Putative dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dolichyl-P-Man:GDP-Man5GlcNAc2-PP-dolichyl alpha-1,3-mannosyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q1L8_LEIMA

TriTrypDb:

LmjF.36.2040 , LMJLV39_360027700 , LMJSD75_360027900

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

Q4Q1L8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L8

Function

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Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	2
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	2
GO:0006629	lipid metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2

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Molecular functions
Term	Name	Level	Count
GO:0000030	mannosyltransferase activity	5	12
GO:0000033	alpha-1,3-mannosyltransferase activity	6	3
GO:0003824	catalytic activity	1	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12
GO:0052925	dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity	7	3

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	296	298	PF00675	0.350
CLV_NRD_NRD_1	303	305	PF00675	0.358
CLV_PCSK_KEX2_1	118	120	PF00082	0.247
CLV_PCSK_KEX2_1	154	156	PF00082	0.497
CLV_PCSK_KEX2_1	296	298	PF00082	0.350
CLV_PCSK_KEX2_1	303	305	PF00082	0.351
CLV_PCSK_PC1ET2_1	118	120	PF00082	0.259
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.552
CLV_PCSK_SKI1_1	231	235	PF00082	0.442
CLV_PCSK_SKI1_1	47	51	PF00082	0.498

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A1	Leptomonas seymouri	60%	92%
A0A0S4J269	Bodo saltans	42%	100%
A0A1X0P7P8	Trypanosomatidae	49%	100%
A0A3R7K2K2	Trypanosoma rangeli	47%	100%
A0A3S7XAS6	Leishmania donovani	94%	100%
A1CBE6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	32%	95%
A1DDZ3	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	31%	100%
A2RA94	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	32%	100%
A3LTB7	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	29%	94%
A4HP72	Leishmania braziliensis	77%	100%

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