TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat/Tetratricopeptide repeat, putative

Species:

Leishmania major

UniProt:

Q4Q1L5_LEIMA

TriTrypDb:

LmjF.36.2070 , LMJLV39_360028000 , LMJSD75_360028200

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1L5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L5

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.455
CLV_NRD_NRD_1	126	128	PF00675	0.262
CLV_PCSK_KEX2_1	128	130	PF00082	0.463
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.350
CLV_PCSK_SKI1_1	13	17	PF00082	0.530
CLV_PCSK_SKI1_1	140	144	PF00082	0.417
CLV_PCSK_SKI1_1	255	259	PF00082	0.539
CLV_PCSK_SKI1_1	4	8	PF00082	0.659
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.536
DOC_PP2B_LxvP_1	71	74	PF13499	0.435
DOC_USP7_UBL2_3	103	107	PF12436	0.468
DOC_WW_Pin1_4	178	183	PF00397	0.631
DOC_WW_Pin1_4	186	191	PF00397	0.731
DOC_WW_Pin1_4	89	94	PF00397	0.463
LIG_14-3-3_CanoR_1	196	204	PF00244	0.446
LIG_14-3-3_CanoR_1	239	244	PF00244	0.691
LIG_14-3-3_CanoR_1	299	309	PF00244	0.606
LIG_14-3-3_CanoR_1	82	90	PF00244	0.411
LIG_CtBP_PxDLS_1	97	103	PF00389	0.400
LIG_FHA_1	304	310	PF00498	0.532
LIG_FHA_1	320	326	PF00498	0.518
LIG_FHA_1	76	82	PF00498	0.434
LIG_FHA_2	23	29	PF00498	0.568
LIG_IRF3_LxIS_1	309	314	PF10401	0.545
LIG_LIR_Gen_1	271	276	PF02991	0.410
LIG_LIR_Nem_3	25	30	PF02991	0.497
LIG_LIR_Nem_3	271	275	PF02991	0.442
LIG_LIR_Nem_3	315	321	PF02991	0.546
LIG_LIR_Nem_3	46	50	PF02991	0.344
LIG_PTB_Apo_2	49	56	PF02174	0.331
LIG_PTB_Phospho_1	49	55	PF10480	0.419
LIG_SH2_CRK	67	71	PF00017	0.469
LIG_SH2_GRB2like	183	186	PF00017	0.636
LIG_SH2_NCK_1	302	306	PF00017	0.601
LIG_SH2_STAP1	67	71	PF00017	0.326
LIG_SH2_STAT5	321	324	PF00017	0.518
LIG_SH2_STAT5	59	62	PF00017	0.343
LIG_SH2_STAT5	89	92	PF00017	0.380
LIG_SH3_3	184	190	PF00018	0.636
LIG_SH3_3	6	12	PF00018	0.503
LIG_TRAF2_1	207	210	PF00917	0.555
LIG_WW_2	9	12	PF00397	0.462
MOD_CDK_SPK_2	186	191	PF00069	0.595
MOD_CK1_1	189	195	PF00069	0.640
MOD_CK1_1	303	309	PF00069	0.597
MOD_CK1_1	83	89	PF00069	0.345
MOD_CK2_1	225	231	PF00069	0.580
MOD_CK2_1	265	271	PF00069	0.572
MOD_GlcNHglycan	162	165	PF01048	0.614
MOD_GlcNHglycan	271	275	PF01048	0.639
MOD_GlcNHglycan	85	88	PF01048	0.352
MOD_GSK3_1	191	198	PF00069	0.605
MOD_N-GLC_1	83	88	PF02516	0.378
MOD_N-GLC_2	278	280	PF02516	0.451
MOD_N-GLC_2	52	54	PF02516	0.328
MOD_NEK2_1	22	27	PF00069	0.516
MOD_NEK2_1	298	303	PF00069	0.685
MOD_PIKK_1	212	218	PF00454	0.596
MOD_PIKK_1	241	247	PF00454	0.571
MOD_PIKK_1	38	44	PF00454	0.458
MOD_PKA_2	195	201	PF00069	0.516
MOD_PKA_2	298	304	PF00069	0.644
MOD_PKB_1	237	245	PF00069	0.644
MOD_Plk_1	270	276	PF00069	0.439
MOD_ProDKin_1	178	184	PF00069	0.632
MOD_ProDKin_1	186	192	PF00069	0.706
MOD_ProDKin_1	89	95	PF00069	0.469
MOD_SUMO_for_1	207	210	PF00179	0.568
MOD_SUMO_rev_2	41	50	PF00179	0.429
MOD_SUMO_rev_2	8	17	PF00179	0.620
TRG_DiLeu_BaEn_4	209	215	PF01217	0.560
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.399
TRG_ENDOCYTIC_2	67	70	PF00928	0.469
TRG_ER_diArg_1	276	279	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	13	18	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7A6	Leptomonas seymouri	54%	100%
A0A0S4IZ49	Bodo saltans	36%	100%
A0A1X0P800	Trypanosomatidae	38%	99%
A0A3Q8IKL8	Leishmania donovani	93%	100%
A0A422N1V8	Trypanosoma rangeli	40%	100%
A4HP75	Leishmania braziliensis	74%	100%
A4IDI0	Leishmania infantum	92%	100%
D0A371	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ASY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BKW9	Trypanosoma cruzi	39%	100%