Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1H3_LEIMA

TriTrypDb:

LmjF.36.2480 , LMJLV39_360032800 , LMJSD75_360032800

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1H3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1H3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.508
CLV_NRD_NRD_1	139	141	PF00675	0.491
CLV_NRD_NRD_1	240	242	PF00675	0.542
CLV_NRD_NRD_1	47	49	PF00675	0.391
CLV_NRD_NRD_1	92	94	PF00675	0.459
CLV_PCSK_FUR_1	92	96	PF00082	0.516
CLV_PCSK_KEX2_1	139	141	PF00082	0.528
CLV_PCSK_KEX2_1	18	20	PF00082	0.392
CLV_PCSK_KEX2_1	47	49	PF00082	0.406
CLV_PCSK_KEX2_1	5	7	PF00082	0.374
CLV_PCSK_KEX2_1	92	94	PF00082	0.457
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.550
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.392
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.374
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.544
CLV_PCSK_SKI1_1	58	62	PF00082	0.512
CLV_Separin_Metazoa	125	129	PF03568	0.658
CLV_Separin_Metazoa	23	27	PF03568	0.463
DEG_APCC_DBOX_1	5	13	PF00400	0.378
DEG_Nend_UBRbox_2	1	3	PF02207	0.457
DOC_USP7_MATH_1	150	154	PF00917	0.483
DOC_USP7_MATH_1	218	222	PF00917	0.660
DOC_USP7_MATH_1	32	36	PF00917	0.529
DOC_USP7_MATH_1	79	83	PF00917	0.385
DOC_USP7_UBL2_3	238	242	PF12436	0.547
DOC_USP7_UBL2_3	254	258	PF12436	0.470
DOC_WW_Pin1_4	28	33	PF00397	0.531
LIG_Actin_WH2_2	56	73	PF00022	0.513
LIG_deltaCOP1_diTrp_1	107	117	PF00928	0.434
LIG_FHA_2	15	21	PF00498	0.374
LIG_FHA_2	235	241	PF00498	0.585
LIG_FHA_2	67	73	PF00498	0.361
LIG_LIR_Apic_2	73	79	PF02991	0.511
LIG_LIR_Gen_1	46	57	PF02991	0.461
LIG_LIR_Nem_3	46	52	PF02991	0.465
LIG_PROFILIN_1	228	234	PF00235	0.620
LIG_SH2_CRK	142	146	PF00017	0.430
LIG_SH2_NCK_1	142	146	PF00017	0.411
LIG_SH2_NCK_1	76	80	PF00017	0.519
LIG_SH2_SRC	166	169	PF00017	0.608
LIG_SH2_SRC	76	79	PF00017	0.521
LIG_SH2_SRC	88	91	PF00017	0.610
LIG_SH2_STAP1	142	146	PF00017	0.411
LIG_SH2_STAP1	84	88	PF00017	0.522
LIG_SH3_2	233	238	PF14604	0.559
LIG_SH3_3	224	230	PF00018	0.636
LIG_SUMO_SIM_par_1	59	65	PF11976	0.502
LIG_TRAF2_1	237	240	PF00917	0.542
MOD_CK1_1	214	220	PF00069	0.753
MOD_CK1_1	82	88	PF00069	0.427
MOD_CK2_1	14	20	PF00069	0.418
MOD_CK2_1	234	240	PF00069	0.587
MOD_GlcNHglycan	180	183	PF01048	0.679
MOD_GlcNHglycan	188	191	PF01048	0.638
MOD_GlcNHglycan	200	203	PF01048	0.622
MOD_GlcNHglycan	243	246	PF01048	0.518
MOD_GlcNHglycan	64	67	PF01048	0.386
MOD_GSK3_1	214	221	PF00069	0.653
MOD_GSK3_1	28	35	PF00069	0.536
MOD_GSK3_1	62	69	PF00069	0.548
MOD_N-GLC_1	26	31	PF02516	0.426
MOD_NEK2_1	118	123	PF00069	0.456
MOD_NEK2_1	70	75	PF00069	0.536
MOD_NEK2_2	66	71	PF00069	0.373
MOD_PKA_1	241	247	PF00069	0.507
MOD_PKA_2	191	197	PF00069	0.697
MOD_PKA_2	70	76	PF00069	0.517
MOD_Plk_1	71	77	PF00069	0.435
MOD_Plk_4	71	77	PF00069	0.516
MOD_ProDKin_1	28	34	PF00069	0.536
MOD_SUMO_rev_2	235	244	PF00179	0.538
MOD_SUMO_rev_2	37	46	PF00179	0.462
MOD_SUMO_rev_2	96	104	PF00179	0.363
TRG_DiLeu_BaEn_1	20	25	PF01217	0.507
TRG_DiLeu_BaEn_4	101	107	PF01217	0.515
TRG_ENDOCYTIC_2	142	145	PF00928	0.396
TRG_ENDOCYTIC_2	49	52	PF00928	0.353
TRG_ER_diArg_1	114	117	PF00400	0.545
TRG_ER_diArg_1	25	28	PF00400	0.396
TRG_ER_diArg_1	47	49	PF00400	0.398
TRG_ER_diArg_1	92	95	PF00400	0.458
TRG_ER_diLys_1	254	259	PF00400	0.585
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXA6	Leptomonas seymouri	66%	92%
A0A0S4JT72	Bodo saltans	43%	100%
A0A1X0P8H3	Trypanosomatidae	54%	91%
A0A3Q8IJE0	Leishmania donovani	91%	100%
A0A422NCV8	Trypanosoma rangeli	44%	93%
A4HPB4	Leishmania braziliensis	77%	95%
A4ICF4	Leishmania infantum	92%	100%
D0A3C3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	97%
E9AT25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	95%
V5D8K3	Trypanosoma cruzi	45%	97%