Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1K1_LEIMA

TriTrypDb:

LmjF.36.2200 , LMJLV39_360029500 , LMJSD75_360029700

Length:

643

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1K1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1K1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	263	267	PF00656	0.499
CLV_C14_Caspase3-7	321	325	PF00656	0.704
CLV_C14_Caspase3-7	417	421	PF00656	0.632
CLV_C14_Caspase3-7	498	502	PF00656	0.647
CLV_NRD_NRD_1	101	103	PF00675	0.604
CLV_NRD_NRD_1	117	119	PF00675	0.488
CLV_NRD_NRD_1	141	143	PF00675	0.674
CLV_NRD_NRD_1	340	342	PF00675	0.760
CLV_NRD_NRD_1	402	404	PF00675	0.723
CLV_NRD_NRD_1	460	462	PF00675	0.689
CLV_NRD_NRD_1	522	524	PF00675	0.650
CLV_NRD_NRD_1	528	530	PF00675	0.610
CLV_NRD_NRD_1	550	552	PF00675	0.597
CLV_NRD_NRD_1	589	591	PF00675	0.741
CLV_NRD_NRD_1	616	618	PF00675	0.839
CLV_PCSK_FUR_1	340	344	PF00082	0.722
CLV_PCSK_FUR_1	535	539	PF00082	0.702
CLV_PCSK_KEX2_1	100	102	PF00082	0.628
CLV_PCSK_KEX2_1	117	119	PF00082	0.483
CLV_PCSK_KEX2_1	340	342	PF00082	0.795
CLV_PCSK_KEX2_1	402	404	PF00082	0.621
CLV_PCSK_KEX2_1	459	461	PF00082	0.693
CLV_PCSK_KEX2_1	522	524	PF00082	0.597
CLV_PCSK_KEX2_1	530	532	PF00082	0.670
CLV_PCSK_KEX2_1	534	536	PF00082	0.720
CLV_PCSK_KEX2_1	537	539	PF00082	0.760
CLV_PCSK_KEX2_1	550	552	PF00082	0.500
CLV_PCSK_KEX2_1	554	556	PF00082	0.528
CLV_PCSK_KEX2_1	588	590	PF00082	0.714
CLV_PCSK_KEX2_1	616	618	PF00082	0.839
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.725
CLV_PCSK_PC1ET2_1	530	532	PF00082	0.682
CLV_PCSK_PC1ET2_1	534	536	PF00082	0.735
CLV_PCSK_PC1ET2_1	537	539	PF00082	0.777
CLV_PCSK_PC1ET2_1	554	556	PF00082	0.528
CLV_PCSK_PC1ET2_1	588	590	PF00082	0.714
CLV_PCSK_PC7_1	456	462	PF00082	0.669
CLV_PCSK_PC7_1	518	524	PF00082	0.581
CLV_PCSK_PC7_1	550	556	PF00082	0.605
CLV_PCSK_SKI1_1	154	158	PF00082	0.519
CLV_PCSK_SKI1_1	21	25	PF00082	0.567
CLV_PCSK_SKI1_1	279	283	PF00082	0.671
CLV_PCSK_SKI1_1	288	292	PF00082	0.601
CLV_PCSK_SKI1_1	368	372	PF00082	0.729
CLV_PCSK_SKI1_1	389	393	PF00082	0.620
CLV_PCSK_SKI1_1	551	555	PF00082	0.725
CLV_PCSK_SKI1_1	607	611	PF00082	0.797
DEG_APCC_DBOX_1	232	240	PF00400	0.551
DEG_APCC_DBOX_1	367	375	PF00400	0.731
DEG_Nend_UBRbox_2	1	3	PF02207	0.592
DOC_CYCLIN_RxL_1	285	296	PF00134	0.625
DOC_CYCLIN_RxL_1	365	373	PF00134	0.738
DOC_CYCLIN_RxL_1	518	528	PF00134	0.717
DOC_CYCLIN_yCln2_LP_2	609	612	PF00134	0.747
DOC_MAPK_gen_1	209	218	PF00069	0.461
DOC_MAPK_gen_1	425	432	PF00069	0.572
DOC_MAPK_gen_1	534	542	PF00069	0.783
DOC_MAPK_gen_1	614	623	PF00069	0.607
DOC_MAPK_MEF2A_6	154	163	PF00069	0.487
DOC_MAPK_MEF2A_6	209	218	PF00069	0.496
DOC_PP1_RVXF_1	105	111	PF00149	0.530
DOC_PP2B_LxvP_1	218	221	PF13499	0.531
DOC_PP2B_LxvP_1	239	242	PF13499	0.527
DOC_PP2B_LxvP_1	290	293	PF13499	0.706
DOC_PP2B_LxvP_1	609	612	PF13499	0.747
DOC_PP4_FxxP_1	163	166	PF00568	0.580
DOC_USP7_MATH_1	186	190	PF00917	0.713
DOC_USP7_MATH_1	194	198	PF00917	0.671
DOC_USP7_MATH_1	242	246	PF00917	0.525
DOC_USP7_MATH_1	255	259	PF00917	0.614
DOC_USP7_MATH_1	268	272	PF00917	0.409
DOC_USP7_MATH_1	32	36	PF00917	0.676
DOC_USP7_MATH_1	47	51	PF00917	0.406
DOC_USP7_MATH_1	476	480	PF00917	0.725
DOC_USP7_MATH_1	59	63	PF00917	0.717
DOC_USP7_MATH_1	593	597	PF00917	0.702
DOC_USP7_MATH_1	601	605	PF00917	0.752
DOC_USP7_MATH_1	9	13	PF00917	0.646
DOC_USP7_MATH_1	96	100	PF00917	0.729
DOC_USP7_UBL2_3	530	534	PF12436	0.757
DOC_USP7_UBL2_3	584	588	PF12436	0.777
DOC_WW_Pin1_4	203	208	PF00397	0.548
DOC_WW_Pin1_4	484	489	PF00397	0.739
DOC_WW_Pin1_4	579	584	PF00397	0.754
DOC_WW_Pin1_4	621	626	PF00397	0.788
DOC_WW_Pin1_4	89	94	PF00397	0.725
LIG_14-3-3_CanoR_1	272	278	PF00244	0.641
LIG_14-3-3_CanoR_1	343	349	PF00244	0.802
LIG_14-3-3_CanoR_1	389	395	PF00244	0.731
LIG_14-3-3_CanoR_1	425	430	PF00244	0.644
LIG_14-3-3_CanoR_1	600	610	PF00244	0.754
LIG_14-3-3_CanoR_1	616	623	PF00244	0.562
LIG_APCC_ABBA_1	445	450	PF00400	0.681
LIG_FHA_1	200	206	PF00498	0.617
LIG_FHA_1	383	389	PF00498	0.727
LIG_FHA_1	424	430	PF00498	0.593
LIG_FHA_1	442	448	PF00498	0.601
LIG_FHA_1	49	55	PF00498	0.574
LIG_FHA_1	604	610	PF00498	0.838
LIG_FHA_1	616	622	PF00498	0.639
LIG_FHA_2	166	172	PF00498	0.611
LIG_FHA_2	261	267	PF00498	0.570
LIG_FHA_2	305	311	PF00498	0.487
LIG_FHA_2	415	421	PF00498	0.646
LIG_FHA_2	493	499	PF00498	0.815
LIG_LIR_Apic_2	393	397	PF02991	0.734
LIG_LIR_Gen_1	304	312	PF02991	0.618
LIG_LIR_Gen_1	363	371	PF02991	0.688
LIG_LIR_Gen_1	385	394	PF02991	0.712
LIG_LIR_Nem_3	304	308	PF02991	0.604
LIG_LIR_Nem_3	351	355	PF02991	0.691
LIG_LIR_Nem_3	363	367	PF02991	0.595
LIG_LIR_Nem_3	385	390	PF02991	0.716
LIG_MAD2	389	397	PF02301	0.610
LIG_NRBOX	235	241	PF00104	0.522
LIG_RPA_C_Fungi	97	109	PF08784	0.456
LIG_SH2_CRK	305	309	PF00017	0.611
LIG_SH2_CRK	364	368	PF00017	0.622
LIG_SH2_CRK	394	398	PF00017	0.721
LIG_SH2_NCK_1	448	452	PF00017	0.609
LIG_SH2_SRC	6	9	PF00017	0.569
LIG_SH2_STAP1	305	309	PF00017	0.566
LIG_SH2_STAP1	448	452	PF00017	0.609
LIG_SH2_STAP1	6	10	PF00017	0.677
LIG_SH2_STAT5	152	155	PF00017	0.551
LIG_SH3_3	41	47	PF00018	0.494
LIG_SH3_3	90	96	PF00018	0.711
LIG_SUMO_SIM_par_1	212	217	PF11976	0.599
LIG_SUMO_SIM_par_1	245	251	PF11976	0.617
LIG_SUMO_SIM_par_1	50	56	PF11976	0.555
LIG_TYR_ITIM	303	308	PF00017	0.607
MOD_CDC14_SPxK_1	206	209	PF00782	0.469
MOD_CDK_SPK_2	579	584	PF00069	0.754
MOD_CDK_SPxK_1	203	209	PF00069	0.520
MOD_CK1_1	12	18	PF00069	0.648
MOD_CK1_1	199	205	PF00069	0.726
MOD_CK1_1	260	266	PF00069	0.581
MOD_CK1_1	271	277	PF00069	0.524
MOD_CK1_1	304	310	PF00069	0.712
MOD_CK1_1	486	492	PF00069	0.676
MOD_CK1_1	50	56	PF00069	0.576
MOD_CK1_1	62	68	PF00069	0.761
MOD_CK1_1	89	95	PF00069	0.718
MOD_CK2_1	223	229	PF00069	0.533
MOD_CK2_1	304	310	PF00069	0.479
MOD_CK2_1	407	413	PF00069	0.633
MOD_CK2_1	460	466	PF00069	0.552
MOD_CK2_1	492	498	PF00069	0.813
MOD_CK2_1	67	73	PF00069	0.758
MOD_CMANNOS	110	113	PF00535	0.605
MOD_Cter_Amidation	532	535	PF01082	0.762
MOD_GlcNHglycan	136	141	PF01048	0.679
MOD_GlcNHglycan	187	191	PF01048	0.654
MOD_GlcNHglycan	196	199	PF01048	0.663
MOD_GlcNHglycan	257	260	PF01048	0.696
MOD_GlcNHglycan	336	339	PF01048	0.695
MOD_GlcNHglycan	34	37	PF01048	0.661
MOD_GlcNHglycan	351	355	PF01048	0.516
MOD_GlcNHglycan	398	401	PF01048	0.602
MOD_GlcNHglycan	462	465	PF01048	0.683
MOD_GlcNHglycan	478	481	PF01048	0.455
MOD_GlcNHglycan	489	492	PF01048	0.624
MOD_GlcNHglycan	501	504	PF01048	0.544
MOD_GlcNHglycan	59	62	PF01048	0.777
MOD_GlcNHglycan	601	604	PF01048	0.762
MOD_GlcNHglycan	75	78	PF01048	0.727
MOD_GlcNHglycan	88	91	PF01048	0.676
MOD_GSK3_1	194	201	PF00069	0.669
MOD_GSK3_1	219	226	PF00069	0.630
MOD_GSK3_1	253	260	PF00069	0.664
MOD_GSK3_1	304	311	PF00069	0.716
MOD_GSK3_1	370	377	PF00069	0.642
MOD_GSK3_1	405	412	PF00069	0.728
MOD_GSK3_1	482	489	PF00069	0.660
MOD_GSK3_1	53	60	PF00069	0.669
MOD_GSK3_1	599	606	PF00069	0.801
MOD_GSK3_1	61	68	PF00069	0.740
MOD_N-GLC_1	374	379	PF02516	0.749
MOD_N-GLC_2	506	508	PF02516	0.713
MOD_NEK2_1	138	143	PF00069	0.730
MOD_NEK2_1	223	228	PF00069	0.522
MOD_NEK2_1	308	313	PF00069	0.645
MOD_NEK2_1	360	365	PF00069	0.619
MOD_NEK2_1	370	375	PF00069	0.631
MOD_NEK2_1	405	410	PF00069	0.655
MOD_NEK2_1	423	428	PF00069	0.595
MOD_NEK2_1	454	459	PF00069	0.651
MOD_PIKK_1	374	380	PF00454	0.655
MOD_PKA_1	460	466	PF00069	0.786
MOD_PKA_2	179	185	PF00069	0.464
MOD_PKA_2	194	200	PF00069	0.695
MOD_PKA_2	229	235	PF00069	0.587
MOD_PKA_2	271	277	PF00069	0.580
MOD_PKA_2	344	350	PF00069	0.694
MOD_PKA_2	460	466	PF00069	0.655
MOD_PKA_2	574	580	PF00069	0.784
MOD_PKA_2	599	605	PF00069	0.757
MOD_PKA_2	615	621	PF00069	0.640
MOD_PKA_2	62	68	PF00069	0.798
MOD_PKA_2	633	639	PF00069	0.493
MOD_Plk_1	248	254	PF00069	0.642
MOD_Plk_2-3	326	332	PF00069	0.676
MOD_Plk_4	219	225	PF00069	0.566
MOD_Plk_4	235	241	PF00069	0.531
MOD_Plk_4	242	248	PF00069	0.529
MOD_Plk_4	273	279	PF00069	0.624
MOD_Plk_4	304	310	PF00069	0.712
MOD_ProDKin_1	203	209	PF00069	0.542
MOD_ProDKin_1	484	490	PF00069	0.741
MOD_ProDKin_1	579	585	PF00069	0.754
MOD_ProDKin_1	621	627	PF00069	0.787
MOD_ProDKin_1	89	95	PF00069	0.718
TRG_DiLeu_BaEn_2	449	455	PF01217	0.725
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.375
TRG_ENDOCYTIC_2	305	308	PF00928	0.610
TRG_ENDOCYTIC_2	364	367	PF00928	0.614
TRG_ER_diArg_1	100	102	PF00400	0.627
TRG_ER_diArg_1	117	120	PF00400	0.478
TRG_ER_diArg_1	340	343	PF00400	0.763
TRG_ER_diArg_1	401	403	PF00400	0.695
TRG_ER_diArg_1	424	427	PF00400	0.605
TRG_ER_diArg_1	459	461	PF00400	0.689
TRG_ER_diArg_1	522	525	PF00400	0.608
TRG_ER_diArg_1	529	532	PF00400	0.659
TRG_ER_diArg_1	542	545	PF00400	0.784
TRG_ER_diArg_1	550	552	PF00400	0.729
TRG_NLS_Bipartite_1	522	538	PF00514	0.639
TRG_NLS_MonoExtC_3	340	345	PF00514	0.685
TRG_NLS_MonoExtC_3	533	538	PF00514	0.724
TRG_NLS_MonoExtN_4	340	346	PF00514	0.724
TRG_NLS_MonoExtN_4	531	538	PF00514	0.672
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILZ5	Leptomonas seymouri	42%	100%
A0A3Q8IJB7	Leishmania donovani	91%	100%
A4HP89	Leishmania braziliensis	74%	100%
A4IDJ4	Leishmania infantum	91%	100%
E9ASZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%