Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1H5_LEIMA

TriTrypDb:

LmjF.36.2460 , LMJLV39_360032500 , LMJSD75_360032500

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1H5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1H5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.687
CLV_C14_Caspase3-7	323	327	PF00656	0.727
CLV_NRD_NRD_1	349	351	PF00675	0.698
CLV_NRD_NRD_1	385	387	PF00675	0.671
CLV_NRD_NRD_1	420	422	PF00675	0.751
CLV_NRD_NRD_1	488	490	PF00675	0.605
CLV_NRD_NRD_1	94	96	PF00675	0.661
CLV_PCSK_KEX2_1	385	387	PF00082	0.671
CLV_PCSK_KEX2_1	420	422	PF00082	0.747
CLV_PCSK_KEX2_1	488	490	PF00082	0.605
CLV_PCSK_KEX2_1	94	96	PF00082	0.661
CLV_PCSK_PC7_1	381	387	PF00082	0.710
CLV_PCSK_SKI1_1	119	123	PF00082	0.477
CLV_PCSK_SKI1_1	371	375	PF00082	0.651
CLV_PCSK_SKI1_1	386	390	PF00082	0.595
CLV_PCSK_SKI1_1	526	530	PF00082	0.594
CLV_PCSK_SKI1_1	582	586	PF00082	0.510
CLV_Separin_Metazoa	523	527	PF03568	0.530
DEG_APCC_DBOX_1	525	533	PF00400	0.550
DEG_APCC_DBOX_1	581	589	PF00400	0.509
DEG_Nend_Nbox_1	1	3	PF02207	0.531
DOC_CYCLIN_yCln2_LP_2	498	504	PF00134	0.566
DOC_MAPK_gen_1	655	665	PF00069	0.549
DOC_MAPK_MEF2A_6	137	145	PF00069	0.545
DOC_MAPK_MEF2A_6	582	590	PF00069	0.605
DOC_PP1_RVXF_1	384	391	PF00149	0.559
DOC_PP1_RVXF_1	659	666	PF00149	0.458
DOC_PP2B_LxvP_1	79	82	PF13499	0.666
DOC_PP4_FxxP_1	445	448	PF00568	0.617
DOC_PP4_FxxP_1	93	96	PF00568	0.578
DOC_USP7_MATH_1	102	106	PF00917	0.678
DOC_USP7_MATH_1	205	209	PF00917	0.678
DOC_USP7_MATH_1	315	319	PF00917	0.728
DOC_USP7_MATH_1	331	335	PF00917	0.603
DOC_USP7_MATH_1	55	59	PF00917	0.601
DOC_USP7_MATH_1	560	564	PF00917	0.692
DOC_USP7_MATH_1	74	78	PF00917	0.576
DOC_WW_Pin1_4	223	228	PF00397	0.696
DOC_WW_Pin1_4	404	409	PF00397	0.684
DOC_WW_Pin1_4	454	459	PF00397	0.736
DOC_WW_Pin1_4	558	563	PF00397	0.828
DOC_WW_Pin1_4	88	93	PF00397	0.781
LIG_14-3-3_CanoR_1	111	117	PF00244	0.556
LIG_14-3-3_CanoR_1	22	26	PF00244	0.623
LIG_14-3-3_CanoR_1	220	226	PF00244	0.716
LIG_14-3-3_CanoR_1	385	391	PF00244	0.611
LIG_14-3-3_CanoR_1	517	521	PF00244	0.633
LIG_BIR_III_2	305	309	PF00653	0.737
LIG_CtBP_PxDLS_1	458	462	PF00389	0.656
LIG_FHA_1	341	347	PF00498	0.675
LIG_FHA_1	413	419	PF00498	0.563
LIG_FHA_1	454	460	PF00498	0.629
LIG_FHA_1	506	512	PF00498	0.557
LIG_FHA_1	58	64	PF00498	0.616
LIG_FHA_1	593	599	PF00498	0.531
LIG_FHA_1	640	646	PF00498	0.521
LIG_FHA_1	675	681	PF00498	0.664
LIG_FHA_2	321	327	PF00498	0.728
LIG_LIR_Apic_2	644	650	PF02991	0.633
LIG_LIR_Apic_2	90	96	PF02991	0.566
LIG_LIR_Gen_1	256	267	PF02991	0.626
LIG_LIR_Gen_1	463	468	PF02991	0.703
LIG_LIR_Nem_3	235	240	PF02991	0.596
LIG_LIR_Nem_3	24	28	PF02991	0.640
LIG_LIR_Nem_3	256	262	PF02991	0.600
LIG_LIR_Nem_3	463	467	PF02991	0.703
LIG_LIR_Nem_3	620	624	PF02991	0.556
LIG_NRBOX	584	590	PF00104	0.600
LIG_PCNA_PIPBox_1	172	181	PF02747	0.407
LIG_PCNA_yPIPBox_3	172	184	PF02747	0.524
LIG_SH2_CRK	259	263	PF00017	0.646
LIG_SH2_NCK_1	259	263	PF00017	0.744
LIG_SH2_NCK_1	536	540	PF00017	0.550
LIG_SH2_SRC	536	539	PF00017	0.650
LIG_SH2_STAP1	254	258	PF00017	0.688
LIG_SH2_STAP1	479	483	PF00017	0.619
LIG_SH2_STAT3	131	134	PF00017	0.384
LIG_SH2_STAT5	131	134	PF00017	0.570
LIG_SH2_STAT5	237	240	PF00017	0.529
LIG_SH2_STAT5	352	355	PF00017	0.801
LIG_SH2_STAT5	68	71	PF00017	0.460
LIG_SH3_3	333	339	PF00018	0.657
LIG_SH3_3	370	376	PF00018	0.521
LIG_SH3_3	440	446	PF00018	0.642
LIG_SUMO_SIM_anti_2	512	517	PF11976	0.638
LIG_SUMO_SIM_par_1	27	34	PF11976	0.418
LIG_SUMO_SIM_par_1	455	463	PF11976	0.719
LIG_SUMO_SIM_par_1	58	66	PF11976	0.600
LIG_TRAF2_1	623	626	PF00917	0.568
LIG_TRFH_1	259	263	PF08558	0.661
LIG_UBA3_1	28	32	PF00899	0.642
LIG_WRC_WIRS_1	461	466	PF05994	0.719
MOD_CDC14_SPxK_1	91	94	PF00782	0.798
MOD_CDK_SPK_2	404	409	PF00069	0.684
MOD_CDK_SPxK_1	88	94	PF00069	0.786
MOD_CDK_SPxxK_3	88	95	PF00069	0.595
MOD_CK1_1	162	168	PF00069	0.640
MOD_CK1_1	208	214	PF00069	0.693
MOD_CK1_1	24	30	PF00069	0.444
MOD_CK1_1	265	271	PF00069	0.730
MOD_CK1_1	430	436	PF00069	0.754
MOD_CK1_1	460	466	PF00069	0.717
MOD_CK1_1	548	554	PF00069	0.511
MOD_CK1_1	641	647	PF00069	0.625
MOD_CK1_1	8	14	PF00069	0.608
MOD_CK2_1	102	108	PF00069	0.614
MOD_CK2_1	112	118	PF00069	0.453
MOD_CK2_1	24	30	PF00069	0.520
MOD_CK2_1	374	380	PF00069	0.626
MOD_Cter_Amidation	418	421	PF01082	0.672
MOD_GlcNHglycan	104	107	PF01048	0.493
MOD_GlcNHglycan	161	164	PF01048	0.625
MOD_GlcNHglycan	189	192	PF01048	0.690
MOD_GlcNHglycan	207	210	PF01048	0.578
MOD_GlcNHglycan	255	258	PF01048	0.581
MOD_GlcNHglycan	309	312	PF01048	0.753
MOD_GlcNHglycan	326	329	PF01048	0.577
MOD_GlcNHglycan	376	379	PF01048	0.608
MOD_GlcNHglycan	436	439	PF01048	0.611
MOD_GlcNHglycan	474	477	PF01048	0.671
MOD_GlcNHglycan	632	635	PF01048	0.570
MOD_GlcNHglycan	651	654	PF01048	0.689
MOD_GlcNHglycan	671	674	PF01048	0.545
MOD_GlcNHglycan	76	79	PF01048	0.551
MOD_GSK3_1	179	186	PF00069	0.542
MOD_GSK3_1	223	230	PF00069	0.729
MOD_GSK3_1	262	269	PF00069	0.594
MOD_GSK3_1	320	327	PF00069	0.716
MOD_GSK3_1	346	353	PF00069	0.612
MOD_GSK3_1	426	433	PF00069	0.641
MOD_GSK3_1	453	460	PF00069	0.627
MOD_GSK3_1	466	473	PF00069	0.616
MOD_GSK3_1	5	12	PF00069	0.593
MOD_GSK3_1	505	512	PF00069	0.643
MOD_GSK3_1	63	70	PF00069	0.532
MOD_GSK3_1	630	637	PF00069	0.663
MOD_GSK3_1	641	648	PF00069	0.448
MOD_NEK2_1	136	141	PF00069	0.546
MOD_NEK2_1	170	175	PF00069	0.577
MOD_NEK2_1	178	183	PF00069	0.472
MOD_NEK2_1	21	26	PF00069	0.650
MOD_NEK2_1	267	272	PF00069	0.757
MOD_NEK2_1	412	417	PF00069	0.628
MOD_NEK2_1	453	458	PF00069	0.634
MOD_NEK2_1	545	550	PF00069	0.565
MOD_NEK2_1	598	603	PF00069	0.546
MOD_NEK2_1	638	643	PF00069	0.632
MOD_NEK2_1	675	680	PF00069	0.639
MOD_PIKK_1	130	136	PF00454	0.391
MOD_PIKK_1	208	214	PF00454	0.654
MOD_PIKK_1	545	551	PF00454	0.576
MOD_PKA_1	350	356	PF00069	0.688
MOD_PKA_1	488	494	PF00069	0.400
MOD_PKA_2	136	142	PF00069	0.648
MOD_PKA_2	205	211	PF00069	0.589
MOD_PKA_2	21	27	PF00069	0.618
MOD_PKA_2	265	271	PF00069	0.642
MOD_PKA_2	488	494	PF00069	0.439
MOD_PKA_2	516	522	PF00069	0.635
MOD_PKA_2	83	89	PF00069	0.697
MOD_Plk_1	426	432	PF00069	0.697
MOD_Plk_1	509	515	PF00069	0.614
MOD_Plk_1	675	681	PF00069	0.594
MOD_Plk_2-3	575	581	PF00069	0.590
MOD_Plk_4	24	30	PF00069	0.648
MOD_Plk_4	42	48	PF00069	0.332
MOD_Plk_4	427	433	PF00069	0.773
MOD_Plk_4	516	522	PF00069	0.553
MOD_Plk_4	617	623	PF00069	0.537
MOD_Plk_4	63	69	PF00069	0.550
MOD_Plk_4	675	681	PF00069	0.616
MOD_ProDKin_1	223	229	PF00069	0.701
MOD_ProDKin_1	404	410	PF00069	0.690
MOD_ProDKin_1	454	460	PF00069	0.731
MOD_ProDKin_1	558	564	PF00069	0.829
MOD_ProDKin_1	88	94	PF00069	0.786
MOD_SUMO_for_1	31	34	PF00179	0.537
TRG_DiLeu_BaEn_1	243	248	PF01217	0.675
TRG_DiLeu_BaEn_2	165	171	PF01217	0.468
TRG_DiLeu_BaEn_2	41	47	PF01217	0.375
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.515
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.527
TRG_DiLeu_BaLyEn_6	448	453	PF01217	0.639
TRG_ENDOCYTIC_2	259	262	PF00928	0.758
TRG_ENDOCYTIC_2	479	482	PF00928	0.515
TRG_ENDOCYTIC_2	536	539	PF00928	0.615
TRG_ER_diArg_1	420	422	PF00400	0.743
TRG_ER_diArg_1	93	95	PF00400	0.618
TRG_Pf-PMV_PEXEL_1	451	455	PF00026	0.648

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBJ6	Leptomonas seymouri	37%	100%
A0A3Q8INV1	Leishmania donovani	91%	100%
A4HPB2	Leishmania braziliensis	75%	100%
A4ICF2	Leishmania infantum	91%	100%
E9AT23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%