Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1L0_LEIMA

TriTrypDb:

LmjF.36.2115 , LMJLV39_360028600 , LMJSD75_360028800

Length:

659

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1L0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1L0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	152	156	PF00656	0.545
CLV_C14_Caspase3-7	74	78	PF00656	0.687
CLV_NRD_NRD_1	174	176	PF00675	0.717
CLV_NRD_NRD_1	239	241	PF00675	0.811
CLV_NRD_NRD_1	250	252	PF00675	0.581
CLV_NRD_NRD_1	275	277	PF00675	0.707
CLV_NRD_NRD_1	411	413	PF00675	0.660
CLV_NRD_NRD_1	427	429	PF00675	0.685
CLV_NRD_NRD_1	482	484	PF00675	0.517
CLV_NRD_NRD_1	569	571	PF00675	0.594
CLV_NRD_NRD_1	606	608	PF00675	0.542
CLV_NRD_NRD_1	65	67	PF00675	0.674
CLV_PCSK_KEX2_1	174	176	PF00082	0.717
CLV_PCSK_KEX2_1	250	252	PF00082	0.613
CLV_PCSK_KEX2_1	275	277	PF00082	0.681
CLV_PCSK_KEX2_1	482	484	PF00082	0.517
CLV_PCSK_KEX2_1	569	571	PF00082	0.585
CLV_PCSK_KEX2_1	606	608	PF00082	0.518
CLV_PCSK_KEX2_1	65	67	PF00082	0.674
CLV_PCSK_SKI1_1	482	486	PF00082	0.536
CLV_PCSK_SKI1_1	497	501	PF00082	0.616
CLV_Separin_Metazoa	114	118	PF03568	0.678
CLV_Separin_Metazoa	425	429	PF03568	0.618
DEG_APCC_DBOX_1	174	182	PF00400	0.643
DEG_APCC_DBOX_1	481	489	PF00400	0.539
DEG_SCF_FBW7_1	640	647	PF00400	0.543
DEG_SCF_FBW7_2	202	208	PF00400	0.573
DEG_SPOP_SBC_1	212	216	PF00917	0.660
DEG_SPOP_SBC_1	38	42	PF00917	0.537
DOC_ANK_TNKS_1	130	137	PF00023	0.637
DOC_CKS1_1	202	207	PF01111	0.605
DOC_CKS1_1	86	91	PF01111	0.728
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.669
DOC_CYCLIN_yCln2_LP_2	21	27	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.604
DOC_MAPK_DCC_7	174	183	PF00069	0.676
DOC_MAPK_gen_1	250	258	PF00069	0.636
DOC_MAPK_gen_1	482	490	PF00069	0.688
DOC_MAPK_MEF2A_6	174	183	PF00069	0.676
DOC_MAPK_MEF2A_6	309	316	PF00069	0.559
DOC_PP2B_LxvP_1	256	259	PF13499	0.615
DOC_PP2B_LxvP_1	499	502	PF13499	0.606
DOC_PP4_FxxP_1	403	406	PF00568	0.744
DOC_PP4_FxxP_1	468	471	PF00568	0.527
DOC_USP7_MATH_1	177	181	PF00917	0.720
DOC_USP7_MATH_1	189	193	PF00917	0.554
DOC_USP7_MATH_1	212	216	PF00917	0.608
DOC_USP7_MATH_1	230	234	PF00917	0.790
DOC_USP7_MATH_1	289	293	PF00917	0.751
DOC_USP7_MATH_1	299	303	PF00917	0.633
DOC_USP7_MATH_1	363	367	PF00917	0.715
DOC_USP7_MATH_1	37	41	PF00917	0.629
DOC_USP7_MATH_1	393	397	PF00917	0.720
DOC_USP7_MATH_1	457	461	PF00917	0.723
DOC_USP7_MATH_1	539	543	PF00917	0.616
DOC_USP7_MATH_1	644	648	PF00917	0.772
DOC_USP7_MATH_2	205	211	PF00917	0.565
DOC_USP7_MATH_2	504	510	PF00917	0.599
DOC_WW_Pin1_4	1	6	PF00397	0.602
DOC_WW_Pin1_4	182	187	PF00397	0.762
DOC_WW_Pin1_4	201	206	PF00397	0.627
DOC_WW_Pin1_4	282	287	PF00397	0.801
DOC_WW_Pin1_4	354	359	PF00397	0.679
DOC_WW_Pin1_4	39	44	PF00397	0.697
DOC_WW_Pin1_4	489	494	PF00397	0.570
DOC_WW_Pin1_4	497	502	PF00397	0.542
DOC_WW_Pin1_4	523	528	PF00397	0.569
DOC_WW_Pin1_4	638	643	PF00397	0.653
DOC_WW_Pin1_4	65	70	PF00397	0.714
DOC_WW_Pin1_4	8	13	PF00397	0.619
DOC_WW_Pin1_4	85	90	PF00397	0.772
LIG_14-3-3_CanoR_1	266	273	PF00244	0.727
LIG_14-3-3_CanoR_1	596	602	PF00244	0.537
LIG_14-3-3_CanoR_1	634	640	PF00244	0.727
LIG_14-3-3_CanoR_1	65	69	PF00244	0.667
LIG_Actin_WH2_2	104	119	PF00022	0.682
LIG_Actin_WH2_2	49	67	PF00022	0.538
LIG_BRCT_BRCA1_1	540	544	PF00533	0.612
LIG_BRCT_BRCA1_1	593	597	PF00533	0.664
LIG_CSL_BTD_1	86	89	PF09270	0.667
LIG_FHA_1	285	291	PF00498	0.628
LIG_FHA_1	422	428	PF00498	0.615
LIG_FHA_1	49	55	PF00498	0.670
LIG_FHA_1	68	74	PF00498	0.579
LIG_FHA_1	86	92	PF00498	0.693
LIG_FHA_2	202	208	PF00498	0.732
LIG_FHA_2	296	302	PF00498	0.743
LIG_FHA_2	400	406	PF00498	0.744
LIG_FHA_2	576	582	PF00498	0.521
LIG_LIR_Apic_2	401	407	PF02991	0.746
LIG_LIR_Apic_2	467	471	PF02991	0.526
LIG_LIR_Gen_1	102	111	PF02991	0.576
LIG_LIR_Gen_1	279	289	PF02991	0.680
LIG_LIR_Gen_1	50	61	PF02991	0.548
LIG_LIR_Nem_3	279	284	PF02991	0.682
LIG_LIR_Nem_3	380	385	PF02991	0.598
LIG_LIR_Nem_3	50	56	PF02991	0.545
LIG_LIR_Nem_3	541	547	PF02991	0.742
LIG_LYPXL_S_1	474	478	PF13949	0.657
LIG_LYPXL_SIV_4	24	32	PF13949	0.569
LIG_LYPXL_yS_3	475	478	PF13949	0.534
LIG_MYND_1	92	96	PF01753	0.633
LIG_PTAP_UEV_1	68	73	PF05743	0.574
LIG_SH2_CRK	130	134	PF00017	0.542
LIG_SH2_CRK	540	544	PF00017	0.544
LIG_SH2_NCK_1	25	29	PF00017	0.567
LIG_SH2_NCK_1	540	544	PF00017	0.544
LIG_SH2_PTP2	473	476	PF00017	0.675
LIG_SH2_SRC	473	476	PF00017	0.557
LIG_SH2_STAP1	120	124	PF00017	0.616
LIG_SH2_STAP1	540	544	PF00017	0.544
LIG_SH2_STAT3	120	123	PF00017	0.677
LIG_SH2_STAT5	190	193	PF00017	0.650
LIG_SH2_STAT5	473	476	PF00017	0.662
LIG_SH3_1	199	205	PF00018	0.577
LIG_SH3_1	241	247	PF00018	0.743
LIG_SH3_1	533	539	PF00018	0.669
LIG_SH3_1	66	72	PF00018	0.670
LIG_SH3_3	131	137	PF00018	0.542
LIG_SH3_3	16	22	PF00018	0.605
LIG_SH3_3	183	189	PF00018	0.675
LIG_SH3_3	199	205	PF00018	0.565
LIG_SH3_3	241	247	PF00018	0.759
LIG_SH3_3	28	34	PF00018	0.581
LIG_SH3_3	280	286	PF00018	0.791
LIG_SH3_3	304	310	PF00018	0.769
LIG_SH3_3	424	430	PF00018	0.642
LIG_SH3_3	498	504	PF00018	0.613
LIG_SH3_3	533	539	PF00018	0.679
LIG_SH3_3	553	559	PF00018	0.746
LIG_SH3_3	6	12	PF00018	0.604
LIG_SH3_3	66	72	PF00018	0.734
LIG_SH3_3	86	92	PF00018	0.725
LIG_SH3_4	429	436	PF00018	0.620
LIG_TRAF2_1	205	208	PF00917	0.633
LIG_TRAF2_1	477	480	PF00917	0.644
LIG_WW_3	500	504	PF00397	0.624
MOD_CDC14_SPxK_1	526	529	PF00782	0.570
MOD_CDK_SPxK_1	497	503	PF00069	0.586
MOD_CDK_SPxK_1	523	529	PF00069	0.572
MOD_CDK_SPxxK_3	1	8	PF00069	0.594
MOD_CK1_1	192	198	PF00069	0.701
MOD_CK1_1	211	217	PF00069	0.691
MOD_CK1_1	221	227	PF00069	0.594
MOD_CK1_1	268	274	PF00069	0.755
MOD_CK1_1	285	291	PF00069	0.678
MOD_CK1_1	302	308	PF00069	0.561
MOD_CK1_1	329	335	PF00069	0.611
MOD_CK1_1	460	466	PF00069	0.802
MOD_CK1_1	520	526	PF00069	0.599
MOD_CK1_1	638	644	PF00069	0.712
MOD_CK1_1	67	73	PF00069	0.616
MOD_CK2_1	129	135	PF00069	0.741
MOD_CK2_1	17	23	PF00069	0.656
MOD_CK2_1	201	207	PF00069	0.669
MOD_CK2_1	268	274	PF00069	0.740
MOD_CK2_1	295	301	PF00069	0.739
MOD_CK2_1	575	581	PF00069	0.545
MOD_CK2_1	622	628	PF00069	0.710
MOD_Cter_Amidation	248	251	PF01082	0.588
MOD_DYRK1A_RPxSP_1	8	12	PF00069	0.602
MOD_GlcNHglycan	151	154	PF01048	0.548
MOD_GlcNHglycan	191	194	PF01048	0.745
MOD_GlcNHglycan	210	213	PF01048	0.802
MOD_GlcNHglycan	220	223	PF01048	0.595
MOD_GlcNHglycan	318	321	PF01048	0.714
MOD_GlcNHglycan	35	38	PF01048	0.770
MOD_GlcNHglycan	367	370	PF01048	0.661
MOD_GlcNHglycan	371	374	PF01048	0.715
MOD_GlcNHglycan	391	394	PF01048	0.681
MOD_GlcNHglycan	395	398	PF01048	0.728
MOD_GlcNHglycan	448	451	PF01048	0.722
MOD_GlcNHglycan	453	456	PF01048	0.769
MOD_GlcNHglycan	459	462	PF01048	0.604
MOD_GlcNHglycan	508	511	PF01048	0.652
MOD_GlcNHglycan	512	515	PF01048	0.655
MOD_GlcNHglycan	519	522	PF01048	0.733
MOD_GlcNHglycan	650	653	PF01048	0.743
MOD_GlcNHglycan	73	76	PF01048	0.805
MOD_GSK3_1	147	154	PF00069	0.699
MOD_GSK3_1	177	184	PF00069	0.616
MOD_GSK3_1	207	214	PF00069	0.749
MOD_GSK3_1	218	225	PF00069	0.611
MOD_GSK3_1	264	271	PF00069	0.709
MOD_GSK3_1	284	291	PF00069	0.632
MOD_GSK3_1	295	302	PF00069	0.661
MOD_GSK3_1	310	317	PF00069	0.625
MOD_GSK3_1	33	40	PF00069	0.719
MOD_GSK3_1	332	339	PF00069	0.676
MOD_GSK3_1	365	372	PF00069	0.617
MOD_GSK3_1	389	396	PF00069	0.612
MOD_GSK3_1	439	446	PF00069	0.696
MOD_GSK3_1	451	458	PF00069	0.703
MOD_GSK3_1	506	513	PF00069	0.786
MOD_GSK3_1	517	524	PF00069	0.553
MOD_GSK3_1	539	546	PF00069	0.677
MOD_GSK3_1	616	623	PF00069	0.580
MOD_GSK3_1	640	647	PF00069	0.605
MOD_GSK3_1	67	74	PF00069	0.690
MOD_GSK3_1	8	15	PF00069	0.611
MOD_GSK3_1	95	102	PF00069	0.687
MOD_N-GLC_1	310	315	PF02516	0.556
MOD_NEK2_1	116	121	PF00069	0.675
MOD_NEK2_1	181	186	PF00069	0.578
MOD_NEK2_1	218	223	PF00069	0.629
MOD_NEK2_1	316	321	PF00069	0.713
MOD_NEK2_1	505	510	PF00069	0.759
MOD_NEK2_1	597	602	PF00069	0.497
MOD_NEK2_1	622	627	PF00069	0.588
MOD_NEK2_1	64	69	PF00069	0.539
MOD_NEK2_2	318	323	PF00069	0.629
MOD_NEK2_2	539	544	PF00069	0.539
MOD_PIKK_1	12	18	PF00454	0.605
MOD_PIKK_1	266	272	PF00454	0.759
MOD_PIKK_1	622	628	PF00454	0.606
MOD_PKA_2	116	122	PF00069	0.575
MOD_PKA_2	137	143	PF00069	0.730
MOD_PKA_2	230	236	PF00069	0.674
MOD_PKA_2	265	271	PF00069	0.726
MOD_PKA_2	363	369	PF00069	0.774
MOD_PKA_2	414	420	PF00069	0.614
MOD_PKA_2	439	445	PF00069	0.754
MOD_PKA_2	446	452	PF00069	0.695
MOD_PKA_2	635	641	PF00069	0.675
MOD_PKA_2	64	70	PF00069	0.712
MOD_PKB_1	147	155	PF00069	0.557
MOD_Plk_1	310	316	PF00069	0.556
MOD_Plk_1	48	54	PF00069	0.695
MOD_Plk_1	581	587	PF00069	0.662
MOD_Plk_2-3	109	115	PF00069	0.613
MOD_Plk_2-3	23	29	PF00069	0.699
MOD_Plk_4	102	108	PF00069	0.699
MOD_Plk_4	214	220	PF00069	0.630
MOD_Plk_4	268	274	PF00069	0.755
MOD_Plk_4	399	405	PF00069	0.749
MOD_Plk_4	49	55	PF00069	0.606
MOD_Plk_4	539	545	PF00069	0.599
MOD_Plk_4	581	587	PF00069	0.565
MOD_ProDKin_1	1	7	PF00069	0.601
MOD_ProDKin_1	182	188	PF00069	0.762
MOD_ProDKin_1	201	207	PF00069	0.629
MOD_ProDKin_1	282	288	PF00069	0.801
MOD_ProDKin_1	354	360	PF00069	0.679
MOD_ProDKin_1	39	45	PF00069	0.698
MOD_ProDKin_1	489	495	PF00069	0.571
MOD_ProDKin_1	497	503	PF00069	0.548
MOD_ProDKin_1	523	529	PF00069	0.572
MOD_ProDKin_1	638	644	PF00069	0.651
MOD_ProDKin_1	65	71	PF00069	0.712
MOD_ProDKin_1	8	14	PF00069	0.618
MOD_ProDKin_1	85	91	PF00069	0.771
MOD_SUMO_for_1	377	380	PF00179	0.732
MOD_SUMO_for_1	564	567	PF00179	0.612
TRG_DiLeu_BaEn_1	480	485	PF01217	0.519
TRG_DiLeu_BaEn_2	48	54	PF01217	0.536
TRG_DiLeu_BaEn_2	580	586	PF01217	0.542
TRG_DiLeu_BaLyEn_6	2	7	PF01217	0.602
TRG_DiLeu_BaLyEn_6	90	95	PF01217	0.714
TRG_DiLeu_LyEn_5	480	485	PF01217	0.519
TRG_ENDOCYTIC_2	130	133	PF00928	0.572
TRG_ENDOCYTIC_2	475	478	PF00928	0.534
TRG_ENDOCYTIC_2	540	543	PF00928	0.600
TRG_ER_diArg_1	275	277	PF00400	0.625
TRG_ER_diArg_1	482	484	PF00400	0.517
TRG_ER_diArg_1	569	571	PF00400	0.594
TRG_ER_diArg_1	605	607	PF00400	0.537
TRG_ER_diArg_1	634	637	PF00400	0.738
TRG_ER_diArg_1	64	66	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	482	487	PF00026	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFC9	Leptomonas seymouri	33%	78%
A0A3S7XAU5	Leishmania donovani	88%	85%
A4HP80	Leishmania braziliensis	59%	83%
A4IDI5	Leishmania infantum	88%	85%
E9ASY8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	85%