LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Serine/threonine-protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine-protein phosphatase
Gene product:
kinetoplastid-specific phospho-protein phosphatase, putative
Species:
Leishmania major
UniProt:
Q4Q1L7_LEIMA
TriTrypDb:
LmjF.36.2050 , LMJLV39_360027800 , LMJSD75_360028000
Length:
898

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 2
GO:0031974 membrane-enclosed lumen 2 2
GO:0031981 nuclear lumen 5 2
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043233 organelle lumen 3 2
GO:0070013 intracellular organelle lumen 4 2
GO:0097014 ciliary plasm 5 2
GO:0099568 cytoplasmic region 3 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4Q1L7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L7

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004721 phosphoprotein phosphatase activity 3 7
GO:0004722 protein serine/threonine phosphatase activity 4 7
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0016791 phosphatase activity 5 7
GO:0017018 myosin phosphatase activity 5 7
GO:0042578 phosphoric ester hydrolase activity 4 7
GO:0140096 catalytic activity, acting on a protein 2 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 131 135 PF00656 0.585
CLV_C14_Caspase3-7 167 171 PF00656 0.521
CLV_C14_Caspase3-7 23 27 PF00656 0.741
CLV_C14_Caspase3-7 508 512 PF00656 0.597
CLV_C14_Caspase3-7 672 676 PF00656 0.745
CLV_C14_Caspase3-7 766 770 PF00656 0.712
CLV_NRD_NRD_1 8 10 PF00675 0.721
CLV_PCSK_SKI1_1 166 170 PF00082 0.548
CLV_PCSK_SKI1_1 186 190 PF00082 0.290
CLV_PCSK_SKI1_1 365 369 PF00082 0.364
CLV_PCSK_SKI1_1 494 498 PF00082 0.558
CLV_PCSK_SKI1_1 602 606 PF00082 0.582
CLV_PCSK_SKI1_1 641 645 PF00082 0.721
CLV_PCSK_SKI1_1 841 845 PF00082 0.429
CLV_Separin_Metazoa 339 343 PF03568 0.603
DEG_APCC_DBOX_1 185 193 PF00400 0.489
DEG_APCC_DBOX_1 364 372 PF00400 0.411
DEG_SCF_TRCP1_1 532 538 PF00400 0.696
DEG_SPOP_SBC_1 678 682 PF00917 0.625
DEG_SPOP_SBC_1 685 689 PF00917 0.615
DOC_ANK_TNKS_1 270 277 PF00023 0.700
DOC_CKS1_1 137 142 PF01111 0.740
DOC_CKS1_1 67 72 PF01111 0.725
DOC_CYCLIN_yClb1_LxF_4 817 823 PF00134 0.470
DOC_CYCLIN_yCln2_LP_2 223 229 PF00134 0.517
DOC_MAPK_gen_1 230 237 PF00069 0.479
DOC_MAPK_gen_1 301 310 PF00069 0.646
DOC_MAPK_gen_1 706 716 PF00069 0.584
DOC_MAPK_gen_1 855 863 PF00069 0.472
DOC_MAPK_MEF2A_6 119 127 PF00069 0.717
DOC_MAPK_MEF2A_6 230 237 PF00069 0.479
DOC_MAPK_MEF2A_6 301 310 PF00069 0.646
DOC_MAPK_MEF2A_6 342 349 PF00069 0.478
DOC_MAPK_NFAT4_5 230 238 PF00069 0.583
DOC_PP2B_LxvP_1 102 105 PF13499 0.814
DOC_PP2B_LxvP_1 695 698 PF13499 0.748
DOC_PP4_FxxP_1 660 663 PF00568 0.644
DOC_PP4_FxxP_1 846 849 PF00568 0.447
DOC_USP7_MATH_1 28 32 PF00917 0.731
DOC_USP7_MATH_1 377 381 PF00917 0.482
DOC_USP7_MATH_1 393 397 PF00917 0.280
DOC_USP7_MATH_1 515 519 PF00917 0.724
DOC_USP7_MATH_1 583 587 PF00917 0.542
DOC_USP7_MATH_1 59 63 PF00917 0.807
DOC_USP7_MATH_1 611 615 PF00917 0.636
DOC_USP7_MATH_1 634 638 PF00917 0.668
DOC_USP7_MATH_1 686 690 PF00917 0.840
DOC_USP7_MATH_1 698 702 PF00917 0.716
DOC_USP7_MATH_1 72 76 PF00917 0.545
DOC_USP7_MATH_1 756 760 PF00917 0.669
DOC_USP7_MATH_1 765 769 PF00917 0.678
DOC_USP7_MATH_1 772 776 PF00917 0.751
DOC_USP7_UBL2_3 10 14 PF12436 0.737
DOC_USP7_UBL2_3 402 406 PF12436 0.408
DOC_USP7_UBL2_3 635 639 PF12436 0.692
DOC_USP7_UBL2_3 641 645 PF12436 0.702
DOC_WW_Pin1_4 112 117 PF00397 0.708
DOC_WW_Pin1_4 136 141 PF00397 0.743
DOC_WW_Pin1_4 26 31 PF00397 0.772
DOC_WW_Pin1_4 385 390 PF00397 0.487
DOC_WW_Pin1_4 455 460 PF00397 0.378
DOC_WW_Pin1_4 519 524 PF00397 0.831
DOC_WW_Pin1_4 560 565 PF00397 0.795
DOC_WW_Pin1_4 60 65 PF00397 0.741
DOC_WW_Pin1_4 659 664 PF00397 0.662
DOC_WW_Pin1_4 66 71 PF00397 0.716
DOC_WW_Pin1_4 667 672 PF00397 0.690
DOC_WW_Pin1_4 690 695 PF00397 0.734
DOC_WW_Pin1_4 721 726 PF00397 0.487
DOC_WW_Pin1_4 79 84 PF00397 0.609
LIG_14-3-3_CanoR_1 119 127 PF00244 0.756
LIG_14-3-3_CanoR_1 285 290 PF00244 0.563
LIG_14-3-3_CanoR_1 440 446 PF00244 0.513
LIG_14-3-3_CanoR_1 517 523 PF00244 0.597
LIG_14-3-3_CanoR_1 715 723 PF00244 0.355
LIG_14-3-3_CanoR_1 841 846 PF00244 0.552
LIG_14-3-3_CterR_2 895 898 PF00244 0.753
LIG_Actin_WH2_2 256 273 PF00022 0.641
LIG_APCC_ABBA_1 723 728 PF00400 0.607
LIG_BIR_III_4 57 61 PF00653 0.734
LIG_BIR_III_4 73 77 PF00653 0.722
LIG_Clathr_ClatBox_1 340 344 PF01394 0.476
LIG_EVH1_1 102 106 PF00568 0.713
LIG_EVH1_1 605 609 PF00568 0.597
LIG_EVH1_2 893 897 PF00568 0.723
LIG_FHA_1 210 216 PF00498 0.601
LIG_FHA_1 27 33 PF00498 0.802
LIG_FHA_1 297 303 PF00498 0.624
LIG_FHA_1 451 457 PF00498 0.411
LIG_FHA_1 459 465 PF00498 0.411
LIG_FHA_1 708 714 PF00498 0.527
LIG_FHA_1 800 806 PF00498 0.516
LIG_FHA_1 815 821 PF00498 0.481
LIG_FHA_2 129 135 PF00498 0.723
LIG_FHA_2 165 171 PF00498 0.586
LIG_FHA_2 31 37 PF00498 0.743
LIG_FHA_2 52 58 PF00498 0.724
LIG_FHA_2 670 676 PF00498 0.739
LIG_FHA_2 686 692 PF00498 0.514
LIG_FHA_2 750 756 PF00498 0.473
LIG_FHA_2 764 770 PF00498 0.721
LIG_FHA_2 875 881 PF00498 0.622
LIG_FHA_2 96 102 PF00498 0.611
LIG_LIR_Apic_2 658 663 PF02991 0.648
LIG_LIR_Apic_2 750 756 PF02991 0.473
LIG_LIR_Apic_2 844 849 PF02991 0.445
LIG_LIR_Gen_1 159 169 PF02991 0.515
LIG_LIR_Gen_1 332 341 PF02991 0.492
LIG_LIR_Nem_3 159 165 PF02991 0.515
LIG_LIR_Nem_3 257 263 PF02991 0.692
LIG_LIR_Nem_3 3 7 PF02991 0.747
LIG_LIR_Nem_3 332 337 PF02991 0.486
LIG_LIR_Nem_3 474 480 PF02991 0.389
LIG_LIR_Nem_3 487 491 PF02991 0.479
LIG_LIR_Nem_3 728 734 PF02991 0.588
LIG_LYPXL_yS_3 488 491 PF13949 0.411
LIG_MYND_1 268 272 PF01753 0.748
LIG_MYND_1 83 87 PF01753 0.734
LIG_NRBOX 218 224 PF00104 0.504
LIG_Pex14_2 209 213 PF04695 0.528
LIG_Pex14_2 290 294 PF04695 0.688
LIG_Pex14_2 656 660 PF04695 0.665
LIG_PTAP_UEV_1 106 111 PF05743 0.598
LIG_PTB_Apo_2 650 657 PF02174 0.668
LIG_Rb_LxCxE_1 247 261 PF01857 0.539
LIG_SH2_CRK 314 318 PF00017 0.565
LIG_SH2_NCK_1 594 598 PF00017 0.546
LIG_SH2_SRC 323 326 PF00017 0.542
LIG_SH2_SRC 594 597 PF00017 0.537
LIG_SH2_STAT5 323 326 PF00017 0.501
LIG_SH2_STAT5 431 434 PF00017 0.411
LIG_SH2_STAT5 437 440 PF00017 0.411
LIG_SH2_STAT5 821 824 PF00017 0.543
LIG_SH2_STAT5 851 854 PF00017 0.504
LIG_SH3_3 100 106 PF00018 0.608
LIG_SH3_3 134 140 PF00018 0.743
LIG_SH3_3 150 156 PF00018 0.489
LIG_SH3_3 347 353 PF00018 0.566
LIG_SH3_3 422 428 PF00018 0.513
LIG_SH3_3 603 609 PF00018 0.662
LIG_SH3_3 691 697 PF00018 0.746
LIG_SH3_3 701 707 PF00018 0.546
LIG_SH3_3 81 87 PF00018 0.812
LIG_SH3_3 888 894 PF00018 0.726
LIG_SUMO_SIM_anti_2 443 449 PF11976 0.280
LIG_SUMO_SIM_par_1 840 847 PF11976 0.461
LIG_SUMO_SIM_par_1 859 864 PF11976 0.439
LIG_TRAF2_1 326 329 PF00917 0.496
LIG_TRAF2_1 505 508 PF00917 0.681
LIG_TRAF2_1 98 101 PF00917 0.773
LIG_WRC_WIRS_1 1 6 PF05994 0.716
LIG_WRC_WIRS_1 165 170 PF05994 0.579
LIG_WW_1 428 431 PF00397 0.436
LIG_WW_3 892 896 PF00397 0.744
MOD_CDK_SPK_2 136 141 PF00069 0.626
MOD_CDK_SPK_2 385 390 PF00069 0.474
MOD_CDK_SPxxK_3 112 119 PF00069 0.731
MOD_CK1_1 151 157 PF00069 0.651
MOD_CK1_1 38 44 PF00069 0.764
MOD_CK1_1 388 394 PF00069 0.438
MOD_CK1_1 401 407 PF00069 0.436
MOD_CK1_1 443 449 PF00069 0.470
MOD_CK1_1 458 464 PF00069 0.328
MOD_CK1_1 518 524 PF00069 0.702
MOD_CK1_1 52 58 PF00069 0.832
MOD_CK1_1 659 665 PF00069 0.656
MOD_CK1_1 687 693 PF00069 0.694
MOD_CK1_1 696 702 PF00069 0.696
MOD_CK1_1 754 760 PF00069 0.535
MOD_CK1_1 883 889 PF00069 0.596
MOD_CK1_1 95 101 PF00069 0.760
MOD_CK2_1 170 176 PF00069 0.528
MOD_CK2_1 290 296 PF00069 0.683
MOD_CK2_1 30 36 PF00069 0.696
MOD_CK2_1 323 329 PF00069 0.486
MOD_CK2_1 501 507 PF00069 0.672
MOD_CK2_1 540 546 PF00069 0.701
MOD_CK2_1 611 617 PF00069 0.689
MOD_CK2_1 652 658 PF00069 0.783
MOD_CK2_1 685 691 PF00069 0.749
MOD_CK2_1 874 880 PF00069 0.548
MOD_CK2_1 95 101 PF00069 0.727
MOD_Cter_Amidation 7 10 PF01082 0.838
MOD_GlcNHglycan 107 110 PF01048 0.721
MOD_GlcNHglycan 120 123 PF01048 0.727
MOD_GlcNHglycan 199 202 PF01048 0.464
MOD_GlcNHglycan 260 263 PF01048 0.585
MOD_GlcNHglycan 280 283 PF01048 0.501
MOD_GlcNHglycan 325 328 PF01048 0.554
MOD_GlcNHglycan 403 406 PF01048 0.368
MOD_GlcNHglycan 414 417 PF01048 0.291
MOD_GlcNHglycan 43 46 PF01048 0.851
MOD_GlcNHglycan 503 506 PF01048 0.688
MOD_GlcNHglycan 517 520 PF01048 0.716
MOD_GlcNHglycan 532 535 PF01048 0.560
MOD_GlcNHglycan 698 701 PF01048 0.783
MOD_GlcNHglycan 716 719 PF01048 0.255
MOD_GlcNHglycan 73 77 PF01048 0.825
MOD_GlcNHglycan 758 761 PF01048 0.614
MOD_GlcNHglycan 783 786 PF01048 0.560
MOD_GlcNHglycan 846 849 PF01048 0.447
MOD_GSK3_1 110 117 PF00069 0.637
MOD_GSK3_1 123 130 PF00069 0.672
MOD_GSK3_1 135 142 PF00069 0.630
MOD_GSK3_1 254 261 PF00069 0.605
MOD_GSK3_1 26 33 PF00069 0.815
MOD_GSK3_1 292 299 PF00069 0.602
MOD_GSK3_1 393 400 PF00069 0.385
MOD_GSK3_1 503 510 PF00069 0.714
MOD_GSK3_1 515 522 PF00069 0.763
MOD_GSK3_1 530 537 PF00069 0.714
MOD_GSK3_1 541 548 PF00069 0.683
MOD_GSK3_1 607 614 PF00069 0.704
MOD_GSK3_1 643 650 PF00069 0.714
MOD_GSK3_1 652 659 PF00069 0.723
MOD_GSK3_1 667 674 PF00069 0.661
MOD_GSK3_1 686 693 PF00069 0.747
MOD_GSK3_1 72 79 PF00069 0.826
MOD_GSK3_1 751 758 PF00069 0.487
MOD_GSK3_1 763 770 PF00069 0.722
MOD_GSK3_1 777 784 PF00069 0.716
MOD_GSK3_1 86 93 PF00069 0.636
MOD_GSK3_1 880 887 PF00069 0.667
MOD_LATS_1 48 54 PF00433 0.806
MOD_N-GLC_1 170 175 PF02516 0.526
MOD_N-GLC_1 296 301 PF02516 0.655
MOD_N-GLC_1 38 43 PF02516 0.853
MOD_N-GLC_1 515 520 PF02516 0.786
MOD_N-GLC_1 525 530 PF02516 0.625
MOD_N-GLC_1 541 546 PF02516 0.729
MOD_N-GLC_1 652 657 PF02516 0.784
MOD_N-GLC_1 772 777 PF02516 0.772
MOD_N-GLC_2 850 852 PF02516 0.485
MOD_NEK2_1 118 123 PF00069 0.772
MOD_NEK2_1 127 132 PF00069 0.686
MOD_NEK2_1 290 295 PF00069 0.738
MOD_NEK2_1 450 455 PF00069 0.372
MOD_NEK2_1 656 661 PF00069 0.554
MOD_NEK2_1 814 819 PF00069 0.480
MOD_NEK2_2 525 530 PF00069 0.584
MOD_PIKK_1 180 186 PF00454 0.418
MOD_PIKK_1 423 429 PF00454 0.319
MOD_PIKK_1 772 778 PF00454 0.805
MOD_PK_1 178 184 PF00069 0.620
MOD_PKA_1 14 20 PF00069 0.656
MOD_PKA_1 635 641 PF00069 0.695
MOD_PKA_1 644 650 PF00069 0.693
MOD_PKA_2 118 124 PF00069 0.798
MOD_PKA_2 423 429 PF00069 0.490
MOD_PKA_2 647 653 PF00069 0.766
MOD_PKA_2 678 684 PF00069 0.745
MOD_PKA_2 714 720 PF00069 0.361
MOD_PKA_2 799 805 PF00069 0.533
MOD_Plk_1 151 157 PF00069 0.563
MOD_Plk_1 195 201 PF00069 0.566
MOD_Plk_1 541 547 PF00069 0.737
MOD_Plk_1 652 658 PF00069 0.745
MOD_Plk_1 727 733 PF00069 0.593
MOD_Plk_1 749 755 PF00069 0.473
MOD_Plk_1 808 814 PF00069 0.479
MOD_Plk_2-3 19 25 PF00069 0.619
MOD_Plk_2-3 808 814 PF00069 0.348
MOD_Plk_4 285 291 PF00069 0.566
MOD_Plk_4 313 319 PF00069 0.495
MOD_Plk_4 443 449 PF00069 0.488
MOD_Plk_4 458 464 PF00069 0.386
MOD_Plk_4 841 847 PF00069 0.449
MOD_ProDKin_1 112 118 PF00069 0.708
MOD_ProDKin_1 136 142 PF00069 0.739
MOD_ProDKin_1 26 32 PF00069 0.772
MOD_ProDKin_1 385 391 PF00069 0.487
MOD_ProDKin_1 455 461 PF00069 0.378
MOD_ProDKin_1 519 525 PF00069 0.830
MOD_ProDKin_1 560 566 PF00069 0.794
MOD_ProDKin_1 60 66 PF00069 0.742
MOD_ProDKin_1 659 665 PF00069 0.665
MOD_ProDKin_1 667 673 PF00069 0.691
MOD_ProDKin_1 690 696 PF00069 0.733
MOD_ProDKin_1 721 727 PF00069 0.486
MOD_ProDKin_1 79 85 PF00069 0.772
MOD_SUMO_for_1 300 303 PF00179 0.713
MOD_SUMO_rev_2 878 883 PF00179 0.715
TRG_DiLeu_BaLyEn_6 81 86 PF01217 0.593
TRG_DiLeu_BaLyEn_6 838 843 PF01217 0.483
TRG_ENDOCYTIC_2 314 317 PF00928 0.459
TRG_ENDOCYTIC_2 431 434 PF00928 0.411
TRG_ENDOCYTIC_2 478 481 PF00928 0.411
TRG_ENDOCYTIC_2 488 491 PF00928 0.353
TRG_ENDOCYTIC_2 594 597 PF00928 0.537
TRG_ENDOCYTIC_2 821 824 PF00928 0.543
TRG_ENDOCYTIC_2 851 854 PF00928 0.445
TRG_ER_diArg_1 229 232 PF00400 0.492
TRG_NES_CRM1_1 332 344 PF08389 0.463
TRG_NLS_MonoExtC_3 13 18 PF00514 0.733
TRG_NLS_MonoExtN_4 11 18 PF00514 0.731
TRG_NLS_MonoExtN_4 706 712 PF00514 0.714
TRG_Pf-PMV_PEXEL_1 148 152 PF00026 0.531
TRG_Pf-PMV_PEXEL_1 365 369 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 554 559 PF00026 0.590

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7N5 Leptomonas seymouri 47% 94%
A0A3S7XAZ4 Leishmania donovani 88% 98%
A4HP73 Leishmania braziliensis 65% 100%
A4IDH8 Leishmania infantum 88% 98%
E9ASY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 98%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS