Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4Q1J4_LEIMA

TriTrypDb:

LmjF.36.2270 , LMJLV39_360030200 , LMJSD75_360030400

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1J4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1J4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.666
CLV_NRD_NRD_1	33	35	PF00675	0.490
CLV_NRD_NRD_1	338	340	PF00675	0.652
CLV_PCSK_KEX2_1	33	35	PF00082	0.490
CLV_PCSK_KEX2_1	338	340	PF00082	0.652
CLV_PCSK_SKI1_1	206	210	PF00082	0.544
CLV_PCSK_SKI1_1	5	9	PF00082	0.478
DEG_COP1_1	229	237	PF00400	0.594
DOC_CKS1_1	214	219	PF01111	0.629
DOC_CYCLIN_yCln2_LP_2	130	136	PF00134	0.601
DOC_PP2B_LxvP_1	207	210	PF13499	0.573
DOC_USP7_MATH_1	101	105	PF00917	0.605
DOC_USP7_MATH_1	208	212	PF00917	0.630
DOC_USP7_MATH_1	228	232	PF00917	0.508
DOC_USP7_MATH_1	312	316	PF00917	0.747
DOC_USP7_MATH_1	369	373	PF00917	0.579
DOC_USP7_MATH_1	375	379	PF00917	0.579
DOC_USP7_MATH_1	412	416	PF00917	0.505
DOC_WW_Pin1_4	209	214	PF00397	0.624
DOC_WW_Pin1_4	226	231	PF00397	0.560
DOC_WW_Pin1_4	263	268	PF00397	0.565
DOC_WW_Pin1_4	308	313	PF00397	0.670
DOC_WW_Pin1_4	365	370	PF00397	0.545
LIG_14-3-3_CanoR_1	126	131	PF00244	0.634
LIG_14-3-3_CanoR_1	181	188	PF00244	0.554
LIG_14-3-3_CanoR_1	243	248	PF00244	0.522
LIG_14-3-3_CanoR_1	304	312	PF00244	0.640
LIG_14-3-3_CanoR_1	333	337	PF00244	0.501
LIG_14-3-3_CanoR_1	394	398	PF00244	0.660
LIG_14-3-3_CanoR_1	56	62	PF00244	0.386
LIG_APCC_ABBA_1	436	441	PF00400	0.467
LIG_BIR_II_1	1	5	PF00653	0.513
LIG_BIR_III_3	1	5	PF00653	0.513
LIG_CaM_IQ_9	55	70	PF13499	0.354
LIG_deltaCOP1_diTrp_1	350	356	PF00928	0.526
LIG_FHA_1	125	131	PF00498	0.605
LIG_FHA_1	263	269	PF00498	0.624
LIG_FHA_1	361	367	PF00498	0.512
LIG_FHA_1	394	400	PF00498	0.581
LIG_FHA_1	441	447	PF00498	0.505
LIG_FHA_1	53	59	PF00498	0.428
LIG_FHA_1	89	95	PF00498	0.586
LIG_FHA_2	214	220	PF00498	0.632
LIG_FHA_2	251	257	PF00498	0.654
LIG_FHA_2	335	341	PF00498	0.617
LIG_FHA_2	41	47	PF00498	0.449
LIG_LIR_Gen_1	125	136	PF02991	0.542
LIG_LIR_Gen_1	198	207	PF02991	0.546
LIG_LIR_Gen_1	350	360	PF02991	0.536
LIG_LIR_Gen_1	437	447	PF02991	0.591
LIG_LIR_Gen_1	60	67	PF02991	0.496
LIG_LIR_Gen_1	73	84	PF02991	0.352
LIG_LIR_Nem_3	198	202	PF02991	0.527
LIG_LIR_Nem_3	350	356	PF02991	0.526
LIG_LIR_Nem_3	437	442	PF02991	0.593
LIG_LIR_Nem_3	60	64	PF02991	0.505
LIG_PCNA_yPIPBox_3	450	459	PF02747	0.457
LIG_PCNA_yPIPBox_3	63	75	PF02747	0.475
LIG_PDZ_Class_2	456	461	PF00595	0.562
LIG_Pex14_1	274	278	PF04695	0.552
LIG_Rb_pABgroove_1	111	119	PF01858	0.359
LIG_RPA_C_Fungi	29	41	PF08784	0.495
LIG_SH2_NCK_1	439	443	PF00017	0.588
LIG_SH2_SRC	439	442	PF00017	0.550
LIG_SH2_STAP1	199	203	PF00017	0.530
LIG_SH2_STAT5	128	131	PF00017	0.548
LIG_SH2_STAT5	292	295	PF00017	0.697
LIG_SH2_STAT5	35	38	PF00017	0.491
LIG_SH2_STAT5	458	461	PF00017	0.611
LIG_SH2_STAT5	61	64	PF00017	0.502
LIG_SH3_3	207	213	PF00018	0.571
LIG_SH3_3	227	233	PF00018	0.567
LIG_SH3_3	363	369	PF00018	0.527
LIG_SUMO_SIM_par_1	134	139	PF11976	0.632
LIG_TRAF2_1	329	332	PF00917	0.589
LIG_TYR_ITIM	197	202	PF00017	0.527
LIG_WRC_WIRS_1	244	249	PF05994	0.528
MOD_CK1_1	122	128	PF00069	0.594
MOD_CK1_1	212	218	PF00069	0.681
MOD_CK1_1	22	28	PF00069	0.475
MOD_CK1_1	257	263	PF00069	0.764
MOD_CK1_1	364	370	PF00069	0.665
MOD_CK2_1	13	19	PF00069	0.510
MOD_CK2_1	250	256	PF00069	0.647
MOD_CK2_1	334	340	PF00069	0.626
MOD_CK2_1	375	381	PF00069	0.666
MOD_CK2_1	412	418	PF00069	0.507
MOD_GlcNHglycan	121	124	PF01048	0.513
MOD_GlcNHglycan	145	148	PF01048	0.567
MOD_GlcNHglycan	15	18	PF01048	0.506
MOD_GlcNHglycan	183	186	PF01048	0.561
MOD_GlcNHglycan	21	24	PF01048	0.400
MOD_GlcNHglycan	223	226	PF01048	0.606
MOD_GlcNHglycan	261	264	PF01048	0.787
MOD_GlcNHglycan	314	317	PF01048	0.660
MOD_GlcNHglycan	36	39	PF01048	0.421
MOD_GlcNHglycan	408	411	PF01048	0.623
MOD_GlcNHglycan	412	415	PF01048	0.598
MOD_GlcNHglycan	82	85	PF01048	0.477
MOD_GSK3_1	122	129	PF00069	0.572
MOD_GSK3_1	13	20	PF00069	0.493
MOD_GSK3_1	208	215	PF00069	0.648
MOD_GSK3_1	250	257	PF00069	0.765
MOD_GSK3_1	258	265	PF00069	0.728
MOD_GSK3_1	303	310	PF00069	0.713
MOD_GSK3_1	360	367	PF00069	0.641
MOD_GSK3_1	398	405	PF00069	0.574
MOD_GSK3_1	406	413	PF00069	0.567
MOD_N-GLC_1	308	313	PF02516	0.605
MOD_NEK2_1	116	121	PF00069	0.551
MOD_NEK2_1	242	247	PF00069	0.636
MOD_NEK2_1	360	365	PF00069	0.740
MOD_NEK2_1	398	403	PF00069	0.603
MOD_NEK2_1	406	411	PF00069	0.633
MOD_NEK2_1	50	55	PF00069	0.451
MOD_PIKK_1	176	182	PF00454	0.560
MOD_PIKK_1	236	242	PF00454	0.466
MOD_PKA_2	242	248	PF00069	0.600
MOD_PKA_2	303	309	PF00069	0.629
MOD_PKA_2	332	338	PF00069	0.507
MOD_PKA_2	393	399	PF00069	0.636
MOD_Plk_4	116	122	PF00069	0.596
MOD_Plk_4	126	132	PF00069	0.444
MOD_Plk_4	57	63	PF00069	0.388
MOD_ProDKin_1	209	215	PF00069	0.629
MOD_ProDKin_1	226	232	PF00069	0.558
MOD_ProDKin_1	263	269	PF00069	0.559
MOD_ProDKin_1	308	314	PF00069	0.668
MOD_ProDKin_1	365	371	PF00069	0.549
MOD_SUMO_rev_2	215	223	PF00179	0.642
TRG_DiLeu_BaEn_4	331	337	PF01217	0.594
TRG_ENDOCYTIC_2	128	131	PF00928	0.504
TRG_ENDOCYTIC_2	199	202	PF00928	0.531
TRG_ENDOCYTIC_2	292	295	PF00928	0.569
TRG_ENDOCYTIC_2	439	442	PF00928	0.594
TRG_ENDOCYTIC_2	61	64	PF00928	0.502
TRG_ER_diArg_1	33	35	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	8	12	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAU2	Leishmania donovani	90%	100%
A4HP96	Leishmania braziliensis	69%	99%
A4IDK1	Leishmania infantum	90%	100%
E9AT04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%