Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid-specific phospho-protein phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q1L7_LEIMA

TriTrypDb:

LmjF.36.2050 , LMJLV39_360027800 , LMJSD75_360028000

Length:

898

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2

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Expansion

Sequence features

Q4Q1L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L7

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.585
CLV_C14_Caspase3-7	167	171	PF00656	0.521
CLV_C14_Caspase3-7	23	27	PF00656	0.741
CLV_C14_Caspase3-7	508	512	PF00656	0.597
CLV_C14_Caspase3-7	672	676	PF00656	0.745
CLV_C14_Caspase3-7	766	770	PF00656	0.712
CLV_NRD_NRD_1	8	10	PF00675	0.721
CLV_PCSK_SKI1_1	166	170	PF00082	0.548
CLV_PCSK_SKI1_1	186	190	PF00082	0.290
CLV_PCSK_SKI1_1	365	369	PF00082	0.364

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N5	Leptomonas seymouri	47%	94%
A0A3S7XAZ4	Leishmania donovani	88%	98%
A4HP73	Leishmania braziliensis	65%	100%
A4IDH8	Leishmania infantum	88%	98%
E9ASY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%

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