FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1H7_LEIMA

TriTrypDb:

LmjF.36.2440 , LMJLV39_360032300 , LMJSD75_360032300

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	2
GO:0020018	ciliary pocket membrane	6	2
GO:0031090	organelle membrane	3	2
GO:0031253	cell projection membrane	4	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0060170	ciliary membrane	5	2
GO:0097014	ciliary plasm	5	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098590	plasma membrane region	3	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1H7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1H7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.566
CLV_C14_Caspase3-7	57	61	PF00656	0.733
CLV_NRD_NRD_1	164	166	PF00675	0.536
CLV_NRD_NRD_1	80	82	PF00675	0.607
CLV_PCSK_FUR_1	78	82	PF00082	0.558
CLV_PCSK_KEX2_1	164	166	PF00082	0.513
CLV_PCSK_KEX2_1	80	82	PF00082	0.554
DOC_ANK_TNKS_1	99	106	PF00023	0.539
DOC_MAPK_gen_1	30	38	PF00069	0.526
DOC_USP7_MATH_1	110	114	PF00917	0.766
DOC_USP7_MATH_1	131	135	PF00917	0.726
DOC_USP7_MATH_1	145	149	PF00917	0.665
DOC_WW_Pin1_4	122	127	PF00397	0.726
DOC_WW_Pin1_4	133	138	PF00397	0.629
DOC_WW_Pin1_4	182	187	PF00397	0.596
LIG_14-3-3_CanoR_1	132	138	PF00244	0.757
LIG_Actin_WH2_2	196	213	PF00022	0.494
LIG_BIR_III_4	28	32	PF00653	0.609
LIG_FHA_1	187	193	PF00498	0.414
LIG_FHA_1	22	28	PF00498	0.602
LIG_FHA_1	33	39	PF00498	0.530
LIG_FHA_2	12	18	PF00498	0.436
LIG_LIR_Nem_3	2	7	PF02991	0.483
LIG_SH2_STAT5	221	224	PF00017	0.425
LIG_SH3_1	174	180	PF00018	0.528
LIG_SH3_2	116	121	PF14604	0.697
LIG_SH3_3	113	119	PF00018	0.690
LIG_SH3_3	120	126	PF00018	0.612
LIG_SH3_3	135	141	PF00018	0.665
LIG_SH3_3	174	180	PF00018	0.528
LIG_WW_2	142	145	PF00397	0.532
LIG_WW_3	129	133	PF00397	0.672
MOD_CDC14_SPxK_1	185	188	PF00782	0.574
MOD_CDK_SPxK_1	182	188	PF00069	0.616
MOD_CK1_1	124	130	PF00069	0.689
MOD_CK2_1	71	77	PF00069	0.598
MOD_GlcNHglycan	127	130	PF01048	0.797
MOD_GlcNHglycan	133	136	PF01048	0.771
MOD_GlcNHglycan	147	150	PF01048	0.697
MOD_GlcNHglycan	50	53	PF01048	0.715
MOD_GlcNHglycan	56	59	PF01048	0.743
MOD_GSK3_1	121	128	PF00069	0.729
MOD_GSK3_1	182	189	PF00069	0.490
MOD_GSK3_1	38	45	PF00069	0.571
MOD_N-GLC_1	182	187	PF02516	0.530
MOD_PIKK_1	147	153	PF00454	0.663
MOD_PKA_2	131	137	PF00069	0.757
MOD_PKA_2	21	27	PF00069	0.591
MOD_Plk_1	186	192	PF00069	0.427
MOD_Plk_2-3	71	77	PF00069	0.643
MOD_ProDKin_1	122	128	PF00069	0.726
MOD_ProDKin_1	133	139	PF00069	0.632
MOD_ProDKin_1	182	188	PF00069	0.581
MOD_SUMO_for_1	29	32	PF00179	0.644
MOD_SUMO_rev_2	214	218	PF00179	0.443
TRG_DiLeu_BaEn_1	187	192	PF01217	0.414
TRG_DiLeu_BaEn_1	194	199	PF01217	0.396
TRG_DiLeu_LyEn_5	187	192	PF01217	0.492
TRG_ENDOCYTIC_2	221	224	PF00928	0.524
TRG_ER_diArg_1	163	165	PF00400	0.530
TRG_ER_diArg_1	80	83	PF00400	0.638
TRG_ER_diArg_1	95	98	PF00400	0.515
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I764	Leptomonas seymouri	51%	85%
A0A0S4JVE6	Bodo saltans	30%	100%
A0A1X0P7S3	Trypanosomatidae	32%	100%
A0A3Q8IR10	Leishmania donovani	90%	91%
A0A422NCC4	Trypanosoma rangeli	35%	100%
A4HPB0	Leishmania braziliensis	67%	100%
A4ICF0	Leishmania infantum	89%	91%
E9AT21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	91%
V5D8K6	Trypanosoma cruzi	38%	100%