Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1H2_LEIMA

TriTrypDb:

LmjF.36.2490 , LMJLV39_360032900 , LMJSD75_360032900

Length:

493

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1H2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	391	393	PF00675	0.541
CLV_PCSK_KEX2_1	143	145	PF00082	0.666
CLV_PCSK_KEX2_1	391	393	PF00082	0.534
CLV_PCSK_KEX2_1	405	407	PF00082	0.434
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.666
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.573
CLV_PCSK_SKI1_1	261	265	PF00082	0.528
DEG_SCF_FBW7_1	62	68	PF00400	0.723
DEG_SPOP_SBC_1	151	155	PF00917	0.688
DEG_SPOP_SBC_1	315	319	PF00917	0.629
DOC_CDC14_PxL_1	438	446	PF14671	0.422
DOC_CKS1_1	28	33	PF01111	0.707
DOC_CKS1_1	59	64	PF01111	0.725
DOC_CYCLIN_RxL_1	258	266	PF00134	0.489
DOC_CYCLIN_yClb5_NLxxxL_5	264	273	PF00134	0.514
DOC_MAPK_gen_1	430	438	PF00069	0.389
DOC_MAPK_MEF2A_6	433	440	PF00069	0.517
DOC_MAPK_NFAT4_5	433	441	PF00069	0.517
DOC_PP1_RVXF_1	51	58	PF00149	0.674
DOC_PP2B_LxvP_1	205	208	PF13499	0.600
DOC_PP2B_LxvP_1	485	488	PF13499	0.651
DOC_SPAK_OSR1_1	386	390	PF12202	0.511
DOC_USP7_MATH_1	151	155	PF00917	0.611
DOC_USP7_MATH_1	308	312	PF00917	0.608
DOC_USP7_MATH_1	467	471	PF00917	0.650
DOC_USP7_MATH_1	480	484	PF00917	0.562
DOC_USP7_MATH_1	488	492	PF00917	0.637
DOC_USP7_MATH_1	78	82	PF00917	0.749
DOC_WW_Pin1_4	24	29	PF00397	0.686
DOC_WW_Pin1_4	446	451	PF00397	0.578
DOC_WW_Pin1_4	55	60	PF00397	0.722
DOC_WW_Pin1_4	61	66	PF00397	0.663
LIG_14-3-3_CanoR_1	134	139	PF00244	0.685
LIG_14-3-3_CanoR_1	245	253	PF00244	0.491
LIG_14-3-3_CanoR_1	386	390	PF00244	0.511
LIG_14-3-3_CanoR_1	391	397	PF00244	0.442
LIG_14-3-3_CanoR_1	73	78	PF00244	0.655
LIG_BIR_III_4	160	164	PF00653	0.676
LIG_BRCT_BRCA1_1	209	213	PF00533	0.590
LIG_BRCT_BRCA1_1	383	387	PF00533	0.501
LIG_CaM_IQ_9	378	394	PF13499	0.507
LIG_EH1_1	284	292	PF00400	0.391
LIG_FHA_1	175	181	PF00498	0.723
LIG_FHA_1	222	228	PF00498	0.471
LIG_FHA_1	291	297	PF00498	0.508
LIG_FHA_1	409	415	PF00498	0.526
LIG_FHA_2	215	221	PF00498	0.544
LIG_FHA_2	453	459	PF00498	0.602
LIG_FHA_2	74	80	PF00498	0.615
LIG_FHA_2	83	89	PF00498	0.668
LIG_IRF3_LxIS_1	348	353	PF10401	0.485
LIG_LIR_Gen_1	232	241	PF02991	0.484
LIG_LIR_Gen_1	281	291	PF02991	0.432
LIG_LIR_Gen_1	30	41	PF02991	0.727
LIG_LIR_Gen_1	424	431	PF02991	0.516
LIG_LIR_LC3C_4	458	462	PF02991	0.595
LIG_LIR_Nem_3	210	216	PF02991	0.486
LIG_LIR_Nem_3	232	237	PF02991	0.485
LIG_LIR_Nem_3	257	263	PF02991	0.478
LIG_LIR_Nem_3	279	285	PF02991	0.490
LIG_LIR_Nem_3	30	36	PF02991	0.728
LIG_LIR_Nem_3	399	404	PF02991	0.534
LIG_LIR_Nem_3	424	429	PF02991	0.513
LIG_PTB_Apo_2	324	331	PF02174	0.625
LIG_PTB_Phospho_1	324	330	PF10480	0.628
LIG_REV1ctd_RIR_1	283	292	PF16727	0.365
LIG_SH2_STAP1	283	287	PF00017	0.436
LIG_SH2_STAP1	300	304	PF00017	0.442
LIG_SH2_STAT3	300	303	PF00017	0.529
LIG_SH2_STAT5	234	237	PF00017	0.622
LIG_SH2_STAT5	300	303	PF00017	0.529
LIG_SH2_STAT5	330	333	PF00017	0.587
LIG_SH3_3	209	215	PF00018	0.617
LIG_SH3_3	25	31	PF00018	0.720
LIG_SH3_3	256	262	PF00018	0.502
LIG_SH3_3	414	420	PF00018	0.559
LIG_SH3_3	436	442	PF00018	0.518
LIG_SH3_3	459	465	PF00018	0.594
LIG_SH3_3	56	62	PF00018	0.775
LIG_SUMO_SIM_anti_2	226	233	PF11976	0.449
LIG_SUMO_SIM_anti_2	236	242	PF11976	0.303
LIG_SUMO_SIM_anti_2	458	463	PF11976	0.587
LIG_SUMO_SIM_par_1	226	233	PF11976	0.449
LIG_SUMO_SIM_par_1	261	266	PF11976	0.498
LIG_SUMO_SIM_par_1	410	416	PF11976	0.535
LIG_SUMO_SIM_par_1	458	463	PF11976	0.587
MOD_CK1_1	103	109	PF00069	0.759
MOD_CK1_1	153	159	PF00069	0.653
MOD_CK1_1	176	182	PF00069	0.750
MOD_CK1_1	226	232	PF00069	0.497
MOD_CK1_1	27	33	PF00069	0.704
MOD_CK1_1	311	317	PF00069	0.625
MOD_CK1_1	353	359	PF00069	0.570
MOD_CK1_1	449	455	PF00069	0.604
MOD_CK1_1	470	476	PF00069	0.668
MOD_CK1_1	58	64	PF00069	0.751
MOD_CK2_1	329	335	PF00069	0.652
MOD_CK2_1	65	71	PF00069	0.684
MOD_CK2_1	78	84	PF00069	0.694
MOD_GlcNHglycan	102	106	PF01048	0.713
MOD_GlcNHglycan	209	212	PF01048	0.671
MOD_GlcNHglycan	248	251	PF01048	0.582
MOD_GlcNHglycan	308	311	PF01048	0.736
MOD_GlcNHglycan	318	321	PF01048	0.657
MOD_GlcNHglycan	322	325	PF01048	0.608
MOD_GlcNHglycan	352	355	PF01048	0.508
MOD_GlcNHglycan	398	401	PF01048	0.552
MOD_GlcNHglycan	477	480	PF01048	0.611
MOD_GlcNHglycan	88	91	PF01048	0.742
MOD_GSK3_1	101	108	PF00069	0.747
MOD_GSK3_1	142	149	PF00069	0.682
MOD_GSK3_1	172	179	PF00069	0.771
MOD_GSK3_1	226	233	PF00069	0.496
MOD_GSK3_1	311	318	PF00069	0.641
MOD_GSK3_1	353	360	PF00069	0.575
MOD_GSK3_1	381	388	PF00069	0.503
MOD_GSK3_1	392	399	PF00069	0.389
MOD_GSK3_1	40	47	PF00069	0.714
MOD_GSK3_1	467	474	PF00069	0.647
MOD_GSK3_1	61	68	PF00069	0.763
MOD_GSK3_1	73	80	PF00069	0.694
MOD_GSK3_1	82	89	PF00069	0.663
MOD_LATS_1	390	396	PF00433	0.497
MOD_N-GLC_1	246	251	PF02516	0.461
MOD_N-GLC_1	374	379	PF02516	0.525
MOD_N-GLC_1	481	486	PF02516	0.696
MOD_NEK2_1	165	170	PF00069	0.723
MOD_NEK2_1	180	185	PF00069	0.603
MOD_NEK2_1	230	235	PF00069	0.496
MOD_NEK2_1	263	268	PF00069	0.528
MOD_NEK2_1	350	355	PF00069	0.502
MOD_NEK2_1	357	362	PF00069	0.528
MOD_NEK2_1	369	374	PF00069	0.289
MOD_NEK2_1	381	386	PF00069	0.391
MOD_NEK2_1	396	401	PF00069	0.383
MOD_NEK2_1	460	465	PF00069	0.598
MOD_NEK2_1	471	476	PF00069	0.564
MOD_NEK2_1	72	77	PF00069	0.709
MOD_NEK2_2	385	390	PF00069	0.506
MOD_NEK2_2	400	405	PF00069	0.440
MOD_PIKK_1	13	19	PF00454	0.670
MOD_PIKK_1	449	455	PF00454	0.604
MOD_PK_1	134	140	PF00069	0.631
MOD_PKA_2	133	139	PF00069	0.655
MOD_PKA_2	311	317	PF00069	0.671
MOD_PKA_2	385	391	PF00069	0.505
MOD_PKA_2	44	50	PF00069	0.692
MOD_PKA_2	72	78	PF00069	0.681
MOD_Plk_1	201	207	PF00069	0.517
MOD_Plk_1	334	340	PF00069	0.609
MOD_Plk_1	374	380	PF00069	0.526
MOD_Plk_1	481	487	PF00069	0.649
MOD_Plk_2-3	334	340	PF00069	0.609
MOD_Plk_4	2	8	PF00069	0.596
MOD_Plk_4	223	229	PF00069	0.507
MOD_Plk_4	236	242	PF00069	0.486
MOD_Plk_4	467	473	PF00069	0.608
MOD_ProDKin_1	24	30	PF00069	0.690
MOD_ProDKin_1	446	452	PF00069	0.569
MOD_ProDKin_1	55	61	PF00069	0.721
MOD_SUMO_rev_2	22	28	PF00179	0.677
MOD_SUMO_rev_2	37	43	PF00179	0.646
TRG_DiLeu_BaEn_1	456	461	PF01217	0.606
TRG_DiLeu_BaLyEn_6	259	264	PF01217	0.468
TRG_DiLeu_BaLyEn_6	268	273	PF01217	0.438
TRG_ENDOCYTIC_2	234	237	PF00928	0.494
TRG_ENDOCYTIC_2	282	285	PF00928	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAX1	Leishmania donovani	92%	100%
A4HPB5	Leishmania braziliensis	74%	100%
A4ICF5	Leishmania infantum	92%	100%
E9AT26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%