Putative endonuclease V

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease V, putative

Species:

Leishmania major

UniProt:

Q4Q1I8_LEIMA

TriTrypDb:

LmjF.36.2330 , LMJLV39_360030800 , LMJSD75_360031000

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1I8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1I8

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006259	DNA metabolic process	4	9
GO:0006281	DNA repair	5	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0006950	response to stress	2	9
GO:0006974	DNA damage response	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0033554	cellular response to stress	3	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0046483	heterocycle metabolic process	3	9
GO:0050896	response to stimulus	1	9
GO:0051716	cellular response to stimulus	2	9
GO:0071704	organic substance metabolic process	2	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003727	single-stranded RNA binding	5	2
GO:0003824	catalytic activity	1	9
GO:0004518	nuclease activity	4	9
GO:0004519	endonuclease activity	5	9
GO:0004521	RNA endonuclease activity	5	2
GO:0004540	RNA nuclease activity	4	2
GO:0005488	binding	1	2
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	2
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	2
GO:0097159	organic cyclic compound binding	2	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.483
CLV_NRD_NRD_1	257	259	PF00675	0.336
CLV_NRD_NRD_1	45	47	PF00675	0.616
CLV_PCSK_KEX2_1	257	259	PF00082	0.340
CLV_PCSK_KEX2_1	45	47	PF00082	0.555
CLV_PCSK_SKI1_1	100	104	PF00082	0.632
CLV_PCSK_SKI1_1	278	282	PF00082	0.336
CLV_PCSK_SKI1_1	380	384	PF00082	0.355
DEG_SPOP_SBC_1	301	305	PF00917	0.555
DEG_SPOP_SBC_1	386	390	PF00917	0.703
DOC_CYCLIN_RxL_1	307	318	PF00134	0.510
DOC_PP2B_LxvP_1	131	134	PF13499	0.390
DOC_PP2B_LxvP_1	269	272	PF13499	0.471
DOC_PP2B_LxvP_1	29	32	PF13499	0.425
DOC_PP2B_LxvP_1	82	85	PF13499	0.532
DOC_PP4_FxxP_1	101	104	PF00568	0.374
DOC_PP4_FxxP_1	137	140	PF00568	0.375
DOC_USP7_MATH_1	153	157	PF00917	0.432
DOC_USP7_MATH_1	211	215	PF00917	0.487
DOC_USP7_MATH_1	301	305	PF00917	0.555
DOC_USP7_MATH_1	38	42	PF00917	0.480
DOC_USP7_MATH_1	382	386	PF00917	0.672
DOC_USP7_MATH_1	387	391	PF00917	0.740
DOC_WW_Pin1_4	136	141	PF00397	0.470
DOC_WW_Pin1_4	302	307	PF00397	0.510
DOC_WW_Pin1_4	316	321	PF00397	0.388
DOC_WW_Pin1_4	339	344	PF00397	0.535
LIG_14-3-3_CanoR_1	154	161	PF00244	0.386
LIG_14-3-3_CanoR_1	205	209	PF00244	0.536
LIG_APCC_ABBA_1	222	227	PF00400	0.419
LIG_BIR_III_4	18	22	PF00653	0.486
LIG_Clathr_ClatBox_1	245	249	PF01394	0.455
LIG_deltaCOP1_diTrp_1	142	150	PF00928	0.415
LIG_FHA_1	128	134	PF00498	0.516
LIG_FHA_1	164	170	PF00498	0.346
LIG_FHA_1	351	357	PF00498	0.488
LIG_FHA_1	77	83	PF00498	0.542
LIG_FHA_2	205	211	PF00498	0.536
LIG_FHA_2	295	301	PF00498	0.496
LIG_GBD_Chelix_1	261	269	PF00786	0.296
LIG_GBD_Chelix_1	351	359	PF00786	0.336
LIG_LIR_Apic_2	135	140	PF02991	0.398
LIG_LIR_Gen_1	138	148	PF02991	0.414
LIG_LIR_Gen_1	214	224	PF02991	0.536
LIG_LIR_Gen_1	227	237	PF02991	0.536
LIG_LIR_LC3C_4	353	357	PF02991	0.419
LIG_LIR_Nem_3	138	144	PF02991	0.459
LIG_LIR_Nem_3	214	219	PF02991	0.536
LIG_LIR_Nem_3	227	232	PF02991	0.477
LIG_LIR_Nem_3	321	327	PF02991	0.496
LIG_LYPXL_yS_3	193	196	PF13949	0.471
LIG_MYND_1	309	313	PF01753	0.510
LIG_Pex14_2	137	141	PF04695	0.366
LIG_Pex14_2	225	229	PF04695	0.419
LIG_SH2_CRK	324	328	PF00017	0.487
LIG_SH2_PTP2	340	343	PF00017	0.555
LIG_SH2_STAT5	326	329	PF00017	0.507
LIG_SH2_STAT5	340	343	PF00017	0.467
LIG_SH2_STAT5	378	381	PF00017	0.607
LIG_SH2_STAT5	68	71	PF00017	0.477
LIG_SH3_3	157	163	PF00018	0.337
LIG_SH3_3	250	256	PF00018	0.489
LIG_SH3_3	303	309	PF00018	0.508
LIG_SH3_4	4	11	PF00018	0.523
LIG_Sin3_3	352	359	PF02671	0.496
LIG_SUMO_SIM_anti_2	166	171	PF11976	0.487
LIG_SUMO_SIM_par_1	244	249	PF11976	0.471
LIG_TRAF2_1	40	43	PF00917	0.479
LIG_WRC_WIRS_1	216	221	PF05994	0.464
MOD_CK1_1	135	141	PF00069	0.503
MOD_CK1_1	304	310	PF00069	0.511
MOD_CK1_1	318	324	PF00069	0.397
MOD_CK1_1	385	391	PF00069	0.657
MOD_CK1_1	41	47	PF00069	0.393
MOD_CK2_1	136	142	PF00069	0.464
MOD_CK2_1	204	210	PF00069	0.536
MOD_CK2_1	215	221	PF00069	0.526
MOD_CK2_1	294	300	PF00069	0.538
MOD_GlcNHglycan	120	124	PF01048	0.685
MOD_GlcNHglycan	155	158	PF01048	0.461
MOD_GlcNHglycan	213	216	PF01048	0.316
MOD_GlcNHglycan	22	25	PF01048	0.708
MOD_GlcNHglycan	33	36	PF01048	0.654
MOD_GlcNHglycan	384	387	PF01048	0.455
MOD_GSK3_1	132	139	PF00069	0.540
MOD_GSK3_1	211	218	PF00069	0.471
MOD_GSK3_1	270	277	PF00069	0.536
MOD_GSK3_1	300	307	PF00069	0.550
MOD_GSK3_1	314	321	PF00069	0.420
MOD_GSK3_1	381	388	PF00069	0.584
MOD_N-GLC_1	76	81	PF02516	0.644
MOD_NEK2_1	106	111	PF00069	0.454
MOD_NEK2_1	228	233	PF00069	0.556
MOD_NEK2_1	236	241	PF00069	0.516
MOD_NEK2_1	314	319	PF00069	0.555
MOD_NEK2_1	355	360	PF00069	0.471
MOD_NEK2_2	215	220	PF00069	0.464
MOD_PIKK_1	236	242	PF00454	0.555
MOD_PIKK_1	318	324	PF00454	0.555
MOD_PKA_2	153	159	PF00069	0.329
MOD_PKA_2	204	210	PF00069	0.536
MOD_Plk_1	106	112	PF00069	0.456
MOD_Plk_1	127	133	PF00069	0.427
MOD_Plk_1	173	179	PF00069	0.471
MOD_Plk_1	76	82	PF00069	0.425
MOD_Plk_4	106	112	PF00069	0.413
MOD_Plk_4	165	171	PF00069	0.562
MOD_Plk_4	355	361	PF00069	0.510
MOD_ProDKin_1	136	142	PF00069	0.466
MOD_ProDKin_1	302	308	PF00069	0.510
MOD_ProDKin_1	316	322	PF00069	0.388
MOD_ProDKin_1	339	345	PF00069	0.535
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.592
TRG_ENDOCYTIC_2	193	196	PF00928	0.471
TRG_ENDOCYTIC_2	324	327	PF00928	0.496
TRG_ER_diArg_1	256	258	PF00400	0.536
TRG_ER_diArg_1	360	363	PF00400	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILN9	Leptomonas seymouri	53%	100%
A0A1X0P8I3	Trypanosomatidae	43%	100%
A0A3S7XAV3	Leishmania donovani	91%	100%
A0A422NIX5	Trypanosoma rangeli	45%	100%
A4HPA1	Leishmania braziliensis	71%	100%
A4IDK7	Leishmania infantum	91%	100%
E9AT10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%