J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chaperone protein DnaJ, putative

Species:

Leishmania major

UniProt:

Q4Q1L1_LEIMA

TriTrypDb:

LmjF.36.2110 , LMJLV39_360028400 , LMJSD75_360028600

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	2
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4Q1L1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	2
GO:0006458	'de novo' protein folding	3	2
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010033	response to organic substance	3	2
GO:0010243	response to organonitrogen compound	4	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0030433	ubiquitin-dependent ERAD pathway	6	2
GO:0033554	cellular response to stress	3	2
GO:0034976	response to endoplasmic reticulum stress	4	2
GO:0035966	response to topologically incorrect protein	3	2
GO:0035967	cellular response to topologically incorrect protein	4	2
GO:0036503	ERAD pathway	5	2
GO:0042221	response to chemical	2	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0050896	response to stimulus	1	2
GO:0051084	'de novo' post-translational protein folding	4	2
GO:0051085	chaperone cofactor-dependent protein refolding	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0051788	response to misfolded protein	4	2
GO:0061077	chaperone-mediated protein folding	3	2
GO:0070887	cellular response to chemical stimulus	3	2
GO:0071218	cellular response to misfolded protein	5	2
GO:0071310	cellular response to organic substance	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901698	response to nitrogen compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030544	Hsp70 protein binding	4	2
GO:0031072	heat shock protein binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.485
CLV_C14_Caspase3-7	247	251	PF00656	0.354
CLV_C14_Caspase3-7	29	33	PF00656	0.387
CLV_C14_Caspase3-7	69	73	PF00656	0.457
CLV_NRD_NRD_1	232	234	PF00675	0.462
CLV_NRD_NRD_1	254	256	PF00675	0.449
CLV_NRD_NRD_1	282	284	PF00675	0.547
CLV_NRD_NRD_1	96	98	PF00675	0.531
CLV_PCSK_KEX2_1	232	234	PF00082	0.483
CLV_PCSK_KEX2_1	254	256	PF00082	0.460
CLV_PCSK_KEX2_1	282	284	PF00082	0.547
CLV_PCSK_KEX2_1	75	77	PF00082	0.249
CLV_PCSK_KEX2_1	96	98	PF00082	0.495
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.260
CLV_PCSK_SKI1_1	113	117	PF00082	0.471
CLV_PCSK_SKI1_1	282	286	PF00082	0.616
CLV_PCSK_SKI1_1	41	45	PF00082	0.320
DEG_Nend_UBRbox_3	1	3	PF02207	0.683
DOC_ANK_TNKS_1	80	87	PF00023	0.640
DOC_CKS1_1	221	226	PF01111	0.354
DOC_CYCLIN_yClb1_LxF_4	149	155	PF00134	0.554
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.421
DOC_MAPK_gen_1	232	238	PF00069	0.304
DOC_MAPK_MEF2A_6	232	240	PF00069	0.331
DOC_PP2B_LxvP_1	153	156	PF13499	0.421
DOC_PP2B_LxvP_1	216	219	PF13499	0.298
DOC_USP7_MATH_1	191	195	PF00917	0.357
DOC_USP7_MATH_1	224	228	PF00917	0.354
DOC_USP7_MATH_1	95	99	PF00917	0.732
DOC_USP7_UBL2_3	36	40	PF12436	0.454
DOC_USP7_UBL2_3	41	45	PF12436	0.442
DOC_USP7_UBL2_3	50	54	PF12436	0.460
DOC_WW_Pin1_4	220	225	PF00397	0.354
LIG_14-3-3_CanoR_1	209	214	PF00244	0.239
LIG_14-3-3_CanoR_1	96	104	PF00244	0.756
LIG_BRCT_BRCA1_1	193	197	PF00533	0.354
LIG_DLG_GKlike_1	209	216	PF00625	0.335
LIG_FHA_1	208	214	PF00498	0.294
LIG_FHA_1	5	11	PF00498	0.632
LIG_FHA_2	170	176	PF00498	0.488
LIG_FHA_2	245	251	PF00498	0.298
LIG_FHA_2	3	9	PF00498	0.590
LIG_FHA_2	67	73	PF00498	0.460
LIG_GBD_Chelix_1	157	165	PF00786	0.339
LIG_LIR_Gen_1	114	121	PF02991	0.611
LIG_LIR_Gen_1	168	179	PF02991	0.635
LIG_LIR_Gen_1	235	245	PF02991	0.299
LIG_LIR_Gen_1	277	285	PF02991	0.338
LIG_LIR_Nem_3	114	119	PF02991	0.588
LIG_LIR_Nem_3	168	174	PF02991	0.616
LIG_LIR_Nem_3	18	24	PF02991	0.469
LIG_LIR_Nem_3	277	281	PF02991	0.326
LIG_LIR_Nem_3	58	63	PF02991	0.449
LIG_Pex14_2	115	119	PF04695	0.590
LIG_PTB_Apo_2	175	182	PF02174	0.475
LIG_SH2_CRK	21	25	PF00017	0.449
LIG_SH2_CRK	221	225	PF00017	0.354
LIG_SH2_NCK_1	171	175	PF00017	0.511
LIG_SH2_STAT3	12	15	PF00017	0.610
LIG_SH2_STAT5	12	15	PF00017	0.596
LIG_SH2_STAT5	171	174	PF00017	0.507
LIG_SH2_STAT5	221	224	PF00017	0.239
LIG_SH2_STAT5	237	240	PF00017	0.241
LIG_SUMO_SIM_par_1	22	29	PF11976	0.488
MOD_CDK_SPK_2	220	225	PF00069	0.298
MOD_CK1_1	169	175	PF00069	0.498
MOD_CK1_1	71	77	PF00069	0.496
MOD_CK2_1	197	203	PF00069	0.335
MOD_CK2_1	2	8	PF00069	0.609
MOD_Cter_Amidation	252	255	PF01082	0.535
MOD_GlcNHglycan	91	94	PF01048	0.412
MOD_GlcNHglycan	97	100	PF01048	0.457
MOD_GSK3_1	165	172	PF00069	0.396
MOD_GSK3_1	191	198	PF00069	0.263
MOD_GSK3_1	220	227	PF00069	0.334
MOD_GSK3_1	244	251	PF00069	0.341
MOD_GSK3_1	62	69	PF00069	0.460
MOD_N-GLC_1	15	20	PF02516	0.356
MOD_NEK2_1	165	170	PF00069	0.304
MOD_NEK2_1	190	195	PF00069	0.494
MOD_NEK2_1	197	202	PF00069	0.341
MOD_NEK2_1	62	67	PF00069	0.488
MOD_PIKK_1	197	203	PF00454	0.341
MOD_PKA_2	208	214	PF00069	0.239
MOD_PKA_2	224	230	PF00069	0.239
MOD_PKA_2	248	254	PF00069	0.289
MOD_PKA_2	95	101	PF00069	0.717
MOD_Plk_4	209	215	PF00069	0.309
MOD_ProDKin_1	220	226	PF00069	0.354
MOD_SUMO_rev_2	235	245	PF00179	0.335
TRG_ENDOCYTIC_2	171	174	PF00928	0.507
TRG_ENDOCYTIC_2	20	23	PF00928	0.449
TRG_ENDOCYTIC_2	237	240	PF00928	0.292
TRG_ENDOCYTIC_2	278	281	PF00928	0.314
TRG_ENDOCYTIC_2	39	42	PF00928	0.449
TRG_ER_diArg_1	105	108	PF00400	0.746
TRG_ER_diArg_1	263	266	PF00400	0.250
TRG_ER_diArg_1	281	283	PF00400	0.343
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7P9	Leptomonas seymouri	67%	99%
A0A0S4JTE9	Bodo saltans	41%	100%
A0A1X0P7N5	Trypanosomatidae	53%	100%
A0A3Q8IH76	Leishmania donovani	98%	100%
A0A3R7LNU2	Trypanosoma rangeli	49%	100%
A4HP79	Leishmania braziliensis	86%	100%
A4IDI4	Leishmania infantum	98%	100%
D0A375	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9ASY7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O13633	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	71%
Q17438	Caenorhabditis elegans	30%	71%
Q58DR2	Bos taurus	30%	77%
Q6G1F8	Bartonella quintana (strain Toulouse)	28%	75%
Q7NBW0	Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))	31%	73%
Q7ZXQ8	Xenopus laevis	33%	77%
Q98PI9	Mycoplasmopsis pulmonis (strain UAB CTIP)	27%	76%
Q9NXW2	Homo sapiens	29%	76%
Q9QYI4	Mus musculus	29%	76%
V5BGE9	Trypanosoma cruzi	49%	100%