Glucokinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Glucokinase

Gene product:

glucokinase

Species:

Leishmania major

UniProt:

Q4Q1I9_LEIMA

TriTrypDb:

LmjF.36.2320 , LMJLV39_360030700 , LMJSD75_360030900

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	2
GO:0020015	glycosome	7	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4Q1I9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1I9

PDB structure(s): 6edi_A , 6edi_B

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	10
GO:0006082	organic acid metabolic process	3	10
GO:0006090	pyruvate metabolic process	7	10
GO:0006091	generation of precursor metabolites and energy	3	10
GO:0006096	glycolytic process	5	10
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006163	purine nucleotide metabolic process	5	10
GO:0006165	obsolete nucleoside diphosphate phosphorylation	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006753	nucleoside phosphate metabolic process	4	10
GO:0006757	obsolete ATP generation from ADP	4	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009056	catabolic process	2	10
GO:0009117	nucleotide metabolic process	5	10
GO:0009132	nucleoside diphosphate metabolic process	5	10
GO:0009135	purine nucleoside diphosphate metabolic process	6	10
GO:0009141	nucleoside triphosphate metabolic process	5	10
GO:0009144	purine nucleoside triphosphate metabolic process	6	10
GO:0009150	purine ribonucleotide metabolic process	6	10
GO:0009179	purine ribonucleoside diphosphate metabolic process	7	10
GO:0009185	ribonucleoside diphosphate metabolic process	6	10
GO:0009199	ribonucleoside triphosphate metabolic process	6	10
GO:0009205	purine ribonucleoside triphosphate metabolic process	7	10
GO:0009259	ribonucleotide metabolic process	5	10
GO:0009987	cellular process	1	10
GO:0016052	carbohydrate catabolic process	4	10
GO:0016310	phosphorylation	5	10
GO:0019637	organophosphate metabolic process	3	10
GO:0019693	ribose phosphate metabolic process	4	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0032787	monocarboxylic acid metabolic process	6	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044281	small molecule metabolic process	2	10
GO:0046031	ADP metabolic process	7	10
GO:0046034	ATP metabolic process	7	10
GO:0046483	heterocycle metabolic process	3	10
GO:0046939	obsolete nucleotide phosphorylation	6	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0072521	purine-containing compound metabolic process	4	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901575	organic substance catabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004340	glucokinase activity	6	10
GO:0004396	hexokinase activity	5	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0005536	glucose binding	4	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0019200	carbohydrate kinase activity	5	10
GO:0030246	carbohydrate binding	2	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0048029	monosaccharide binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	94	96	PF00675	0.338
CLV_PCSK_KEX2_1	64	66	PF00082	0.324
CLV_PCSK_KEX2_1	94	96	PF00082	0.284
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.324
CLV_PCSK_SKI1_1	137	141	PF00082	0.292
CLV_PCSK_SKI1_1	295	299	PF00082	0.323
CLV_PCSK_SKI1_1	366	370	PF00082	0.528
CLV_PCSK_SKI1_1	68	72	PF00082	0.361
DOC_CYCLIN_RxL_1	362	374	PF00134	0.477
DOC_MAPK_gen_1	311	319	PF00069	0.536
DOC_MAPK_gen_1	378	387	PF00069	0.369
DOC_MAPK_gen_1	64	73	PF00069	0.521
DOC_MAPK_MEF2A_6	378	387	PF00069	0.386
DOC_PP1_RVXF_1	163	169	PF00149	0.536
DOC_PP1_RVXF_1	364	371	PF00149	0.482
DOC_PP1_RVXF_1	37	43	PF00149	0.506
DOC_PP4_FxxP_1	346	349	PF00568	0.500
DOC_SPAK_OSR1_1	59	63	PF12202	0.566
DOC_USP7_MATH_1	181	185	PF00917	0.506
DOC_USP7_MATH_1	265	269	PF00917	0.551
DOC_USP7_MATH_1	281	285	PF00917	0.508
DOC_USP7_MATH_1	286	290	PF00917	0.535
DOC_USP7_MATH_1	406	410	PF00917	0.731
DOC_USP7_UBL2_3	165	169	PF12436	0.515
DOC_USP7_UBL2_3	247	251	PF12436	0.523
DOC_USP7_UBL2_3	278	282	PF12436	0.563
LIG_14-3-3_CanoR_1	135	144	PF00244	0.485
LIG_14-3-3_CanoR_1	373	377	PF00244	0.359
LIG_14-3-3_CanoR_1	378	384	PF00244	0.361
LIG_Actin_WH2_2	364	380	PF00022	0.518
LIG_Actin_WH2_2	78	96	PF00022	0.566
LIG_BRCT_BRCA1_1	160	164	PF00533	0.506
LIG_BRCT_BRCA1_1	340	344	PF00533	0.467
LIG_FHA_1	2	8	PF00498	0.518
LIG_FHA_1	22	28	PF00498	0.479
LIG_FHA_1	329	335	PF00498	0.465
LIG_FHA_1	372	378	PF00498	0.455
LIG_FHA_2	169	175	PF00498	0.566
LIG_FHA_2	61	67	PF00498	0.511
LIG_LIR_Apic_2	343	349	PF02991	0.487
LIG_LIR_Gen_1	171	181	PF02991	0.520
LIG_LIR_Gen_1	211	219	PF02991	0.483
LIG_LIR_Gen_1	72	81	PF02991	0.506
LIG_LIR_Nem_3	148	152	PF02991	0.519
LIG_LIR_Nem_3	161	166	PF02991	0.444
LIG_LIR_Nem_3	171	176	PF02991	0.474
LIG_LIR_Nem_3	211	217	PF02991	0.483
LIG_LIR_Nem_3	310	316	PF02991	0.506
LIG_LIR_Nem_3	324	330	PF02991	0.506
LIG_LIR_Nem_3	72	77	PF02991	0.506
LIG_MLH1_MIPbox_1	160	164	PF16413	0.506
LIG_MLH1_MIPbox_1	342	346	PF16413	0.463
LIG_PDZ_Class_1	406	411	PF00595	0.673
LIG_Pex14_2	164	168	PF04695	0.475
LIG_PTB_Apo_2	339	346	PF02174	0.390
LIG_PTB_Phospho_1	339	345	PF10480	0.507
LIG_SH2_CRK	149	153	PF00017	0.506
LIG_SH2_CRK	313	317	PF00017	0.536
LIG_SH2_PTP2	207	210	PF00017	0.526
LIG_SH2_PTP2	214	217	PF00017	0.481
LIG_SH2_STAT5	163	166	PF00017	0.462
LIG_SH2_STAT5	207	210	PF00017	0.507
LIG_SH2_STAT5	214	217	PF00017	0.456
LIG_SH2_STAT5	236	239	PF00017	0.506
LIG_SH2_STAT5	28	31	PF00017	0.447
LIG_SH2_STAT5	345	348	PF00017	0.440
LIG_SH2_STAT5	57	60	PF00017	0.494
LIG_SH3_3	190	196	PF00018	0.476
LIG_SH3_3	98	104	PF00018	0.465
LIG_SUMO_SIM_par_1	150	155	PF11976	0.476
LIG_SUMO_SIM_par_1	215	220	PF11976	0.511
LIG_TYR_ITIM	205	210	PF00017	0.536
MOD_CK1_1	21	27	PF00069	0.490
MOD_CK1_1	338	344	PF00069	0.506
MOD_CK1_1	372	378	PF00069	0.356
MOD_CK1_1	395	401	PF00069	0.592
MOD_CK2_1	265	271	PF00069	0.574
MOD_CK2_1	286	292	PF00069	0.511
MOD_GlcNHglycan	137	140	PF01048	0.275
MOD_GlcNHglycan	267	270	PF01048	0.247
MOD_GlcNHglycan	283	286	PF01048	0.319
MOD_GlcNHglycan	288	291	PF01048	0.323
MOD_GlcNHglycan	49	53	PF01048	0.368
MOD_GlcNHglycan	97	100	PF01048	0.323
MOD_GSK3_1	195	202	PF00069	0.476
MOD_GSK3_1	317	324	PF00069	0.566
MOD_GSK3_1	95	102	PF00069	0.544
MOD_N-GLC_1	265	270	PF02516	0.367
MOD_NEK2_1	152	157	PF00069	0.536
MOD_NEK2_1	224	229	PF00069	0.517
MOD_NEK2_1	253	258	PF00069	0.556
MOD_NEK2_1	335	340	PF00069	0.560
MOD_NEK2_1	371	376	PF00069	0.477
MOD_NEK2_1	60	65	PF00069	0.550
MOD_PIKK_1	168	174	PF00454	0.506
MOD_PIKK_1	392	398	PF00454	0.486
MOD_PKA_2	372	378	PF00069	0.361
MOD_PKA_2	60	66	PF00069	0.488
MOD_Plk_1	18	24	PF00069	0.534
MOD_Plk_1	253	259	PF00069	0.536
MOD_Plk_1	321	327	PF00069	0.483
MOD_Plk_1	360	366	PF00069	0.496
MOD_Plk_4	200	206	PF00069	0.475
MOD_Plk_4	210	216	PF00069	0.454
MOD_Plk_4	335	341	PF00069	0.525
MOD_Plk_4	372	378	PF00069	0.356
MOD_SUMO_rev_2	174	182	PF00179	0.566
MOD_SUMO_rev_2	227	237	PF00179	0.540
TRG_ENDOCYTIC_2	149	152	PF00928	0.491
TRG_ENDOCYTIC_2	163	166	PF00928	0.418
TRG_ENDOCYTIC_2	207	210	PF00928	0.465
TRG_ENDOCYTIC_2	214	217	PF00928	0.465
TRG_ENDOCYTIC_2	313	316	PF00928	0.507
TRG_ENDOCYTIC_2	57	60	PF00928	0.506
TRG_ER_diArg_1	134	137	PF00400	0.404
TRG_ER_diArg_1	93	95	PF00400	0.538
TRG_Pf-PMV_PEXEL_1	65	69	PF00026	0.367
TRG_PTS1	408	411	PF00515	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZF4	Leptomonas seymouri	65%	100%
A0A0S4JSI6	Bodo saltans	31%	100%
A0A3R7L110	Trypanosoma rangeli	42%	100%
A0A3S7XAU3	Leishmania donovani	96%	100%
A4HPA0	Leishmania braziliensis	86%	100%
A4IDK6	Leishmania infantum	96%	100%
E9AT09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q9GTW8	Trichomonas vaginalis	25%	100%
Q9GTW9	Trichomonas vaginalis	26%	100%
V5BBU8	Trypanosoma cruzi	43%	100%