Short chain dehydrogenase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

short-chain dehydrogenase, putative

Species:

Leishmania major

UniProt:

Q4Q1I7_LEIMA

TriTrypDb:

LmjF.36.2340 , LMJLV39_360030900 , LMJSD75_360031100

Length:

409

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4Q1I7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1I7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.564
CLV_C14_Caspase3-7	82	86	PF00656	0.548
CLV_NRD_NRD_1	192	194	PF00675	0.357
CLV_NRD_NRD_1	266	268	PF00675	0.377
CLV_NRD_NRD_1	44	46	PF00675	0.334
CLV_PCSK_FUR_1	264	268	PF00082	0.392
CLV_PCSK_KEX2_1	141	143	PF00082	0.313
CLV_PCSK_KEX2_1	192	194	PF00082	0.335
CLV_PCSK_KEX2_1	266	268	PF00082	0.443
CLV_PCSK_KEX2_1	347	349	PF00082	0.415
CLV_PCSK_KEX2_1	44	46	PF00082	0.346
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.267
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.392
CLV_PCSK_SKI1_1	119	123	PF00082	0.248
CLV_PCSK_SKI1_1	167	171	PF00082	0.238
DEG_APCC_DBOX_1	166	174	PF00400	0.421
DEG_APCC_DBOX_1	272	280	PF00400	0.520
DEG_Nend_Nbox_1	1	3	PF02207	0.279
DOC_CKS1_1	401	406	PF01111	0.423
DOC_CYCLIN_yClb5_NLxxxL_5	154	163	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	124	130	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.504
DOC_MAPK_gen_1	270	279	PF00069	0.559
DOC_MAPK_gen_1	44	50	PF00069	0.549
DOC_MAPK_MEF2A_6	167	174	PF00069	0.467
DOC_MAPK_NFAT4_5	167	175	PF00069	0.467
DOC_PP1_RVXF_1	393	400	PF00149	0.427
DOC_PP1_RVXF_1	54	61	PF00149	0.479
DOC_USP7_MATH_1	147	151	PF00917	0.479
DOC_USP7_MATH_1	176	180	PF00917	0.436
DOC_USP7_MATH_1	260	264	PF00917	0.649
DOC_USP7_MATH_1	298	302	PF00917	0.649
DOC_USP7_MATH_1	309	313	PF00917	0.731
DOC_USP7_MATH_1	95	99	PF00917	0.660
DOC_WW_Pin1_4	158	163	PF00397	0.467
DOC_WW_Pin1_4	212	217	PF00397	0.420
DOC_WW_Pin1_4	294	299	PF00397	0.642
DOC_WW_Pin1_4	305	310	PF00397	0.628
DOC_WW_Pin1_4	315	320	PF00397	0.671
DOC_WW_Pin1_4	400	405	PF00397	0.434
LIG_14-3-3_CanoR_1	273	277	PF00244	0.487
LIG_14-3-3_CanoR_1	305	309	PF00244	0.609
LIG_14-3-3_CanoR_1	330	337	PF00244	0.672
LIG_Actin_WH2_2	63	78	PF00022	0.520
LIG_BIR_III_4	85	89	PF00653	0.545
LIG_BRCT_BRCA1_1	100	104	PF00533	0.485
LIG_DCNL_PONY_1	1	4	PF03556	0.314
LIG_deltaCOP1_diTrp_1	234	237	PF00928	0.437
LIG_FHA_1	106	112	PF00498	0.443
LIG_FHA_1	155	161	PF00498	0.528
LIG_FHA_1	272	278	PF00498	0.554
LIG_FHA_1	30	36	PF00498	0.453
LIG_FHA_1	340	346	PF00498	0.658
LIG_FHA_1	376	382	PF00498	0.372
LIG_FHA_2	334	340	PF00498	0.683
LIG_Integrin_RGD_1	193	195	PF01839	0.236
LIG_LIR_Apic_2	281	287	PF02991	0.593
LIG_LIR_Gen_1	101	111	PF02991	0.548
LIG_LIR_Gen_1	195	203	PF02991	0.485
LIG_LIR_Gen_1	339	345	PF02991	0.503
LIG_LIR_Gen_1	61	70	PF02991	0.548
LIG_LIR_Nem_3	19	23	PF02991	0.459
LIG_LIR_Nem_3	195	199	PF02991	0.485
LIG_LIR_Nem_3	221	226	PF02991	0.421
LIG_LIR_Nem_3	339	344	PF02991	0.586
LIG_LIR_Nem_3	379	385	PF02991	0.362
LIG_LIR_Nem_3	61	65	PF02991	0.551
LIG_LYPXL_S_1	381	385	PF13949	0.320
LIG_LYPXL_yS_3	382	385	PF13949	0.320
LIG_SH2_CRK	196	200	PF00017	0.504
LIG_SH2_CRK	284	288	PF00017	0.666
LIG_SH2_CRK	341	345	PF00017	0.527
LIG_SH2_CRK	62	66	PF00017	0.559
LIG_SH2_STAP1	196	200	PF00017	0.504
LIG_SH2_STAP1	341	345	PF00017	0.549
LIG_SH2_STAP1	372	376	PF00017	0.454
LIG_SH2_STAT5	209	212	PF00017	0.489
LIG_SH2_STAT5	341	344	PF00017	0.609
LIG_SH2_STAT5	370	373	PF00017	0.568
LIG_SH3_3	377	383	PF00018	0.404
LIG_SUMO_SIM_anti_2	161	167	PF11976	0.467
LIG_SUMO_SIM_par_1	107	113	PF11976	0.458
LIG_SUMO_SIM_par_1	170	175	PF11976	0.467
LIG_SUMO_SIM_par_1	198	204	PF11976	0.436
LIG_SUMO_SIM_par_1	31	36	PF11976	0.462
LIG_TYR_ITIM	380	385	PF00017	0.320
LIG_WRC_WIRS_1	17	22	PF05994	0.334
MOD_CK1_1	16	22	PF00069	0.345
MOD_CK1_1	177	183	PF00069	0.393
MOD_CK1_1	212	218	PF00069	0.469
MOD_CK1_1	29	35	PF00069	0.447
MOD_CK1_1	292	298	PF00069	0.591
MOD_CK1_1	312	318	PF00069	0.768
MOD_CK1_1	326	332	PF00069	0.571
MOD_CK1_1	333	339	PF00069	0.511
MOD_CK1_1	98	104	PF00069	0.495
MOD_CK2_1	228	234	PF00069	0.320
MOD_CMANNOS	12	15	PF00535	0.255
MOD_Cter_Amidation	42	45	PF01082	0.412
MOD_DYRK1A_RPxSP_1	305	309	PF00069	0.585
MOD_GlcNHglycan	100	103	PF01048	0.569
MOD_GlcNHglycan	148	152	PF01048	0.470
MOD_GlcNHglycan	174	177	PF01048	0.254
MOD_GlcNHglycan	203	206	PF01048	0.276
MOD_GlcNHglycan	246	249	PF01048	0.629
MOD_GlcNHglycan	28	31	PF01048	0.422
MOD_GlcNHglycan	314	317	PF01048	0.739
MOD_GlcNHglycan	332	335	PF01048	0.572
MOD_GlcNHglycan	373	376	PF01048	0.276
MOD_GSK3_1	105	112	PF00069	0.422
MOD_GSK3_1	154	161	PF00069	0.320
MOD_GSK3_1	172	179	PF00069	0.372
MOD_GSK3_1	242	249	PF00069	0.594
MOD_GSK3_1	250	257	PF00069	0.641
MOD_GSK3_1	285	292	PF00069	0.515
MOD_GSK3_1	29	36	PF00069	0.359
MOD_GSK3_1	294	301	PF00069	0.599
MOD_GSK3_1	305	312	PF00069	0.726
MOD_GSK3_1	326	333	PF00069	0.585
MOD_GSK3_1	371	378	PF00069	0.372
MOD_N-GLC_1	177	182	PF02516	0.311
MOD_N-GLC_1	207	212	PF02516	0.369
MOD_NEK2_1	154	159	PF00069	0.411
MOD_NEK2_1	172	177	PF00069	0.298
MOD_NEK2_1	228	233	PF00069	0.326
MOD_NEK2_1	244	249	PF00069	0.445
MOD_NEK2_1	293	298	PF00069	0.620
MOD_NEK2_1	311	316	PF00069	0.657
MOD_NEK2_2	95	100	PF00069	0.492
MOD_PIKK_1	218	224	PF00454	0.298
MOD_PIKK_1	339	345	PF00454	0.436
MOD_PKA_2	272	278	PF00069	0.349
MOD_PKA_2	304	310	PF00069	0.565
MOD_PKA_2	337	343	PF00069	0.519
MOD_PKB_1	24	32	PF00069	0.404
MOD_Plk_1	207	213	PF00069	0.276
MOD_Plk_2-3	80	86	PF00069	0.416
MOD_Plk_4	16	22	PF00069	0.275
MOD_Plk_4	198	204	PF00069	0.276
MOD_Plk_4	272	278	PF00069	0.326
MOD_Plk_4	285	291	PF00069	0.489
MOD_Plk_4	29	35	PF00069	0.294
MOD_Plk_4	376	382	PF00069	0.291
MOD_ProDKin_1	158	164	PF00069	0.320
MOD_ProDKin_1	212	218	PF00069	0.254
MOD_ProDKin_1	294	300	PF00069	0.568
MOD_ProDKin_1	305	311	PF00069	0.548
MOD_ProDKin_1	315	321	PF00069	0.604
MOD_ProDKin_1	400	406	PF00069	0.558
MOD_SUMO_rev_2	249	258	PF00179	0.615
TRG_DiLeu_BaLyEn_6	150	155	PF01217	0.261
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.276
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.298
TRG_DiLeu_BaLyEn_6	392	397	PF01217	0.411
TRG_ENDOCYTIC_2	196	199	PF00928	0.372
TRG_ENDOCYTIC_2	341	344	PF00928	0.376
TRG_ENDOCYTIC_2	382	385	PF00928	0.423
TRG_ENDOCYTIC_2	62	65	PF00928	0.450
TRG_ER_diArg_1	23	26	PF00400	0.357
TRG_ER_diArg_1	264	267	PF00400	0.606
TRG_ER_diArg_1	44	46	PF00400	0.409
TRG_Pf-PMV_PEXEL_1	44	49	PF00026	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B0	Leptomonas seymouri	49%	100%
A0A1X0P7L9	Trypanosomatidae	29%	100%
A0A3Q8IQZ6	Leishmania donovani	93%	100%
A4HPA2	Leishmania braziliensis	75%	100%
A4IDK8	Leishmania infantum	93%	100%
A5JYX5	Caenorhabditis elegans	23%	100%
D0A3A6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AT11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q5XGF7	Xenopus tropicalis	21%	100%
Q6DCT3	Xenopus laevis	21%	100%
Q7TQA3	Mus musculus	23%	100%
Q8HZT6	Bos taurus	23%	100%
Q8IZV5	Homo sapiens	23%	100%
V5DCK9	Trypanosoma cruzi	27%	100%