Suppressor of disruption of TFIIS

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1K7_LEIMA

TriTrypDb:

LmjF.36.2140 , LMJLV39_360028900 , LMJSD75_360029100

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1K7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1K7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	311	315	PF00656	0.460
CLV_NRD_NRD_1	73	75	PF00675	0.478
CLV_PCSK_KEX2_1	269	271	PF00082	0.623
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.580
CLV_PCSK_SKI1_1	156	160	PF00082	0.413
CLV_PCSK_SKI1_1	165	169	PF00082	0.438
CLV_PCSK_SKI1_1	334	338	PF00082	0.485
DEG_APCC_KENBOX_2	178	182	PF00400	0.457
DEG_SPOP_SBC_1	239	243	PF00917	0.630
DOC_MAPK_gen_1	170	178	PF00069	0.601
DOC_MAPK_gen_1	272	281	PF00069	0.372
DOC_MAPK_JIP1_4	172	178	PF00069	0.581
DOC_MAPK_MEF2A_6	114	123	PF00069	0.484
DOC_MAPK_MEF2A_6	170	178	PF00069	0.601
DOC_PP4_FxxP_1	168	171	PF00568	0.519
DOC_USP7_MATH_1	10	14	PF00917	0.540
DOC_USP7_MATH_1	150	154	PF00917	0.467
DOC_USP7_MATH_1	250	254	PF00917	0.702
DOC_USP7_MATH_1	324	328	PF00917	0.435
DOC_WW_Pin1_4	19	24	PF00397	0.409
DOC_WW_Pin1_4	4	9	PF00397	0.623
LIG_14-3-3_CanoR_1	258	266	PF00244	0.664
LIG_14-3-3_CterR_2	352	356	PF00244	0.636
LIG_Actin_WH2_2	326	342	PF00022	0.477
LIG_BIR_III_4	160	164	PF00653	0.435
LIG_Clathr_ClatBox_1	285	289	PF01394	0.467
LIG_Clathr_ClatBox_1	31	35	PF01394	0.329
LIG_CtBP_PxDLS_1	291	295	PF00389	0.434
LIG_deltaCOP1_diTrp_1	195	199	PF00928	0.486
LIG_deltaCOP1_diTrp_1	293	300	PF00928	0.431
LIG_FHA_1	303	309	PF00498	0.373
LIG_FHA_2	137	143	PF00498	0.635
LIG_FHA_2	206	212	PF00498	0.461
LIG_FHA_2	35	41	PF00498	0.438
LIG_HCF-1_HBM_1	142	145	PF13415	0.486
LIG_LIR_Gen_1	106	115	PF02991	0.348
LIG_LIR_Gen_1	27	34	PF02991	0.497
LIG_LIR_Gen_1	276	286	PF02991	0.487
LIG_LIR_Gen_1	293	302	PF02991	0.386
LIG_LIR_Gen_1	97	102	PF02991	0.444
LIG_LIR_Nem_3	106	110	PF02991	0.334
LIG_LIR_Nem_3	195	199	PF02991	0.486
LIG_LIR_Nem_3	222	228	PF02991	0.437
LIG_LIR_Nem_3	27	32	PF02991	0.502
LIG_LIR_Nem_3	276	281	PF02991	0.488
LIG_LIR_Nem_3	293	299	PF02991	0.432
LIG_LIR_Nem_3	83	88	PF02991	0.384
LIG_LIR_Nem_3	97	101	PF02991	0.346
LIG_PCNA_yPIPBox_3	109	120	PF02747	0.474
LIG_PTB_Apo_2	33	40	PF02174	0.314
LIG_PTB_Phospho_1	33	39	PF10480	0.308
LIG_SH2_CRK	107	111	PF00017	0.494
LIG_SH2_CRK	112	116	PF00017	0.480
LIG_SH2_CRK	85	89	PF00017	0.435
LIG_SH2_NCK_1	221	225	PF00017	0.440
LIG_SH2_SRC	39	42	PF00017	0.474
LIG_SH2_STAP1	201	205	PF00017	0.357
LIG_SH2_STAP1	221	225	PF00017	0.440
LIG_SH2_STAP1	321	325	PF00017	0.471
LIG_SH2_STAP1	98	102	PF00017	0.463
LIG_SH2_STAT3	201	204	PF00017	0.357
LIG_SH2_STAT5	146	149	PF00017	0.355
LIG_SH2_STAT5	87	90	PF00017	0.516
LIG_SH3_3	171	177	PF00018	0.683
LIG_SH3_4	215	222	PF00018	0.300
LIG_SUMO_SIM_anti_2	118	124	PF11976	0.288
LIG_SUMO_SIM_par_1	30	35	PF11976	0.338
MOD_CK1_1	254	260	PF00069	0.610
MOD_CK2_1	205	211	PF00069	0.483
MOD_CK2_1	34	40	PF00069	0.382
MOD_GlcNHglycan	12	15	PF01048	0.544
MOD_GlcNHglycan	246	249	PF01048	0.683
MOD_GlcNHglycan	254	257	PF01048	0.657
MOD_GlcNHglycan	296	299	PF01048	0.384
MOD_GlcNHglycan	316	319	PF01048	0.318
MOD_GlcNHglycan	326	329	PF01048	0.375
MOD_GlcNHglycan	352	355	PF01048	0.515
MOD_GSK3_1	240	247	PF00069	0.631
MOD_GSK3_1	250	257	PF00069	0.556
MOD_GSK3_1	348	355	PF00069	0.591
MOD_N-GLC_1	150	155	PF02516	0.432
MOD_N-GLC_1	314	319	PF02516	0.558
MOD_NEK2_1	238	243	PF00069	0.616
MOD_NEK2_1	251	256	PF00069	0.675
MOD_NEK2_1	294	299	PF00069	0.382
MOD_NEK2_2	80	85	PF00069	0.446
MOD_PIKK_1	302	308	PF00454	0.366
MOD_PKA_2	136	142	PF00069	0.520
MOD_PKA_2	257	263	PF00069	0.694
MOD_Plk_1	281	287	PF00069	0.473
MOD_Plk_1	34	40	PF00069	0.315
MOD_Plk_4	24	30	PF00069	0.436
MOD_Plk_4	281	287	PF00069	0.483
MOD_Plk_4	34	40	PF00069	0.280
MOD_Plk_4	80	86	PF00069	0.423
MOD_ProDKin_1	19	25	PF00069	0.413
MOD_ProDKin_1	4	10	PF00069	0.624
TRG_DiLeu_BaEn_1	234	239	PF01217	0.573
TRG_DiLeu_BaEn_2	96	102	PF01217	0.478
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.410
TRG_ENDOCYTIC_2	107	110	PF00928	0.436
TRG_ENDOCYTIC_2	221	224	PF00928	0.381
TRG_ENDOCYTIC_2	225	228	PF00928	0.390
TRG_ENDOCYTIC_2	85	88	PF00928	0.424
TRG_ENDOCYTIC_2	98	101	PF00928	0.520
TRG_ER_diArg_1	170	173	PF00400	0.617
TRG_ER_diArg_1	270	273	PF00400	0.411
TRG_NLS_MonoExtN_4	267	273	PF00514	0.438
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I684	Leptomonas seymouri	65%	100%
A0A1X0P7P0	Trypanosomatidae	29%	100%
A0A3S7XB03	Leishmania donovani	93%	100%
A0A422N520	Trypanosoma rangeli	27%	100%
A4HP83	Leishmania braziliensis	81%	100%
A4IDI8	Leishmania infantum	93%	100%
E9ASZ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BKX8	Trypanosoma cruzi	28%	100%