N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1L2_LEIMA

TriTrypDb:

LmjF.36.2100 , LMJLV39_360028300 , LMJSD75_360028500

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1L2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016407	acetyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	126	128	PF00675	0.644
CLV_NRD_NRD_1	197	199	PF00675	0.504
CLV_NRD_NRD_1	334	336	PF00675	0.714
CLV_PCSK_KEX2_1	126	128	PF00082	0.629
CLV_PCSK_KEX2_1	199	201	PF00082	0.458
CLV_PCSK_KEX2_1	334	336	PF00082	0.676
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.571
CLV_PCSK_SKI1_1	288	292	PF00082	0.449
CLV_PCSK_SKI1_1	334	338	PF00082	0.605
CLV_PCSK_SKI1_1	351	355	PF00082	0.464
CLV_PCSK_SKI1_1	58	62	PF00082	0.541
DEG_APCC_DBOX_1	350	358	PF00400	0.386
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DOC_ANK_TNKS_1	358	365	PF00023	0.379
DOC_MAPK_gen_1	162	170	PF00069	0.395
DOC_MAPK_gen_1	292	300	PF00069	0.451
DOC_PP1_RVXF_1	295	301	PF00149	0.376
DOC_PP1_RVXF_1	56	63	PF00149	0.546
DOC_PP4_FxxP_1	175	178	PF00568	0.407
DOC_PP4_FxxP_1	50	53	PF00568	0.577
DOC_SPAK_OSR1_1	359	363	PF12202	0.359
DOC_USP7_MATH_1	188	192	PF00917	0.570
DOC_USP7_MATH_1	336	340	PF00917	0.679
DOC_WW_Pin1_4	113	118	PF00397	0.677
DOC_WW_Pin1_4	99	104	PF00397	0.696
LIG_14-3-3_CanoR_1	126	134	PF00244	0.585
LIG_14-3-3_CanoR_1	210	218	PF00244	0.382
LIG_14-3-3_CanoR_1	66	76	PF00244	0.552
LIG_BRCT_BRCA1_1	171	175	PF00533	0.371
LIG_EVH1_2	108	112	PF00568	0.498
LIG_FHA_1	14	20	PF00498	0.467
LIG_FHA_1	212	218	PF00498	0.365
LIG_FHA_1	220	226	PF00498	0.376
LIG_FHA_1	341	347	PF00498	0.536
LIG_FHA_2	135	141	PF00498	0.577
LIG_FHA_2	20	26	PF00498	0.465
LIG_FHA_2	289	295	PF00498	0.435
LIG_FHA_2	33	39	PF00498	0.528
LIG_FHA_2	47	53	PF00498	0.571
LIG_LIR_Apic_2	172	178	PF02991	0.405
LIG_LIR_Apic_2	49	53	PF02991	0.568
LIG_LIR_Gen_1	230	240	PF02991	0.339
LIG_LIR_Gen_1	268	276	PF02991	0.363
LIG_LIR_Nem_3	140	145	PF02991	0.441
LIG_LIR_Nem_3	202	208	PF02991	0.367
LIG_LIR_Nem_3	268	272	PF02991	0.324
LIG_PCNA_PIPBox_1	7	16	PF02747	0.390
LIG_PCNA_yPIPBox_3	7	18	PF02747	0.389
LIG_SH2_CRK	14	18	PF00017	0.479
LIG_SH2_STAP1	151	155	PF00017	0.481
LIG_SH2_STAP1	171	175	PF00017	0.378
LIG_SH2_STAP1	205	209	PF00017	0.297
LIG_SH2_STAP1	46	50	PF00017	0.448
LIG_SH2_STAT3	151	154	PF00017	0.472
LIG_SH2_STAT3	171	174	PF00017	0.375
LIG_SH2_STAT5	208	211	PF00017	0.302
LIG_SH2_STAT5	318	321	PF00017	0.397
LIG_SH3_3	175	181	PF00018	0.401
LIG_SH3_3	184	190	PF00018	0.380
LIG_SH3_3	359	365	PF00018	0.361
LIG_SUMO_SIM_par_1	165	173	PF11976	0.493
LIG_SUMO_SIM_par_1	185	192	PF11976	0.616
LIG_TRAF2_1	137	140	PF00917	0.578
LIG_TRAF2_1	213	216	PF00917	0.428
LIG_TRAF2_1	3	6	PF00917	0.601
LIG_TRAF2_1	35	38	PF00917	0.482
LIG_TYR_ITIM	316	321	PF00017	0.407
MOD_CK1_1	116	122	PF00069	0.530
MOD_CK1_1	191	197	PF00069	0.497
MOD_CK1_1	339	345	PF00069	0.657
MOD_CK1_1	77	83	PF00069	0.493
MOD_CK1_1	99	105	PF00069	0.721
MOD_CK2_1	134	140	PF00069	0.575
MOD_CK2_1	157	163	PF00069	0.393
MOD_CK2_1	288	294	PF00069	0.392
MOD_CK2_1	32	38	PF00069	0.544
MOD_CK2_1	92	98	PF00069	0.616
MOD_Cter_Amidation	332	335	PF01082	0.483
MOD_GlcNHglycan	201	204	PF01048	0.505
MOD_GlcNHglycan	272	275	PF01048	0.326
MOD_GlcNHglycan	328	331	PF01048	0.692
MOD_GlcNHglycan	338	341	PF01048	0.677
MOD_GlcNHglycan	94	97	PF01048	0.752
MOD_GlcNHglycan	98	101	PF01048	0.788
MOD_GSK3_1	188	195	PF00069	0.607
MOD_GSK3_1	199	206	PF00069	0.526
MOD_GSK3_1	336	343	PF00069	0.609
MOD_GSK3_1	92	99	PF00069	0.660
MOD_N-GLC_1	324	329	PF02516	0.531
MOD_NEK2_1	133	138	PF00069	0.453
MOD_NEK2_1	170	175	PF00069	0.433
MOD_NEK2_1	19	24	PF00069	0.569
MOD_NEK2_1	238	243	PF00069	0.316
MOD_NEK2_1	346	351	PF00069	0.515
MOD_NEK2_1	67	72	PF00069	0.587
MOD_NEK2_1	76	81	PF00069	0.678
MOD_NEK2_2	13	18	PF00069	0.609
MOD_PIKK_1	170	176	PF00454	0.438
MOD_PIKK_1	19	25	PF00454	0.458
MOD_PIKK_1	211	217	PF00454	0.430
MOD_PKA_1	199	205	PF00069	0.526
MOD_PKA_2	125	131	PF00069	0.591
MOD_PKA_2	134	140	PF00069	0.584
MOD_PKA_2	199	205	PF00069	0.526
MOD_PKA_2	65	71	PF00069	0.664
MOD_Plk_4	108	114	PF00069	0.766
MOD_Plk_4	203	209	PF00069	0.313
MOD_Plk_4	311	317	PF00069	0.448
MOD_Plk_4	46	52	PF00069	0.438
MOD_Plk_4	6	12	PF00069	0.599
MOD_ProDKin_1	113	119	PF00069	0.677
MOD_ProDKin_1	99	105	PF00069	0.697
TRG_DiLeu_BaEn_1	6	11	PF01217	0.486
TRG_DiLeu_BaEn_4	165	171	PF01217	0.498
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.334
TRG_DiLeu_BaLyEn_6	55	60	PF01217	0.489
TRG_ENDOCYTIC_2	14	17	PF00928	0.460
TRG_ENDOCYTIC_2	287	290	PF00928	0.354
TRG_ENDOCYTIC_2	318	321	PF00928	0.434
TRG_ER_diArg_1	125	127	PF00400	0.715
TRG_ER_diArg_1	198	201	PF00400	0.482
TRG_NLS_MonoExtN_4	196	202	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9D4	Leptomonas seymouri	68%	99%
A0A0S4IZI8	Bodo saltans	39%	86%
A0A1X0P7V3	Trypanosomatidae	47%	100%
A0A3R7K298	Trypanosoma rangeli	46%	100%
A0A3S7XAU7	Leishmania donovani	93%	100%
A4HP78	Leishmania braziliensis	85%	100%
A4IDI3	Leishmania infantum	93%	100%
D0A374	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ASY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DCI4	Trypanosoma cruzi	45%	100%