Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function DUF72, putative

Species:

Leishmania major

UniProt:

Q4Q1L6_LEIMA

TriTrypDb:

LmjF.36.2060 , LMJLV39_360027900 , LMJSD75_360028100

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1L6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	376	380	PF00656	0.418
CLV_C14_Caspase3-7	409	413	PF00656	0.394
CLV_NRD_NRD_1	287	289	PF00675	0.444
CLV_NRD_NRD_1	99	101	PF00675	0.462
CLV_PCSK_KEX2_1	287	289	PF00082	0.420
CLV_PCSK_KEX2_1	487	489	PF00082	0.787
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.798
CLV_PCSK_SKI1_1	313	317	PF00082	0.404
CLV_PCSK_SKI1_1	390	394	PF00082	0.385
CLV_PCSK_SKI1_1	421	425	PF00082	0.515
CLV_PCSK_SKI1_1	93	97	PF00082	0.496
DEG_COP1_1	77	85	PF00400	0.562
DEG_Nend_Nbox_1	1	3	PF02207	0.650
DEG_SPOP_SBC_1	15	19	PF00917	0.679
DEG_SPOP_SBC_1	266	270	PF00917	0.398
DEG_SPOP_SBC_1	277	281	PF00917	0.259
DOC_CYCLIN_RxL_1	418	428	PF00134	0.569
DOC_MAPK_gen_1	284	293	PF00069	0.349
DOC_MAPK_gen_1	310	318	PF00069	0.381
DOC_MAPK_MEF2A_6	284	293	PF00069	0.335
DOC_PP2B_PxIxI_1	69	75	PF00149	0.454
DOC_PP4_FxxP_1	220	223	PF00568	0.423
DOC_PP4_FxxP_1	58	61	PF00568	0.542
DOC_USP7_MATH_1	13	17	PF00917	0.609
DOC_USP7_MATH_1	266	270	PF00917	0.472
DOC_USP7_MATH_1	276	280	PF00917	0.314
DOC_USP7_MATH_1	443	447	PF00917	0.738
DOC_USP7_MATH_1	458	462	PF00917	0.734
DOC_USP7_MATH_1	492	496	PF00917	0.779
DOC_USP7_MATH_1	6	10	PF00917	0.588
DOC_WW_Pin1_4	164	169	PF00397	0.655
DOC_WW_Pin1_4	260	265	PF00397	0.411
DOC_WW_Pin1_4	272	277	PF00397	0.341
DOC_WW_Pin1_4	371	376	PF00397	0.478
DOC_WW_Pin1_4	39	44	PF00397	0.469
DOC_WW_Pin1_4	437	442	PF00397	0.755
DOC_WW_Pin1_4	480	485	PF00397	0.780
LIG_14-3-3_CanoR_1	138	143	PF00244	0.775
LIG_14-3-3_CanoR_1	296	301	PF00244	0.355
LIG_14-3-3_CanoR_1	470	474	PF00244	0.767
LIG_14-3-3_CanoR_1	48	53	PF00244	0.501
LIG_14-3-3_CanoR_1	90	96	PF00244	0.477
LIG_eIF4E_1	52	58	PF01652	0.478
LIG_FHA_1	303	309	PF00498	0.404
LIG_FHA_1	387	393	PF00498	0.477
LIG_FHA_1	405	411	PF00498	0.409
LIG_FHA_1	61	67	PF00498	0.475
LIG_FHA_2	374	380	PF00498	0.371
LIG_FHA_2	386	392	PF00498	0.453
LIG_FHA_2	496	502	PF00498	0.719
LIG_LIR_Apic_2	218	223	PF02991	0.449
LIG_LIR_Gen_1	303	312	PF02991	0.358
LIG_LIR_Gen_1	324	335	PF02991	0.446
LIG_LIR_Gen_1	391	400	PF02991	0.449
LIG_LIR_Nem_3	303	309	PF02991	0.353
LIG_LIR_Nem_3	311	317	PF02991	0.360
LIG_LIR_Nem_3	324	330	PF02991	0.413
LIG_LIR_Nem_3	352	356	PF02991	0.331
LIG_LIR_Nem_3	391	396	PF02991	0.344
LIG_LIR_Nem_3	51	57	PF02991	0.523
LIG_MYND_1	215	219	PF01753	0.449
LIG_NRBOX	244	250	PF00104	0.437
LIG_Pex14_1	54	58	PF04695	0.478
LIG_REV1ctd_RIR_1	207	214	PF16727	0.317
LIG_SH2_CRK	112	116	PF00017	0.512
LIG_SH2_CRK	327	331	PF00017	0.398
LIG_SH2_CRK	353	357	PF00017	0.344
LIG_SH2_NCK_1	234	238	PF00017	0.281
LIG_SH2_PTP2	339	342	PF00017	0.385
LIG_SH2_SRC	368	371	PF00017	0.428
LIG_SH2_STAP1	181	185	PF00017	0.385
LIG_SH2_STAP1	327	331	PF00017	0.475
LIG_SH2_STAT5	181	184	PF00017	0.345
LIG_SH2_STAT5	339	342	PF00017	0.328
LIG_SH2_STAT5	368	371	PF00017	0.385
LIG_SH3_2	43	48	PF14604	0.560
LIG_SH3_3	142	148	PF00018	0.698
LIG_SH3_3	165	171	PF00018	0.654
LIG_SH3_3	223	229	PF00018	0.370
LIG_SH3_3	40	46	PF00018	0.489
LIG_SH3_3	479	485	PF00018	0.746
LIG_SH3_3	64	70	PF00018	0.538
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.398
LIG_SUMO_SIM_par_1	252	258	PF11976	0.398
LIG_SUMO_SIM_par_1	9	19	PF11976	0.496
LIG_TRAF2_1	250	253	PF00917	0.449
LIG_WRC_WIRS_1	309	314	PF05994	0.449
LIG_WRC_WIRS_1	7	12	PF05994	0.492
MOD_CDK_SPxxK_3	480	487	PF00069	0.784
MOD_CK1_1	141	147	PF00069	0.657
MOD_CK1_1	16	22	PF00069	0.691
MOD_CK1_1	269	275	PF00069	0.430
MOD_CK1_1	371	377	PF00069	0.466
MOD_CK1_1	47	53	PF00069	0.575
MOD_CK1_1	495	501	PF00069	0.716
MOD_CK1_1	88	94	PF00069	0.563
MOD_CK2_1	247	253	PF00069	0.449
MOD_CK2_1	385	391	PF00069	0.447
MOD_CMANNOS	121	124	PF00535	0.415
MOD_GlcNHglycan	145	148	PF01048	0.739
MOD_GlcNHglycan	162	165	PF01048	0.704
MOD_GlcNHglycan	18	21	PF01048	0.616
MOD_GlcNHglycan	234	237	PF01048	0.281
MOD_GlcNHglycan	269	272	PF01048	0.437
MOD_GlcNHglycan	280	283	PF01048	0.437
MOD_GlcNHglycan	381	384	PF01048	0.462
MOD_GlcNHglycan	445	448	PF01048	0.776
MOD_GlcNHglycan	495	498	PF01048	0.774
MOD_GSK3_1	160	167	PF00069	0.721
MOD_GSK3_1	228	235	PF00069	0.439
MOD_GSK3_1	258	265	PF00069	0.439
MOD_GSK3_1	266	273	PF00069	0.400
MOD_GSK3_1	278	285	PF00069	0.385
MOD_GSK3_1	433	440	PF00069	0.658
MOD_GSK3_1	44	51	PF00069	0.469
MOD_GSK3_1	488	495	PF00069	0.786
MOD_GSK3_1	81	88	PF00069	0.584
MOD_N-GLC_1	396	401	PF02516	0.346
MOD_N-GLC_1	48	53	PF02516	0.572
MOD_NEK2_1	14	19	PF00069	0.599
MOD_NEK2_1	179	184	PF00069	0.327
MOD_NEK2_1	232	237	PF00069	0.383
MOD_NEK2_1	257	262	PF00069	0.454
MOD_NEK2_1	267	272	PF00069	0.434
MOD_NEK2_1	308	313	PF00069	0.441
MOD_NEK2_1	424	429	PF00069	0.673
MOD_NEK2_1	62	67	PF00069	0.541
MOD_PIKK_1	21	27	PF00454	0.464
MOD_PIKK_1	247	253	PF00454	0.482
MOD_PIKK_1	282	288	PF00454	0.242
MOD_PIKK_1	325	331	PF00454	0.398
MOD_PIKK_1	94	100	PF00454	0.503
MOD_PKA_2	128	134	PF00069	0.600
MOD_PKA_2	240	246	PF00069	0.441
MOD_PKA_2	469	475	PF00069	0.767
MOD_PKA_2	47	53	PF00069	0.563
MOD_PKA_2	493	499	PF00069	0.780
MOD_Plk_1	257	263	PF00069	0.442
MOD_Plk_1	302	308	PF00069	0.421
MOD_Plk_1	411	417	PF00069	0.404
MOD_Plk_1	458	464	PF00069	0.545
MOD_Plk_1	48	54	PF00069	0.573
MOD_Plk_1	88	94	PF00069	0.595
MOD_Plk_4	34	40	PF00069	0.544
MOD_Plk_4	406	412	PF00069	0.420
MOD_Plk_4	6	12	PF00069	0.666
MOD_ProDKin_1	164	170	PF00069	0.654
MOD_ProDKin_1	260	266	PF00069	0.411
MOD_ProDKin_1	272	278	PF00069	0.341
MOD_ProDKin_1	371	377	PF00069	0.478
MOD_ProDKin_1	39	45	PF00069	0.469
MOD_ProDKin_1	437	443	PF00069	0.754
MOD_ProDKin_1	480	486	PF00069	0.782
TRG_AP2beta_CARGO_1	303	313	PF09066	0.451
TRG_DiLeu_BaEn_1	252	257	PF01217	0.398
TRG_DiLeu_BaEn_1	304	309	PF01217	0.385
TRG_DiLeu_BaEn_2	390	396	PF01217	0.449
TRG_DiLeu_BaEn_4	252	258	PF01217	0.398
TRG_DiLeu_LyEn_5	212	217	PF01217	0.475
TRG_ENDOCYTIC_2	112	115	PF00928	0.487
TRG_ENDOCYTIC_2	327	330	PF00928	0.475
TRG_ENDOCYTIC_2	339	342	PF00928	0.319
TRG_ENDOCYTIC_2	353	356	PF00928	0.344
TRG_ER_diArg_1	287	290	PF00400	0.397
TRG_ER_diArg_1	295	298	PF00400	0.330
TRG_NLS_MonoExtN_4	484	491	PF00514	0.764
TRG_Pf-PMV_PEXEL_1	421	425	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	93	98	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN3	Leptomonas seymouri	55%	100%
A0A0S4J806	Bodo saltans	36%	100%
A0A1X0P7Q2	Trypanosomatidae	43%	100%
A0A3Q8IG26	Leishmania donovani	90%	100%
A0A422N1S4	Trypanosoma rangeli	40%	100%
A4HP74	Leishmania braziliensis	72%	100%
A4IDH9	Leishmania infantum	90%	100%
D0A370	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9ASY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BGE6	Trypanosoma cruzi	43%	100%