Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

dynein light chain, putative

Species:

Leishmania major

UniProt:

Q4Q1K5_LEIMA

TriTrypDb:

LmjF.36.2160 , LMJLV39_360029100 , LMJSD75_360029300

Length:

129

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	10
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005874	microtubule	6	10
GO:0005875	microtubule associated complex	2	10
GO:0030286	dynein complex	3	10
GO:0032991	protein-containing complex	1	10
GO:0099080	supramolecular complex	2	10
GO:0099081	supramolecular polymer	3	10
GO:0099512	supramolecular fiber	4	10
GO:0099513	polymeric cytoskeletal fiber	5	10
GO:0110165	cellular anatomical entity	1	10
GO:1902494	catalytic complex	2	10

Expansion

Sequence features

Q4Q1K5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1K5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	10
GO:0009987	cellular process	1	10

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045505	dynein intermediate chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_gen_1	18	28	PF00069	0.607
DOC_USP7_MATH_1	108	112	PF00917	0.512
DOC_USP7_MATH_1	117	121	PF00917	0.630
DOC_USP7_UBL2_3	14	18	PF12436	0.639
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_FHA_1	14	20	PF00498	0.645
LIG_FHA_1	74	80	PF00498	0.449
LIG_FHA_2	34	40	PF00498	0.555
LIG_FHA_2	55	61	PF00498	0.503
LIG_FHA_2	88	94	PF00498	0.529
LIG_GBD_Chelix_1	61	69	PF00786	0.258
LIG_LIR_Gen_1	76	85	PF02991	0.458
LIG_LIR_Nem_3	50	54	PF02991	0.464
LIG_LIR_Nem_3	55	61	PF02991	0.453
LIG_LIR_Nem_3	76	80	PF02991	0.458
LIG_PCNA_yPIPBox_3	98	110	PF02747	0.529
LIG_SH2_STAP1	7	11	PF00017	0.705
LIG_SH2_STAT5	105	108	PF00017	0.500
LIG_SH2_STAT5	56	59	PF00017	0.392
LIG_SH3_3	111	117	PF00018	0.548
LIG_Sin3_3	45	52	PF02671	0.448
LIG_TRAF2_1	2	5	PF00917	0.661
LIG_UBA3_1	96	100	PF00899	0.527
MOD_CK2_1	33	39	PF00069	0.472
MOD_GlcNHglycan	110	113	PF01048	0.382
MOD_GlcNHglycan	119	122	PF01048	0.637
MOD_N-GLC_1	33	38	PF02516	0.248
MOD_N-GLC_1	87	92	PF02516	0.270
MOD_PKA_1	13	19	PF00069	0.494
MOD_Plk_1	33	39	PF00069	0.526
MOD_Plk_1	54	60	PF00069	0.560
MOD_Plk_1	92	98	PF00069	0.529
MOD_Plk_4	92	98	PF00069	0.458
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.596
TRG_ENDOCYTIC_2	58	61	PF00928	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT5	Leptomonas seymouri	74%	100%
A0A1X0P7U5	Trypanosomatidae	55%	100%
A0A3Q8IJ25	Leishmania donovani	95%	100%
A0A422NIV0	Trypanosoma rangeli	56%	100%
A4HP85	Leishmania braziliensis	82%	100%
A4IDJ0	Leishmania infantum	94%	100%
D0A385	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ASZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O02414	Heliocidaris crassispina	32%	100%
Q94748	Schistosoma mansoni	38%	100%
Q94758	Schistosoma mansoni	33%	100%