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1N0

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	8
GO:0006511	ubiquitin-dependent protein catabolic process	7	8
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	6	2
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	2
GO:0008152	metabolic process	1	8
GO:0009056	catabolic process	2	8
GO:0009057	macromolecule catabolic process	4	8
GO:0009987	cellular process	1	8
GO:0010033	response to organic substance	3	2
GO:0010243	response to organonitrogen compound	4	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	8
GO:0019941	modification-dependent protein catabolic process	6	8
GO:0030163	protein catabolic process	4	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0036503	ERAD pathway	5	2
GO:0042221	response to chemical	2	2
GO:0043170	macromolecule metabolic process	3	8
GO:0043632	modification-dependent macromolecule catabolic process	5	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044248	cellular catabolic process	3	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044265	obsolete cellular macromolecule catabolic process	4	8
GO:0050896	response to stimulus	1	2
GO:0051603	proteolysis involved in protein catabolic process	5	8
GO:0051716	cellular response to stimulus	2	2
GO:0071704	organic substance metabolic process	2	8
GO:0071712	ER-associated misfolded protein catabolic process	6	2
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	8
GO:1901698	response to nitrogen compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0004842	ubiquitin-protein transferase activity	4	8
GO:0005488	binding	1	8
GO:0005515	protein binding	2	2
GO:0016740	transferase activity	2	8
GO:0019787	ubiquitin-like protein transferase activity	3	8
GO:0019899	enzyme binding	3	2
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0044390	ubiquitin-like protein conjugating enzyme binding	4	2
GO:0046872	metal ion binding	4	8
GO:0061630	ubiquitin protein ligase activity	5	8
GO:0061659	ubiquitin-like protein ligase activity	4	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:0016746	acyltransferase activity	3	1
GO:0061631	ubiquitin conjugating enzyme activity	5	1
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.502
CLV_PCSK_KEX2_1	130	132	PF00082	0.502
DEG_SPOP_SBC_1	89	93	PF00917	0.749
DOC_MAPK_MEF2A_6	175	182	PF00069	0.690
DOC_MAPK_MEF2A_6	281	289	PF00069	0.357
DOC_MAPK_NFAT4_5	175	183	PF00069	0.684
DOC_PP4_FxxP_1	115	118	PF00568	0.680
DOC_USP7_MATH_1	104	108	PF00917	0.797
DOC_USP7_MATH_1	129	133	PF00917	0.712
DOC_USP7_MATH_1	234	238	PF00917	0.525
DOC_USP7_MATH_1	263	267	PF00917	0.517
DOC_USP7_MATH_1	99	103	PF00917	0.761
DOC_WW_Pin1_4	250	255	PF00397	0.519
DOC_WW_Pin1_4	272	277	PF00397	0.469
LIG_14-3-3_CanoR_1	259	267	PF00244	0.418
LIG_BIR_III_2	273	277	PF00653	0.364
LIG_BRCT_BRCA1_1	183	187	PF00533	0.478
LIG_deltaCOP1_diTrp_1	215	223	PF00928	0.408
LIG_FHA_1	103	109	PF00498	0.604
LIG_FHA_1	19	25	PF00498	0.506
LIG_FHA_1	191	197	PF00498	0.381
LIG_FHA_2	17	23	PF00498	0.487
LIG_GBD_Chelix_1	279	287	PF00786	0.369
LIG_GBD_Chelix_1	289	297	PF00786	0.270
LIG_IRF3_LxIS_1	279	286	PF10401	0.346
LIG_LIR_Apic_2	112	118	PF02991	0.665
LIG_LIR_Gen_1	215	224	PF02991	0.409
LIG_LIR_Gen_1	286	296	PF02991	0.477
LIG_LIR_LC3C_4	198	202	PF02991	0.252
LIG_LIR_Nem_3	215	219	PF02991	0.407
LIG_LIR_Nem_3	286	291	PF02991	0.477
LIG_NRBOX	292	298	PF00104	0.333
LIG_Rb_LxCxE_1	26	49	PF01857	0.512
LIG_REV1ctd_RIR_1	112	117	PF16727	0.683
LIG_SH2_CRK	224	228	PF00017	0.413
LIG_SH3_3	143	149	PF00018	0.678
LIG_SH3_3	154	160	PF00018	0.690
LIG_SH3_3	45	51	PF00018	0.504
LIG_SH3_3	83	89	PF00018	0.688
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.301
LIG_SUMO_SIM_par_1	104	109	PF11976	0.604
LIG_SUMO_SIM_par_1	200	206	PF11976	0.369
LIG_TRAF2_1	109	112	PF00917	0.674
LIG_UBA3_1	65	71	PF00899	0.585
LIG_WW_3	156	160	PF00397	0.703
MOD_CK1_1	102	108	PF00069	0.751
MOD_CK1_1	116	122	PF00069	0.616
MOD_CK1_1	262	268	PF00069	0.486
MOD_CK1_1	275	281	PF00069	0.264
MOD_CK2_1	106	112	PF00069	0.606
MOD_CK2_1	16	22	PF00069	0.487
MOD_CK2_1	234	240	PF00069	0.554
MOD_CK2_1	262	268	PF00069	0.520
MOD_CMANNOS	213	216	PF00535	0.612
MOD_DYRK1A_RPxSP_1	250	254	PF00069	0.441
MOD_GlcNHglycan	101	104	PF01048	0.528
MOD_GlcNHglycan	108	111	PF01048	0.497
MOD_GlcNHglycan	118	121	PF01048	0.388
MOD_GlcNHglycan	131	134	PF01048	0.525
MOD_GlcNHglycan	183	186	PF01048	0.469
MOD_GlcNHglycan	219	222	PF01048	0.613
MOD_GlcNHglycan	261	264	PF01048	0.734
MOD_GlcNHglycan	4	7	PF01048	0.448
MOD_GlcNHglycan	42	45	PF01048	0.310
MOD_GlcNHglycan	80	83	PF01048	0.623
MOD_GlcNHglycan	86	89	PF01048	0.518
MOD_GSK3_1	102	109	PF00069	0.723
MOD_GSK3_1	129	136	PF00069	0.700
MOD_GSK3_1	242	249	PF00069	0.599
MOD_GSK3_1	259	266	PF00069	0.514
MOD_GSK3_1	268	275	PF00069	0.511
MOD_GSK3_1	74	81	PF00069	0.680
MOD_GSK3_1	84	91	PF00069	0.656
MOD_N-GLC_1	234	239	PF02516	0.747
MOD_NEK2_1	1	6	PF00069	0.681
MOD_NEK2_1	283	288	PF00069	0.367
MOD_NEK2_2	203	208	PF00069	0.466
MOD_PIKK_1	134	140	PF00454	0.787
MOD_PIKK_1	234	240	PF00454	0.562
MOD_PKA_2	116	122	PF00069	0.686
MOD_PKA_2	129	135	PF00069	0.721
MOD_PKA_2	246	252	PF00069	0.499
MOD_Plk_4	275	281	PF00069	0.288
MOD_ProDKin_1	250	256	PF00069	0.520
MOD_ProDKin_1	272	278	PF00069	0.463
TRG_ENDOCYTIC_2	224	227	PF00928	0.422
TRG_ER_diArg_1	158	161	PF00400	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L3	Leptomonas seymouri	56%	99%
A0A3Q8IKK1	Leishmania donovani	93%	100%
A0A3R7KB29	Trypanosoma rangeli	40%	100%
A4HP59	Leishmania braziliensis	78%	100%
A4IDG5	Leishmania infantum	91%	98%
E9ASW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%