SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania major

UniProt:

Q4Q1K4_LEIMA

TriTrypDb:

LmjF.36.2170 , LMJLV39_360029200 , LMJSD75_360029400

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q1K4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1K4

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	9
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009451	RNA modification	5	9
GO:0009987	cellular process	1	9
GO:0016070	RNA metabolic process	5	9
GO:0032259	methylation	2	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0043414	macromolecule methylation	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0000049	tRNA binding	5	3
GO:0008173	RNA methyltransferase activity	4	3
GO:0008175	tRNA methyltransferase activity	5	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	3
GO:0016427	tRNA (cytosine) methyltransferase activity	6	3
GO:0016428	tRNA (cytosine-5-)-methyltransferase activity	7	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140101	catalytic activity, acting on a tRNA	4	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	410	414	PF00656	0.490
CLV_C14_Caspase3-7	69	73	PF00656	0.518
CLV_NRD_NRD_1	15	17	PF00675	0.560
CLV_NRD_NRD_1	158	160	PF00675	0.386
CLV_NRD_NRD_1	322	324	PF00675	0.226
CLV_NRD_NRD_1	655	657	PF00675	0.477
CLV_PCSK_FUR_1	477	481	PF00082	0.363
CLV_PCSK_KEX2_1	15	17	PF00082	0.547
CLV_PCSK_KEX2_1	160	162	PF00082	0.396
CLV_PCSK_KEX2_1	253	255	PF00082	0.195
CLV_PCSK_KEX2_1	263	265	PF00082	0.195
CLV_PCSK_KEX2_1	479	481	PF00082	0.419
CLV_PCSK_KEX2_1	514	516	PF00082	0.601
CLV_PCSK_KEX2_1	655	657	PF00082	0.477
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.414
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.195
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.195
CLV_PCSK_PC1ET2_1	479	481	PF00082	0.419
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.601
CLV_PCSK_SKI1_1	19	23	PF00082	0.563
CLV_PCSK_SKI1_1	266	270	PF00082	0.195
CLV_PCSK_SKI1_1	394	398	PF00082	0.200
CLV_PCSK_SKI1_1	568	572	PF00082	0.397
CLV_Separin_Metazoa	303	307	PF03568	0.388
DEG_APCC_DBOX_1	393	401	PF00400	0.400
DEG_APCC_DBOX_1	691	699	PF00400	0.299
DEG_SCF_FBW7_1	103	110	PF00400	0.328
DOC_CKS1_1	104	109	PF01111	0.332
DOC_CKS1_1	32	37	PF01111	0.467
DOC_CKS1_1	433	438	PF01111	0.397
DOC_CYCLIN_yCln2_LP_2	267	273	PF00134	0.398
DOC_MAPK_gen_1	253	259	PF00069	0.395
DOC_MAPK_gen_1	263	269	PF00069	0.395
DOC_MAPK_gen_1	383	390	PF00069	0.406
DOC_MAPK_gen_1	615	624	PF00069	0.493
DOC_MAPK_gen_1	655	665	PF00069	0.316
DOC_MAPK_gen_1	692	700	PF00069	0.344
DOC_MAPK_gen_1	723	732	PF00069	0.273
DOC_MAPK_HePTP_8	653	665	PF00069	0.325
DOC_MAPK_HePTP_8	720	732	PF00069	0.256
DOC_MAPK_MEF2A_6	212	220	PF00069	0.301
DOC_MAPK_MEF2A_6	342	349	PF00069	0.395
DOC_MAPK_MEF2A_6	656	665	PF00069	0.307
DOC_MAPK_MEF2A_6	723	732	PF00069	0.307
DOC_MAPK_NFAT4_5	725	733	PF00069	0.305
DOC_MIT_MIM_1	688	698	PF04212	0.352
DOC_PP1_RVXF_1	264	270	PF00149	0.395
DOC_PP1_RVXF_1	627	634	PF00149	0.425
DOC_PP2B_LxvP_1	430	433	PF13499	0.395
DOC_PP4_FxxP_1	104	107	PF00568	0.295
DOC_PP4_FxxP_1	419	422	PF00568	0.423
DOC_PP4_MxPP_1	188	191	PF00568	0.300
DOC_USP7_MATH_1	227	231	PF00917	0.392
DOC_USP7_MATH_1	283	287	PF00917	0.516
DOC_USP7_MATH_1	492	496	PF00917	0.584
DOC_USP7_MATH_1	643	647	PF00917	0.268
DOC_USP7_MATH_1	73	77	PF00917	0.642
DOC_USP7_MATH_1	78	82	PF00917	0.643
DOC_USP7_UBL2_3	485	489	PF12436	0.529
DOC_USP7_UBL2_3	5	9	PF12436	0.558
DOC_USP7_UBL2_3	514	518	PF12436	0.664
DOC_USP7_UBL2_3	677	681	PF12436	0.469
DOC_WW_Pin1_4	103	108	PF00397	0.330
DOC_WW_Pin1_4	205	210	PF00397	0.289
DOC_WW_Pin1_4	230	235	PF00397	0.356
DOC_WW_Pin1_4	31	36	PF00397	0.476
DOC_WW_Pin1_4	330	335	PF00397	0.395
DOC_WW_Pin1_4	432	437	PF00397	0.397
DOC_WW_Pin1_4	595	600	PF00397	0.527
LIG_14-3-3_CanoR_1	173	180	PF00244	0.407
LIG_14-3-3_CanoR_1	360	370	PF00244	0.412
LIG_14-3-3_CanoR_1	408	418	PF00244	0.388
LIG_14-3-3_CanoR_1	568	576	PF00244	0.453
LIG_14-3-3_CanoR_1	615	624	PF00244	0.453
LIG_14-3-3_CanoR_1	641	650	PF00244	0.293
LIG_14-3-3_CanoR_1	655	663	PF00244	0.278
LIG_Actin_WH2_2	307	325	PF00022	0.458
LIG_Actin_WH2_2	340	358	PF00022	0.425
LIG_BIR_III_2	231	235	PF00653	0.432
LIG_BIR_III_4	413	417	PF00653	0.490
LIG_Clathr_ClatBox_1	704	708	PF01394	0.264
LIG_CSL_BTD_1	331	334	PF09270	0.395
LIG_eIF4E_1	239	245	PF01652	0.223
LIG_FHA_1	104	110	PF00498	0.313
LIG_FHA_1	115	121	PF00498	0.301
LIG_FHA_1	300	306	PF00498	0.509
LIG_FHA_1	363	369	PF00498	0.529
LIG_FHA_1	616	622	PF00498	0.366
LIG_FHA_2	21	27	PF00498	0.518
LIG_FHA_2	273	279	PF00498	0.426
LIG_FHA_2	408	414	PF00498	0.520
LIG_FHA_2	543	549	PF00498	0.500
LIG_FHA_2	67	73	PF00498	0.553
LIG_FHA_2	82	88	PF00498	0.373
LIG_LIR_Apic_2	102	107	PF02991	0.314
LIG_LIR_Nem_3	140	144	PF02991	0.314
LIG_LIR_Nem_3	571	576	PF02991	0.382
LIG_MAD2	60	68	PF02301	0.363
LIG_PCNA_PIPBox_1	164	173	PF02747	0.349
LIG_PCNA_PIPBox_1	567	576	PF02747	0.435
LIG_PDZ_Class_3	758	763	PF00595	0.696
LIG_PTB_Apo_2	42	49	PF02174	0.513
LIG_SH2_CRK	52	56	PF00017	0.432
LIG_SH2_NCK_1	439	443	PF00017	0.431
LIG_SH2_SRC	25	28	PF00017	0.559
LIG_SH2_SRC	574	577	PF00017	0.307
LIG_SH2_STAP1	439	443	PF00017	0.423
LIG_SH2_STAP1	718	722	PF00017	0.261
LIG_SH2_STAT5	170	173	PF00017	0.465
LIG_SH2_STAT5	281	284	PF00017	0.406
LIG_SH3_3	29	35	PF00018	0.603
LIG_SH3_3	430	436	PF00018	0.425
LIG_SH3_3	546	552	PF00018	0.585
LIG_SH3_3	557	563	PF00018	0.315
LIG_SH3_3	658	664	PF00018	0.441
LIG_SH3_3	745	751	PF00018	0.473
LIG_SUMO_SIM_anti_2	618	625	PF11976	0.361
LIG_SUMO_SIM_par_1	618	625	PF11976	0.332
LIG_SUMO_SIM_par_1	703	708	PF11976	0.286
LIG_TRAF2_1	181	184	PF00917	0.323
LIG_UBA3_1	216	224	PF00899	0.284
LIG_UBA3_1	328	335	PF00899	0.334
LIG_UBA3_1	704	711	PF00899	0.474
LIG_WRC_WIRS_1	109	114	PF05994	0.392
LIG_WRC_WIRS_1	8	13	PF05994	0.469
MOD_CDK_SPK_2	330	335	PF00069	0.223
MOD_CDK_SPxxK_3	205	212	PF00069	0.285
MOD_CK1_1	20	26	PF00069	0.547
MOD_CK1_1	208	214	PF00069	0.320
MOD_CK1_1	230	236	PF00069	0.354
MOD_CK1_1	286	292	PF00069	0.211
MOD_CK1_1	364	370	PF00069	0.251
MOD_CK1_1	522	528	PF00069	0.494
MOD_CK1_1	601	607	PF00069	0.405
MOD_CK1_1	76	82	PF00069	0.748
MOD_CK2_1	131	137	PF00069	0.301
MOD_CK2_1	178	184	PF00069	0.317
MOD_CK2_1	21	27	PF00069	0.566
MOD_CK2_1	330	336	PF00069	0.223
MOD_CK2_1	492	498	PF00069	0.715
MOD_CK2_1	542	548	PF00069	0.500
MOD_CK2_1	690	696	PF00069	0.302
MOD_GlcNHglycan	19	22	PF01048	0.613
MOD_GlcNHglycan	316	319	PF01048	0.283
MOD_GlcNHglycan	440	443	PF01048	0.353
MOD_GlcNHglycan	487	492	PF01048	0.547
MOD_GlcNHglycan	624	627	PF01048	0.409
MOD_GlcNHglycan	645	648	PF01048	0.307
MOD_GlcNHglycan	673	676	PF01048	0.462
MOD_GlcNHglycan	758	761	PF01048	0.613
MOD_GlcNHglycan	76	79	PF01048	0.517
MOD_GlcNHglycan	87	91	PF01048	0.363
MOD_GSK3_1	103	110	PF00069	0.349
MOD_GSK3_1	127	134	PF00069	0.358
MOD_GSK3_1	17	24	PF00069	0.622
MOD_GSK3_1	172	179	PF00069	0.338
MOD_GSK3_1	295	302	PF00069	0.271
MOD_GSK3_1	314	321	PF00069	0.267
MOD_GSK3_1	498	505	PF00069	0.570
MOD_GSK3_1	521	528	PF00069	0.690
MOD_GSK3_1	62	69	PF00069	0.585
MOD_GSK3_1	682	689	PF00069	0.413
MOD_GSK3_1	73	80	PF00069	0.609
MOD_N-GLC_1	114	119	PF02516	0.290
MOD_NEK2_1	108	113	PF00069	0.376
MOD_NEK2_1	361	366	PF00069	0.285
MOD_NEK2_1	447	452	PF00069	0.278
MOD_NEK2_1	585	590	PF00069	0.491
MOD_NEK2_1	622	627	PF00069	0.368
MOD_NEK2_1	654	659	PF00069	0.451
MOD_NEK2_1	671	676	PF00069	0.581
MOD_NEK2_2	318	323	PF00069	0.284
MOD_PIKK_1	286	292	PF00454	0.167
MOD_PIKK_1	574	580	PF00454	0.349
MOD_PKA_1	655	661	PF00069	0.327
MOD_PKA_2	172	178	PF00069	0.433
MOD_PKA_2	407	413	PF00069	0.213
MOD_PKA_2	502	508	PF00069	0.683
MOD_PKA_2	654	660	PF00069	0.407
MOD_PKA_2	73	79	PF00069	0.447
MOD_Plk_1	184	190	PF00069	0.271
MOD_Plk_1	283	289	PF00069	0.304
MOD_Plk_1	447	453	PF00069	0.262
MOD_Plk_1	574	580	PF00069	0.524
MOD_Plk_1	686	692	PF00069	0.461
MOD_Plk_4	108	114	PF00069	0.214
MOD_Plk_4	131	137	PF00069	0.328
MOD_Plk_4	184	190	PF00069	0.306
MOD_Plk_4	502	508	PF00069	0.556
MOD_Plk_4	601	607	PF00069	0.327
MOD_Plk_4	663	669	PF00069	0.375
MOD_Plk_4	92	98	PF00069	0.361
MOD_ProDKin_1	103	109	PF00069	0.330
MOD_ProDKin_1	205	211	PF00069	0.289
MOD_ProDKin_1	230	236	PF00069	0.351
MOD_ProDKin_1	31	37	PF00069	0.473
MOD_ProDKin_1	330	336	PF00069	0.223
MOD_ProDKin_1	432	438	PF00069	0.226
MOD_ProDKin_1	595	601	PF00069	0.516
MOD_SUMO_for_1	513	516	PF00179	0.684
MOD_SUMO_for_1	755	758	PF00179	0.648
MOD_SUMO_rev_2	249	255	PF00179	0.223
MOD_SUMO_rev_2	482	491	PF00179	0.648
TRG_DiLeu_BaLyEn_6	104	109	PF01217	0.426
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.231
TRG_ENDOCYTIC_2	52	55	PF00928	0.307
TRG_ER_diArg_1	158	161	PF00400	0.349
TRG_ER_diArg_1	264	267	PF00400	0.223
TRG_ER_diArg_1	654	656	PF00400	0.465
TRG_ER_diArg_1	691	694	PF00400	0.341
TRG_ER_diArg_1	722	725	PF00400	0.272
TRG_NLS_Bipartite_1	253	267	PF00514	0.223
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.342
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.213
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZE7	Leptomonas seymouri	76%	98%
A0A1X0P6Y3	Trypanosomatidae	26%	93%
A0A1X0P7M3	Trypanosomatidae	59%	100%
A0A3Q8IJ07	Leishmania donovani	32%	100%
A0A3Q8INR5	Leishmania donovani	94%	99%
A0A3R7NNX1	Trypanosoma rangeli	58%	100%
A4HP86	Leishmania braziliensis	84%	100%
A4IDJ1	Leishmania infantum	94%	99%
D0A386	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AHJ5	Leishmania infantum	32%	100%
E9ASZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
O13935	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
P38205	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q08J23	Homo sapiens	31%	99%
Q1HFZ0	Mus musculus	31%	100%
Q28E61	Xenopus tropicalis	31%	96%
Q4V7N2	Xenopus laevis	30%	100%
Q5ZLV4	Gallus gallus	32%	96%
V5DCJ5	Trypanosoma cruzi	63%	100%