Putative endonuclease V

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease V, putative

Species:

Leishmania major

UniProt:

Q4Q1I8_LEIMA

TriTrypDb:

LmjF.36.2330 , LMJLV39_360030800 , LMJSD75_360031000

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4Q1I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1I8

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006259	DNA metabolic process	4	9
GO:0006281	DNA repair	5	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0006950	response to stress	2	9
GO:0006974	DNA damage response	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0033554	cellular response to stress	3	9

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003727	single-stranded RNA binding	5	2
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	9
GO:0004519	endonuclease activity	5	9
GO:0004521	RNA endonuclease activity	5	2
GO:0004540	RNA nuclease activity	4	2
GO:0005488	binding	1	2
GO:0016787	hydrolase activity	2	9

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.483
CLV_NRD_NRD_1	257	259	PF00675	0.336
CLV_NRD_NRD_1	45	47	PF00675	0.616
CLV_PCSK_KEX2_1	257	259	PF00082	0.340
CLV_PCSK_KEX2_1	45	47	PF00082	0.555
CLV_PCSK_SKI1_1	100	104	PF00082	0.632
CLV_PCSK_SKI1_1	278	282	PF00082	0.336
CLV_PCSK_SKI1_1	380	384	PF00082	0.355
DEG_SPOP_SBC_1	301	305	PF00917	0.555
DEG_SPOP_SBC_1	386	390	PF00917	0.703

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN9	Leptomonas seymouri	53%	100%
A0A1X0P8I3	Trypanosomatidae	43%	100%
A0A3S7XAV3	Leishmania donovani	91%	100%
A0A422NIX5	Trypanosoma rangeli	45%	100%
A4HPA1	Leishmania braziliensis	71%	100%
A4IDK7	Leishmania infantum	91%	100%
E9AT10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%

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