Putative acid phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acid phosphatase, putative

Species:

Leishmania major

UniProt:

Q4Q1H4_LEIMA

TriTrypDb:

LmjF.36.2470 , LMJLV39_360032600 , LMJSD75_360032600

Length:

445

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1H4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1H4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016311	dephosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016791	phosphatase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3
GO:0003993	acid phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.386
CLV_NRD_NRD_1	16	18	PF00675	0.705
CLV_NRD_NRD_1	192	194	PF00675	0.436
CLV_NRD_NRD_1	51	53	PF00675	0.497
CLV_PCSK_KEX2_1	16	18	PF00082	0.705
CLV_PCSK_KEX2_1	192	194	PF00082	0.420
CLV_PCSK_KEX2_1	204	206	PF00082	0.425
CLV_PCSK_KEX2_1	92	94	PF00082	0.348
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.546
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.449
CLV_PCSK_PC7_1	200	206	PF00082	0.459
CLV_PCSK_SKI1_1	217	221	PF00082	0.485
CLV_PCSK_SKI1_1	255	259	PF00082	0.554
CLV_PCSK_SKI1_1	297	301	PF00082	0.498
CLV_PCSK_SKI1_1	332	336	PF00082	0.371
CLV_PCSK_SKI1_1	53	57	PF00082	0.568
CLV_PCSK_SKI1_1	59	63	PF00082	0.507
DEG_APCC_DBOX_1	296	304	PF00400	0.553
DEG_Nend_UBRbox_3	1	3	PF02207	0.743
DOC_CKS1_1	387	392	PF01111	0.376
DOC_MAPK_gen_1	258	267	PF00069	0.521
DOC_MAPK_MEF2A_6	270	278	PF00069	0.399
DOC_USP7_MATH_1	24	28	PF00917	0.612
DOC_USP7_MATH_1	357	361	PF00917	0.377
DOC_USP7_UBL2_3	49	53	PF12436	0.610
DOC_WW_Pin1_4	259	264	PF00397	0.406
DOC_WW_Pin1_4	308	313	PF00397	0.567
DOC_WW_Pin1_4	386	391	PF00397	0.361
DOC_WW_Pin1_4	431	436	PF00397	0.506
LIG_14-3-3_CanoR_1	117	121	PF00244	0.329
LIG_14-3-3_CanoR_1	142	150	PF00244	0.368
LIG_14-3-3_CanoR_1	270	275	PF00244	0.368
LIG_14-3-3_CanoR_1	5	12	PF00244	0.767
LIG_Actin_WH2_2	239	257	PF00022	0.531
LIG_AP2alpha_1	155	159	PF02296	0.353
LIG_APCC_ABBA_1	172	177	PF00400	0.417
LIG_APCC_ABBA_1	367	372	PF00400	0.550
LIG_CSL_BTD_1	387	390	PF09270	0.411
LIG_DLG_GKlike_1	270	277	PF00625	0.376
LIG_FHA_1	213	219	PF00498	0.550
LIG_FHA_1	394	400	PF00498	0.442
LIG_FHA_1	439	445	PF00498	0.685
LIG_FHA_1	61	67	PF00498	0.421
LIG_FHA_2	20	26	PF00498	0.738
LIG_FHA_2	239	245	PF00498	0.393
LIG_FHA_2	319	325	PF00498	0.455
LIG_FHA_2	432	438	PF00498	0.454
LIG_FHA_2	46	52	PF00498	0.592
LIG_LIR_Gen_1	119	128	PF02991	0.428
LIG_LIR_Gen_1	203	213	PF02991	0.501
LIG_LIR_Gen_1	234	243	PF02991	0.427
LIG_LIR_Gen_1	289	296	PF02991	0.362
LIG_LIR_Gen_1	379	390	PF02991	0.462
LIG_LIR_Gen_1	424	435	PF02991	0.448
LIG_LIR_LC3C_4	63	67	PF02991	0.486
LIG_LIR_Nem_3	109	115	PF02991	0.406
LIG_LIR_Nem_3	119	123	PF02991	0.365
LIG_LIR_Nem_3	203	209	PF02991	0.561
LIG_LIR_Nem_3	234	239	PF02991	0.472
LIG_LIR_Nem_3	289	293	PF02991	0.375
LIG_LIR_Nem_3	379	385	PF02991	0.423
LIG_LIR_Nem_3	386	391	PF02991	0.367
LIG_LIR_Nem_3	424	430	PF02991	0.409
LIG_PCNA_PIPBox_1	275	284	PF02747	0.422
LIG_PCNA_yPIPBox_3	270	282	PF02747	0.407
LIG_Pex14_2	155	159	PF04695	0.355
LIG_Pex14_2	171	175	PF04695	0.348
LIG_Pex14_2	338	342	PF04695	0.390
LIG_SH2_CRK	236	240	PF00017	0.443
LIG_SH2_CRK	391	395	PF00017	0.541
LIG_SH2_GRB2like	206	209	PF00017	0.448
LIG_SH2_NCK_1	346	350	PF00017	0.451
LIG_SH2_PTP2	382	385	PF00017	0.354
LIG_SH2_SRC	164	167	PF00017	0.594
LIG_SH2_SRC	236	239	PF00017	0.501
LIG_SH2_SRC	382	385	PF00017	0.270
LIG_SH2_STAP1	374	378	PF00017	0.469
LIG_SH2_STAP1	94	98	PF00017	0.364
LIG_SH2_STAT3	433	436	PF00017	0.612
LIG_SH2_STAT5	115	118	PF00017	0.322
LIG_SH2_STAT5	134	137	PF00017	0.452
LIG_SH2_STAT5	164	167	PF00017	0.557
LIG_SH2_STAT5	183	186	PF00017	0.333
LIG_SH2_STAT5	229	232	PF00017	0.571
LIG_SH2_STAT5	238	241	PF00017	0.306
LIG_SH2_STAT5	328	331	PF00017	0.387
LIG_SH2_STAT5	382	385	PF00017	0.356
LIG_SH2_STAT5	395	398	PF00017	0.398
LIG_SH2_STAT5	415	418	PF00017	0.500
LIG_SH2_STAT5	433	436	PF00017	0.470
LIG_SH3_3	135	141	PF00018	0.328
LIG_SH3_3	163	169	PF00018	0.439
LIG_SH3_3	26	32	PF00018	0.579
LIG_SH3_3	290	296	PF00018	0.380
LIG_SH3_3	73	79	PF00018	0.396
LIG_SUMO_SIM_anti_2	63	69	PF11976	0.423
LIG_TRAF2_1	321	324	PF00917	0.434
LIG_TRAF2_1	434	437	PF00917	0.662
LIG_TRAF2_2	312	317	PF00917	0.647
LIG_TYR_ITSM	387	394	PF00017	0.494
MOD_CK1_1	42	48	PF00069	0.647
MOD_CK2_1	19	25	PF00069	0.763
MOD_CK2_1	318	324	PF00069	0.485
MOD_CK2_1	431	437	PF00069	0.437
MOD_CK2_1	45	51	PF00069	0.582
MOD_Cter_Amidation	14	17	PF01082	0.537
MOD_GlcNHglycan	13	16	PF01048	0.742
MOD_GlcNHglycan	145	148	PF01048	0.328
MOD_GlcNHglycan	7	10	PF01048	0.734
MOD_GlcNHglycan	95	99	PF01048	0.440
MOD_GSK3_1	173	180	PF00069	0.458
MOD_GSK3_1	19	26	PF00069	0.712
MOD_GSK3_1	299	306	PF00069	0.512
MOD_GSK3_1	318	325	PF00069	0.419
MOD_GSK3_1	372	379	PF00069	0.575
MOD_GSK3_1	393	400	PF00069	0.456
MOD_N-GLC_1	195	200	PF02516	0.473
MOD_N-GLC_1	270	275	PF02516	0.377
MOD_N-GLC_1	303	308	PF02516	0.507
MOD_N-GLC_1	36	41	PF02516	0.605
MOD_N-GLC_1	376	381	PF02516	0.582
MOD_N-GLC_1	421	426	PF02516	0.377
MOD_N-GLC_1	431	436	PF02516	0.390
MOD_N-GLC_1	45	50	PF02516	0.563
MOD_NEK2_1	265	270	PF00069	0.516
MOD_NEK2_1	303	308	PF00069	0.468
MOD_NEK2_1	318	323	PF00069	0.428
MOD_NEK2_1	60	65	PF00069	0.381
MOD_NEK2_2	398	403	PF00069	0.473
MOD_PIKK_1	36	42	PF00454	0.679
MOD_PKA_2	116	122	PF00069	0.428
MOD_Plk_1	24	30	PF00069	0.701
MOD_Plk_1	270	276	PF00069	0.365
MOD_Plk_1	303	309	PF00069	0.549
MOD_Plk_1	323	329	PF00069	0.399
MOD_Plk_1	376	382	PF00069	0.547
MOD_Plk_4	286	292	PF00069	0.489
MOD_Plk_4	323	329	PF00069	0.430
MOD_Plk_4	358	364	PF00069	0.381
MOD_ProDKin_1	259	265	PF00069	0.400
MOD_ProDKin_1	308	314	PF00069	0.571
MOD_ProDKin_1	386	392	PF00069	0.368
MOD_ProDKin_1	431	437	PF00069	0.517
MOD_SUMO_rev_2	406	413	PF00179	0.509
MOD_SUMO_rev_2	45	55	PF00179	0.589
TRG_ENDOCYTIC_2	120	123	PF00928	0.344
TRG_ENDOCYTIC_2	206	209	PF00928	0.526
TRG_ENDOCYTIC_2	236	239	PF00928	0.399
TRG_ENDOCYTIC_2	290	293	PF00928	0.362
TRG_ENDOCYTIC_2	382	385	PF00928	0.372
TRG_ENDOCYTIC_2	391	394	PF00928	0.433
TRG_ER_diArg_1	191	193	PF00400	0.447
TRG_NES_CRM1_1	264	275	PF08389	0.449
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKN6	Leptomonas seymouri	76%	97%
A0A0S4JT27	Bodo saltans	51%	100%
A0A1X0P7L7	Trypanosomatidae	59%	92%
A0A3S7XAY1	Leishmania donovani	96%	100%
A0A422NCB6	Trypanosoma rangeli	61%	97%
A4HPB3	Leishmania braziliensis	81%	100%
A4ICF3	Leishmania infantum	96%	100%
D0A3C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AT24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BCK5	Trypanosoma cruzi	62%	98%