Putative dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q1L8_LEIMA

TriTrypDb:

LmjF.36.2040 , LMJLV39_360027700 , LMJSD75_360027900

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q1L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L8

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	2
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	2
GO:0006629	lipid metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043413	macromolecule glycosylation	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044255	cellular lipid metabolic process	3	2
GO:0070085	glycosylation	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	12
GO:0000033	alpha-1,3-mannosyltransferase activity	6	3
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0052925	dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	7	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	296	298	PF00675	0.350
CLV_NRD_NRD_1	303	305	PF00675	0.358
CLV_PCSK_KEX2_1	118	120	PF00082	0.247
CLV_PCSK_KEX2_1	154	156	PF00082	0.497
CLV_PCSK_KEX2_1	296	298	PF00082	0.350
CLV_PCSK_KEX2_1	303	305	PF00082	0.351
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.259
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.552
CLV_PCSK_SKI1_1	231	235	PF00082	0.442
CLV_PCSK_SKI1_1	47	51	PF00082	0.498
DEG_MDM2_SWIB_1	129	136	PF02201	0.334
DEG_Nend_UBRbox_1	1	4	PF02207	0.611
DEG_SCF_FBW7_1	385	391	PF00400	0.333
DOC_AGCK_PIF_2	214	219	PF00069	0.213
DOC_ANK_TNKS_1	303	310	PF00023	0.497
DOC_CKS1_1	298	303	PF01111	0.386
DOC_CKS1_1	385	390	PF01111	0.333
DOC_CYCLIN_RxL_1	364	373	PF00134	0.369
DOC_MAPK_gen_1	118	128	PF00069	0.471
DOC_MAPK_gen_1	74	81	PF00069	0.352
DOC_MAPK_MEF2A_6	109	116	PF00069	0.435
DOC_MAPK_NFAT4_5	109	117	PF00069	0.432
DOC_PP1_RVXF_1	193	199	PF00149	0.550
DOC_PP1_RVXF_1	368	375	PF00149	0.378
DOC_PP2B_LxvP_1	178	181	PF13499	0.300
DOC_PP2B_LxvP_1	20	23	PF13499	0.408
DOC_PP4_FxxP_1	249	252	PF00568	0.288
DOC_USP7_MATH_1	140	144	PF00917	0.369
DOC_USP7_MATH_1	153	157	PF00917	0.179
DOC_USP7_MATH_1	388	392	PF00917	0.256
DOC_WW_Pin1_4	297	302	PF00397	0.519
DOC_WW_Pin1_4	384	389	PF00397	0.333
LIG_14-3-3_CanoR_1	103	109	PF00244	0.540
LIG_14-3-3_CanoR_1	119	124	PF00244	0.395
LIG_14-3-3_CanoR_1	236	240	PF00244	0.316
LIG_14-3-3_CanoR_1	277	287	PF00244	0.542
LIG_14-3-3_CanoR_1	370	375	PF00244	0.400
LIG_Actin_WH2_2	37	52	PF00022	0.352
LIG_APCC_ABBA_1	126	131	PF00400	0.300
LIG_BIR_III_4	439	443	PF00653	0.601
LIG_BRCT_BRCA1_1	223	227	PF00533	0.308
LIG_deltaCOP1_diTrp_1	131	139	PF00928	0.357
LIG_DLG_GKlike_1	119	126	PF00625	0.472
LIG_eIF4E_1	86	92	PF01652	0.447
LIG_EVH1_1	384	388	PF00568	0.333
LIG_FHA_1	15	21	PF00498	0.330
LIG_FHA_1	263	269	PF00498	0.420
LIG_FHA_1	51	57	PF00498	0.247
LIG_FHA_1	91	97	PF00498	0.319
LIG_FHA_2	23	29	PF00498	0.247
LIG_FHA_2	279	285	PF00498	0.533
LIG_FHA_2	310	316	PF00498	0.460
LIG_FHA_2	327	333	PF00498	0.434
LIG_FHA_2	415	421	PF00498	0.715
LIG_FHA_2	439	445	PF00498	0.764
LIG_LIR_Apic_2	247	252	PF02991	0.290
LIG_LIR_Gen_1	131	141	PF02991	0.334
LIG_LIR_Gen_1	21	32	PF02991	0.413
LIG_LIR_Gen_1	238	249	PF02991	0.308
LIG_LIR_Gen_1	373	381	PF02991	0.458
LIG_LIR_Gen_1	401	408	PF02991	0.361
LIG_LIR_Nem_3	131	136	PF02991	0.323
LIG_LIR_Nem_3	190	196	PF02991	0.456
LIG_LIR_Nem_3	21	27	PF02991	0.333
LIG_LIR_Nem_3	218	222	PF02991	0.186
LIG_LIR_Nem_3	238	244	PF02991	0.238
LIG_LIR_Nem_3	265	269	PF02991	0.303
LIG_LIR_Nem_3	28	32	PF02991	0.241
LIG_LIR_Nem_3	343	349	PF02991	0.451
LIG_LIR_Nem_3	350	356	PF02991	0.292
LIG_LIR_Nem_3	363	368	PF02991	0.385
LIG_LIR_Nem_3	373	377	PF02991	0.382
LIG_LIR_Nem_3	401	406	PF02991	0.395
LIG_LIR_Nem_3	43	49	PF02991	0.233
LIG_NRP_CendR_1	445	447	PF00754	0.497
LIG_PCNA_PIPBox_1	33	42	PF02747	0.247
LIG_Pex14_1	133	137	PF04695	0.420
LIG_Pex14_1	237	241	PF04695	0.247
LIG_Pex14_2	129	133	PF04695	0.334
LIG_Pex14_2	233	237	PF04695	0.247
LIG_Pex14_2	348	352	PF04695	0.300
LIG_Pex14_2	403	407	PF04695	0.340
LIG_SH2_CRK	241	245	PF00017	0.269
LIG_SH2_CRK	354	358	PF00017	0.391
LIG_SH2_CRK	46	50	PF00017	0.259
LIG_SH2_CRK	66	70	PF00017	0.116
LIG_SH2_CRK	86	90	PF00017	0.385
LIG_SH2_NCK_1	24	28	PF00017	0.272
LIG_SH2_PTP2	185	188	PF00017	0.420
LIG_SH2_STAP1	166	170	PF00017	0.292
LIG_SH2_STAP1	217	221	PF00017	0.297
LIG_SH2_STAP1	323	327	PF00017	0.552
LIG_SH2_STAP1	349	353	PF00017	0.385
LIG_SH2_STAP1	66	70	PF00017	0.242
LIG_SH2_STAT5	101	104	PF00017	0.315
LIG_SH2_STAT5	124	127	PF00017	0.385
LIG_SH2_STAT5	185	188	PF00017	0.420
LIG_SH2_STAT5	199	202	PF00017	0.357
LIG_SH2_STAT5	222	225	PF00017	0.252
LIG_SH2_STAT5	24	27	PF00017	0.260
LIG_SH2_STAT5	279	282	PF00017	0.550
LIG_SH2_STAT5	349	352	PF00017	0.393
LIG_SH2_STAT5	362	365	PF00017	0.357
LIG_SH2_STAT5	71	74	PF00017	0.258
LIG_SH2_STAT5	90	93	PF00017	0.302
LIG_SH3_3	284	290	PF00018	0.552
LIG_SH3_3	382	388	PF00018	0.333
LIG_SH3_3	426	432	PF00018	0.762
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.447
LIG_SUMO_SIM_anti_2	93	98	PF11976	0.364
LIG_SUMO_SIM_par_1	11	17	PF11976	0.360
LIG_SUMO_SIM_par_1	90	95	PF11976	0.369
LIG_SxIP_EBH_1	105	119	PF03271	0.497
LIG_TRAF2_1	417	420	PF00917	0.692
LIG_TYR_ITIM	22	27	PF00017	0.334
LIG_TYR_ITIM	239	244	PF00017	0.357
LIG_TYR_ITIM	44	49	PF00017	0.315
LIG_UBA3_1	111	118	PF00899	0.319
LIG_WRC_WIRS_1	327	332	PF05994	0.447
LIG_WRC_WIRS_1	371	376	PF05994	0.369
MOD_CDK_SPK_2	384	389	PF00069	0.447
MOD_CDK_SPxK_1	297	303	PF00069	0.213
MOD_CDK_SPxxK_3	297	304	PF00069	0.213
MOD_CK1_1	104	110	PF00069	0.447
MOD_CK2_1	278	284	PF00069	0.400
MOD_CK2_1	326	332	PF00069	0.319
MOD_CK2_1	414	420	PF00069	0.674
MOD_CK2_1	438	444	PF00069	0.724
MOD_GlcNHglycan	103	106	PF01048	0.420
MOD_GlcNHglycan	149	152	PF01048	0.439
MOD_GSK3_1	14	21	PF00069	0.432
MOD_GSK3_1	164	171	PF00069	0.295
MOD_GSK3_1	380	387	PF00069	0.311
MOD_GSK3_1	434	441	PF00069	0.719
MOD_N-GLC_2	130	132	PF02516	0.315
MOD_NEK2_1	114	119	PF00069	0.299
MOD_NEK2_1	164	169	PF00069	0.295
MOD_NEK2_1	187	192	PF00069	0.334
MOD_NEK2_1	259	264	PF00069	0.293
MOD_NEK2_1	269	274	PF00069	0.386
MOD_NEK2_1	340	345	PF00069	0.345
MOD_NEK2_1	360	365	PF00069	0.116
MOD_NEK2_1	398	403	PF00069	0.360
MOD_PIKK_1	431	437	PF00454	0.775
MOD_PKA_1	303	309	PF00069	0.252
MOD_PKA_2	147	153	PF00069	0.439
MOD_PKA_2	235	241	PF00069	0.311
MOD_PKA_2	303	309	PF00069	0.417
MOD_Plk_1	309	315	PF00069	0.452
MOD_Plk_4	107	113	PF00069	0.116
MOD_Plk_4	140	146	PF00069	0.388
MOD_Plk_4	262	268	PF00069	0.325
MOD_Plk_4	323	329	PF00069	0.314
MOD_Plk_4	347	353	PF00069	0.385
MOD_Plk_4	388	394	PF00069	0.372
MOD_Plk_4	398	404	PF00069	0.327
MOD_Plk_4	64	70	PF00069	0.372
MOD_Plk_4	92	98	PF00069	0.458
MOD_ProDKin_1	297	303	PF00069	0.400
MOD_ProDKin_1	384	390	PF00069	0.420
MOD_SUMO_for_1	250	253	PF00179	0.369
MOD_SUMO_rev_2	26	31	PF00179	0.408
MOD_SUMO_rev_2	426	432	PF00179	0.735
TRG_DiLeu_BaEn_3	34	40	PF01217	0.420
TRG_ENDOCYTIC_2	185	188	PF00928	0.400
TRG_ENDOCYTIC_2	199	202	PF00928	0.286
TRG_ENDOCYTIC_2	24	27	PF00928	0.315
TRG_ENDOCYTIC_2	241	244	PF00928	0.357
TRG_ENDOCYTIC_2	349	352	PF00928	0.309
TRG_ENDOCYTIC_2	362	365	PF00928	0.343
TRG_ENDOCYTIC_2	46	49	PF00928	0.303
TRG_ENDOCYTIC_2	66	69	PF00928	0.116
TRG_ENDOCYTIC_2	86	89	PF00928	0.334
TRG_ER_diArg_1	270	273	PF00400	0.301
TRG_ER_diArg_1	302	304	PF00400	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A1	Leptomonas seymouri	60%	92%
A0A0S4J269	Bodo saltans	42%	100%
A0A1X0P7P8	Trypanosomatidae	49%	100%
A0A3R7K2K2	Trypanosoma rangeli	47%	100%
A0A3S7XAS6	Leishmania donovani	94%	100%
A1CBE6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	32%	95%
A1DDZ3	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	31%	100%
A2RA94	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	32%	100%
A3LTB7	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	29%	94%
A4HP72	Leishmania braziliensis	77%	100%
A4IDH7	Leishmania infantum	94%	100%
A5DJQ5	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	31%	94%
D0A365	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ASY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O82244	Arabidopsis thaliana	39%	100%
P0CN92	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	33%	100%
P0CN93	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	33%	100%
P38179	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	98%
P82149	Drosophila melanogaster	37%	92%
Q24332	Drosophila virilis	35%	85%
Q27333	Drosophila melanogaster	36%	88%
Q2U6A4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	100%
Q4WVG2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	32%	100%
Q55F69	Dictyostelium discoideum	32%	100%
Q6BYY8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	30%	93%
Q6CMF1	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	32%	97%
Q6DNA2	Komagataella phaffii (strain GS115 / ATCC 20864)	32%	96%
Q6FXS2	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	33%	100%
Q751K5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	35%	100%
Q8K2A8	Mus musculus	39%	100%
Q92685	Homo sapiens	36%	100%
Q9C1K8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	36%	100%
Q9Y7I4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5BKW5	Trypanosoma cruzi	45%	100%