Methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Methyltransferase

Gene product:

sterol 24-c-methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q1I3_LEIMA

TriTrypDb:

LmjF.36.2380 , LMJLV39_360031600 , LMJSD75_360031700

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005783	endoplasmic reticulum	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

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Expansion

Sequence features

Q4Q1I3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1I3

Function

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Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	15
GO:0006694	steroid biosynthetic process	5	15
GO:0008152	metabolic process	1	15
GO:0008202	steroid metabolic process	4	15
GO:0008610	lipid biosynthetic process	4	15
GO:0009058	biosynthetic process	2	15
GO:0016125	sterol metabolic process	4	3
GO:0016126	sterol biosynthetic process	5	3
GO:0032259	methylation	2	15
GO:0044238	primary metabolic process	2	15

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0003838	sterol 24-C-methyltransferase activity	6	3
GO:0008168	methyltransferase activity	4	15
GO:0008169	C-methyltransferase activity	5	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	3
GO:0016740	transferase activity	2	15
GO:0016741	transferase activity, transferring one-carbon groups	3	15

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.463
CLV_C14_Caspase3-7	229	233	PF00656	0.405
CLV_NRD_NRD_1	142	144	PF00675	0.326
CLV_NRD_NRD_1	16	18	PF00675	0.546
CLV_NRD_NRD_1	346	348	PF00675	0.303
CLV_NRD_NRD_1	44	46	PF00675	0.471
CLV_PCSK_FUR_1	140	144	PF00082	0.326
CLV_PCSK_KEX2_1	142	144	PF00082	0.326
CLV_PCSK_KEX2_1	15	17	PF00082	0.568
CLV_PCSK_SKI1_1	195	199	PF00082	0.313

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0E0SMA3	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	42%	93%
A0A0N0P458	Leptomonas seymouri	84%	100%
A0A0S4JSP5	Bodo saltans	62%	100%
A0A1X0NFC9	Trypanosomatidae	65%	98%
A0A3Q8IK91	Leishmania donovani	96%	100%
A0A3S7XAX3	Leishmania donovani	97%	100%
A0A422N3F9	Trypanosoma rangeli	68%	98%
A4HPA5	Leishmania braziliensis	86%	100%
A4IDL2	Leishmania infantum	97%	100%
A4IDL3	Leishmania infantum	97%	100%

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