WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1L9_LEIMA

TriTrypDb:

LmjF.36.2035 , LMJLV39_360027600 , LMJSD75_360027800

Length:

682

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	2
GO:0000152	nuclear ubiquitin ligase complex	3	2
GO:0005680	anaphase-promoting complex	4	2
GO:0031461	cullin-RING ubiquitin ligase complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990234	transferase complex	3	2

Expansion

Sequence features

Q4Q1L9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009893	positive regulation of metabolic process	4	7
GO:0009894	regulation of catabolic process	4	2
GO:0009896	positive regulation of catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0010604	positive regulation of macromolecule metabolic process	5	7
GO:0019222	regulation of metabolic process	3	7
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030162	regulation of proteolysis	6	2
GO:0030163	protein catabolic process	4	2
GO:0031145	anaphase-promoting complex-dependent catabolic process	7	2
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031325	positive regulation of cellular metabolic process	5	2
GO:0031329	regulation of cellular catabolic process	5	2
GO:0031331	positive regulation of cellular catabolic process	6	2
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process	7	2
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	8	2
GO:0042176	regulation of protein catabolic process	5	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0045732	positive regulation of protein catabolic process	6	2
GO:0045862	positive regulation of proteolysis	7	2
GO:0048518	positive regulation of biological process	3	7
GO:0048522	positive regulation of cellular process	4	2
GO:0050789	regulation of biological process	2	7
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	7
GO:0051173	positive regulation of nitrogen compound metabolic process	5	7
GO:0051246	regulation of protein metabolic process	5	7
GO:0051247	positive regulation of protein metabolic process	6	7
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	7
GO:0061136	regulation of proteasomal protein catabolic process	6	2
GO:0065007	biological regulation	1	7
GO:0071704	organic substance metabolic process	2	2
GO:0080090	regulation of primary metabolic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901800	positive regulation of proteasomal protein catabolic process	7	2
GO:1903050	regulation of proteolysis involved in protein catabolic process	7	2
GO:1903052	positive regulation of proteolysis involved in protein catabolic process	8	2
GO:1905784	regulation of anaphase-promoting complex-dependent catabolic process	8	2
GO:1905786	positive regulation of anaphase-promoting complex-dependent catabolic process	9	2
GO:2000058	regulation of ubiquitin-dependent protein catabolic process	6	2
GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	7	2
GO:0031396	regulation of protein ubiquitination	8	5
GO:0031398	positive regulation of protein ubiquitination	9	5
GO:0031399	regulation of protein modification process	6	5
GO:0031401	positive regulation of protein modification process	7	5
GO:0043085	positive regulation of catalytic activity	4	5
GO:0044093	positive regulation of molecular function	3	5
GO:0050790	regulation of catalytic activity	3	5
GO:0051338	regulation of transferase activity	4	5
GO:0051347	positive regulation of transferase activity	5	5
GO:0051438	regulation of ubiquitin-protein transferase activity	5	5
GO:0051443	positive regulation of ubiquitin-protein transferase activity	6	5
GO:0065009	regulation of molecular function	2	5
GO:1903320	regulation of protein modification by small protein conjugation or removal	7	5
GO:1903322	positive regulation of protein modification by small protein conjugation or removal	8	5
GO:1904666	regulation of ubiquitin protein ligase activity	6	5
GO:1904668	positive regulation of ubiquitin protein ligase activity	7	5

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0008047	enzyme activator activity	3	7
GO:0010997	anaphase-promoting complex binding	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0044877	protein-containing complex binding	2	7
GO:0055106	ubiquitin-protein transferase regulator activity	3	7
GO:0097027	ubiquitin-protein transferase activator activity	4	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7
GO:1990757	ubiquitin ligase activator activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.642
CLV_C14_Caspase3-7	649	653	PF00656	0.497
CLV_NRD_NRD_1	129	131	PF00675	0.433
CLV_NRD_NRD_1	290	292	PF00675	0.327
CLV_NRD_NRD_1	543	545	PF00675	0.783
CLV_NRD_NRD_1	659	661	PF00675	0.574
CLV_PCSK_KEX2_1	129	131	PF00082	0.433
CLV_PCSK_KEX2_1	542	544	PF00082	0.727
CLV_PCSK_KEX2_1	659	661	PF00082	0.575
CLV_PCSK_PC7_1	539	545	PF00082	0.560
CLV_PCSK_SKI1_1	129	133	PF00082	0.423
CLV_PCSK_SKI1_1	533	537	PF00082	0.570
CLV_PCSK_SKI1_1	613	617	PF00082	0.470
DEG_Nend_UBRbox_1	1	4	PF02207	0.639
DEG_SPOP_SBC_1	217	221	PF00917	0.553
DEG_SPOP_SBC_1	263	267	PF00917	0.600
DEG_SPOP_SBC_1	375	379	PF00917	0.402
DEG_SPOP_SBC_1	408	412	PF00917	0.671
DEG_SPOP_SBC_1	455	459	PF00917	0.644
DOC_CKS1_1	104	109	PF01111	0.625
DOC_CKS1_1	676	681	PF01111	0.571
DOC_CYCLIN_RxL_1	199	210	PF00134	0.624
DOC_MAPK_MEF2A_6	242	250	PF00069	0.493
DOC_PP1_RVXF_1	164	171	PF00149	0.531
DOC_PP1_RVXF_1	339	346	PF00149	0.503
DOC_PP2B_LxvP_1	32	35	PF13499	0.604
DOC_PP2B_LxvP_1	322	325	PF13499	0.479
DOC_PP2B_LxvP_1	413	416	PF13499	0.609
DOC_PP4_FxxP_1	125	128	PF00568	0.519
DOC_PP4_FxxP_1	170	173	PF00568	0.475
DOC_PP4_MxPP_1	172	175	PF00568	0.607
DOC_USP7_MATH_1	10	14	PF00917	0.698
DOC_USP7_MATH_1	22	26	PF00917	0.585
DOC_USP7_MATH_1	263	267	PF00917	0.632
DOC_USP7_MATH_1	270	274	PF00917	0.621
DOC_USP7_MATH_1	303	307	PF00917	0.492
DOC_USP7_MATH_1	309	313	PF00917	0.492
DOC_USP7_MATH_1	35	39	PF00917	0.702
DOC_USP7_MATH_1	408	412	PF00917	0.614
DOC_USP7_MATH_1	455	459	PF00917	0.680
DOC_USP7_MATH_1	498	502	PF00917	0.702
DOC_USP7_MATH_1	509	513	PF00917	0.538
DOC_WW_Pin1_4	103	108	PF00397	0.611
DOC_WW_Pin1_4	12	17	PF00397	0.664
DOC_WW_Pin1_4	192	197	PF00397	0.632
DOC_WW_Pin1_4	346	351	PF00397	0.531
DOC_WW_Pin1_4	404	409	PF00397	0.594
DOC_WW_Pin1_4	480	485	PF00397	0.756
DOC_WW_Pin1_4	621	626	PF00397	0.511
DOC_WW_Pin1_4	675	680	PF00397	0.565
LIG_14-3-3_CanoR_1	129	136	PF00244	0.413
LIG_14-3-3_CanoR_1	208	217	PF00244	0.459
LIG_14-3-3_CanoR_1	21	27	PF00244	0.743
LIG_14-3-3_CanoR_1	234	240	PF00244	0.468
LIG_14-3-3_CanoR_1	264	269	PF00244	0.750
LIG_14-3-3_CanoR_1	285	290	PF00244	0.655
LIG_14-3-3_CanoR_1	295	300	PF00244	0.461
LIG_14-3-3_CanoR_1	327	333	PF00244	0.458
LIG_14-3-3_CanoR_1	40	48	PF00244	0.464
LIG_14-3-3_CanoR_1	447	453	PF00244	0.664
LIG_14-3-3_CanoR_1	50	56	PF00244	0.559
LIG_14-3-3_CanoR_1	96	104	PF00244	0.510
LIG_Actin_WH2_2	564	582	PF00022	0.551
LIG_BRCT_BRCA1_1	121	125	PF00533	0.574
LIG_Clathr_ClatBox_1	236	240	PF01394	0.422
LIG_eIF4E_1	531	537	PF01652	0.688
LIG_EVH1_1	413	417	PF00568	0.536
LIG_EVH1_2	414	418	PF00568	0.536
LIG_FHA_1	15	21	PF00498	0.711
LIG_FHA_1	175	181	PF00498	0.525
LIG_FHA_1	302	308	PF00498	0.502
LIG_FHA_1	329	335	PF00498	0.544
LIG_FHA_1	364	370	PF00498	0.426
LIG_FHA_1	385	391	PF00498	0.436
LIG_FHA_1	490	496	PF00498	0.604
LIG_FHA_1	67	73	PF00498	0.422
LIG_FHA_1	676	682	PF00498	0.579
LIG_FHA_1	74	80	PF00498	0.404
LIG_FHA_1	99	105	PF00498	0.499
LIG_FHA_2	22	28	PF00498	0.627
LIG_FHA_2	250	256	PF00498	0.725
LIG_FHA_2	647	653	PF00498	0.512
LIG_FHA_2	666	672	PF00498	0.557
LIG_GBD_Chelix_1	79	87	PF00786	0.308
LIG_HP1_1	350	354	PF01393	0.481
LIG_Integrin_RGD_1	159	161	PF01839	0.509
LIG_LIR_Apic_2	122	128	PF02991	0.546
LIG_LIR_Apic_2	167	173	PF02991	0.481
LIG_LIR_Gen_1	349	359	PF02991	0.411
LIG_LIR_Gen_1	52	63	PF02991	0.461
LIG_LIR_Nem_3	349	354	PF02991	0.397
LIG_LIR_Nem_3	52	58	PF02991	0.480
LIG_LIR_Nem_3	640	646	PF02991	0.591
LIG_OCRL_FandH_1	288	300	PF00620	0.389
LIG_PCNA_PIPBox_1	326	335	PF02747	0.420
LIG_Pex14_1	601	605	PF04695	0.717
LIG_Pex14_2	643	647	PF04695	0.504
LIG_SH2_CRK	55	59	PF00017	0.465
LIG_SH2_CRK	605	609	PF00017	0.724
LIG_SH2_CRK	630	634	PF00017	0.459
LIG_SH2_NCK_1	605	609	PF00017	0.724
LIG_SH2_NCK_1	630	634	PF00017	0.577
LIG_SH2_PTP2	351	354	PF00017	0.539
LIG_SH2_STAP1	630	634	PF00017	0.459
LIG_SH2_STAP1	68	72	PF00017	0.417
LIG_SH2_STAT5	179	182	PF00017	0.542
LIG_SH2_STAT5	351	354	PF00017	0.539
LIG_SH2_STAT5	531	534	PF00017	0.753
LIG_SH2_STAT5	55	58	PF00017	0.461
LIG_SH2_STAT5	68	71	PF00017	0.423
LIG_SH3_3	16	22	PF00018	0.642
LIG_SH3_3	170	176	PF00018	0.490
LIG_SH3_3	322	328	PF00018	0.480
LIG_SH3_3	344	350	PF00018	0.399
LIG_SH3_3	402	408	PF00018	0.630
LIG_SH3_3	411	417	PF00018	0.585
LIG_SH3_3	478	484	PF00018	0.696
LIG_SH3_3	619	625	PF00018	0.502
LIG_SH3_3	89	95	PF00018	0.457
LIG_SUMO_SIM_par_1	235	240	PF11976	0.427
LIG_TRAF2_1	668	671	PF00917	0.557
LIG_TRAF2_1	82	85	PF00917	0.552
LIG_WRC_WIRS_1	329	334	PF05994	0.425
MOD_CDK_SPxxK_3	192	199	PF00069	0.575
MOD_CDK_SPxxK_3	675	682	PF00069	0.572
MOD_CK1_1	195	201	PF00069	0.626
MOD_CK1_1	209	215	PF00069	0.327
MOD_CK1_1	228	234	PF00069	0.353
MOD_CK1_1	25	31	PF00069	0.730
MOD_CK1_1	266	272	PF00069	0.629
MOD_CK1_1	274	280	PF00069	0.629
MOD_CK1_1	39	45	PF00069	0.530
MOD_CK1_1	407	413	PF00069	0.625
MOD_CK1_1	448	454	PF00069	0.653
MOD_CK1_1	457	463	PF00069	0.654
MOD_CK1_1	483	489	PF00069	0.704
MOD_CK1_1	501	507	PF00069	0.585
MOD_CK1_1	651	657	PF00069	0.515
MOD_CK1_1	666	672	PF00069	0.559
MOD_CK1_1	70	76	PF00069	0.404
MOD_CK2_1	21	27	PF00069	0.631
MOD_CK2_1	249	255	PF00069	0.547
MOD_CK2_1	367	373	PF00069	0.451
MOD_CK2_1	471	477	PF00069	0.761
MOD_CK2_1	665	671	PF00069	0.528
MOD_GlcNHglycan	121	124	PF01048	0.719
MOD_GlcNHglycan	125	128	PF01048	0.594
MOD_GlcNHglycan	227	230	PF01048	0.535
MOD_GlcNHglycan	268	271	PF01048	0.590
MOD_GlcNHglycan	272	276	PF01048	0.698
MOD_GlcNHglycan	311	314	PF01048	0.298
MOD_GlcNHglycan	322	325	PF01048	0.470
MOD_GlcNHglycan	357	360	PF01048	0.467
MOD_GlcNHglycan	368	372	PF01048	0.452
MOD_GlcNHglycan	433	436	PF01048	0.737
MOD_GlcNHglycan	453	456	PF01048	0.533
MOD_GlcNHglycan	459	462	PF01048	0.656
MOD_GlcNHglycan	464	467	PF01048	0.593
MOD_GlcNHglycan	485	488	PF01048	0.768
MOD_GlcNHglycan	502	506	PF01048	0.558
MOD_GlcNHglycan	511	514	PF01048	0.657
MOD_GlcNHglycan	58	61	PF01048	0.445
MOD_GlcNHglycan	665	668	PF01048	0.569
MOD_GSK3_1	10	17	PF00069	0.650
MOD_GSK3_1	112	119	PF00069	0.626
MOD_GSK3_1	160	167	PF00069	0.579
MOD_GSK3_1	174	181	PF00069	0.439
MOD_GSK3_1	2	9	PF00069	0.730
MOD_GSK3_1	206	213	PF00069	0.457
MOD_GSK3_1	21	28	PF00069	0.680
MOD_GSK3_1	262	269	PF00069	0.644
MOD_GSK3_1	270	277	PF00069	0.613
MOD_GSK3_1	297	304	PF00069	0.492
MOD_GSK3_1	307	314	PF00069	0.492
MOD_GSK3_1	35	42	PF00069	0.609
MOD_GSK3_1	363	370	PF00069	0.417
MOD_GSK3_1	375	382	PF00069	0.476
MOD_GSK3_1	404	411	PF00069	0.632
MOD_GSK3_1	427	434	PF00069	0.562
MOD_GSK3_1	447	454	PF00069	0.659
MOD_GSK3_1	46	53	PF00069	0.524
MOD_GSK3_1	462	469	PF00069	0.656
MOD_GSK3_1	485	492	PF00069	0.639
MOD_GSK3_1	500	507	PF00069	0.626
MOD_GSK3_1	558	565	PF00069	0.733
MOD_GSK3_1	647	654	PF00069	0.630
MOD_GSK3_1	66	73	PF00069	0.274
MOD_GSK3_1	98	105	PF00069	0.503
MOD_LATS_1	293	299	PF00433	0.576
MOD_LATS_1	94	100	PF00433	0.512
MOD_N-GLC_1	301	306	PF02516	0.292
MOD_N-GLC_1	544	549	PF02516	0.602
MOD_NEK2_1	139	144	PF00069	0.465
MOD_NEK2_1	146	151	PF00069	0.379
MOD_NEK2_1	164	169	PF00069	0.538
MOD_NEK2_1	206	211	PF00069	0.488
MOD_NEK2_1	30	35	PF00069	0.728
MOD_NEK2_1	307	312	PF00069	0.497
MOD_NEK2_1	376	381	PF00069	0.530
MOD_NEK2_1	427	432	PF00069	0.731
MOD_NEK2_1	471	476	PF00069	0.591
MOD_NEK2_1	489	494	PF00069	0.619
MOD_NEK2_1	51	56	PF00069	0.471
MOD_NEK2_1	579	584	PF00069	0.756
MOD_NEK2_1	646	651	PF00069	0.505
MOD_NEK2_1	67	72	PF00069	0.425
MOD_PIKK_1	10	16	PF00454	0.699
MOD_PIKK_1	384	390	PF00454	0.442
MOD_PIKK_1	666	672	PF00454	0.559
MOD_PK_1	264	270	PF00069	0.695
MOD_PK_1	295	301	PF00069	0.492
MOD_PKA_1	129	135	PF00069	0.416
MOD_PKA_1	543	549	PF00069	0.728
MOD_PKA_2	102	108	PF00069	0.581
MOD_PKA_2	129	135	PF00069	0.416
MOD_PKA_2	20	26	PF00069	0.630
MOD_PKA_2	207	213	PF00069	0.485
MOD_PKA_2	263	269	PF00069	0.695
MOD_PKA_2	39	45	PF00069	0.616
MOD_PKA_2	446	452	PF00069	0.655
MOD_PKA_2	49	55	PF00069	0.465
MOD_PKA_2	543	549	PF00069	0.728
MOD_PKA_2	579	585	PF00069	0.682
MOD_PKB_1	542	550	PF00069	0.586
MOD_Plk_1	140	146	PF00069	0.415
MOD_Plk_1	271	277	PF00069	0.663
MOD_Plk_1	336	342	PF00069	0.420
MOD_Plk_1	580	586	PF00069	0.803
MOD_Plk_1	651	657	PF00069	0.655
MOD_Plk_2-3	558	564	PF00069	0.713
MOD_Plk_4	179	185	PF00069	0.544
MOD_Plk_4	25	31	PF00069	0.695
MOD_Plk_4	285	291	PF00069	0.740
MOD_Plk_4	303	309	PF00069	0.492
MOD_Plk_4	328	334	PF00069	0.429
MOD_Plk_4	42	48	PF00069	0.532
MOD_Plk_4	466	472	PF00069	0.790
MOD_Plk_4	580	586	PF00069	0.692
MOD_ProDKin_1	103	109	PF00069	0.621
MOD_ProDKin_1	12	18	PF00069	0.664
MOD_ProDKin_1	192	198	PF00069	0.621
MOD_ProDKin_1	346	352	PF00069	0.525
MOD_ProDKin_1	404	410	PF00069	0.603
MOD_ProDKin_1	480	486	PF00069	0.757
MOD_ProDKin_1	621	627	PF00069	0.511
MOD_ProDKin_1	675	681	PF00069	0.568
TRG_DiLeu_BaEn_1	671	676	PF01217	0.550
TRG_DiLeu_BaEn_2	140	146	PF01217	0.415
TRG_DiLeu_BaLyEn_6	611	616	PF01217	0.485
TRG_ENDOCYTIC_2	351	354	PF00928	0.408
TRG_ENDOCYTIC_2	55	58	PF00928	0.461
TRG_ENDOCYTIC_2	630	633	PF00928	0.461
TRG_ER_diArg_1	128	130	PF00400	0.474
TRG_ER_diArg_1	542	544	PF00400	0.703
TRG_ER_diArg_1	611	614	PF00400	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZD9	Leptomonas seymouri	57%	89%
A0A3S7XAS2	Leishmania donovani	94%	100%
A4HP71	Leishmania braziliensis	80%	90%
A4IDH6	Leishmania infantum	94%	100%
E9ASX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%