LeishMANIAdb
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Choline transporter-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Choline transporter-like protein
Gene product:
Plasma-membrane choline transporter, putative
Species:
Leishmania major
UniProt:
Q4Q1K0_LEIMA
TriTrypDb:
LmjF.36.2210 * , LMJLV39_360029600 * , LMJSD75_360029800 *
Length:
484

Annotations

LeishMANIAdb annotations

Highly homologous to other eukaryotic choline transporters. The protein family expanded in parazitic kinetoplastids.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 23
NetGPI no yes: 0, no: 23
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005886 plasma membrane 3 24
GO:0016020 membrane 2 24
GO:0020016 ciliary pocket 2 2
GO:0110165 cellular anatomical entity 1 24

Expansion

Sequence features

Q4Q1K0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1K0

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 3
GO:0009987 cellular process 1 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 24
GO:0022857 transmembrane transporter activity 2 24

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 3 7 PF00656 0.576
CLV_PCSK_KEX2_1 295 297 PF00082 0.390
CLV_PCSK_KEX2_1 372 374 PF00082 0.217
CLV_PCSK_PC1ET2_1 295 297 PF00082 0.395
CLV_PCSK_PC1ET2_1 372 374 PF00082 0.236
CLV_PCSK_SKI1_1 295 299 PF00082 0.405
CLV_PCSK_SKI1_1 354 358 PF00082 0.325
CLV_PCSK_SKI1_1 373 377 PF00082 0.316
DEG_MDM2_SWIB_1 174 182 PF02201 0.364
DEG_MDM2_SWIB_1 253 261 PF02201 0.310
DEG_MDM2_SWIB_1 58 66 PF02201 0.555
DEG_MDM2_SWIB_1 73 80 PF02201 0.334
DEG_SPOP_SBC_1 297 301 PF00917 0.297
DOC_CKS1_1 260 265 PF01111 0.388
DOC_MAPK_MEF2A_6 159 168 PF00069 0.309
DOC_MAPK_MEF2A_6 204 213 PF00069 0.508
DOC_MAPK_MEF2A_6 354 362 PF00069 0.525
DOC_MAPK_MEF2A_6 416 424 PF00069 0.297
DOC_PP4_FxxP_1 435 438 PF00568 0.435
DOC_SPAK_OSR1_1 52 56 PF12202 0.469
DOC_USP7_MATH_1 116 120 PF00917 0.308
DOC_USP7_MATH_1 411 415 PF00917 0.378
DOC_USP7_MATH_1 438 442 PF00917 0.316
DOC_WW_Pin1_4 259 264 PF00397 0.388
DOC_WW_Pin1_4 31 36 PF00397 0.626
DOC_WW_Pin1_4 390 395 PF00397 0.216
DOC_WW_Pin1_4 92 97 PF00397 0.443
LIG_14-3-3_CanoR_1 198 204 PF00244 0.543
LIG_14-3-3_CanoR_1 296 305 PF00244 0.229
LIG_14-3-3_CanoR_1 373 378 PF00244 0.400
LIG_Actin_WH2_2 179 196 PF00022 0.273
LIG_BIR_II_1 1 5 PF00653 0.595
LIG_BIR_III_2 88 92 PF00653 0.269
LIG_BIR_III_4 472 476 PF00653 0.604
LIG_BIR_III_4 6 10 PF00653 0.584
LIG_BRCT_BRCA1_1 303 307 PF00533 0.224
LIG_BRCT_BRCA1_1 403 407 PF00533 0.381
LIG_BRCT_BRCA1_1 432 436 PF00533 0.366
LIG_deltaCOP1_diTrp_1 60 67 PF00928 0.431
LIG_EH1_1 245 253 PF00400 0.407
LIG_EH1_1 424 432 PF00400 0.311
LIG_eIF4E_1 386 392 PF01652 0.440
LIG_FHA_1 200 206 PF00498 0.473
LIG_FHA_1 260 266 PF00498 0.423
LIG_FHA_1 268 274 PF00498 0.229
LIG_FHA_1 372 378 PF00498 0.431
LIG_FHA_1 398 404 PF00498 0.294
LIG_FHA_1 443 449 PF00498 0.445
LIG_GBD_Chelix_1 247 255 PF00786 0.276
LIG_GBD_Chelix_1 401 409 PF00786 0.358
LIG_GBD_Chelix_1 426 434 PF00786 0.225
LIG_LIR_Apic_2 433 438 PF02991 0.465
LIG_LIR_Gen_1 145 155 PF02991 0.338
LIG_LIR_Gen_1 217 228 PF02991 0.324
LIG_LIR_Gen_1 404 413 PF02991 0.444
LIG_LIR_Gen_1 444 454 PF02991 0.476
LIG_LIR_Gen_1 60 70 PF02991 0.435
LIG_LIR_Gen_1 74 85 PF02991 0.279
LIG_LIR_LC3C_4 309 312 PF02991 0.245
LIG_LIR_Nem_3 145 150 PF02991 0.318
LIG_LIR_Nem_3 20 26 PF02991 0.677
LIG_LIR_Nem_3 215 221 PF02991 0.320
LIG_LIR_Nem_3 299 305 PF02991 0.275
LIG_LIR_Nem_3 350 355 PF02991 0.384
LIG_LIR_Nem_3 404 410 PF02991 0.390
LIG_LIR_Nem_3 433 439 PF02991 0.328
LIG_LIR_Nem_3 444 450 PF02991 0.404
LIG_LIR_Nem_3 60 65 PF02991 0.432
LIG_LIR_Nem_3 74 80 PF02991 0.283
LIG_MLH1_MIPbox_1 432 436 PF16413 0.245
LIG_NRBOX 333 339 PF00104 0.367
LIG_Pex14_2 174 178 PF04695 0.318
LIG_Pex14_2 253 257 PF04695 0.289
LIG_Pex14_2 383 387 PF04695 0.446
LIG_Pex14_2 58 62 PF04695 0.592
LIG_Pex14_2 73 77 PF04695 0.300
LIG_SH2_CRK 23 27 PF00017 0.663
LIG_SH2_CRK 244 248 PF00017 0.369
LIG_SH2_CRK 355 359 PF00017 0.440
LIG_SH2_CRK 465 469 PF00017 0.496
LIG_SH2_GRB2like 329 332 PF00017 0.409
LIG_SH2_GRB2like 351 354 PF00017 0.434
LIG_SH2_GRB2like 386 389 PF00017 0.440
LIG_SH2_PTP2 107 110 PF00017 0.321
LIG_SH2_PTP2 220 223 PF00017 0.407
LIG_SH2_SRC 329 332 PF00017 0.409
LIG_SH2_SRC 367 370 PF00017 0.455
LIG_SH2_STAT3 236 239 PF00017 0.188
LIG_SH2_STAT5 107 110 PF00017 0.283
LIG_SH2_STAT5 139 142 PF00017 0.359
LIG_SH2_STAT5 220 223 PF00017 0.315
LIG_SH2_STAT5 278 281 PF00017 0.273
LIG_SH2_STAT5 351 354 PF00017 0.424
LIG_SH2_STAT5 367 370 PF00017 0.424
LIG_SH2_STAT5 386 389 PF00017 0.440
LIG_SH3_3 225 231 PF00018 0.366
LIG_SH3_3 23 29 PF00018 0.653
LIG_SH3_3 283 289 PF00018 0.240
LIG_SH3_3 32 38 PF00018 0.498
LIG_SH3_3 42 48 PF00018 0.566
LIG_Sin3_3 189 196 PF02671 0.464
LIG_SUMO_SIM_par_1 399 404 PF11976 0.348
LIG_TYR_ITIM 105 110 PF00017 0.258
LIG_WRC_WIRS_1 291 296 PF05994 0.218
MOD_CK1_1 119 125 PF00069 0.370
MOD_CK1_1 259 265 PF00069 0.446
MOD_CK1_1 301 307 PF00069 0.292
MOD_CK1_1 324 330 PF00069 0.509
MOD_CK1_1 414 420 PF00069 0.291
MOD_CK1_1 441 447 PF00069 0.439
MOD_CK1_1 95 101 PF00069 0.457
MOD_CK2_1 324 330 PF00069 0.415
MOD_CK2_1 363 369 PF00069 0.511
MOD_GlcNHglycan 114 117 PF01048 0.389
MOD_GlcNHglycan 151 154 PF01048 0.321
MOD_GlcNHglycan 2 5 PF01048 0.520
MOD_GlcNHglycan 23 26 PF01048 0.480
MOD_GlcNHglycan 270 273 PF01048 0.319
MOD_GlcNHglycan 323 326 PF01048 0.275
MOD_GlcNHglycan 440 443 PF01048 0.212
MOD_GlcNHglycan 97 100 PF01048 0.547
MOD_GSK3_1 112 119 PF00069 0.402
MOD_GSK3_1 199 206 PF00069 0.503
MOD_GSK3_1 297 304 PF00069 0.279
MOD_GSK3_1 397 404 PF00069 0.255
MOD_GSK3_1 438 445 PF00069 0.265
MOD_GSK3_1 71 78 PF00069 0.294
MOD_N-GLC_1 473 478 PF02516 0.311
MOD_N-GLC_2 388 390 PF02516 0.325
MOD_NEK2_1 149 154 PF00069 0.338
MOD_NEK2_1 192 197 PF00069 0.458
MOD_NEK2_1 199 204 PF00069 0.525
MOD_NEK2_1 212 217 PF00069 0.314
MOD_NEK2_1 251 256 PF00069 0.239
MOD_NEK2_1 266 271 PF00069 0.158
MOD_NEK2_1 273 278 PF00069 0.293
MOD_NEK2_1 321 326 PF00069 0.487
MOD_NEK2_1 401 406 PF00069 0.277
MOD_NEK2_1 430 435 PF00069 0.305
MOD_NEK2_1 464 469 PF00069 0.523
MOD_NEK2_2 442 447 PF00069 0.442
MOD_PIKK_1 11 17 PF00454 0.703
MOD_PIKK_1 256 262 PF00454 0.248
MOD_PIKK_1 90 96 PF00454 0.396
MOD_PKA_1 295 301 PF00069 0.203
MOD_PKA_2 295 301 PF00069 0.254
MOD_PKA_2 457 463 PF00069 0.589
MOD_PKA_2 48 54 PF00069 0.574
MOD_Plk_4 116 122 PF00069 0.332
MOD_Plk_4 142 148 PF00069 0.399
MOD_Plk_4 203 209 PF00069 0.437
MOD_Plk_4 273 279 PF00069 0.280
MOD_Plk_4 306 312 PF00069 0.289
MOD_Plk_4 363 369 PF00069 0.503
MOD_Plk_4 401 407 PF00069 0.347
MOD_Plk_4 430 436 PF00069 0.315
MOD_Plk_4 442 448 PF00069 0.394
MOD_Plk_4 61 67 PF00069 0.300
MOD_ProDKin_1 259 265 PF00069 0.388
MOD_ProDKin_1 31 37 PF00069 0.618
MOD_ProDKin_1 390 396 PF00069 0.216
MOD_ProDKin_1 92 98 PF00069 0.443
TRG_DiLeu_BaLyEn_6 195 200 PF01217 0.409
TRG_ENDOCYTIC_2 107 110 PF00928 0.292
TRG_ENDOCYTIC_2 220 223 PF00928 0.383
TRG_ENDOCYTIC_2 23 26 PF00928 0.670
TRG_ENDOCYTIC_2 244 247 PF00928 0.387
TRG_ENDOCYTIC_2 355 358 PF00928 0.425
TRG_ENDOCYTIC_2 465 468 PF00928 0.519
TRG_Pf-PMV_PEXEL_1 319 323 PF00026 0.294

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9D8 Leptomonas seymouri 63% 96%
A0A0N1PA24 Leptomonas seymouri 33% 82%
A0A0S4IW21 Bodo saltans 37% 90%
A0A0S4KHP0 Bodo saltans 43% 97%
A0A1X0P8J3 Trypanosomatidae 46% 99%
A0A3Q8I9V7 Leishmania donovani 34% 80%
A0A3R7MAJ2 Trypanosoma rangeli 33% 96%
A0A3S5IRA1 Trypanosoma rangeli 47% 99%
A0A3S7XAV8 Leishmania donovani 92% 95%
A4H7J7 Leishmania braziliensis 36% 80%
A4HP90 Leishmania braziliensis 76% 95%
A4HVY0 Leishmania infantum 34% 80%
A4IDJ5 Leishmania infantum 92% 95%
A5PMW0 Danio rerio 24% 69%
D0A390 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 99%
D0A391 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 99%
D0A392 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 96%
D0A393 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 94%
E9APN1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 80%
E9ASZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 95%
P0CM92 Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) 32% 88%
P0CM93 Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) 32% 88%
Q12412 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 90%
Q4I8E9 Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1) 28% 90%
Q4PIP8 Ustilago maydis (strain 521 / FGSC 9021) 26% 91%
Q4QFU7 Leishmania major 36% 80%
Q4WYG7 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 28% 90%
Q54IJ2 Dictyostelium discoideum 25% 88%
Q5AB93 Candida albicans (strain SC5314 / ATCC MYA-2876) 27% 93%
Q6BIV4 Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968) 30% 94%
Q6C938 Yarrowia lipolytica (strain CLIB 122 / E 150) 27% 85%
Q6CY85 Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) 26% 88%
Q6FLC9 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 27% 87%
Q75EG5 Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) 27% 88%
Q870V7 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 28% 87%
V5AWF7 Trypanosoma cruzi 47% 100%
V5BMB4 Trypanosoma cruzi 34% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS