Protein-tyrosine phosphatase 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein-tyrosine phosphatase 1-like protein

Species:

Leishmania major

UniProt:

Q4Q1K3_LEIMA

TriTrypDb:

LmjF.36.2180 , LMJLV39_360029300 , LMJSD75_360029500

Length:

523

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1K3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1K3

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004721	phosphoprotein phosphatase activity	3	7
GO:0004725	protein tyrosine phosphatase activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.399
CLV_NRD_NRD_1	201	203	PF00675	0.636
CLV_NRD_NRD_1	323	325	PF00675	0.466
CLV_NRD_NRD_1	454	456	PF00675	0.344
CLV_NRD_NRD_1	460	462	PF00675	0.347
CLV_NRD_NRD_1	489	491	PF00675	0.578
CLV_PCSK_KEX2_1	201	203	PF00082	0.635
CLV_PCSK_KEX2_1	323	325	PF00082	0.466
CLV_PCSK_KEX2_1	454	456	PF00082	0.466
CLV_PCSK_KEX2_1	83	85	PF00082	0.511
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.511
CLV_PCSK_SKI1_1	180	184	PF00082	0.685
CLV_PCSK_SKI1_1	455	459	PF00082	0.344
CLV_PCSK_SKI1_1	513	517	PF00082	0.655
CLV_PCSK_SKI1_1	519	523	PF00082	0.616
CLV_Separin_Metazoa	320	324	PF03568	0.466
DEG_APCC_DBOX_1	498	506	PF00400	0.416
DOC_CYCLIN_yCln2_LP_2	415	421	PF00134	0.466
DOC_MAPK_MEF2A_6	414	421	PF00069	0.344
DOC_MAPK_MEF2A_6	470	479	PF00069	0.339
DOC_MAPK_RevD_3	475	491	PF00069	0.516
DOC_PP2B_LxvP_1	415	418	PF13499	0.466
DOC_USP7_MATH_1	178	182	PF00917	0.714
DOC_USP7_MATH_1	26	30	PF00917	0.743
DOC_USP7_MATH_1	288	292	PF00917	0.344
DOC_USP7_MATH_1	388	392	PF00917	0.352
DOC_USP7_MATH_1	394	398	PF00917	0.324
DOC_USP7_MATH_1	79	83	PF00917	0.661
DOC_WW_Pin1_4	165	170	PF00397	0.797
DOC_WW_Pin1_4	174	179	PF00397	0.685
DOC_WW_Pin1_4	37	42	PF00397	0.815
DOC_WW_Pin1_4	372	377	PF00397	0.339
DOC_WW_Pin1_4	413	418	PF00397	0.466
LIG_14-3-3_CanoR_1	162	170	PF00244	0.647
LIG_14-3-3_CanoR_1	20	25	PF00244	0.721
LIG_14-3-3_CanoR_1	323	327	PF00244	0.266
LIG_14-3-3_CanoR_1	490	498	PF00244	0.494
LIG_AP_GAE_1	105	111	PF02883	0.562
LIG_APCC_ABBA_1	303	308	PF00400	0.339
LIG_BIR_II_1	1	5	PF00653	0.820
LIG_CtBP_PxDLS_1	169	173	PF00389	0.752
LIG_FHA_1	216	222	PF00498	0.776
LIG_FHA_1	265	271	PF00498	0.506
LIG_FHA_1	414	420	PF00498	0.438
LIG_FHA_1	428	434	PF00498	0.259
LIG_FHA_1	68	74	PF00498	0.709
LIG_FHA_2	235	241	PF00498	0.399
LIG_FHA_2	271	277	PF00498	0.339
LIG_FHA_2	46	52	PF00498	0.604
LIG_LIR_Apic_2	325	330	PF02991	0.266
LIG_LIR_Apic_2	91	96	PF02991	0.383
LIG_LIR_Gen_1	255	262	PF02991	0.466
LIG_LIR_Gen_1	358	368	PF02991	0.339
LIG_LIR_Gen_1	472	482	PF02991	0.339
LIG_LIR_Gen_1	98	109	PF02991	0.425
LIG_LIR_Nem_3	105	111	PF02991	0.375
LIG_LIR_Nem_3	255	260	PF02991	0.466
LIG_LIR_Nem_3	358	364	PF02991	0.339
LIG_LIR_Nem_3	472	477	PF02991	0.339
LIG_LIR_Nem_3	89	93	PF02991	0.485
LIG_LIR_Nem_3	98	104	PF02991	0.382
LIG_NRP_CendR_1	522	523	PF00754	0.674
LIG_PCNA_PIPBox_1	251	260	PF02747	0.466
LIG_PTB_Apo_2	84	91	PF02174	0.462
LIG_SH2_CRK	344	348	PF00017	0.466
LIG_SH2_CRK	437	441	PF00017	0.339
LIG_SH2_CRK	474	478	PF00017	0.339
LIG_SH2_CRK	93	97	PF00017	0.520
LIG_SH2_GRB2like	135	138	PF00017	0.468
LIG_SH2_GRB2like	229	232	PF00017	0.339
LIG_SH2_PTP2	135	138	PF00017	0.468
LIG_SH2_PTP2	327	330	PF00017	0.466
LIG_SH2_SRC	135	138	PF00017	0.468
LIG_SH2_SRC	229	232	PF00017	0.466
LIG_SH2_SRC	344	347	PF00017	0.466
LIG_SH2_STAP1	262	266	PF00017	0.466
LIG_SH2_STAP1	313	317	PF00017	0.339
LIG_SH2_STAT5	135	138	PF00017	0.468
LIG_SH2_STAT5	229	232	PF00017	0.339
LIG_SH2_STAT5	313	316	PF00017	0.339
LIG_SH2_STAT5	327	330	PF00017	0.339
LIG_SH2_STAT5	346	349	PF00017	0.196
LIG_SH2_STAT5	371	374	PF00017	0.366
LIG_SH2_STAT5	437	440	PF00017	0.339
LIG_SH2_STAT5	59	62	PF00017	0.620
LIG_SH3_3	344	350	PF00018	0.473
LIG_SH3_3	375	381	PF00018	0.406
LIG_SH3_3	5	11	PF00018	0.702
LIG_SUMO_SIM_anti_2	255	263	PF11976	0.466
LIG_SUMO_SIM_anti_2	265	270	PF11976	0.324
LIG_SUMO_SIM_par_1	267	274	PF11976	0.344
LIG_TRAF2_1	140	143	PF00917	0.423
LIG_TRAF2_1	249	252	PF00917	0.466
LIG_TRAF2_1	360	363	PF00917	0.339
LIG_TYR_ITIM	342	347	PF00017	0.466
LIG_WRC_WIRS_1	297	302	PF05994	0.366
MOD_CDC14_SPxK_1	177	180	PF00782	0.638
MOD_CDK_SPxK_1	174	180	PF00069	0.683
MOD_CDK_SPxxK_3	372	379	PF00069	0.266
MOD_CK1_1	15	21	PF00069	0.676
MOD_CK1_1	150	156	PF00069	0.624
MOD_CK1_1	161	167	PF00069	0.683
MOD_CK1_1	168	174	PF00069	0.787
MOD_CK1_1	29	35	PF00069	0.612
MOD_CK1_1	299	305	PF00069	0.399
MOD_CK1_1	331	337	PF00069	0.466
MOD_CK1_1	357	363	PF00069	0.339
MOD_CK1_1	392	398	PF00069	0.389
MOD_CK1_1	6	12	PF00069	0.632
MOD_CK1_1	69	75	PF00069	0.744
MOD_CK2_1	18	24	PF00069	0.694
MOD_CK2_1	234	240	PF00069	0.399
MOD_CK2_1	270	276	PF00069	0.339
MOD_CK2_1	357	363	PF00069	0.339
MOD_CK2_1	79	85	PF00069	0.602
MOD_GlcNHglycan	152	155	PF01048	0.736
MOD_GlcNHglycan	165	168	PF01048	0.714
MOD_GlcNHglycan	173	176	PF01048	0.618
MOD_GlcNHglycan	289	293	PF01048	0.352
MOD_GlcNHglycan	31	34	PF01048	0.752
MOD_GlcNHglycan	330	333	PF01048	0.483
MOD_GlcNHglycan	386	389	PF01048	0.362
MOD_GlcNHglycan	396	399	PF01048	0.272
MOD_GlcNHglycan	407	410	PF01048	0.349
MOD_GlcNHglycan	411	414	PF01048	0.395
MOD_GlcNHglycan	423	426	PF01048	0.317
MOD_GlcNHglycan	48	51	PF01048	0.622
MOD_GlcNHglycan	492	495	PF01048	0.560
MOD_GlcNHglycan	55	58	PF01048	0.646
MOD_GSK3_1	12	19	PF00069	0.690
MOD_GSK3_1	146	153	PF00069	0.657
MOD_GSK3_1	154	161	PF00069	0.686
MOD_GSK3_1	174	181	PF00069	0.733
MOD_GSK3_1	215	222	PF00069	0.564
MOD_GSK3_1	260	267	PF00069	0.498
MOD_GSK3_1	29	36	PF00069	0.568
MOD_GSK3_1	37	44	PF00069	0.738
MOD_GSK3_1	384	391	PF00069	0.374
MOD_GSK3_1	399	406	PF00069	0.264
MOD_GSK3_1	409	416	PF00069	0.335
MOD_GSK3_1	53	60	PF00069	0.601
MOD_N-GLC_1	121	126	PF02516	0.412
MOD_N-GLC_1	15	20	PF02516	0.752
MOD_N-GLC_1	449	454	PF02516	0.466
MOD_NEK2_1	123	128	PF00069	0.453
MOD_NEK2_1	14	19	PF00069	0.605
MOD_NEK2_1	163	168	PF00069	0.688
MOD_NEK2_1	197	202	PF00069	0.622
MOD_NEK2_1	243	248	PF00069	0.338
MOD_NEK2_1	448	453	PF00069	0.466
MOD_NEK2_1	66	71	PF00069	0.685
MOD_PIKK_1	243	249	PF00454	0.339
MOD_PIKK_1	331	337	PF00454	0.399
MOD_PIKK_1	43	49	PF00454	0.742
MOD_PKA_1	490	496	PF00069	0.567
MOD_PKA_2	161	167	PF00069	0.660
MOD_PKA_2	19	25	PF00069	0.595
MOD_PKA_2	322	328	PF00069	0.383
MOD_PKA_2	6	12	PF00069	0.689
MOD_Plk_1	111	117	PF00069	0.507
MOD_Plk_1	141	147	PF00069	0.427
MOD_Plk_1	235	241	PF00069	0.466
MOD_Plk_1	26	32	PF00069	0.668
MOD_Plk_1	264	270	PF00069	0.466
MOD_Plk_1	3	9	PF00069	0.765
MOD_Plk_1	449	455	PF00069	0.466
MOD_Plk_4	141	147	PF00069	0.427
MOD_Plk_4	264	270	PF00069	0.439
MOD_Plk_4	429	435	PF00069	0.339
MOD_Plk_4	9	15	PF00069	0.682
MOD_ProDKin_1	165	171	PF00069	0.796
MOD_ProDKin_1	174	180	PF00069	0.683
MOD_ProDKin_1	37	43	PF00069	0.816
MOD_ProDKin_1	372	378	PF00069	0.339
MOD_ProDKin_1	413	419	PF00069	0.466
TRG_DiLeu_BaEn_2	275	281	PF01217	0.466
TRG_DiLeu_BaEn_2	471	477	PF01217	0.339
TRG_DiLeu_BaEn_3	362	368	PF01217	0.339
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.542
TRG_ENDOCYTIC_2	135	138	PF00928	0.468
TRG_ENDOCYTIC_2	344	347	PF00928	0.466
TRG_ENDOCYTIC_2	437	440	PF00928	0.339
TRG_ENDOCYTIC_2	474	477	PF00928	0.345
TRG_ENDOCYTIC_2	478	481	PF00928	0.339
TRG_ER_diArg_1	322	324	PF00400	0.466
TRG_ER_diArg_1	453	455	PF00400	0.466
TRG_NES_CRM1_1	295	309	PF08389	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN6	Leptomonas seymouri	51%	100%
A0A3S7XAX7	Leishmania donovani	90%	100%
A4HP87	Leishmania braziliensis	75%	100%
A4IDJ2	Leishmania infantum	90%	100%
E9ASZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%