LeishMANIAdb
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Inosine-guanosine transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Inosine-guanosine transporter
Gene product:
inosine-guanosine transporter
Species:
Leishmania major
UniProt:
Q4Q1M9_LEIMA
TriTrypDb:
LmjF.36.1940 , LMJLV39_360026200 * , LMJSD75_360026300
Length:
499

Annotations

LeishMANIAdb annotations

An expanded family of eukaryotic equlibrative nuceloside transporters.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 6
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54

Expansion

Sequence features

Q4Q1M9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1M9

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0015851 nucleobase transport 5 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
GO:0071702 organic substance transport 4 2
GO:0071705 nitrogen compound transport 4 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 54
GO:0005337 nucleoside transmembrane transporter activity 4 54
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 54
GO:0022857 transmembrane transporter activity 2 54
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 54
GO:0015205 nucleobase transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 259 263 PF00656 0.539
CLV_NRD_NRD_1 251 253 PF00675 0.360
CLV_PCSK_KEX2_1 250 252 PF00082 0.368
CLV_PCSK_KEX2_1 343 345 PF00082 0.353
CLV_PCSK_PC1ET2_1 343 345 PF00082 0.309
CLV_PCSK_SKI1_1 111 115 PF00082 0.315
CLV_PCSK_SKI1_1 325 329 PF00082 0.420
CLV_PCSK_SKI1_1 393 397 PF00082 0.360
DOC_CKS1_1 459 464 PF01111 0.533
DOC_MAPK_DCC_7 415 424 PF00069 0.363
DOC_MAPK_DCC_7 427 435 PF00069 0.313
DOC_MAPK_gen_1 343 350 PF00069 0.530
DOC_MAPK_gen_1 399 409 PF00069 0.573
DOC_MAPK_HePTP_8 108 120 PF00069 0.547
DOC_MAPK_MEF2A_6 104 112 PF00069 0.563
DOC_MAPK_MEF2A_6 211 220 PF00069 0.426
DOC_MAPK_MEF2A_6 373 382 PF00069 0.418
DOC_MAPK_MEF2A_6 393 400 PF00069 0.478
DOC_MAPK_MEF2A_6 402 409 PF00069 0.533
DOC_MAPK_MEF2A_6 415 424 PF00069 0.388
DOC_MAPK_MEF2A_6 427 435 PF00069 0.326
DOC_MAPK_NFAT4_5 111 119 PF00069 0.466
DOC_PP1_RVXF_1 209 215 PF00149 0.299
DOC_PP2B_LxvP_1 116 119 PF13499 0.344
DOC_PP2B_PxIxI_1 435 441 PF00149 0.386
DOC_PP4_FxxP_1 368 371 PF00568 0.364
DOC_USP7_MATH_1 295 299 PF00917 0.434
DOC_USP7_MATH_1 371 375 PF00917 0.404
DOC_USP7_MATH_1 47 51 PF00917 0.427
DOC_USP7_UBL2_3 276 280 PF12436 0.437
DOC_WW_Pin1_4 401 406 PF00397 0.511
DOC_WW_Pin1_4 458 463 PF00397 0.500
DOC_WW_Pin1_4 97 102 PF00397 0.438
LIG_14-3-3_CanoR_1 335 339 PF00244 0.594
LIG_Actin_WH2_2 387 404 PF00022 0.431
LIG_BRCT_BRCA1_1 297 301 PF00533 0.422
LIG_CORNRBOX 187 195 PF00104 0.452
LIG_EH_1 233 237 PF12763 0.520
LIG_eIF4E_1 31 37 PF01652 0.379
LIG_eIF4E_1 437 443 PF01652 0.384
LIG_FHA_1 160 166 PF00498 0.548
LIG_FHA_1 266 272 PF00498 0.624
LIG_FHA_1 288 294 PF00498 0.569
LIG_FHA_1 31 37 PF00498 0.372
LIG_FHA_1 322 328 PF00498 0.504
LIG_FHA_1 356 362 PF00498 0.355
LIG_FHA_1 377 383 PF00498 0.393
LIG_FHA_1 43 49 PF00498 0.324
LIG_FHA_1 459 465 PF00498 0.482
LIG_FHA_2 200 206 PF00498 0.237
LIG_FHA_2 22 28 PF00498 0.554
LIG_FHA_2 326 332 PF00498 0.540
LIG_IRF3_LxIS_1 203 210 PF10401 0.238
LIG_LIR_Gen_1 201 209 PF02991 0.327
LIG_LIR_Gen_1 30 39 PF02991 0.341
LIG_LIR_Gen_1 337 347 PF02991 0.608
LIG_LIR_Gen_1 354 364 PF02991 0.259
LIG_LIR_Gen_1 374 385 PF02991 0.377
LIG_LIR_Gen_1 434 445 PF02991 0.419
LIG_LIR_LC3C_4 122 125 PF02991 0.234
LIG_LIR_Nem_3 201 206 PF02991 0.336
LIG_LIR_Nem_3 210 216 PF02991 0.265
LIG_LIR_Nem_3 27 31 PF02991 0.508
LIG_LIR_Nem_3 33 37 PF02991 0.359
LIG_LIR_Nem_3 337 342 PF02991 0.576
LIG_LIR_Nem_3 354 360 PF02991 0.285
LIG_LIR_Nem_3 374 380 PF02991 0.336
LIG_LIR_Nem_3 412 416 PF02991 0.400
LIG_LIR_Nem_3 434 440 PF02991 0.353
LIG_LIR_Nem_3 56 61 PF02991 0.372
LIG_LYPXL_S_1 345 349 PF13949 0.392
LIG_LYPXL_yS_3 346 349 PF13949 0.592
LIG_PCNA_PIPBox_1 378 387 PF02747 0.351
LIG_Pex14_2 169 173 PF04695 0.526
LIG_Pex14_2 353 357 PF04695 0.317
LIG_Pex14_2 363 367 PF04695 0.297
LIG_PTB_Apo_2 444 451 PF02174 0.366
LIG_SH2_CRK 377 381 PF00017 0.299
LIG_SH2_PTP2 437 440 PF00017 0.446
LIG_SH2_STAP1 31 35 PF00017 0.389
LIG_SH2_STAP1 88 92 PF00017 0.435
LIG_SH2_STAT3 88 91 PF00017 0.475
LIG_SH2_STAT5 213 216 PF00017 0.330
LIG_SH2_STAT5 240 243 PF00017 0.542
LIG_SH2_STAT5 437 440 PF00017 0.377
LIG_SH2_STAT5 449 452 PF00017 0.343
LIG_SH2_STAT5 58 61 PF00017 0.355
LIG_SH3_3 397 403 PF00018 0.523
LIG_SH3_3 430 436 PF00018 0.326
LIG_SH3_3 456 462 PF00018 0.575
LIG_SUMO_SIM_anti_2 122 128 PF11976 0.357
LIG_SUMO_SIM_anti_2 182 189 PF11976 0.419
LIG_SUMO_SIM_anti_2 477 483 PF11976 0.385
LIG_SUMO_SIM_par_1 205 210 PF11976 0.358
LIG_SUMO_SIM_par_1 316 322 PF11976 0.542
LIG_SUMO_SIM_par_1 378 383 PF11976 0.417
LIG_SUMO_SIM_par_1 406 412 PF11976 0.547
LIG_TRFH_1 367 371 PF08558 0.359
LIG_TYR_ITIM 435 440 PF00017 0.361
LIG_UBA3_1 397 406 PF00899 0.538
LIG_WRC_WIRS_1 31 36 PF05994 0.303
LIG_WRC_WIRS_1 410 415 PF05994 0.270
MOD_CDK_SPK_2 401 406 PF00069 0.478
MOD_CDK_SPxxK_3 97 104 PF00069 0.432
MOD_CK1_1 198 204 PF00069 0.272
MOD_CK1_1 337 343 PF00069 0.546
MOD_CK1_1 46 52 PF00069 0.431
MOD_CK1_1 477 483 PF00069 0.313
MOD_CK1_1 489 495 PF00069 0.375
MOD_CK2_1 21 27 PF00069 0.569
MOD_CK2_1 325 331 PF00069 0.557
MOD_GlcNHglycan 12 15 PF01048 0.462
MOD_GlcNHglycan 304 307 PF01048 0.409
MOD_GlcNHglycan 373 376 PF01048 0.545
MOD_GlcNHglycan 4 7 PF01048 0.408
MOD_GlcNHglycan 45 48 PF01048 0.394
MOD_GlcNHglycan 476 479 PF01048 0.362
MOD_GlcNHglycan 49 52 PF01048 0.597
MOD_GSK3_1 195 202 PF00069 0.312
MOD_GSK3_1 321 328 PF00069 0.561
MOD_GSK3_1 351 358 PF00069 0.396
MOD_GSK3_1 376 383 PF00069 0.399
MOD_GSK3_1 42 49 PF00069 0.371
MOD_GSK3_1 489 496 PF00069 0.466
MOD_GSK3_1 91 98 PF00069 0.410
MOD_N-GLC_1 325 330 PF02516 0.327
MOD_N-GLC_1 489 494 PF02516 0.458
MOD_NEK2_1 102 107 PF00069 0.554
MOD_NEK2_1 157 162 PF00069 0.384
MOD_NEK2_1 186 191 PF00069 0.358
MOD_NEK2_1 195 200 PF00069 0.326
MOD_NEK2_1 207 212 PF00069 0.271
MOD_NEK2_1 321 326 PF00069 0.563
MOD_NEK2_1 334 339 PF00069 0.531
MOD_NEK2_1 356 361 PF00069 0.395
MOD_NEK2_1 37 42 PF00069 0.352
MOD_NEK2_1 43 48 PF00069 0.365
MOD_NEK2_1 443 448 PF00069 0.436
MOD_NEK2_1 493 498 PF00069 0.501
MOD_NEK2_1 8 13 PF00069 0.675
MOD_NEK2_2 351 356 PF00069 0.433
MOD_PIKK_1 133 139 PF00454 0.415
MOD_PKA_2 334 340 PF00069 0.570
MOD_Plk_1 468 474 PF00069 0.514
MOD_Plk_1 489 495 PF00069 0.468
MOD_Plk_4 179 185 PF00069 0.428
MOD_Plk_4 186 192 PF00069 0.359
MOD_Plk_4 30 36 PF00069 0.363
MOD_Plk_4 334 340 PF00069 0.507
MOD_Plk_4 356 362 PF00069 0.331
MOD_Plk_4 37 43 PF00069 0.380
MOD_Plk_4 376 382 PF00069 0.364
MOD_Plk_4 78 84 PF00069 0.336
MOD_ProDKin_1 401 407 PF00069 0.511
MOD_ProDKin_1 458 464 PF00069 0.500
MOD_ProDKin_1 97 103 PF00069 0.434
MOD_SUMO_rev_2 256 266 PF00179 0.528
TRG_DiLeu_BaLyEn_6 417 422 PF01217 0.412
TRG_ENDOCYTIC_2 213 216 PF00928 0.305
TRG_ENDOCYTIC_2 233 236 PF00928 0.526
TRG_ENDOCYTIC_2 31 34 PF00928 0.365
TRG_ENDOCYTIC_2 346 349 PF00928 0.573
TRG_ENDOCYTIC_2 377 380 PF00928 0.271
TRG_ENDOCYTIC_2 437 440 PF00928 0.408
TRG_ER_diArg_1 249 252 PF00400 0.577

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P486 Leptomonas seymouri 32% 100%
A0A0N0P6Z5 Leptomonas seymouri 68% 100%
A0A0N1I1J0 Leptomonas seymouri 30% 100%
A0A0N1I8E8 Leptomonas seymouri 26% 100%
A0A0N1PBQ1 Leptomonas seymouri 33% 99%
A0A0S4JBS4 Bodo saltans 32% 100%
A0A1X0NN91 Trypanosomatidae 33% 100%
A0A1X0NPL0 Trypanosomatidae 35% 100%
A0A1X0NV38 Trypanosomatidae 34% 100%
A0A1X0NWJ5 Trypanosomatidae 32% 100%
A0A3Q8ICX7 Leishmania donovani 33% 100%
A0A3R7NQR3 Trypanosoma rangeli 34% 100%
A0A3S7WTL0 Leishmania donovani 31% 100%
A0A3S7XAS5 Leishmania donovani 95% 100%
A0A422MQ08 Trypanosoma rangeli 33% 100%
A0A422N8M2 Trypanosoma rangeli 45% 100%
A0A422NHH9 Trypanosoma rangeli 46% 100%
A0A422NR81 Trypanosoma rangeli 30% 100%
A1L272 Danio rerio 24% 96%
A4H6I0 Leishmania braziliensis 31% 90%
A4H7A5 Leishmania braziliensis 34% 100%
A4HG96 Leishmania braziliensis 26% 99%
A4HP60 Leishmania braziliensis 79% 100%
A4HUW2 Leishmania infantum 33% 91%
A4HVP9 Leishmania infantum 33% 100%
A4HWK9 Leishmania infantum 31% 100%
A4IDG6 Leishmania infantum 95% 100%
C9ZJU3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZJU5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZJU7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 100%
C9ZKT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZN88 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
C9ZY31 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
C9ZZR9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 100%
D0A6J2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A6J4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A6J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AGM5 Leishmania infantum 31% 100%
E9AGM6 Leishmania infantum 31% 100%
E9AGM7 Leishmania infantum 31% 100%
E9ANK1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 91%
E9APE5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AQB5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AQB6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9ASW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
O76343 Leishmania donovani 32% 100%
Q4QF58 Leishmania major 32% 100%
Q4QF59 Leishmania major 32% 76%
Q4QG33 Leishmania major 31% 100%
Q4QH25 Leishmania major 32% 91%
Q7RTT9 Homo sapiens 23% 94%
V5BGB1 Trypanosoma cruzi 35% 100%
V5BRM5 Trypanosoma cruzi 33% 100%
V5DSF4 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS