Nitrogen permease regulator 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

base J-associated glucosyltransferase

Species:

Leishmania major

UniProt:

Q4Q1I4_LEIMA

TriTrypDb:

LmjF.36.2370 , LMJLV39_360031500 , LMJSD75_360031600

Length:

954

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1I4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1I4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006304	DNA modification	5	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2
GO:0016757	glycosyltransferase activity	3	2
GO:0016758	hexosyltransferase activity	4	2
GO:0046527	glucosyltransferase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.673
CLV_C14_Caspase3-7	752	756	PF00656	0.665
CLV_C14_Caspase3-7	894	898	PF00656	0.590
CLV_NRD_NRD_1	259	261	PF00675	0.470
CLV_NRD_NRD_1	361	363	PF00675	0.519
CLV_NRD_NRD_1	607	609	PF00675	0.403
CLV_NRD_NRD_1	702	704	PF00675	0.496
CLV_NRD_NRD_1	770	772	PF00675	0.699
CLV_NRD_NRD_1	793	795	PF00675	0.623
CLV_PCSK_KEX2_1	259	261	PF00082	0.470
CLV_PCSK_KEX2_1	361	363	PF00082	0.519
CLV_PCSK_KEX2_1	607	609	PF00082	0.403
CLV_PCSK_KEX2_1	702	704	PF00082	0.431
CLV_PCSK_KEX2_1	772	774	PF00082	0.644
CLV_PCSK_KEX2_1	793	795	PF00082	0.623
CLV_PCSK_PC1ET2_1	772	774	PF00082	0.644
CLV_PCSK_SKI1_1	126	130	PF00082	0.403
CLV_PCSK_SKI1_1	274	278	PF00082	0.406
CLV_PCSK_SKI1_1	563	567	PF00082	0.496
CLV_PCSK_SKI1_1	682	686	PF00082	0.390
DEG_APCC_DBOX_1	125	133	PF00400	0.390
DEG_Nend_Nbox_1	1	3	PF02207	0.593
DEG_SCF_FBW7_1	194	200	PF00400	0.585
DEG_SPOP_SBC_1	163	167	PF00917	0.586
DEG_SPOP_SBC_1	363	367	PF00917	0.555
DEG_SPOP_SBC_1	403	407	PF00917	0.664
DEG_SPOP_SBC_1	410	414	PF00917	0.754
DEG_SPOP_SBC_1	750	754	PF00917	0.665
DEG_SPOP_SBC_1	806	810	PF00917	0.672
DEG_SPOP_SBC_1	9	13	PF00917	0.535
DOC_ANK_TNKS_1	118	125	PF00023	0.361
DOC_ANK_TNKS_1	319	326	PF00023	0.526
DOC_ANK_TNKS_1	596	603	PF00023	0.387
DOC_CKS1_1	194	199	PF01111	0.595
DOC_CKS1_1	248	253	PF01111	0.531
DOC_CKS1_1	494	499	PF01111	0.577
DOC_CKS1_1	72	77	PF01111	0.562
DOC_CYCLIN_RxL_1	202	212	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	685	691	PF00134	0.344
DOC_MAPK_DCC_7	108	116	PF00069	0.349
DOC_MAPK_gen_1	702	708	PF00069	0.405
DOC_MAPK_MEF2A_6	100	107	PF00069	0.405
DOC_MAPK_MEF2A_6	108	116	PF00069	0.312
DOC_MAPK_MEF2A_6	238	246	PF00069	0.522
DOC_MAPK_MEF2A_6	293	301	PF00069	0.411
DOC_MAPK_MEF2A_6	916	923	PF00069	0.454
DOC_PP1_RVXF_1	647	654	PF00149	0.340
DOC_PP1_RVXF_1	705	711	PF00149	0.395
DOC_PP1_RVXF_1	903	909	PF00149	0.474
DOC_PP2B_LxvP_1	392	395	PF13499	0.576
DOC_PP2B_LxvP_1	727	730	PF13499	0.362
DOC_PP2B_LxvP_1	774	777	PF13499	0.681
DOC_PP4_FxxP_1	494	497	PF00568	0.586
DOC_PP4_FxxP_1	653	656	PF00568	0.357
DOC_PP4_FxxP_1	927	930	PF00568	0.445
DOC_SPAK_OSR1_1	625	629	PF12202	0.351
DOC_USP7_MATH_1	10	14	PF00917	0.592
DOC_USP7_MATH_1	234	238	PF00917	0.520
DOC_USP7_MATH_1	403	407	PF00917	0.646
DOC_USP7_MATH_1	410	414	PF00917	0.571
DOC_USP7_MATH_1	498	502	PF00917	0.587
DOC_USP7_MATH_1	63	67	PF00917	0.646
DOC_USP7_MATH_1	784	788	PF00917	0.692
DOC_USP7_MATH_1	800	804	PF00917	0.501
DOC_USP7_MATH_1	805	809	PF00917	0.610
DOC_USP7_MATH_1	877	881	PF00917	0.600
DOC_USP7_MATH_1	898	902	PF00917	0.540
DOC_USP7_MATH_1	937	941	PF00917	0.445
DOC_WW_Pin1_4	15	20	PF00397	0.622
DOC_WW_Pin1_4	166	171	PF00397	0.595
DOC_WW_Pin1_4	187	192	PF00397	0.628
DOC_WW_Pin1_4	193	198	PF00397	0.577
DOC_WW_Pin1_4	238	243	PF00397	0.698
DOC_WW_Pin1_4	244	249	PF00397	0.741
DOC_WW_Pin1_4	328	333	PF00397	0.517
DOC_WW_Pin1_4	41	46	PF00397	0.631
DOC_WW_Pin1_4	422	427	PF00397	0.548
DOC_WW_Pin1_4	480	485	PF00397	0.485
DOC_WW_Pin1_4	493	498	PF00397	0.560
DOC_WW_Pin1_4	505	510	PF00397	0.531
DOC_WW_Pin1_4	65	70	PF00397	0.670
DOC_WW_Pin1_4	71	76	PF00397	0.628
DOC_WW_Pin1_4	711	716	PF00397	0.391
DOC_WW_Pin1_4	775	780	PF00397	0.637
DOC_WW_Pin1_4	900	905	PF00397	0.492
LIG_14-3-3_CanoR_1	100	104	PF00244	0.375
LIG_14-3-3_CanoR_1	287	292	PF00244	0.370
LIG_14-3-3_CanoR_1	361	370	PF00244	0.579
LIG_14-3-3_CanoR_1	458	465	PF00244	0.402
LIG_14-3-3_CanoR_1	641	647	PF00244	0.331
LIG_14-3-3_CanoR_1	867	871	PF00244	0.471
LIG_14-3-3_CanoR_1	905	915	PF00244	0.465
LIG_APCC_ABBA_1	855	860	PF00400	0.452
LIG_BRCT_BRCA1_1	211	215	PF00533	0.468
LIG_BRCT_BRCA1_1	261	265	PF00533	0.459
LIG_BRCT_BRCA1_1	649	653	PF00533	0.402
LIG_Clathr_ClatBox_1	276	280	PF01394	0.364
LIG_deltaCOP1_diTrp_1	172	176	PF00928	0.519
LIG_eIF4E_1	295	301	PF01652	0.411
LIG_EVH1_2	490	494	PF00568	0.620
LIG_FHA_1	100	106	PF00498	0.431
LIG_FHA_1	194	200	PF00498	0.628
LIG_FHA_1	30	36	PF00498	0.645
LIG_FHA_1	365	371	PF00498	0.582
LIG_FHA_1	423	429	PF00498	0.540
LIG_FHA_1	570	576	PF00498	0.393
LIG_FHA_1	633	639	PF00498	0.321
LIG_FHA_1	849	855	PF00498	0.450
LIG_FHA_1	901	907	PF00498	0.452
LIG_FHA_2	167	173	PF00498	0.521
LIG_FHA_2	452	458	PF00498	0.535
LIG_FHA_2	522	528	PF00498	0.397
LIG_FHA_2	566	572	PF00498	0.501
LIG_FHA_2	759	765	PF00498	0.676
LIG_FHA_2	867	873	PF00498	0.416
LIG_FHA_2	923	929	PF00498	0.443
LIG_GBD_Chelix_1	613	621	PF00786	0.466
LIG_LIR_Apic_2	172	177	PF02991	0.501
LIG_LIR_Apic_2	492	497	PF02991	0.698
LIG_LIR_Apic_2	650	656	PF02991	0.355
LIG_LIR_Apic_2	924	930	PF02991	0.383
LIG_LIR_Gen_1	27	38	PF02991	0.585
LIG_LIR_Gen_1	343	349	PF02991	0.587
LIG_LIR_Gen_1	354	363	PF02991	0.461
LIG_LIR_Gen_1	558	569	PF02991	0.398
LIG_LIR_Gen_1	577	585	PF02991	0.342
LIG_LIR_Gen_1	942	952	PF02991	0.455
LIG_LIR_Nem_3	27	33	PF02991	0.586
LIG_LIR_Nem_3	343	348	PF02991	0.516
LIG_LIR_Nem_3	354	360	PF02991	0.519
LIG_LIR_Nem_3	441	447	PF02991	0.347
LIG_LIR_Nem_3	558	564	PF02991	0.364
LIG_LIR_Nem_3	577	581	PF02991	0.360
LIG_LIR_Nem_3	620	626	PF02991	0.377
LIG_LIR_Nem_3	645	651	PF02991	0.332
LIG_LIR_Nem_3	822	827	PF02991	0.506
LIG_MYND_1	732	736	PF01753	0.494
LIG_Pex14_1	815	819	PF04695	0.587
LIG_Pex14_2	433	437	PF04695	0.345
LIG_Pex14_2	683	687	PF04695	0.374
LIG_PTAP_UEV_1	778	783	PF05743	0.651
LIG_REV1ctd_RIR_1	856	862	PF16727	0.470
LIG_REV1ctd_RIR_1	942	951	PF16727	0.509
LIG_SH2_CRK	578	582	PF00017	0.353
LIG_SH2_CRK	587	591	PF00017	0.347
LIG_SH2_NCK_1	578	582	PF00017	0.353
LIG_SH2_SRC	357	360	PF00017	0.569
LIG_SH2_SRC	59	62	PF00017	0.634
LIG_SH2_SRC	616	619	PF00017	0.567
LIG_SH2_STAP1	548	552	PF00017	0.296
LIG_SH2_STAP1	632	636	PF00017	0.412
LIG_SH2_STAT3	295	298	PF00017	0.345
LIG_SH2_STAT5	136	139	PF00017	0.459
LIG_SH2_STAT5	219	222	PF00017	0.399
LIG_SH2_STAT5	291	294	PF00017	0.397
LIG_SH2_STAT5	295	298	PF00017	0.387
LIG_SH2_STAT5	357	360	PF00017	0.504
LIG_SH2_STAT5	510	513	PF00017	0.640
LIG_SH2_STAT5	552	555	PF00017	0.369
LIG_SH2_STAT5	598	601	PF00017	0.394
LIG_SH2_STAT5	616	619	PF00017	0.599
LIG_SH2_STAT5	726	729	PF00017	0.390
LIG_SH2_STAT5	819	822	PF00017	0.576
LIG_SH3_1	598	604	PF00018	0.442
LIG_SH3_1	773	779	PF00018	0.639
LIG_SH3_2	72	77	PF14604	0.575
LIG_SH3_3	188	194	PF00018	0.637
LIG_SH3_3	217	223	PF00018	0.454
LIG_SH3_3	237	243	PF00018	0.626
LIG_SH3_3	245	251	PF00018	0.655
LIG_SH3_3	296	302	PF00018	0.345
LIG_SH3_3	478	484	PF00018	0.472
LIG_SH3_3	494	500	PF00018	0.521
LIG_SH3_3	598	604	PF00018	0.440
LIG_SH3_3	66	72	PF00018	0.602
LIG_SH3_3	773	779	PF00018	0.639
LIG_SH3_3	792	798	PF00018	0.619
LIG_SH3_3	81	87	PF00018	0.486
LIG_SH3_3	851	857	PF00018	0.453
LIG_SUMO_SIM_anti_2	851	856	PF11976	0.441
LIG_SUMO_SIM_par_1	113	118	PF11976	0.345
LIG_SUMO_SIM_par_1	241	247	PF11976	0.593
LIG_SUMO_SIM_par_1	31	37	PF11976	0.667
LIG_SUMO_SIM_par_1	571	577	PF11976	0.426
LIG_SUMO_SIM_par_1	837	842	PF11976	0.480
LIG_TRAF2_1	828	831	PF00917	0.492
LIG_UBA3_1	1	7	PF00899	0.660
MOD_CDC14_SPxK_1	714	717	PF00782	0.401
MOD_CDK_SPK_2	422	427	PF00069	0.571
MOD_CDK_SPK_2	900	905	PF00069	0.492
MOD_CDK_SPxK_1	71	77	PF00069	0.583
MOD_CDK_SPxK_1	711	717	PF00069	0.396
MOD_CK1_1	11	17	PF00069	0.608
MOD_CK1_1	165	171	PF00069	0.566
MOD_CK1_1	190	196	PF00069	0.651
MOD_CK1_1	247	253	PF00069	0.676
MOD_CK1_1	364	370	PF00069	0.675
MOD_CK1_1	373	379	PF00069	0.579
MOD_CK1_1	393	399	PF00069	0.578
MOD_CK1_1	40	46	PF00069	0.624
MOD_CK1_1	405	411	PF00069	0.578
MOD_CK1_1	413	419	PF00069	0.547
MOD_CK1_1	449	455	PF00069	0.531
MOD_CK1_1	460	466	PF00069	0.363
MOD_CK1_1	501	507	PF00069	0.610
MOD_CK1_1	574	580	PF00069	0.357
MOD_CK1_1	68	74	PF00069	0.610
MOD_CK1_1	740	746	PF00069	0.652
MOD_CK1_1	749	755	PF00069	0.621
MOD_CK1_1	756	762	PF00069	0.551
MOD_CK1_1	880	886	PF00069	0.602
MOD_CK2_1	343	349	PF00069	0.579
MOD_CK2_1	451	457	PF00069	0.542
MOD_CK2_1	521	527	PF00069	0.404
MOD_CK2_1	758	764	PF00069	0.675
MOD_CK2_1	825	831	PF00069	0.509
MOD_CK2_1	866	872	PF00069	0.405
MOD_CK2_1	888	894	PF00069	0.673
MOD_CK2_1	922	928	PF00069	0.450
MOD_Cter_Amidation	791	794	PF01082	0.695
MOD_DYRK1A_RPxSP_1	775	779	PF00069	0.636
MOD_GlcNHglycan	13	16	PF01048	0.620
MOD_GlcNHglycan	199	202	PF01048	0.574
MOD_GlcNHglycan	211	214	PF01048	0.459
MOD_GlcNHglycan	224	227	PF01048	0.523
MOD_GlcNHglycan	251	254	PF01048	0.612
MOD_GlcNHglycan	261	264	PF01048	0.464
MOD_GlcNHglycan	311	315	PF01048	0.471
MOD_GlcNHglycan	345	348	PF01048	0.527
MOD_GlcNHglycan	375	378	PF01048	0.664
MOD_GlcNHglycan	385	388	PF01048	0.716
MOD_GlcNHglycan	392	395	PF01048	0.485
MOD_GlcNHglycan	407	410	PF01048	0.560
MOD_GlcNHglycan	416	419	PF01048	0.611
MOD_GlcNHglycan	49	52	PF01048	0.629
MOD_GlcNHglycan	501	504	PF01048	0.608
MOD_GlcNHglycan	53	56	PF01048	0.633
MOD_GlcNHglycan	535	538	PF01048	0.489
MOD_GlcNHglycan	727	730	PF01048	0.435
MOD_GlcNHglycan	755	758	PF01048	0.636
MOD_GlcNHglycan	802	805	PF01048	0.680
MOD_GlcNHglycan	883	886	PF01048	0.642
MOD_GSK3_1	140	147	PF00069	0.495
MOD_GSK3_1	162	169	PF00069	0.717
MOD_GSK3_1	183	190	PF00069	0.678
MOD_GSK3_1	193	200	PF00069	0.565
MOD_GSK3_1	234	241	PF00069	0.760
MOD_GSK3_1	242	249	PF00069	0.631
MOD_GSK3_1	349	356	PF00069	0.617
MOD_GSK3_1	364	371	PF00069	0.485
MOD_GSK3_1	37	44	PF00069	0.681
MOD_GSK3_1	373	380	PF00069	0.604
MOD_GSK3_1	405	412	PF00069	0.663
MOD_GSK3_1	446	453	PF00069	0.484
MOD_GSK3_1	47	54	PF00069	0.674
MOD_GSK3_1	485	492	PF00069	0.551
MOD_GSK3_1	5	12	PF00069	0.573
MOD_GSK3_1	501	508	PF00069	0.523
MOD_GSK3_1	546	553	PF00069	0.387
MOD_GSK3_1	565	572	PF00069	0.409
MOD_GSK3_1	711	718	PF00069	0.328
MOD_GSK3_1	737	744	PF00069	0.635
MOD_GSK3_1	746	753	PF00069	0.599
MOD_GSK3_1	763	770	PF00069	0.537
MOD_GSK3_1	780	787	PF00069	0.733
MOD_GSK3_1	877	884	PF00069	0.620
MOD_GSK3_1	89	96	PF00069	0.372
MOD_GSK3_1	947	954	PF00069	0.434
MOD_N-GLC_1	238	243	PF02516	0.682
MOD_N-GLC_1	47	52	PF02516	0.689
MOD_N-GLC_1	546	551	PF02516	0.305
MOD_N-GLC_1	746	751	PF02516	0.602
MOD_N-GLC_1	888	893	PF02516	0.672
MOD_NEK2_1	209	214	PF00069	0.485
MOD_NEK2_1	404	409	PF00069	0.633
MOD_NEK2_1	446	451	PF00069	0.462
MOD_NEK2_1	521	526	PF00069	0.467
MOD_NEK2_1	550	555	PF00069	0.359
MOD_NEK2_1	617	622	PF00069	0.452
MOD_NEK2_1	725	730	PF00069	0.481
MOD_NEK2_1	807	812	PF00069	0.623
MOD_NEK2_1	98	103	PF00069	0.443
MOD_NEK2_2	642	647	PF00069	0.329
MOD_PK_1	647	653	PF00069	0.377
MOD_PKA_1	259	265	PF00069	0.487
MOD_PKA_1	361	367	PF00069	0.660
MOD_PKA_2	209	215	PF00069	0.476
MOD_PKA_2	259	265	PF00069	0.530
MOD_PKA_2	361	367	PF00069	0.569
MOD_PKA_2	410	416	PF00069	0.654
MOD_PKA_2	457	463	PF00069	0.417
MOD_PKA_2	737	743	PF00069	0.634
MOD_PKA_2	866	872	PF00069	0.429
MOD_PKA_2	99	105	PF00069	0.381
MOD_PKB_1	823	831	PF00069	0.530
MOD_Plk_1	546	552	PF00069	0.307
MOD_Plk_1	617	623	PF00069	0.561
MOD_Plk_1	632	638	PF00069	0.243
MOD_Plk_1	98	104	PF00069	0.387
MOD_Plk_2-3	349	355	PF00069	0.512
MOD_Plk_2-3	37	43	PF00069	0.613
MOD_Plk_4	287	293	PF00069	0.374
MOD_Plk_4	353	359	PF00069	0.663
MOD_Plk_4	546	552	PF00069	0.307
MOD_Plk_4	617	623	PF00069	0.444
MOD_Plk_4	746	752	PF00069	0.536
MOD_Plk_4	861	867	PF00069	0.425
MOD_ProDKin_1	15	21	PF00069	0.622
MOD_ProDKin_1	166	172	PF00069	0.591
MOD_ProDKin_1	187	193	PF00069	0.629
MOD_ProDKin_1	238	244	PF00069	0.698
MOD_ProDKin_1	247	253	PF00069	0.716
MOD_ProDKin_1	328	334	PF00069	0.517
MOD_ProDKin_1	41	47	PF00069	0.632
MOD_ProDKin_1	422	428	PF00069	0.539
MOD_ProDKin_1	480	486	PF00069	0.488
MOD_ProDKin_1	493	499	PF00069	0.557
MOD_ProDKin_1	505	511	PF00069	0.529
MOD_ProDKin_1	65	71	PF00069	0.663
MOD_ProDKin_1	711	717	PF00069	0.396
MOD_ProDKin_1	775	781	PF00069	0.634
MOD_ProDKin_1	900	906	PF00069	0.475
MOD_SUMO_for_1	946	949	PF00179	0.478
MOD_SUMO_rev_2	343	352	PF00179	0.572
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.510
TRG_ENDOCYTIC_2	125	128	PF00928	0.380
TRG_ENDOCYTIC_2	136	139	PF00928	0.394
TRG_ENDOCYTIC_2	345	348	PF00928	0.515
TRG_ENDOCYTIC_2	357	360	PF00928	0.504
TRG_ENDOCYTIC_2	436	439	PF00928	0.352
TRG_ENDOCYTIC_2	561	564	PF00928	0.483
TRG_ENDOCYTIC_2	578	581	PF00928	0.361
TRG_ENDOCYTIC_2	587	590	PF00928	0.347
TRG_ER_diArg_1	259	261	PF00400	0.470
TRG_ER_diArg_1	360	362	PF00400	0.483
TRG_ER_diArg_1	470	473	PF00400	0.434
TRG_ER_diArg_1	606	608	PF00400	0.394
TRG_ER_diArg_1	706	709	PF00400	0.393
TRG_ER_diArg_1	771	774	PF00400	0.652
TRG_ER_diArg_1	793	795	PF00400	0.688
TRG_NLS_MonoExtC_3	770	775	PF00514	0.645
TRG_NLS_MonoExtN_4	771	776	PF00514	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3R8	Leptomonas seymouri	54%	100%
A0A3Q8IKQ0	Leishmania donovani	94%	100%
A4HPA4	Leishmania braziliensis	81%	100%
A4IDL1	Leishmania infantum	94%	100%
E9AT14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%