Methyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Methyltransferase

Gene product:

sterol 24-c-methyltransferase, putative

Species:

Leishmania major

UniProt:

Q4Q1I2_LEIMA

TriTrypDb:

LmjF.36.2390 , LMJLV39_360031600 , LMJSD75_360031700

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0005783	endoplasmic reticulum	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4Q1I2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1I2

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	15
GO:0006694	steroid biosynthetic process	5	15
GO:0008152	metabolic process	1	15
GO:0008202	steroid metabolic process	4	15
GO:0008610	lipid biosynthetic process	4	15
GO:0009058	biosynthetic process	2	15
GO:0016125	sterol metabolic process	4	3
GO:0016126	sterol biosynthetic process	5	3
GO:0032259	methylation	2	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15
GO:1901360	organic cyclic compound metabolic process	3	15
GO:1901362	organic cyclic compound biosynthetic process	4	15
GO:1901576	organic substance biosynthetic process	3	15
GO:1901615	organic hydroxy compound metabolic process	3	3
GO:1901617	organic hydroxy compound biosynthetic process	4	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0003838	sterol 24-C-methyltransferase activity	6	3
GO:0008168	methyltransferase activity	4	15
GO:0008169	C-methyltransferase activity	5	3
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	3
GO:0016740	transferase activity	2	15
GO:0016741	transferase activity, transferring one-carbon groups	3	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.463
CLV_C14_Caspase3-7	229	233	PF00656	0.416
CLV_NRD_NRD_1	142	144	PF00675	0.330
CLV_NRD_NRD_1	16	18	PF00675	0.616
CLV_NRD_NRD_1	346	348	PF00675	0.305
CLV_NRD_NRD_1	44	46	PF00675	0.486
CLV_PCSK_FUR_1	140	144	PF00082	0.342
CLV_PCSK_KEX2_1	142	144	PF00082	0.330
CLV_PCSK_KEX2_1	15	17	PF00082	0.630
CLV_PCSK_SKI1_1	195	199	PF00082	0.318
CLV_PCSK_SKI1_1	222	226	PF00082	0.526
CLV_PCSK_SKI1_1	295	299	PF00082	0.319
CLV_PCSK_SKI1_1	46	50	PF00082	0.569
CLV_PCSK_SKI1_1	6	10	PF00082	0.449
DEG_SPOP_SBC_1	47	51	PF00917	0.597
DOC_ANK_TNKS_1	288	295	PF00023	0.425
DOC_CKS1_1	337	342	PF01111	0.319
DOC_MAPK_gen_1	222	230	PF00069	0.410
DOC_PP1_RVXF_1	301	308	PF00149	0.425
DOC_USP7_MATH_1	148	152	PF00917	0.435
DOC_USP7_MATH_1	268	272	PF00917	0.529
DOC_USP7_MATH_1	325	329	PF00917	0.398
DOC_USP7_UBL2_3	184	188	PF12436	0.435
DOC_USP7_UBL2_3	313	317	PF12436	0.363
DOC_WW_Pin1_4	264	269	PF00397	0.450
DOC_WW_Pin1_4	288	293	PF00397	0.303
DOC_WW_Pin1_4	336	341	PF00397	0.313
DOC_WW_Pin1_4	6	11	PF00397	0.641
LIG_14-3-3_CanoR_1	45	53	PF00244	0.616
LIG_BIR_II_1	1	5	PF00653	0.612
LIG_BRCT_BRCA1_1	190	194	PF00533	0.366
LIG_deltaCOP1_diTrp_1	65	74	PF00928	0.416
LIG_FHA_1	199	205	PF00498	0.467
LIG_FHA_1	317	323	PF00498	0.306
LIG_FHA_1	48	54	PF00498	0.478
LIG_FHA_2	39	45	PF00498	0.558
LIG_FHA_2	80	86	PF00498	0.425
LIG_LIR_Apic_2	271	277	PF02991	0.419
LIG_LIR_Gen_1	159	167	PF02991	0.342
LIG_LIR_Gen_1	281	288	PF02991	0.459
LIG_LIR_Gen_1	306	312	PF02991	0.401
LIG_LIR_Gen_1	55	64	PF02991	0.441
LIG_LIR_Gen_1	81	92	PF02991	0.378
LIG_LIR_LC3C_4	327	331	PF02991	0.351
LIG_LIR_Nem_3	191	197	PF02991	0.324
LIG_LIR_Nem_3	201	206	PF02991	0.321
LIG_LIR_Nem_3	281	285	PF02991	0.467
LIG_LIR_Nem_3	306	310	PF02991	0.384
LIG_LIR_Nem_3	55	60	PF02991	0.433
LIG_LIR_Nem_3	61	66	PF02991	0.451
LIG_LIR_Nem_3	81	87	PF02991	0.205
LIG_Pex14_1	68	72	PF04695	0.411
LIG_Pex14_2	33	37	PF04695	0.516
LIG_Pex14_2	338	342	PF04695	0.304
LIG_PTB_Apo_2	130	137	PF02174	0.323
LIG_PTB_Apo_2	51	58	PF02174	0.452
LIG_PTB_Phospho_1	130	136	PF10480	0.323
LIG_PTB_Phospho_1	51	57	PF10480	0.449
LIG_SH2_CRK	275	279	PF00017	0.438
LIG_SH2_CRK	282	286	PF00017	0.496
LIG_SH2_CRK	57	61	PF00017	0.436
LIG_SH2_NCK_1	190	194	PF00017	0.342
LIG_SH2_NCK_1	57	61	PF00017	0.436
LIG_SH2_SRC	136	139	PF00017	0.327
LIG_SH2_SRC	64	67	PF00017	0.465
LIG_SH2_STAP1	175	179	PF00017	0.323
LIG_SH2_STAP1	190	194	PF00017	0.338
LIG_SH2_STAP1	206	210	PF00017	0.284
LIG_SH2_STAT5	156	159	PF00017	0.366
LIG_SH2_STAT5	343	346	PF00017	0.433
LIG_SH2_STAT5	92	95	PF00017	0.438
LIG_SH3_3	110	116	PF00018	0.342
LIG_SH3_3	193	199	PF00018	0.342
LIG_SUMO_SIM_anti_2	255	262	PF11976	0.520
LIG_TRAF2_1	41	44	PF00917	0.616
MOD_CDC14_SPxK_1	267	270	PF00782	0.493
MOD_CDK_SPxK_1	264	270	PF00069	0.485
MOD_CDK_SPxxK_3	288	295	PF00069	0.303
MOD_CK2_1	259	265	PF00069	0.480
MOD_CK2_1	38	44	PF00069	0.548
MOD_CK2_1	79	85	PF00069	0.417
MOD_GlcNHglycan	1	4	PF01048	0.616
MOD_GSK3_1	259	266	PF00069	0.529
MOD_GSK3_1	312	319	PF00069	0.303
MOD_GSK3_1	79	86	PF00069	0.408
MOD_N-GLC_1	126	131	PF02516	0.405
MOD_N-GLC_1	162	167	PF02516	0.417
MOD_NEK2_1	83	88	PF00069	0.378
MOD_NEK2_2	148	153	PF00069	0.226
MOD_NEK2_2	220	225	PF00069	0.449
MOD_NEK2_2	79	84	PF00069	0.558
MOD_PIKK_1	259	265	PF00454	0.480
MOD_PKA_1	347	353	PF00069	0.530
MOD_PKA_2	121	127	PF00069	0.342
MOD_PKB_1	345	353	PF00069	0.401
MOD_Plk_1	162	168	PF00069	0.445
MOD_Plk_1	280	286	PF00069	0.563
MOD_Plk_2-3	38	44	PF00069	0.615
MOD_Plk_4	325	331	PF00069	0.401
MOD_Plk_4	338	344	PF00069	0.339
MOD_Plk_4	48	54	PF00069	0.480
MOD_Plk_4	79	85	PF00069	0.402
MOD_ProDKin_1	264	270	PF00069	0.453
MOD_ProDKin_1	288	294	PF00069	0.303
MOD_ProDKin_1	336	342	PF00069	0.313
MOD_ProDKin_1	6	12	PF00069	0.641
MOD_SUMO_rev_2	38	48	PF00179	0.524
TRG_DiLeu_BaEn_1	55	60	PF01217	0.458
TRG_ENDOCYTIC_2	190	193	PF00928	0.326
TRG_ENDOCYTIC_2	275	278	PF00928	0.389
TRG_ENDOCYTIC_2	282	285	PF00928	0.459
TRG_ENDOCYTIC_2	56	59	PF00928	0.434
TRG_ER_diArg_1	14	17	PF00400	0.613
TRG_ER_diArg_1	140	143	PF00400	0.328
TRG_ER_diArg_1	33	36	PF00400	0.296
TRG_ER_diArg_1	344	347	PF00400	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0E0SMA3	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	42%	93%
A0A0N0P458	Leptomonas seymouri	83%	100%
A0A0S4JSP5	Bodo saltans	62%	100%
A0A1X0NFC9	Trypanosomatidae	65%	98%
A0A3Q8IK91	Leishmania donovani	96%	100%
A0A3S7XAX3	Leishmania donovani	96%	100%
A0A422N3F9	Trypanosoma rangeli	67%	98%
A4HPA5	Leishmania braziliensis	86%	100%
A4IDL2	Leishmania infantum	96%	100%
A4IDL3	Leishmania infantum	96%	100%
D0A3B2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	98%
E9AT15	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AT16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
H2E7T5	Botryococcus braunii	36%	93%
H2E7T6	Botryococcus braunii	35%	93%
H2E7T7	Botryococcus braunii	35%	93%
H2E7T8	Botryococcus braunii	34%	91%
H2E7T9	Botryococcus braunii	36%	91%
H2E7U0	Botryococcus braunii	36%	90%
I1RGC4	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	43%	93%
L0E172	Penicillium fellutanum	41%	100%
L7IP31	Magnaporthe oryzae (strain Y34)	43%	91%
O14321	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	93%
O74198	Candida albicans (strain SC5314 / ATCC MYA-2876)	41%	94%
O82427	Oryza sativa subsp. japonica	38%	97%
P0CT10	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	43%	91%
P25087	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	92%
Q39227	Arabidopsis thaliana	35%	98%
Q4Q1I3	Leishmania major	99%	100%
Q4W9V1	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	44%	94%
Q54I98	Dictyostelium discoideum	46%	100%
Q6BRB7	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	43%	94%
Q6C2D9	Yarrowia lipolytica (strain CLIB 122 / E 150)	40%	93%
Q6CYB3	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	43%	95%
Q6FRZ7	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	42%	95%
Q6ZIX2	Oryza sativa subsp. japonica	47%	100%
Q759S7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	44%	95%
Q875K1	Clavispora lusitaniae (strain ATCC 42720)	45%	94%
Q94JS4	Arabidopsis thaliana	35%	98%
Q96WX4	Pneumocystis carinii (strain B80)	40%	94%
Q9LM02	Arabidopsis thaliana	47%	100%
Q9P3R1	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	93%
Q9TYP1	Caenorhabditis elegans	25%	100%