Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1J1_LEIMA

TriTrypDb:

LmjF.36.2300 , LMJLV39_360030500 , LMJSD75_360030700

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q1J1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1J1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	257	259	PF00675	0.731
CLV_NRD_NRD_1	390	392	PF00675	0.506
CLV_PCSK_KEX2_1	257	259	PF00082	0.731
CLV_PCSK_KEX2_1	390	392	PF00082	0.506
CLV_PCSK_SKI1_1	257	261	PF00082	0.735
CLV_PCSK_SKI1_1	468	472	PF00082	0.543
DEG_Nend_UBRbox_2	1	3	PF02207	0.582
DOC_CKS1_1	227	232	PF01111	0.444
DOC_CKS1_1	350	355	PF01111	0.721
DOC_CYCLIN_RxL_1	95	105	PF00134	0.436
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.516
DOC_MAPK_gen_1	120	128	PF00069	0.770
DOC_MAPK_gen_1	257	265	PF00069	0.482
DOC_PP1_RVXF_1	250	256	PF00149	0.483
DOC_PP2B_LxvP_1	224	227	PF13499	0.557
DOC_PP4_FxxP_1	147	150	PF00568	0.767
DOC_USP7_MATH_1	167	171	PF00917	0.403
DOC_USP7_MATH_1	215	219	PF00917	0.489
DOC_USP7_MATH_1	220	224	PF00917	0.506
DOC_USP7_MATH_1	377	381	PF00917	0.718
DOC_USP7_MATH_1	447	451	PF00917	0.815
DOC_USP7_MATH_1	85	89	PF00917	0.547
DOC_USP7_MATH_1	9	13	PF00917	0.530
DOC_WW_Pin1_4	216	221	PF00397	0.505
DOC_WW_Pin1_4	226	231	PF00397	0.425
DOC_WW_Pin1_4	349	354	PF00397	0.765
DOC_WW_Pin1_4	422	427	PF00397	0.734
DOC_WW_Pin1_4	451	456	PF00397	0.800
DOC_WW_Pin1_4	472	477	PF00397	0.817
LIG_14-3-3_CanoR_1	114	119	PF00244	0.729
LIG_14-3-3_CanoR_1	257	266	PF00244	0.537
LIG_14-3-3_CanoR_1	343	349	PF00244	0.737
LIG_14-3-3_CanoR_1	37	44	PF00244	0.548
LIG_14-3-3_CanoR_1	71	79	PF00244	0.530
LIG_Actin_RPEL_3	91	110	PF02755	0.513
LIG_Actin_WH2_2	17	34	PF00022	0.552
LIG_BRCT_BRCA1_1	246	250	PF00533	0.511
LIG_BRCT_BRCA1_1	368	372	PF00533	0.727
LIG_BRCT_BRCA1_2	246	252	PF00533	0.487
LIG_FHA_1	103	109	PF00498	0.374
LIG_FHA_1	158	164	PF00498	0.588
LIG_FHA_1	196	202	PF00498	0.468
LIG_FHA_1	234	240	PF00498	0.475
LIG_FHA_1	258	264	PF00498	0.535
LIG_FHA_1	462	468	PF00498	0.688
LIG_FHA_1	64	70	PF00498	0.536
LIG_FHA_1	79	85	PF00498	0.391
LIG_FHA_1	8	14	PF00498	0.519
LIG_FHA_1	90	96	PF00498	0.327
LIG_FHA_2	227	233	PF00498	0.474
LIG_FHA_2	350	356	PF00498	0.639
LIG_FHA_2	37	43	PF00498	0.513
LIG_FHA_2	384	390	PF00498	0.780
LIG_FHA_2	439	445	PF00498	0.777
LIG_GBD_Chelix_1	100	108	PF00786	0.436
LIG_GBD_Chelix_1	171	179	PF00786	0.411
LIG_GBD_Chelix_1	241	249	PF00786	0.662
LIG_LIR_Apic_2	145	150	PF02991	0.767
LIG_LIR_Gen_1	105	115	PF02991	0.486
LIG_LIR_Gen_1	16	24	PF02991	0.483
LIG_LIR_Gen_1	236	245	PF02991	0.496
LIG_LIR_Gen_1	247	256	PF02991	0.443
LIG_LIR_Gen_1	59	69	PF02991	0.515
LIG_LIR_Gen_1	92	102	PF02991	0.360
LIG_LIR_Nem_3	105	109	PF02991	0.366
LIG_LIR_Nem_3	16	20	PF02991	0.486
LIG_LIR_Nem_3	236	241	PF02991	0.534
LIG_LIR_Nem_3	247	253	PF02991	0.439
LIG_LIR_Nem_3	59	65	PF02991	0.571
LIG_LIR_Nem_3	92	97	PF02991	0.475
LIG_NRBOX	189	195	PF00104	0.515
LIG_NRBOX	95	101	PF00104	0.411
LIG_Pex14_1	282	286	PF04695	0.411
LIG_SH2_STAP1	17	21	PF00017	0.553
LIG_SH2_STAP1	234	238	PF00017	0.559
LIG_SH2_STAP1	286	290	PF00017	0.703
LIG_SH2_STAT5	267	270	PF00017	0.499
LIG_SH2_STAT5	300	303	PF00017	0.778
LIG_SH2_STAT5	359	362	PF00017	0.728
LIG_SH3_3	129	135	PF00018	0.611
LIG_SH3_3	209	215	PF00018	0.516
LIG_SH3_3	224	230	PF00018	0.451
LIG_SH3_3	347	353	PF00018	0.683
LIG_SUMO_SIM_anti_2	187	192	PF11976	0.501
LIG_SUMO_SIM_anti_2	236	243	PF11976	0.472
LIG_SUMO_SIM_par_1	159	164	PF11976	0.605
LIG_SUMO_SIM_par_1	99	105	PF11976	0.436
LIG_TRAF2_1	312	315	PF00917	0.675
LIG_TRAF2_1	457	460	PF00917	0.795
LIG_WW_1	14	17	PF00397	0.642
MOD_CDK_SPK_2	349	354	PF00069	0.651
MOD_CDK_SPxxK_3	349	356	PF00069	0.655
MOD_CK1_1	137	143	PF00069	0.486
MOD_CK1_1	16	22	PF00069	0.650
MOD_CK1_1	216	222	PF00069	0.670
MOD_CK1_1	237	243	PF00069	0.626
MOD_CK1_1	380	386	PF00069	0.678
MOD_CK1_1	422	428	PF00069	0.691
MOD_CK1_1	450	456	PF00069	0.844
MOD_CK2_1	226	232	PF00069	0.593
MOD_CK2_1	349	355	PF00069	0.536
MOD_CK2_1	383	389	PF00069	0.689
MOD_CK2_1	438	444	PF00069	0.693
MOD_GlcNHglycan	139	142	PF01048	0.507
MOD_GlcNHglycan	165	168	PF01048	0.486
MOD_GlcNHglycan	242	245	PF01048	0.612
MOD_GlcNHglycan	379	382	PF01048	0.602
MOD_GlcNHglycan	409	412	PF01048	0.732
MOD_GlcNHglycan	421	424	PF01048	0.747
MOD_GlcNHglycan	438	441	PF01048	0.592
MOD_GlcNHglycan	85	88	PF01048	0.642
MOD_GSK3_1	133	140	PF00069	0.497
MOD_GSK3_1	157	164	PF00069	0.454
MOD_GSK3_1	203	210	PF00069	0.565
MOD_GSK3_1	216	223	PF00069	0.648
MOD_GSK3_1	233	240	PF00069	0.580
MOD_GSK3_1	286	293	PF00069	0.486
MOD_GSK3_1	379	386	PF00069	0.783
MOD_GSK3_1	447	454	PF00069	0.798
MOD_GSK3_1	79	86	PF00069	0.640
MOD_GSK3_1	9	16	PF00069	0.687
MOD_N-GLC_1	157	162	PF02516	0.653
MOD_N-GLC_1	216	221	PF02516	0.640
MOD_N-GLC_1	245	250	PF02516	0.609
MOD_N-GLC_1	294	299	PF02516	0.585
MOD_N-GLC_1	7	12	PF02516	0.665
MOD_N-GLC_2	407	409	PF02516	0.602
MOD_NEK2_1	102	107	PF00069	0.474
MOD_NEK2_1	161	166	PF00069	0.513
MOD_NEK2_1	23	28	PF00069	0.693
MOD_NEK2_1	245	250	PF00069	0.603
MOD_NEK2_1	284	289	PF00069	0.596
MOD_NEK2_1	290	295	PF00069	0.553
MOD_NEK2_1	330	335	PF00069	0.613
MOD_NEK2_1	344	349	PF00069	0.538
MOD_NEK2_1	65	70	PF00069	0.671
MOD_NEK2_1	79	84	PF00069	0.472
MOD_PIKK_1	257	263	PF00454	0.675
MOD_PIKK_1	330	336	PF00454	0.578
MOD_PKA_1	257	263	PF00069	0.675
MOD_PKA_2	113	119	PF00069	0.634
MOD_PKA_2	257	263	PF00069	0.675
MOD_PKA_2	36	42	PF00069	0.619
MOD_PKA_2	70	76	PF00069	0.662
MOD_Plk_1	157	163	PF00069	0.513
MOD_Plk_1	245	251	PF00069	0.611
MOD_Plk_1	294	300	PF00069	0.593
MOD_Plk_1	89	95	PF00069	0.299
MOD_Plk_4	102	108	PF00069	0.424
MOD_Plk_4	157	163	PF00069	0.478
MOD_Plk_4	16	22	PF00069	0.699
MOD_Plk_4	203	209	PF00069	0.638
MOD_Plk_4	234	240	PF00069	0.719
MOD_Plk_4	245	251	PF00069	0.528
MOD_Plk_4	272	278	PF00069	0.416
MOD_Plk_4	286	292	PF00069	0.556
MOD_Plk_4	65	71	PF00069	0.706
MOD_Plk_4	79	85	PF00069	0.551
MOD_ProDKin_1	216	222	PF00069	0.636
MOD_ProDKin_1	226	232	PF00069	0.519
MOD_ProDKin_1	349	355	PF00069	0.719
MOD_ProDKin_1	422	428	PF00069	0.670
MOD_ProDKin_1	451	457	PF00069	0.763
MOD_ProDKin_1	472	478	PF00069	0.795
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.667
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.513
TRG_DiLeu_LyEn_5	303	308	PF01217	0.716
TRG_ENDOCYTIC_2	17	20	PF00928	0.705
TRG_ENDOCYTIC_2	359	362	PF00928	0.661
TRG_ENDOCYTIC_2	62	65	PF00928	0.731
TRG_ER_diArg_1	119	122	PF00400	0.633
TRG_ER_diArg_1	256	258	PF00400	0.689
TRG_ER_diArg_1	356	359	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.471
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I690	Leptomonas seymouri	25%	100%
A0A3S7XAV6	Leishmania donovani	87%	99%
A4HP98	Leishmania braziliensis	60%	99%
A4IDK4	Leishmania infantum	88%	99%
E9AT07	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%