Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid-specific phospho-protein phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q1L7_LEIMA

TriTrypDb:

LmjF.36.2050 , LMJLV39_360027800 , LMJSD75_360028000

Length:

898

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1L7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004722	protein serine/threonine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0017018	myosin phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.585
CLV_C14_Caspase3-7	167	171	PF00656	0.521
CLV_C14_Caspase3-7	23	27	PF00656	0.741
CLV_C14_Caspase3-7	508	512	PF00656	0.597
CLV_C14_Caspase3-7	672	676	PF00656	0.745
CLV_C14_Caspase3-7	766	770	PF00656	0.712
CLV_NRD_NRD_1	8	10	PF00675	0.721
CLV_PCSK_SKI1_1	166	170	PF00082	0.548
CLV_PCSK_SKI1_1	186	190	PF00082	0.290
CLV_PCSK_SKI1_1	365	369	PF00082	0.364
CLV_PCSK_SKI1_1	494	498	PF00082	0.558
CLV_PCSK_SKI1_1	602	606	PF00082	0.582
CLV_PCSK_SKI1_1	641	645	PF00082	0.721
CLV_PCSK_SKI1_1	841	845	PF00082	0.429
CLV_Separin_Metazoa	339	343	PF03568	0.603
DEG_APCC_DBOX_1	185	193	PF00400	0.489
DEG_APCC_DBOX_1	364	372	PF00400	0.411
DEG_SCF_TRCP1_1	532	538	PF00400	0.696
DEG_SPOP_SBC_1	678	682	PF00917	0.625
DEG_SPOP_SBC_1	685	689	PF00917	0.615
DOC_ANK_TNKS_1	270	277	PF00023	0.700
DOC_CKS1_1	137	142	PF01111	0.740
DOC_CKS1_1	67	72	PF01111	0.725
DOC_CYCLIN_yClb1_LxF_4	817	823	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	223	229	PF00134	0.517
DOC_MAPK_gen_1	230	237	PF00069	0.479
DOC_MAPK_gen_1	301	310	PF00069	0.646
DOC_MAPK_gen_1	706	716	PF00069	0.584
DOC_MAPK_gen_1	855	863	PF00069	0.472
DOC_MAPK_MEF2A_6	119	127	PF00069	0.717
DOC_MAPK_MEF2A_6	230	237	PF00069	0.479
DOC_MAPK_MEF2A_6	301	310	PF00069	0.646
DOC_MAPK_MEF2A_6	342	349	PF00069	0.478
DOC_MAPK_NFAT4_5	230	238	PF00069	0.583
DOC_PP2B_LxvP_1	102	105	PF13499	0.814
DOC_PP2B_LxvP_1	695	698	PF13499	0.748
DOC_PP4_FxxP_1	660	663	PF00568	0.644
DOC_PP4_FxxP_1	846	849	PF00568	0.447
DOC_USP7_MATH_1	28	32	PF00917	0.731
DOC_USP7_MATH_1	377	381	PF00917	0.482
DOC_USP7_MATH_1	393	397	PF00917	0.280
DOC_USP7_MATH_1	515	519	PF00917	0.724
DOC_USP7_MATH_1	583	587	PF00917	0.542
DOC_USP7_MATH_1	59	63	PF00917	0.807
DOC_USP7_MATH_1	611	615	PF00917	0.636
DOC_USP7_MATH_1	634	638	PF00917	0.668
DOC_USP7_MATH_1	686	690	PF00917	0.840
DOC_USP7_MATH_1	698	702	PF00917	0.716
DOC_USP7_MATH_1	72	76	PF00917	0.545
DOC_USP7_MATH_1	756	760	PF00917	0.669
DOC_USP7_MATH_1	765	769	PF00917	0.678
DOC_USP7_MATH_1	772	776	PF00917	0.751
DOC_USP7_UBL2_3	10	14	PF12436	0.737
DOC_USP7_UBL2_3	402	406	PF12436	0.408
DOC_USP7_UBL2_3	635	639	PF12436	0.692
DOC_USP7_UBL2_3	641	645	PF12436	0.702
DOC_WW_Pin1_4	112	117	PF00397	0.708
DOC_WW_Pin1_4	136	141	PF00397	0.743
DOC_WW_Pin1_4	26	31	PF00397	0.772
DOC_WW_Pin1_4	385	390	PF00397	0.487
DOC_WW_Pin1_4	455	460	PF00397	0.378
DOC_WW_Pin1_4	519	524	PF00397	0.831
DOC_WW_Pin1_4	560	565	PF00397	0.795
DOC_WW_Pin1_4	60	65	PF00397	0.741
DOC_WW_Pin1_4	659	664	PF00397	0.662
DOC_WW_Pin1_4	66	71	PF00397	0.716
DOC_WW_Pin1_4	667	672	PF00397	0.690
DOC_WW_Pin1_4	690	695	PF00397	0.734
DOC_WW_Pin1_4	721	726	PF00397	0.487
DOC_WW_Pin1_4	79	84	PF00397	0.609
LIG_14-3-3_CanoR_1	119	127	PF00244	0.756
LIG_14-3-3_CanoR_1	285	290	PF00244	0.563
LIG_14-3-3_CanoR_1	440	446	PF00244	0.513
LIG_14-3-3_CanoR_1	517	523	PF00244	0.597
LIG_14-3-3_CanoR_1	715	723	PF00244	0.355
LIG_14-3-3_CanoR_1	841	846	PF00244	0.552
LIG_14-3-3_CterR_2	895	898	PF00244	0.753
LIG_Actin_WH2_2	256	273	PF00022	0.641
LIG_APCC_ABBA_1	723	728	PF00400	0.607
LIG_BIR_III_4	57	61	PF00653	0.734
LIG_BIR_III_4	73	77	PF00653	0.722
LIG_Clathr_ClatBox_1	340	344	PF01394	0.476
LIG_EVH1_1	102	106	PF00568	0.713
LIG_EVH1_1	605	609	PF00568	0.597
LIG_EVH1_2	893	897	PF00568	0.723
LIG_FHA_1	210	216	PF00498	0.601
LIG_FHA_1	27	33	PF00498	0.802
LIG_FHA_1	297	303	PF00498	0.624
LIG_FHA_1	451	457	PF00498	0.411
LIG_FHA_1	459	465	PF00498	0.411
LIG_FHA_1	708	714	PF00498	0.527
LIG_FHA_1	800	806	PF00498	0.516
LIG_FHA_1	815	821	PF00498	0.481
LIG_FHA_2	129	135	PF00498	0.723
LIG_FHA_2	165	171	PF00498	0.586
LIG_FHA_2	31	37	PF00498	0.743
LIG_FHA_2	52	58	PF00498	0.724
LIG_FHA_2	670	676	PF00498	0.739
LIG_FHA_2	686	692	PF00498	0.514
LIG_FHA_2	750	756	PF00498	0.473
LIG_FHA_2	764	770	PF00498	0.721
LIG_FHA_2	875	881	PF00498	0.622
LIG_FHA_2	96	102	PF00498	0.611
LIG_LIR_Apic_2	658	663	PF02991	0.648
LIG_LIR_Apic_2	750	756	PF02991	0.473
LIG_LIR_Apic_2	844	849	PF02991	0.445
LIG_LIR_Gen_1	159	169	PF02991	0.515
LIG_LIR_Gen_1	332	341	PF02991	0.492
LIG_LIR_Nem_3	159	165	PF02991	0.515
LIG_LIR_Nem_3	257	263	PF02991	0.692
LIG_LIR_Nem_3	3	7	PF02991	0.747
LIG_LIR_Nem_3	332	337	PF02991	0.486
LIG_LIR_Nem_3	474	480	PF02991	0.389
LIG_LIR_Nem_3	487	491	PF02991	0.479
LIG_LIR_Nem_3	728	734	PF02991	0.588
LIG_LYPXL_yS_3	488	491	PF13949	0.411
LIG_MYND_1	268	272	PF01753	0.748
LIG_MYND_1	83	87	PF01753	0.734
LIG_NRBOX	218	224	PF00104	0.504
LIG_Pex14_2	209	213	PF04695	0.528
LIG_Pex14_2	290	294	PF04695	0.688
LIG_Pex14_2	656	660	PF04695	0.665
LIG_PTAP_UEV_1	106	111	PF05743	0.598
LIG_PTB_Apo_2	650	657	PF02174	0.668
LIG_Rb_LxCxE_1	247	261	PF01857	0.539
LIG_SH2_CRK	314	318	PF00017	0.565
LIG_SH2_NCK_1	594	598	PF00017	0.546
LIG_SH2_SRC	323	326	PF00017	0.542
LIG_SH2_SRC	594	597	PF00017	0.537
LIG_SH2_STAT5	323	326	PF00017	0.501
LIG_SH2_STAT5	431	434	PF00017	0.411
LIG_SH2_STAT5	437	440	PF00017	0.411
LIG_SH2_STAT5	821	824	PF00017	0.543
LIG_SH2_STAT5	851	854	PF00017	0.504
LIG_SH3_3	100	106	PF00018	0.608
LIG_SH3_3	134	140	PF00018	0.743
LIG_SH3_3	150	156	PF00018	0.489
LIG_SH3_3	347	353	PF00018	0.566
LIG_SH3_3	422	428	PF00018	0.513
LIG_SH3_3	603	609	PF00018	0.662
LIG_SH3_3	691	697	PF00018	0.746
LIG_SH3_3	701	707	PF00018	0.546
LIG_SH3_3	81	87	PF00018	0.812
LIG_SH3_3	888	894	PF00018	0.726
LIG_SUMO_SIM_anti_2	443	449	PF11976	0.280
LIG_SUMO_SIM_par_1	840	847	PF11976	0.461
LIG_SUMO_SIM_par_1	859	864	PF11976	0.439
LIG_TRAF2_1	326	329	PF00917	0.496
LIG_TRAF2_1	505	508	PF00917	0.681
LIG_TRAF2_1	98	101	PF00917	0.773
LIG_WRC_WIRS_1	1	6	PF05994	0.716
LIG_WRC_WIRS_1	165	170	PF05994	0.579
LIG_WW_1	428	431	PF00397	0.436
LIG_WW_3	892	896	PF00397	0.744
MOD_CDK_SPK_2	136	141	PF00069	0.626
MOD_CDK_SPK_2	385	390	PF00069	0.474
MOD_CDK_SPxxK_3	112	119	PF00069	0.731
MOD_CK1_1	151	157	PF00069	0.651
MOD_CK1_1	38	44	PF00069	0.764
MOD_CK1_1	388	394	PF00069	0.438
MOD_CK1_1	401	407	PF00069	0.436
MOD_CK1_1	443	449	PF00069	0.470
MOD_CK1_1	458	464	PF00069	0.328
MOD_CK1_1	518	524	PF00069	0.702
MOD_CK1_1	52	58	PF00069	0.832
MOD_CK1_1	659	665	PF00069	0.656
MOD_CK1_1	687	693	PF00069	0.694
MOD_CK1_1	696	702	PF00069	0.696
MOD_CK1_1	754	760	PF00069	0.535
MOD_CK1_1	883	889	PF00069	0.596
MOD_CK1_1	95	101	PF00069	0.760
MOD_CK2_1	170	176	PF00069	0.528
MOD_CK2_1	290	296	PF00069	0.683
MOD_CK2_1	30	36	PF00069	0.696
MOD_CK2_1	323	329	PF00069	0.486
MOD_CK2_1	501	507	PF00069	0.672
MOD_CK2_1	540	546	PF00069	0.701
MOD_CK2_1	611	617	PF00069	0.689
MOD_CK2_1	652	658	PF00069	0.783
MOD_CK2_1	685	691	PF00069	0.749
MOD_CK2_1	874	880	PF00069	0.548
MOD_CK2_1	95	101	PF00069	0.727
MOD_Cter_Amidation	7	10	PF01082	0.838
MOD_GlcNHglycan	107	110	PF01048	0.721
MOD_GlcNHglycan	120	123	PF01048	0.727
MOD_GlcNHglycan	199	202	PF01048	0.464
MOD_GlcNHglycan	260	263	PF01048	0.585
MOD_GlcNHglycan	280	283	PF01048	0.501
MOD_GlcNHglycan	325	328	PF01048	0.554
MOD_GlcNHglycan	403	406	PF01048	0.368
MOD_GlcNHglycan	414	417	PF01048	0.291
MOD_GlcNHglycan	43	46	PF01048	0.851
MOD_GlcNHglycan	503	506	PF01048	0.688
MOD_GlcNHglycan	517	520	PF01048	0.716
MOD_GlcNHglycan	532	535	PF01048	0.560
MOD_GlcNHglycan	698	701	PF01048	0.783
MOD_GlcNHglycan	716	719	PF01048	0.255
MOD_GlcNHglycan	73	77	PF01048	0.825
MOD_GlcNHglycan	758	761	PF01048	0.614
MOD_GlcNHglycan	783	786	PF01048	0.560
MOD_GlcNHglycan	846	849	PF01048	0.447
MOD_GSK3_1	110	117	PF00069	0.637
MOD_GSK3_1	123	130	PF00069	0.672
MOD_GSK3_1	135	142	PF00069	0.630
MOD_GSK3_1	254	261	PF00069	0.605
MOD_GSK3_1	26	33	PF00069	0.815
MOD_GSK3_1	292	299	PF00069	0.602
MOD_GSK3_1	393	400	PF00069	0.385
MOD_GSK3_1	503	510	PF00069	0.714
MOD_GSK3_1	515	522	PF00069	0.763
MOD_GSK3_1	530	537	PF00069	0.714
MOD_GSK3_1	541	548	PF00069	0.683
MOD_GSK3_1	607	614	PF00069	0.704
MOD_GSK3_1	643	650	PF00069	0.714
MOD_GSK3_1	652	659	PF00069	0.723
MOD_GSK3_1	667	674	PF00069	0.661
MOD_GSK3_1	686	693	PF00069	0.747
MOD_GSK3_1	72	79	PF00069	0.826
MOD_GSK3_1	751	758	PF00069	0.487
MOD_GSK3_1	763	770	PF00069	0.722
MOD_GSK3_1	777	784	PF00069	0.716
MOD_GSK3_1	86	93	PF00069	0.636
MOD_GSK3_1	880	887	PF00069	0.667
MOD_LATS_1	48	54	PF00433	0.806
MOD_N-GLC_1	170	175	PF02516	0.526
MOD_N-GLC_1	296	301	PF02516	0.655
MOD_N-GLC_1	38	43	PF02516	0.853
MOD_N-GLC_1	515	520	PF02516	0.786
MOD_N-GLC_1	525	530	PF02516	0.625
MOD_N-GLC_1	541	546	PF02516	0.729
MOD_N-GLC_1	652	657	PF02516	0.784
MOD_N-GLC_1	772	777	PF02516	0.772
MOD_N-GLC_2	850	852	PF02516	0.485
MOD_NEK2_1	118	123	PF00069	0.772
MOD_NEK2_1	127	132	PF00069	0.686
MOD_NEK2_1	290	295	PF00069	0.738
MOD_NEK2_1	450	455	PF00069	0.372
MOD_NEK2_1	656	661	PF00069	0.554
MOD_NEK2_1	814	819	PF00069	0.480
MOD_NEK2_2	525	530	PF00069	0.584
MOD_PIKK_1	180	186	PF00454	0.418
MOD_PIKK_1	423	429	PF00454	0.319
MOD_PIKK_1	772	778	PF00454	0.805
MOD_PK_1	178	184	PF00069	0.620
MOD_PKA_1	14	20	PF00069	0.656
MOD_PKA_1	635	641	PF00069	0.695
MOD_PKA_1	644	650	PF00069	0.693
MOD_PKA_2	118	124	PF00069	0.798
MOD_PKA_2	423	429	PF00069	0.490
MOD_PKA_2	647	653	PF00069	0.766
MOD_PKA_2	678	684	PF00069	0.745
MOD_PKA_2	714	720	PF00069	0.361
MOD_PKA_2	799	805	PF00069	0.533
MOD_Plk_1	151	157	PF00069	0.563
MOD_Plk_1	195	201	PF00069	0.566
MOD_Plk_1	541	547	PF00069	0.737
MOD_Plk_1	652	658	PF00069	0.745
MOD_Plk_1	727	733	PF00069	0.593
MOD_Plk_1	749	755	PF00069	0.473
MOD_Plk_1	808	814	PF00069	0.479
MOD_Plk_2-3	19	25	PF00069	0.619
MOD_Plk_2-3	808	814	PF00069	0.348
MOD_Plk_4	285	291	PF00069	0.566
MOD_Plk_4	313	319	PF00069	0.495
MOD_Plk_4	443	449	PF00069	0.488
MOD_Plk_4	458	464	PF00069	0.386
MOD_Plk_4	841	847	PF00069	0.449
MOD_ProDKin_1	112	118	PF00069	0.708
MOD_ProDKin_1	136	142	PF00069	0.739
MOD_ProDKin_1	26	32	PF00069	0.772
MOD_ProDKin_1	385	391	PF00069	0.487
MOD_ProDKin_1	455	461	PF00069	0.378
MOD_ProDKin_1	519	525	PF00069	0.830
MOD_ProDKin_1	560	566	PF00069	0.794
MOD_ProDKin_1	60	66	PF00069	0.742
MOD_ProDKin_1	659	665	PF00069	0.665
MOD_ProDKin_1	667	673	PF00069	0.691
MOD_ProDKin_1	690	696	PF00069	0.733
MOD_ProDKin_1	721	727	PF00069	0.486
MOD_ProDKin_1	79	85	PF00069	0.772
MOD_SUMO_for_1	300	303	PF00179	0.713
MOD_SUMO_rev_2	878	883	PF00179	0.715
TRG_DiLeu_BaLyEn_6	81	86	PF01217	0.593
TRG_DiLeu_BaLyEn_6	838	843	PF01217	0.483
TRG_ENDOCYTIC_2	314	317	PF00928	0.459
TRG_ENDOCYTIC_2	431	434	PF00928	0.411
TRG_ENDOCYTIC_2	478	481	PF00928	0.411
TRG_ENDOCYTIC_2	488	491	PF00928	0.353
TRG_ENDOCYTIC_2	594	597	PF00928	0.537
TRG_ENDOCYTIC_2	821	824	PF00928	0.543
TRG_ENDOCYTIC_2	851	854	PF00928	0.445
TRG_ER_diArg_1	229	232	PF00400	0.492
TRG_NES_CRM1_1	332	344	PF08389	0.463
TRG_NLS_MonoExtC_3	13	18	PF00514	0.733
TRG_NLS_MonoExtN_4	11	18	PF00514	0.731
TRG_NLS_MonoExtN_4	706	712	PF00514	0.714
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	554	559	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7N5	Leptomonas seymouri	47%	94%
A0A3S7XAZ4	Leishmania donovani	88%	98%
A4HP73	Leishmania braziliensis	65%	100%
A4IDH8	Leishmania infantum	88%	98%
E9ASY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%