Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1M2_LEIMA

TriTrypDb:

LmjF.36.2010 , LMJLV39_360027300 , LMJSD75_360027500

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1M2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1M2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.518
CLV_C14_Caspase3-7	64	68	PF00656	0.651
CLV_NRD_NRD_1	116	118	PF00675	0.563
CLV_NRD_NRD_1	134	136	PF00675	0.592
CLV_NRD_NRD_1	254	256	PF00675	0.558
CLV_PCSK_FUR_1	114	118	PF00082	0.374
CLV_PCSK_KEX2_1	116	118	PF00082	0.531
CLV_PCSK_KEX2_1	134	136	PF00082	0.599
CLV_PCSK_KEX2_1	254	256	PF00082	0.533
CLV_PCSK_SKI1_1	223	227	PF00082	0.608
CLV_PCSK_SKI1_1	352	356	PF00082	0.587
DEG_APCC_DBOX_1	115	123	PF00400	0.585
DEG_APCC_DBOX_1	246	254	PF00400	0.618
DEG_Nend_UBRbox_1	1	4	PF02207	0.698
DOC_CYCLIN_RxL_1	140	154	PF00134	0.343
DOC_MAPK_MEF2A_6	73	80	PF00069	0.682
DOC_USP7_MATH_1	232	236	PF00917	0.631
DOC_USP7_MATH_1	277	281	PF00917	0.568
DOC_USP7_MATH_1	69	73	PF00917	0.540
DOC_WW_Pin1_4	35	40	PF00397	0.651
DOC_WW_Pin1_4	6	11	PF00397	0.776
LIG_14-3-3_CanoR_1	170	180	PF00244	0.344
LIG_14-3-3_CanoR_1	58	63	PF00244	0.601
LIG_14-3-3_CanoR_1	73	79	PF00244	0.706
LIG_14-3-3_CanoR_1	97	105	PF00244	0.748
LIG_Actin_WH2_2	112	129	PF00022	0.561
LIG_BRCT_BRCA1_1	41	45	PF00533	0.705
LIG_FHA_1	100	106	PF00498	0.776
LIG_FHA_1	107	113	PF00498	0.679
LIG_FHA_1	121	127	PF00498	0.578
LIG_FHA_1	23	29	PF00498	0.573
LIG_FHA_1	328	334	PF00498	0.494
LIG_FHA_2	236	242	PF00498	0.627
LIG_FHA_2	62	68	PF00498	0.755
LIG_FHA_2	83	89	PF00498	0.553
LIG_LIR_Gen_1	145	153	PF02991	0.598
LIG_LIR_Gen_1	27	37	PF02991	0.629
LIG_LIR_Gen_1	330	340	PF02991	0.494
LIG_LIR_Nem_3	145	150	PF02991	0.609
LIG_LIR_Nem_3	27	32	PF02991	0.746
LIG_LIR_Nem_3	330	335	PF02991	0.544
LIG_MYND_1	317	321	PF01753	0.631
LIG_PCNA_PIPBox_1	279	288	PF02747	0.603
LIG_PCNA_yPIPBox_3	278	286	PF02747	0.529
LIG_Rb_LxCxE_1	166	186	PF01857	0.534
LIG_SH2_CRK	344	348	PF00017	0.439
LIG_SH2_STAT5	285	288	PF00017	0.582
LIG_SH2_STAT5	294	297	PF00017	0.485
LIG_SH3_3	303	309	PF00018	0.467
LIG_SH3_3	311	317	PF00018	0.482
LIG_SH3_3	330	336	PF00018	0.375
LIG_SH3_3	41	47	PF00018	0.728
LIG_SH3_3	63	69	PF00018	0.756
LIG_SH3_3	8	14	PF00018	0.692
LIG_SH3_3	88	94	PF00018	0.703
LIG_SUMO_SIM_par_1	74	79	PF11976	0.649
LIG_SUMO_SIM_par_1	87	95	PF11976	0.546
LIG_TRAF2_1	163	166	PF00917	0.329
LIG_TRAF2_1	263	266	PF00917	0.618
LIG_TRAF2_1	85	88	PF00917	0.601
LIG_TRFH_1	332	336	PF08558	0.474
LIG_TRFH_1	344	348	PF08558	0.439
MOD_CDK_SPxxK_3	6	13	PF00069	0.641
MOD_CK1_1	100	106	PF00069	0.658
MOD_CK1_1	151	157	PF00069	0.548
MOD_CK1_1	235	241	PF00069	0.623
MOD_CK1_1	27	33	PF00069	0.565
MOD_CK1_1	38	44	PF00069	0.656
MOD_CK2_1	160	166	PF00069	0.469
MOD_CK2_1	214	220	PF00069	0.521
MOD_CK2_1	235	241	PF00069	0.630
MOD_CK2_1	260	266	PF00069	0.622
MOD_CK2_1	82	88	PF00069	0.551
MOD_GlcNHglycan	234	237	PF01048	0.587
MOD_GlcNHglycan	256	259	PF01048	0.549
MOD_GlcNHglycan	272	275	PF01048	0.337
MOD_GlcNHglycan	41	44	PF01048	0.662
MOD_GSK3_1	160	167	PF00069	0.590
MOD_GSK3_1	228	235	PF00069	0.616
MOD_GSK3_1	35	42	PF00069	0.685
MOD_GSK3_1	97	104	PF00069	0.656
MOD_N-GLC_1	106	111	PF02516	0.670
MOD_N-GLC_1	151	156	PF02516	0.518
MOD_N-GLC_1	6	11	PF02516	0.687
MOD_NEK2_1	253	258	PF00069	0.591
MOD_PIKK_1	225	231	PF00454	0.592
MOD_PIKK_1	268	274	PF00454	0.506
MOD_PIKK_1	321	327	PF00454	0.614
MOD_PKA_1	254	260	PF00069	0.414
MOD_PKA_2	253	259	PF00069	0.615
MOD_PKA_2	98	104	PF00069	0.700
MOD_PKB_1	97	105	PF00069	0.733
MOD_Plk_4	24	30	PF00069	0.621
MOD_Plk_4	61	67	PF00069	0.627
MOD_ProDKin_1	35	41	PF00069	0.656
MOD_ProDKin_1	6	12	PF00069	0.777
MOD_SUMO_rev_2	120	129	PF00179	0.398
MOD_SUMO_rev_2	204	213	PF00179	0.531
MOD_SUMO_rev_2	259	269	PF00179	0.629
MOD_SUMO_rev_2	357	363	PF00179	0.535
TRG_DiLeu_BaEn_2	327	333	PF01217	0.552
TRG_DiLeu_BaEn_4	241	247	PF01217	0.596
TRG_DiLeu_BaLyEn_6	154	159	PF01217	0.588
TRG_DiLeu_BaLyEn_6	167	172	PF01217	0.426
TRG_ENDOCYTIC_2	344	347	PF00928	0.433
TRG_ER_diArg_1	114	117	PF00400	0.589
TRG_ER_diArg_1	253	255	PF00400	0.557
TRG_ER_diArg_1	57	60	PF00400	0.757
TRG_ER_diArg_1	96	99	PF00400	0.670
TRG_ER_diLys_1	362	367	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	170	175	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6L0	Leptomonas seymouri	46%	100%
A0A1X0P8R8	Trypanosomatidae	31%	100%
A0A3Q8INP8	Leishmania donovani	90%	100%
A4HP68	Leishmania braziliensis	73%	100%
A4IDH3	Leishmania infantum	91%	100%
D0A360	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9ASX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
V5BGD4	Trypanosoma cruzi	33%	100%