DUF4456 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1K2_LEIMA

TriTrypDb:

LmjF.36.2190 , LMJLV39_360029400 , LMJSD75_360029600

Length:

586

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1K2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1K2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.701
CLV_C14_Caspase3-7	432	436	PF00656	0.571
CLV_NRD_NRD_1	125	127	PF00675	0.531
CLV_NRD_NRD_1	204	206	PF00675	0.644
CLV_NRD_NRD_1	303	305	PF00675	0.780
CLV_NRD_NRD_1	31	33	PF00675	0.552
CLV_NRD_NRD_1	420	422	PF00675	0.667
CLV_NRD_NRD_1	470	472	PF00675	0.596
CLV_NRD_NRD_1	491	493	PF00675	0.641
CLV_NRD_NRD_1	555	557	PF00675	0.654
CLV_NRD_NRD_1	63	65	PF00675	0.608
CLV_PCSK_FUR_1	420	424	PF00082	0.662
CLV_PCSK_KEX2_1	125	127	PF00082	0.491
CLV_PCSK_KEX2_1	196	198	PF00082	0.565
CLV_PCSK_KEX2_1	204	206	PF00082	0.571
CLV_PCSK_KEX2_1	31	33	PF00082	0.552
CLV_PCSK_KEX2_1	420	422	PF00082	0.801
CLV_PCSK_KEX2_1	470	472	PF00082	0.582
CLV_PCSK_KEX2_1	510	512	PF00082	0.649
CLV_PCSK_KEX2_1	534	536	PF00082	0.721
CLV_PCSK_KEX2_1	63	65	PF00082	0.605
CLV_PCSK_PC1ET2_1	196	198	PF00082	0.587
CLV_PCSK_PC1ET2_1	422	424	PF00082	0.688
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.617
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.721
CLV_PCSK_SKI1_1	191	195	PF00082	0.536
CLV_PCSK_SKI1_1	204	208	PF00082	0.509
CLV_PCSK_SKI1_1	32	36	PF00082	0.626
CLV_PCSK_SKI1_1	449	453	PF00082	0.625
CLV_PCSK_SKI1_1	497	501	PF00082	0.533
CLV_PCSK_SKI1_1	561	565	PF00082	0.659
DEG_APCC_DBOX_1	555	563	PF00400	0.561
DEG_Kelch_Keap1_1	94	99	PF01344	0.670
DOC_CKS1_1	228	233	PF01111	0.592
DOC_CYCLIN_yClb3_PxF_3	578	584	PF00134	0.619
DOC_MAPK_FxFP_2	575	578	PF00069	0.626
DOC_PP2B_LxvP_1	357	360	PF13499	0.549
DOC_PP4_FxxP_1	570	573	PF00568	0.631
DOC_PP4_FxxP_1	575	578	PF00568	0.644
DOC_USP7_MATH_1	128	132	PF00917	0.592
DOC_USP7_MATH_1	137	141	PF00917	0.635
DOC_USP7_MATH_1	245	249	PF00917	0.631
DOC_USP7_MATH_1	279	283	PF00917	0.652
DOC_USP7_UBL2_3	308	312	PF12436	0.630
DOC_USP7_UBL2_3	493	497	PF12436	0.626
DOC_USP7_UBL2_3	510	514	PF12436	0.615
DOC_USP7_UBL2_3	549	553	PF12436	0.696
DOC_USP7_UBL2_3	557	561	PF12436	0.546
DOC_WW_Pin1_4	209	214	PF00397	0.661
DOC_WW_Pin1_4	227	232	PF00397	0.489
DOC_WW_Pin1_4	292	297	PF00397	0.626
DOC_WW_Pin1_4	355	360	PF00397	0.656
DOC_WW_Pin1_4	377	382	PF00397	0.573
DOC_WW_Pin1_4	49	54	PF00397	0.615
LIG_14-3-3_CanoR_1	204	213	PF00244	0.610
LIG_14-3-3_CanoR_1	238	242	PF00244	0.690
LIG_14-3-3_CanoR_1	492	496	PF00244	0.534
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_BIR_III_2	275	279	PF00653	0.533
LIG_BIR_III_4	433	437	PF00653	0.657
LIG_EVH1_1	570	574	PF00568	0.653
LIG_EVH1_1	577	581	PF00568	0.594
LIG_FHA_1	261	267	PF00498	0.613
LIG_FHA_1	498	504	PF00498	0.514
LIG_FHA_1	516	522	PF00498	0.587
LIG_FHA_2	406	412	PF00498	0.572
LIG_FHA_2	68	74	PF00498	0.700
LIG_FHA_2	83	89	PF00498	0.589
LIG_FHA_2	95	101	PF00498	0.622
LIG_LIR_Gen_1	120	129	PF02991	0.569
LIG_LIR_Gen_1	457	467	PF02991	0.525
LIG_LIR_Gen_1	494	503	PF02991	0.546
LIG_LIR_Nem_3	120	124	PF02991	0.572
LIG_LIR_Nem_3	457	462	PF02991	0.522
LIG_LIR_Nem_3	494	498	PF02991	0.537
LIG_NRBOX	219	225	PF00104	0.702
LIG_Pex14_1	491	495	PF04695	0.537
LIG_Pex14_2	250	254	PF04695	0.626
LIG_RPA_C_Fungi	466	478	PF08784	0.564
LIG_SH2_CRK	495	499	PF00017	0.538
LIG_SH2_STAP1	337	341	PF00017	0.604
LIG_SH2_STAP1	495	499	PF00017	0.538
LIG_SH3_2	10	15	PF14604	0.657
LIG_SH3_2	228	233	PF14604	0.634
LIG_SH3_3	210	216	PF00018	0.659
LIG_SH3_3	225	231	PF00018	0.530
LIG_SH3_3	568	574	PF00018	0.645
LIG_SH3_3	575	581	PF00018	0.598
LIG_SH3_3	7	13	PF00018	0.795
LIG_TRAF2_1	527	530	PF00917	0.645
LIG_TRAF2_1	72	75	PF00917	0.631
LIG_TRAF2_1	97	100	PF00917	0.670
LIG_TRFH_1	570	574	PF08558	0.569
MOD_CDK_SPK_2	292	297	PF00069	0.585
MOD_CDK_SPK_2	377	382	PF00069	0.517
MOD_CDK_SPxK_1	227	233	PF00069	0.587
MOD_CDK_SPxxK_3	292	299	PF00069	0.627
MOD_CDK_SPxxK_3	355	362	PF00069	0.578
MOD_CK1_1	358	364	PF00069	0.664
MOD_CK1_1	368	374	PF00069	0.530
MOD_CK2_1	405	411	PF00069	0.568
MOD_CK2_1	513	519	PF00069	0.642
MOD_CK2_1	69	75	PF00069	0.697
MOD_CK2_1	94	100	PF00069	0.614
MOD_Cter_Amidation	508	511	PF01082	0.635
MOD_GlcNHglycan	188	191	PF01048	0.539
MOD_GlcNHglycan	21	25	PF01048	0.789
MOD_GlcNHglycan	247	250	PF01048	0.625
MOD_GlcNHglycan	292	295	PF01048	0.761
MOD_GlcNHglycan	415	418	PF01048	0.685
MOD_GlcNHglycan	465	468	PF01048	0.611
MOD_GSK3_1	105	112	PF00069	0.659
MOD_GSK3_1	204	211	PF00069	0.656
MOD_GSK3_1	237	244	PF00069	0.722
MOD_GSK3_1	351	358	PF00069	0.766
MOD_GSK3_1	423	430	PF00069	0.644
MOD_GSK3_1	487	494	PF00069	0.462
MOD_GSK3_1	497	504	PF00069	0.489
MOD_GSK3_1	65	72	PF00069	0.575
MOD_N-GLC_1	65	70	PF02516	0.574
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	484	489	PF00069	0.504
MOD_NEK2_1	65	70	PF00069	0.574
MOD_PIKK_1	204	210	PF00454	0.605
MOD_PIKK_1	260	266	PF00454	0.542
MOD_PIKK_1	375	381	PF00454	0.527
MOD_PK_1	277	283	PF00069	0.651
MOD_PKA_1	204	210	PF00069	0.605
MOD_PKA_1	304	310	PF00069	0.538
MOD_PKA_1	396	402	PF00069	0.609
MOD_PKA_2	105	111	PF00069	0.753
MOD_PKA_2	204	210	PF00069	0.713
MOD_PKA_2	237	243	PF00069	0.691
MOD_PKA_2	463	469	PF00069	0.458
MOD_PKA_2	491	497	PF00069	0.545
MOD_PKA_2	66	72	PF00069	0.706
MOD_PKB_1	421	429	PF00069	0.546
MOD_Plk_1	484	490	PF00069	0.502
MOD_Plk_4	105	111	PF00069	0.573
MOD_Plk_4	396	402	PF00069	0.609
MOD_ProDKin_1	209	215	PF00069	0.660
MOD_ProDKin_1	227	233	PF00069	0.493
MOD_ProDKin_1	292	298	PF00069	0.627
MOD_ProDKin_1	355	361	PF00069	0.657
MOD_ProDKin_1	377	383	PF00069	0.572
MOD_ProDKin_1	49	55	PF00069	0.615
MOD_SUMO_for_1	552	555	PF00179	0.443
MOD_SUMO_rev_2	270	279	PF00179	0.630
MOD_SUMO_rev_2	389	399	PF00179	0.558
MOD_SUMO_rev_2	442	451	PF00179	0.637
TRG_DiLeu_BaEn_1	315	320	PF01217	0.605
TRG_DiLeu_BaEn_3	149	155	PF01217	0.634
TRG_ENDOCYTIC_2	337	340	PF00928	0.744
TRG_ENDOCYTIC_2	495	498	PF00928	0.539
TRG_ER_diArg_1	124	126	PF00400	0.568
TRG_ER_diArg_1	296	299	PF00400	0.780
TRG_ER_diArg_1	419	421	PF00400	0.670
TRG_ER_diArg_1	62	64	PF00400	0.599
TRG_NLS_MonoExtN_4	420	425	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.679
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAV9	Leishmania donovani	89%	100%
A4HP88	Leishmania braziliensis	64%	99%
A4IDJ3	Leishmania infantum	89%	100%
E9ASZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%