Putative Bardet-Biedl syndrome 4 protein homolog (BBS4-like protein 4)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

bardet-biedl syndrome 4 protein

Species:

Leishmania major

UniProt:

Q4Q1J3_LEIMA

TriTrypDb:

LmjF.36.2280 , LMJLV39_360030300 , LMJSD75_360030500

Length:

495

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	11
GO:0012506	vesicle membrane	4	2
GO:0016020	membrane	2	11
GO:0020018	ciliary pocket membrane	6	2
GO:0030659	cytoplasmic vesicle membrane	5	2
GO:0030662	coated vesicle membrane	5	2
GO:0030665	clathrin-coated vesicle membrane	6	2
GO:0031090	organelle membrane	3	11
GO:0031253	cell projection membrane	4	11
GO:0032991	protein-containing complex	1	2
GO:0034464	BBSome	2	2
GO:0035869	ciliary transition zone	2	2
GO:0036064	ciliary basal body	3	2
GO:0060170	ciliary membrane	5	11
GO:0098588	bounding membrane of organelle	4	11
GO:0098590	plasma membrane region	3	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q1J3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1J3

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	2
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006826	iron ion transport	8	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0030001	metal ion transport	6	2
GO:0030030	cell projection organization	4	2
GO:0030031	cell projection assembly	5	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0033572	transferrin transport	5	2
GO:0044782	cilium organization	5	2
GO:0045184	establishment of protein localization	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0060271	cilium assembly	6	2
GO:0061512	protein localization to cilium	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0070925	organelle assembly	5	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0120031	plasma membrane bounded cell projection assembly	6	2
GO:0120036	plasma membrane bounded cell projection organization	5	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030276	clathrin binding	3	2
GO:0032050	clathrin heavy chain binding	4	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.424
CLV_C14_Caspase3-7	471	475	PF00656	0.487
CLV_NRD_NRD_1	183	185	PF00675	0.532
CLV_NRD_NRD_1	187	189	PF00675	0.431
CLV_NRD_NRD_1	328	330	PF00675	0.307
CLV_NRD_NRD_1	444	446	PF00675	0.471
CLV_NRD_NRD_1	6	8	PF00675	0.687
CLV_NRD_NRD_1	64	66	PF00675	0.328
CLV_PCSK_FUR_1	62	66	PF00082	0.346
CLV_PCSK_KEX2_1	107	109	PF00082	0.360
CLV_PCSK_KEX2_1	183	185	PF00082	0.361
CLV_PCSK_KEX2_1	187	189	PF00082	0.327
CLV_PCSK_KEX2_1	444	446	PF00082	0.471
CLV_PCSK_KEX2_1	64	66	PF00082	0.328
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.340
CLV_PCSK_PC7_1	183	189	PF00082	0.319
CLV_PCSK_SKI1_1	103	107	PF00082	0.276
CLV_PCSK_SKI1_1	161	165	PF00082	0.460
CLV_PCSK_SKI1_1	211	215	PF00082	0.393
CLV_PCSK_SKI1_1	262	266	PF00082	0.313
CLV_PCSK_SKI1_1	318	322	PF00082	0.361
CLV_PCSK_SKI1_1	330	334	PF00082	0.460
DEG_APCC_DBOX_1	64	72	PF00400	0.446
DEG_MDM2_SWIB_1	432	439	PF02201	0.469
DEG_Nend_UBRbox_3	1	3	PF02207	0.675
DEG_SPOP_SBC_1	469	473	PF00917	0.692
DOC_CKS1_1	438	443	PF01111	0.438
DOC_CYCLIN_RxL_1	100	110	PF00134	0.302
DOC_MAPK_gen_1	62	71	PF00069	0.463
DOC_PP2B_LxvP_1	462	465	PF13499	0.487
DOC_PP4_FxxP_1	333	336	PF00568	0.444
DOC_USP7_MATH_1	276	280	PF00917	0.286
DOC_USP7_MATH_1	477	481	PF00917	0.693
DOC_USP7_UBL2_3	103	107	PF12436	0.312
DOC_WW_Pin1_4	124	129	PF00397	0.420
DOC_WW_Pin1_4	230	235	PF00397	0.238
DOC_WW_Pin1_4	264	269	PF00397	0.248
DOC_WW_Pin1_4	31	36	PF00397	0.595
DOC_WW_Pin1_4	437	442	PF00397	0.490
LIG_14-3-3_CanoR_1	329	333	PF00244	0.355
LIG_14-3-3_CanoR_1	354	362	PF00244	0.406
LIG_Actin_WH2_2	313	331	PF00022	0.333
LIG_APCC_ABBA_1	223	228	PF00400	0.279
LIG_APCC_ABBA_1	366	371	PF00400	0.325
LIG_BIR_III_2	474	478	PF00653	0.484
LIG_FHA_1	120	126	PF00498	0.372
LIG_FHA_2	233	239	PF00498	0.361
LIG_FHA_2	267	273	PF00498	0.428
LIG_IRF3_LxIS_1	260	267	PF10401	0.226
LIG_LIR_Apic_2	331	336	PF02991	0.426
LIG_LIR_Gen_1	203	214	PF02991	0.433
LIG_LIR_Gen_1	321	328	PF02991	0.344
LIG_LIR_Gen_1	424	432	PF02991	0.356
LIG_LIR_Nem_3	173	178	PF02991	0.462
LIG_LIR_Nem_3	203	209	PF02991	0.435
LIG_LIR_Nem_3	292	297	PF02991	0.371
LIG_LIR_Nem_3	321	325	PF02991	0.380
LIG_LIR_Nem_3	404	409	PF02991	0.427
LIG_LIR_Nem_3	424	429	PF02991	0.393
LIG_LIR_Nem_3	95	101	PF02991	0.303
LIG_NRBOX	457	463	PF00104	0.407
LIG_NRBOX	67	73	PF00104	0.352
LIG_PCNA_TLS_4	187	194	PF02747	0.310
LIG_Pex14_1	170	174	PF04695	0.307
LIG_Pex14_1	339	343	PF04695	0.274
LIG_Pex14_2	333	337	PF04695	0.415
LIG_Pex14_2	432	436	PF04695	0.339
LIG_SH2_CRK	294	298	PF00017	0.371
LIG_SH2_CRK	322	326	PF00017	0.425
LIG_SH2_GRB2like	409	412	PF00017	0.405
LIG_SH2_GRB2like	78	81	PF00017	0.353
LIG_SH2_NCK_1	322	326	PF00017	0.449
LIG_SH2_PTP2	175	178	PF00017	0.415
LIG_SH2_SRC	226	229	PF00017	0.371
LIG_SH2_SRC	396	399	PF00017	0.430
LIG_SH2_STAP1	219	223	PF00017	0.279
LIG_SH2_STAP1	226	230	PF00017	0.279
LIG_SH2_STAP1	287	291	PF00017	0.371
LIG_SH2_STAP1	322	326	PF00017	0.466
LIG_SH2_STAP1	396	400	PF00017	0.334
LIG_SH2_STAP1	412	416	PF00017	0.158
LIG_SH2_STAP1	78	82	PF00017	0.309
LIG_SH2_STAP1	98	102	PF00017	0.175
LIG_SH2_STAT3	247	250	PF00017	0.286
LIG_SH2_STAT3	73	76	PF00017	0.323
LIG_SH2_STAT5	101	104	PF00017	0.293
LIG_SH2_STAT5	175	178	PF00017	0.336
LIG_SH2_STAT5	206	209	PF00017	0.427
LIG_SH2_STAT5	247	250	PF00017	0.266
LIG_SH2_STAT5	259	262	PF00017	0.253
LIG_SH2_STAT5	355	358	PF00017	0.319
LIG_SH2_STAT5	409	412	PF00017	0.334
LIG_SH2_STAT5	73	76	PF00017	0.323
LIG_SH3_3	231	237	PF00018	0.322
LIG_SH3_3	29	35	PF00018	0.562
LIG_SH3_3	462	468	PF00018	0.630
LIG_SUMO_SIM_anti_2	114	122	PF11976	0.437
LIG_TRAF2_1	153	156	PF00917	0.407
LIG_TRAF2_1	421	424	PF00917	0.349
MOD_CDC14_SPxK_1	34	37	PF00782	0.527
MOD_CDK_SPxK_1	31	37	PF00069	0.536
MOD_CDK_SPxxK_3	437	444	PF00069	0.484
MOD_CK1_1	39	45	PF00069	0.553
MOD_CK2_1	109	115	PF00069	0.369
MOD_CK2_1	418	424	PF00069	0.390
MOD_Cter_Amidation	316	319	PF01082	0.438
MOD_Cter_Amidation	5	8	PF01082	0.742
MOD_GlcNHglycan	283	286	PF01048	0.356
MOD_GlcNHglycan	303	306	PF01048	0.151
MOD_GlcNHglycan	356	359	PF01048	0.300
MOD_GlcNHglycan	38	42	PF01048	0.501
MOD_GlcNHglycan	478	482	PF01048	0.715
MOD_GSK3_1	109	116	PF00069	0.364
MOD_GSK3_1	12	19	PF00069	0.558
MOD_GSK3_1	228	235	PF00069	0.379
MOD_GSK3_1	262	269	PF00069	0.320
MOD_GSK3_1	39	46	PF00069	0.546
MOD_N-GLC_2	391	393	PF02516	0.332
MOD_NEK2_1	109	114	PF00069	0.254
MOD_NEK2_1	119	124	PF00069	0.267
MOD_NEK2_1	17	22	PF00069	0.706
MOD_NEK2_1	193	198	PF00069	0.356
MOD_NEK2_1	28	33	PF00069	0.636
MOD_NEK2_1	328	333	PF00069	0.419
MOD_NEK2_1	89	94	PF00069	0.457
MOD_NEK2_2	412	417	PF00069	0.322
MOD_PIKK_1	132	138	PF00454	0.379
MOD_PK_1	418	424	PF00069	0.330
MOD_PKA_1	318	324	PF00069	0.349
MOD_PKA_2	328	334	PF00069	0.412
MOD_PKA_2	36	42	PF00069	0.676
MOD_PKA_2	89	95	PF00069	0.484
MOD_Plk_1	445	451	PF00069	0.540
MOD_Plk_4	276	282	PF00069	0.286
MOD_Plk_4	328	334	PF00069	0.419
MOD_Plk_4	412	418	PF00069	0.417
MOD_Plk_4	446	452	PF00069	0.520
MOD_ProDKin_1	124	130	PF00069	0.419
MOD_ProDKin_1	230	236	PF00069	0.238
MOD_ProDKin_1	264	270	PF00069	0.242
MOD_ProDKin_1	31	37	PF00069	0.595
MOD_ProDKin_1	437	443	PF00069	0.491
TRG_DiLeu_BaEn_1	115	120	PF01217	0.425
TRG_DiLeu_BaEn_1	446	451	PF01217	0.458
TRG_ENDOCYTIC_2	175	178	PF00928	0.320
TRG_ENDOCYTIC_2	206	209	PF00928	0.410
TRG_ENDOCYTIC_2	294	297	PF00928	0.371
TRG_ENDOCYTIC_2	322	325	PF00928	0.443
TRG_ENDOCYTIC_2	426	429	PF00928	0.368
TRG_ER_diArg_1	186	188	PF00400	0.451
TRG_NES_CRM1_1	115	129	PF08389	0.447
TRG_NES_CRM1_1	238	250	PF08389	0.255
TRG_Pf-PMV_PEXEL_1	456	460	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PED7	Leptomonas seymouri	70%	100%
A0A1X0P7L4	Trypanosomatidae	47%	87%
A0A3Q8IH89	Leishmania donovani	98%	100%
A0A3R7MGH4	Trypanosoma rangeli	48%	100%
A1Z8E9	Drosophila melanogaster	31%	100%
A4HP97	Leishmania braziliensis	84%	100%
A4IDK2	Leishmania infantum	98%	100%
D0A3A0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AT05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q1JQ97	Bos taurus	42%	95%
Q28G25	Xenopus tropicalis	42%	96%
Q5CZ52	Caenorhabditis elegans	27%	100%
Q8C1Z7	Mus musculus	43%	95%
Q96RK4	Homo sapiens	44%	95%
Q9STS3	Arabidopsis thaliana	20%	85%
V5BSG3	Trypanosoma cruzi	20%	70%
V5DCK5	Trypanosoma cruzi	47%	100%