Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1H6_LEIMA

TriTrypDb:

LmjF.36.2450 , LMJLV39_360032400 , LMJSD75_360032400

Length:

451

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q1H6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1H6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.674
CLV_C14_Caspase3-7	200	204	PF00656	0.755
CLV_C14_Caspase3-7	326	330	PF00656	0.643
CLV_C14_Caspase3-7	62	66	PF00656	0.657
CLV_MEL_PAP_1	26	32	PF00089	0.516
CLV_NRD_NRD_1	345	347	PF00675	0.377
CLV_NRD_NRD_1	35	37	PF00675	0.432
CLV_NRD_NRD_1	99	101	PF00675	0.321
CLV_PCSK_KEX2_1	34	36	PF00082	0.432
CLV_PCSK_KEX2_1	345	347	PF00082	0.377
CLV_PCSK_KEX2_1	40	42	PF00082	0.473
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.493
CLV_PCSK_PC7_1	36	42	PF00082	0.509
CLV_PCSK_SKI1_1	174	178	PF00082	0.378
CLV_PCSK_SKI1_1	444	448	PF00082	0.554
DEG_APCC_DBOX_1	324	332	PF00400	0.561
DEG_Nend_UBRbox_3	1	3	PF02207	0.375
DOC_CKS1_1	19	24	PF01111	0.312
DOC_CYCLIN_RxL_1	169	179	PF00134	0.607
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.360
DOC_MAPK_gen_1	342	351	PF00069	0.624
DOC_MAPK_JIP1_4	134	140	PF00069	0.475
DOC_MAPK_MEF2A_6	345	353	PF00069	0.506
DOC_PP1_RVXF_1	338	344	PF00149	0.599
DOC_PP2B_LxvP_1	272	275	PF13499	0.772
DOC_PP2B_LxvP_1	349	352	PF13499	0.336
DOC_PP4_FxxP_1	278	281	PF00568	0.773
DOC_PP4_FxxP_1	418	421	PF00568	0.391
DOC_USP7_MATH_1	248	252	PF00917	0.727
DOC_USP7_MATH_1	321	325	PF00917	0.596
DOC_USP7_MATH_1	352	356	PF00917	0.481
DOC_USP7_MATH_1	50	54	PF00917	0.744
DOC_USP7_UBL2_3	101	105	PF12436	0.546
DOC_USP7_UBL2_3	40	44	PF12436	0.601
DOC_USP7_UBL2_3	440	444	PF12436	0.453
DOC_WW_Pin1_4	18	23	PF00397	0.312
DOC_WW_Pin1_4	220	225	PF00397	0.721
DOC_WW_Pin1_4	277	282	PF00397	0.693
DOC_WW_Pin1_4	304	309	PF00397	0.635
LIG_14-3-3_CanoR_1	167	177	PF00244	0.539
LIG_14-3-3_CanoR_1	196	206	PF00244	0.702
LIG_14-3-3_CanoR_1	345	350	PF00244	0.568
LIG_14-3-3_CanoR_1	405	415	PF00244	0.432
LIG_14-3-3_CanoR_1	41	49	PF00244	0.720
LIG_14-3-3_CanoR_1	428	434	PF00244	0.384
LIG_APCC_ABBAyCdc20_2	430	436	PF00400	0.427
LIG_BIR_III_4	285	289	PF00653	0.628
LIG_BIR_III_4	65	69	PF00653	0.563
LIG_Clathr_ClatBox_1	149	153	PF01394	0.569
LIG_deltaCOP1_diTrp_1	92	98	PF00928	0.503
LIG_EVH1_2	274	278	PF00568	0.675
LIG_FHA_1	19	25	PF00498	0.462
LIG_FHA_1	298	304	PF00498	0.676
LIG_FHA_1	331	337	PF00498	0.617
LIG_FHA_1	352	358	PF00498	0.284
LIG_FHA_1	367	373	PF00498	0.360
LIG_FHA_1	407	413	PF00498	0.416
LIG_FHA_1	445	451	PF00498	0.381
LIG_FHA_1	79	85	PF00498	0.541
LIG_FHA_2	198	204	PF00498	0.715
LIG_FHA_2	324	330	PF00498	0.629
LIG_GBD_Chelix_1	150	158	PF00786	0.398
LIG_LIR_Apic_2	276	281	PF02991	0.777
LIG_LIR_Gen_1	314	321	PF02991	0.637
LIG_LIR_Gen_1	359	368	PF02991	0.312
LIG_LIR_Gen_1	92	103	PF02991	0.521
LIG_LIR_LC3C_4	348	351	PF02991	0.467
LIG_LIR_Nem_3	314	319	PF02991	0.625
LIG_LIR_Nem_3	359	364	PF02991	0.312
LIG_LIR_Nem_3	397	403	PF02991	0.436
LIG_LIR_Nem_3	408	414	PF02991	0.360
LIG_LIR_Nem_3	65	70	PF02991	0.648
LIG_LIR_Nem_3	92	98	PF02991	0.503
LIG_MYND_1	270	274	PF01753	0.685
LIG_NRBOX	153	159	PF00104	0.592
LIG_PDZ_Class_1	446	451	PF00595	0.413
LIG_Pex14_2	414	418	PF04695	0.459
LIG_Pex14_2	67	71	PF04695	0.576
LIG_SH2_CRK	316	320	PF00017	0.582
LIG_SH2_CRK	361	365	PF00017	0.379
LIG_SH2_GRB2like	142	145	PF00017	0.615
LIG_SH2_SRC	419	422	PF00017	0.399
LIG_SH2_SRC	49	52	PF00017	0.695
LIG_SH2_STAP1	282	286	PF00017	0.665
LIG_SH2_STAT5	115	118	PF00017	0.606
LIG_SH2_STAT5	199	202	PF00017	0.710
LIG_SH2_STAT5	401	404	PF00017	0.371
LIG_SH2_STAT5	419	422	PF00017	0.391
LIG_SH2_STAT5	434	437	PF00017	0.420
LIG_SH2_STAT5	54	57	PF00017	0.713
LIG_SH2_STAT5	85	88	PF00017	0.497
LIG_SH3_1	129	135	PF00018	0.576
LIG_SH3_3	129	135	PF00018	0.605
LIG_SH3_3	256	262	PF00018	0.778
LIG_SH3_3	264	270	PF00018	0.687
LIG_SH3_3	291	297	PF00018	0.641
LIG_SH3_4	101	108	PF00018	0.542
LIG_SUMO_SIM_anti_2	148	153	PF11976	0.608
LIG_SUMO_SIM_par_1	136	141	PF11976	0.597
LIG_SUMO_SIM_par_1	148	153	PF11976	0.614
LIG_SUMO_SIM_par_1	173	179	PF11976	0.539
LIG_SUMO_SIM_par_1	304	312	PF11976	0.630
LIG_TYR_ITSM	312	319	PF00017	0.318
LIG_WRC_WIRS_1	117	122	PF05994	0.463
MOD_CK1_1	276	282	PF00069	0.719
MOD_CK1_1	375	381	PF00069	0.604
MOD_CK1_1	39	45	PF00069	0.761
MOD_CK1_1	438	444	PF00069	0.534
MOD_CK2_1	321	327	PF00069	0.536
MOD_GlcNHglycan	109	112	PF01048	0.415
MOD_GlcNHglycan	250	253	PF01048	0.708
MOD_GlcNHglycan	285	289	PF01048	0.705
MOD_GlcNHglycan	354	357	PF01048	0.484
MOD_GlcNHglycan	358	361	PF01048	0.391
MOD_GlcNHglycan	377	380	PF01048	0.404
MOD_GSK3_1	250	257	PF00069	0.655
MOD_GSK3_1	273	280	PF00069	0.736
MOD_GSK3_1	297	304	PF00069	0.493
MOD_GSK3_1	307	314	PF00069	0.500
MOD_GSK3_1	35	42	PF00069	0.684
MOD_GSK3_1	352	359	PF00069	0.408
MOD_GSK3_1	366	373	PF00069	0.335
MOD_N-GLC_1	276	281	PF02516	0.683
MOD_N-GLC_1	321	326	PF02516	0.537
MOD_N-GLC_1	406	411	PF02516	0.507
MOD_N-GLC_1	42	47	PF02516	0.576
MOD_N-GLC_1	436	441	PF02516	0.496
MOD_NEK2_1	138	143	PF00069	0.491
MOD_NEK2_1	176	181	PF00069	0.449
MOD_NEK2_1	236	241	PF00069	0.621
MOD_NEK2_1	446	451	PF00069	0.595
MOD_NEK2_2	429	434	PF00069	0.465
MOD_PIKK_1	207	213	PF00454	0.723
MOD_PIKK_1	406	412	PF00454	0.520
MOD_PKA_1	345	351	PF00069	0.502
MOD_PKA_1	35	41	PF00069	0.559
MOD_PKA_2	159	165	PF00069	0.433
MOD_PKA_2	168	174	PF00069	0.403
MOD_PKA_2	345	351	PF00069	0.441
MOD_PKA_2	35	41	PF00069	0.614
MOD_PKA_2	429	435	PF00069	0.530
MOD_PKB_1	34	42	PF00069	0.648
MOD_Plk_1	202	208	PF00069	0.558
MOD_Plk_1	370	376	PF00069	0.423
MOD_Plk_1	406	412	PF00069	0.511
MOD_Plk_1	50	56	PF00069	0.552
MOD_Plk_2-3	366	372	PF00069	0.432
MOD_Plk_4	138	144	PF00069	0.384
MOD_Plk_4	145	151	PF00069	0.447
MOD_Plk_4	312	318	PF00069	0.464
MOD_Plk_4	345	351	PF00069	0.518
MOD_Plk_4	387	393	PF00069	0.450
MOD_Plk_4	429	435	PF00069	0.474
MOD_ProDKin_1	18	24	PF00069	0.312
MOD_ProDKin_1	220	226	PF00069	0.667
MOD_ProDKin_1	277	283	PF00069	0.627
MOD_ProDKin_1	304	310	PF00069	0.537
TRG_DiLeu_BaEn_1	173	178	PF01217	0.407
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.484
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.257
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.433
TRG_ENDOCYTIC_2	316	319	PF00928	0.514
TRG_ENDOCYTIC_2	361	364	PF00928	0.413
TRG_ENDOCYTIC_2	400	403	PF00928	0.500
TRG_ER_diArg_1	34	36	PF00400	0.548
TRG_ER_diArg_1	340	343	PF00400	0.550
TRG_ER_diArg_1	427	430	PF00400	0.482
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL22	Leptomonas seymouri	52%	98%
A0A3Q8IJ49	Leishmania donovani	92%	100%
A0A3R7KBE0	Trypanosoma rangeli	26%	100%
A4HPB1	Leishmania braziliensis	69%	100%
A4ICF1	Leishmania infantum	92%	100%
D0A3C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AT22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5B844	Trypanosoma cruzi	26%	100%