Guanylate kinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanylate kinase-like protein

Species:

Leishmania major

UniProt:

Q4Q1J5_LEIMA

TriTrypDb:

LmjF.36.2260 , LMJLV39_360030100 , LMJSD75_360030300

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1J5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1J5

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0044237	cellular metabolic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004385	guanylate kinase activity	6	3
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	3
GO:0019205	nucleobase-containing compound kinase activity	5	3
GO:0050145	nucleoside monophosphate kinase activity	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.239
CLV_NRD_NRD_1	164	166	PF00675	0.482
CLV_NRD_NRD_1	21	23	PF00675	0.493
CLV_NRD_NRD_1	268	270	PF00675	0.334
CLV_NRD_NRD_1	39	41	PF00675	0.429
CLV_NRD_NRD_1	60	62	PF00675	0.312
CLV_PCSK_KEX2_1	164	166	PF00082	0.390
CLV_PCSK_KEX2_1	39	41	PF00082	0.519
CLV_PCSK_KEX2_1	60	62	PF00082	0.397
CLV_PCSK_SKI1_1	138	142	PF00082	0.371
CLV_PCSK_SKI1_1	149	153	PF00082	0.282
CLV_Separin_Metazoa	316	320	PF03568	0.312
DEG_SPOP_SBC_1	117	121	PF00917	0.412
DEG_SPOP_SBC_1	171	175	PF00917	0.403
DOC_CKS1_1	203	208	PF01111	0.561
DOC_MAPK_gen_1	245	254	PF00069	0.287
DOC_MAPK_gen_1	39	47	PF00069	0.431
DOC_MAPK_HePTP_8	36	48	PF00069	0.450
DOC_MAPK_MEF2A_6	245	254	PF00069	0.287
DOC_MAPK_MEF2A_6	39	48	PF00069	0.447
DOC_PP2B_LxvP_1	114	117	PF13499	0.336
DOC_PP4_FxxP_1	253	256	PF00568	0.400
DOC_PP4_FxxP_1	47	50	PF00568	0.284
DOC_USP7_MATH_1	11	15	PF00917	0.718
DOC_USP7_MATH_1	117	121	PF00917	0.397
DOC_USP7_MATH_1	16	20	PF00917	0.677
DOC_USP7_MATH_1	182	186	PF00917	0.743
DOC_USP7_MATH_1	224	228	PF00917	0.662
DOC_WW_Pin1_4	120	125	PF00397	0.352
DOC_WW_Pin1_4	172	177	PF00397	0.469
DOC_WW_Pin1_4	202	207	PF00397	0.675
DOC_WW_Pin1_4	232	237	PF00397	0.358
LIG_14-3-3_CanoR_1	22	31	PF00244	0.480
LIG_14-3-3_CanoR_1	269	277	PF00244	0.400
LIG_14-3-3_CanoR_1	280	284	PF00244	0.400
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_deltaCOP1_diTrp_1	65	72	PF00928	0.400
LIG_FHA_1	121	127	PF00498	0.388
LIG_FHA_1	153	159	PF00498	0.354
LIG_FHA_1	172	178	PF00498	0.507
LIG_FHA_1	242	248	PF00498	0.402
LIG_FHA_1	33	39	PF00498	0.573
LIG_FHA_2	269	275	PF00498	0.457
LIG_FHA_2	66	72	PF00498	0.312
LIG_FHA_2	93	99	PF00498	0.360
LIG_LIR_Gen_1	110	117	PF02991	0.323
LIG_LIR_Gen_1	308	318	PF02991	0.386
LIG_LIR_Gen_1	97	105	PF02991	0.335
LIG_LIR_Nem_3	110	114	PF02991	0.400
LIG_LIR_Nem_3	296	301	PF02991	0.288
LIG_LIR_Nem_3	308	314	PF02991	0.275
LIG_LIR_Nem_3	65	69	PF02991	0.413
LIG_LIR_Nem_3	97	102	PF02991	0.304
LIG_PDZ_Class_1	324	329	PF00595	0.474
LIG_Pex14_1	66	70	PF04695	0.284
LIG_RPA_C_Fungi	17	29	PF08784	0.485
LIG_SH2_CRK	111	115	PF00017	0.308
LIG_SH2_CRK	311	315	PF00017	0.360
LIG_SH2_STAT5	166	169	PF00017	0.375
LIG_SH2_STAT5	301	304	PF00017	0.431
LIG_SH2_STAT5	92	95	PF00017	0.312
LIG_SH3_3	2	8	PF00018	0.708
LIG_SUMO_SIM_par_1	173	180	PF11976	0.553
LIG_SUMO_SIM_par_1	199	205	PF11976	0.656
LIG_SUMO_SIM_par_1	321	328	PF11976	0.538
LIG_TRAF2_1	95	98	PF00917	0.400
LIG_TYR_ITIM	109	114	PF00017	0.308
LIG_TYR_ITIM	309	314	PF00017	0.379
MOD_CDK_SPK_2	202	207	PF00069	0.557
MOD_CK1_1	120	126	PF00069	0.434
MOD_CK1_1	175	181	PF00069	0.636
MOD_CK1_1	223	229	PF00069	0.533
MOD_CK1_1	230	236	PF00069	0.311
MOD_CK1_1	75	81	PF00069	0.288
MOD_CK2_1	268	274	PF00069	0.458
MOD_CK2_1	65	71	PF00069	0.312
MOD_CK2_1	92	98	PF00069	0.344
MOD_CMANNOS	287	290	PF00535	0.320
MOD_GlcNHglycan	18	21	PF01048	0.666
MOD_GlcNHglycan	222	225	PF01048	0.420
MOD_GlcNHglycan	50	53	PF01048	0.310
MOD_GSK3_1	116	123	PF00069	0.354
MOD_GSK3_1	171	178	PF00069	0.582
MOD_GSK3_1	220	227	PF00069	0.680
MOD_GSK3_1	230	237	PF00069	0.375
MOD_GSK3_1	70	77	PF00069	0.287
MOD_N-GLC_1	293	298	PF02516	0.397
MOD_NEK2_1	133	138	PF00069	0.368
MOD_NEK2_1	201	206	PF00069	0.606
MOD_NEK2_1	279	284	PF00069	0.349
MOD_NEK2_1	32	37	PF00069	0.567
MOD_NEK2_1	324	329	PF00069	0.663
MOD_NEK2_1	70	75	PF00069	0.298
MOD_PIKK_1	22	28	PF00454	0.484
MOD_PKA_1	22	28	PF00069	0.484
MOD_PKA_2	268	274	PF00069	0.284
MOD_PKA_2	279	285	PF00069	0.284
MOD_Plk_1	109	115	PF00069	0.400
MOD_Plk_1	273	279	PF00069	0.335
MOD_Plk_1	293	299	PF00069	0.155
MOD_Plk_1	70	76	PF00069	0.360
MOD_Plk_2-3	268	274	PF00069	0.344
MOD_Plk_2-3	293	299	PF00069	0.360
MOD_Plk_2-3	65	71	PF00069	0.312
MOD_Plk_4	140	146	PF00069	0.412
MOD_Plk_4	227	233	PF00069	0.321
MOD_Plk_4	293	299	PF00069	0.420
MOD_Plk_4	54	60	PF00069	0.319
MOD_Plk_4	65	71	PF00069	0.321
MOD_ProDKin_1	120	126	PF00069	0.352
MOD_ProDKin_1	172	178	PF00069	0.475
MOD_ProDKin_1	202	208	PF00069	0.676
MOD_ProDKin_1	232	238	PF00069	0.358
MOD_SUMO_rev_2	263	271	PF00179	0.400
TRG_DiLeu_BaEn_1	98	103	PF01217	0.400
TRG_ENDOCYTIC_2	111	114	PF00928	0.327
TRG_ENDOCYTIC_2	311	314	PF00928	0.474
TRG_ENDOCYTIC_2	91	94	PF00928	0.308
TRG_ER_diArg_1	163	165	PF00400	0.332
TRG_ER_diArg_1	38	40	PF00400	0.494
TRG_ER_diArg_1	59	61	PF00400	0.312
TRG_Pf-PMV_PEXEL_1	184	188	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	60	65	PF00026	0.312

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I117	Leptomonas seymouri	51%	100%
A0A1X0P7T4	Trypanosomatidae	31%	100%
A0A3S7XAW4	Leishmania donovani	88%	100%
A4HP95	Leishmania braziliensis	71%	100%
A4IDK0	Leishmania infantum	89%	100%
D0A398	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AT03	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5BBU2	Trypanosoma cruzi	31%	100%