LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
chromatin assembly factor 1 subunit b-like protein
Species:
Leishmania major
UniProt:
Q4Q1H1_LEIMA
TriTrypDb:
LmjF.36.2500 , LMJLV39_360033000 * , LMJSD75_360033000 *
Length:
674

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0000417 HIR complex 2 2
GO:0005654 nucleoplasm 2 2
GO:0005840 ribosome 5 7
GO:0032991 protein-containing complex 1 7
GO:0043226 organelle 2 11
GO:0043228 non-membrane-bounded organelle 3 7
GO:0043229 intracellular organelle 3 11
GO:0043232 intracellular non-membrane-bounded organelle 4 7
GO:0110165 cellular anatomical entity 1 11
GO:1990904 ribonucleoprotein complex 2 7
GO:0005634 nucleus 5 9
GO:0043227 membrane-bounded organelle 3 9
GO:0043231 intracellular membrane-bounded organelle 4 9

Expansion

Sequence features

Q4Q1H1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1H1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 11
GO:0006325 chromatin organization 4 11
GO:0006351 DNA-templated transcription 7 11
GO:0006725 cellular aromatic compound metabolic process 3 11
GO:0006807 nitrogen compound metabolic process 2 11
GO:0008152 metabolic process 1 11
GO:0009058 biosynthetic process 2 11
GO:0009059 macromolecule biosynthetic process 4 11
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 11
GO:0016070 RNA metabolic process 5 11
GO:0018130 heterocycle biosynthetic process 4 11
GO:0019438 aromatic compound biosynthetic process 4 11
GO:0032774 RNA biosynthetic process 5 11
GO:0034641 cellular nitrogen compound metabolic process 3 11
GO:0034654 nucleobase-containing compound biosynthetic process 4 11
GO:0043170 macromolecule metabolic process 3 11
GO:0044237 cellular metabolic process 2 11
GO:0044238 primary metabolic process 2 11
GO:0044249 cellular biosynthetic process 3 11
GO:0044271 cellular nitrogen compound biosynthetic process 4 11
GO:0046483 heterocycle metabolic process 3 11
GO:0071704 organic substance metabolic process 2 11
GO:0071840 cellular component organization or biogenesis 2 11
GO:0090304 nucleic acid metabolic process 4 11
GO:0097659 nucleic acid-templated transcription 6 11
GO:1901360 organic cyclic compound metabolic process 3 11
GO:1901362 organic cyclic compound biosynthetic process 4 11
GO:1901576 organic substance biosynthetic process 3 11
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 379 383 PF00656 0.545
CLV_C14_Caspase3-7 80 84 PF00656 0.506
CLV_NRD_NRD_1 277 279 PF00675 0.469
CLV_NRD_NRD_1 284 286 PF00675 0.389
CLV_NRD_NRD_1 301 303 PF00675 0.294
CLV_NRD_NRD_1 492 494 PF00675 0.590
CLV_NRD_NRD_1 614 616 PF00675 0.765
CLV_NRD_NRD_1 638 640 PF00675 0.622
CLV_NRD_NRD_1 641 643 PF00675 0.616
CLV_PCSK_FUR_1 490 494 PF00082 0.657
CLV_PCSK_FUR_1 639 643 PF00082 0.584
CLV_PCSK_KEX2_1 277 279 PF00082 0.463
CLV_PCSK_KEX2_1 301 303 PF00082 0.313
CLV_PCSK_KEX2_1 492 494 PF00082 0.588
CLV_PCSK_KEX2_1 641 643 PF00082 0.640
CLV_PCSK_PC1ET2_1 641 643 PF00082 0.617
CLV_PCSK_SKI1_1 189 193 PF00082 0.326
CLV_PCSK_SKI1_1 208 212 PF00082 0.161
CLV_PCSK_SKI1_1 419 423 PF00082 0.346
CLV_PCSK_SKI1_1 533 537 PF00082 0.428
CLV_PCSK_SKI1_1 76 80 PF00082 0.236
CLV_Separin_Fungi 596 602 PF03568 0.536
DOC_MAPK_gen_1 589 597 PF00069 0.584
DOC_MAPK_MEF2A_6 589 597 PF00069 0.549
DOC_PP1_RVXF_1 241 248 PF00149 0.302
DOC_PP1_RVXF_1 299 306 PF00149 0.397
DOC_PP1_RVXF_1 417 424 PF00149 0.313
DOC_PP2B_LxvP_1 312 315 PF13499 0.387
DOC_PP2B_LxvP_1 422 425 PF13499 0.346
DOC_PP4_FxxP_1 427 430 PF00568 0.436
DOC_USP7_MATH_1 152 156 PF00917 0.622
DOC_USP7_MATH_1 159 163 PF00917 0.694
DOC_USP7_MATH_1 478 482 PF00917 0.551
DOC_USP7_MATH_1 579 583 PF00917 0.616
DOC_USP7_MATH_1 599 603 PF00917 0.626
DOC_USP7_MATH_1 621 625 PF00917 0.555
DOC_USP7_MATH_1 631 635 PF00917 0.699
DOC_USP7_MATH_1 652 656 PF00917 0.571
DOC_WW_Pin1_4 126 131 PF00397 0.447
DOC_WW_Pin1_4 303 308 PF00397 0.317
DOC_WW_Pin1_4 356 361 PF00397 0.731
DOC_WW_Pin1_4 574 579 PF00397 0.607
LIG_14-3-3_CanoR_1 116 122 PF00244 0.436
LIG_14-3-3_CanoR_1 252 258 PF00244 0.353
LIG_14-3-3_CanoR_1 413 422 PF00244 0.377
LIG_14-3-3_CanoR_1 523 530 PF00244 0.424
LIG_14-3-3_CanoR_1 533 540 PF00244 0.352
LIG_14-3-3_CanoR_1 592 598 PF00244 0.558
LIG_AP2alpha_2 248 250 PF02296 0.331
LIG_deltaCOP1_diTrp_1 248 257 PF00928 0.336
LIG_deltaCOP1_diTrp_1 40 45 PF00928 0.520
LIG_FHA_1 190 196 PF00498 0.553
LIG_FHA_1 226 232 PF00498 0.343
LIG_FHA_1 249 255 PF00498 0.460
LIG_FHA_1 328 334 PF00498 0.628
LIG_FHA_1 36 42 PF00498 0.430
LIG_FHA_1 458 464 PF00498 0.516
LIG_FHA_1 547 553 PF00498 0.302
LIG_FHA_1 60 66 PF00498 0.462
LIG_FHA_2 101 107 PF00498 0.463
LIG_FHA_2 377 383 PF00498 0.725
LIG_FHA_2 4 10 PF00498 0.621
LIG_FHA_2 64 70 PF00498 0.502
LIG_FHA_2 78 84 PF00498 0.449
LIG_LIR_Gen_1 248 257 PF02991 0.450
LIG_LIR_Gen_1 500 507 PF02991 0.265
LIG_LIR_Gen_1 525 535 PF02991 0.379
LIG_LIR_Gen_1 553 561 PF02991 0.334
LIG_LIR_Nem_3 119 124 PF02991 0.394
LIG_LIR_Nem_3 183 188 PF02991 0.400
LIG_LIR_Nem_3 248 253 PF02991 0.355
LIG_LIR_Nem_3 299 303 PF02991 0.332
LIG_LIR_Nem_3 500 505 PF02991 0.281
LIG_LIR_Nem_3 525 530 PF02991 0.384
LIG_LIR_Nem_3 553 558 PF02991 0.335
LIG_NRBOX 582 588 PF00104 0.589
LIG_PDZ_Class_1 669 674 PF00595 0.636
LIG_Pex14_1 423 427 PF04695 0.341
LIG_Pex14_2 253 257 PF04695 0.425
LIG_SH2_CRK 300 304 PF00017 0.388
LIG_SH2_CRK 316 320 PF00017 0.508
LIG_SH2_PTP2 555 558 PF00017 0.304
LIG_SH2_STAP1 199 203 PF00017 0.467
LIG_SH2_STAP1 548 552 PF00017 0.409
LIG_SH2_STAT5 209 212 PF00017 0.452
LIG_SH2_STAT5 291 294 PF00017 0.435
LIG_SH2_STAT5 396 399 PF00017 0.329
LIG_SH2_STAT5 501 504 PF00017 0.391
LIG_SH2_STAT5 516 519 PF00017 0.362
LIG_SH2_STAT5 548 551 PF00017 0.335
LIG_SH2_STAT5 555 558 PF00017 0.385
LIG_SH2_STAT5 573 576 PF00017 0.631
LIG_SH3_2 30 35 PF14604 0.456
LIG_SH3_3 27 33 PF00018 0.515
LIG_SUMO_SIM_anti_2 38 43 PF11976 0.383
LIG_SUMO_SIM_anti_2 633 639 PF11976 0.678
LIG_SUMO_SIM_par_1 332 338 PF11976 0.400
LIG_TYR_ITIM 298 303 PF00017 0.460
LIG_TYR_ITIM 314 319 PF00017 0.367
LIG_UBA3_1 333 342 PF00899 0.587
LIG_WRC_WIRS_1 254 259 PF05994 0.311
MOD_CDK_SPxxK_3 356 363 PF00069 0.554
MOD_CDK_SPxxK_3 574 581 PF00069 0.605
MOD_CK1_1 166 172 PF00069 0.705
MOD_CK1_1 175 181 PF00069 0.451
MOD_CK1_1 204 210 PF00069 0.289
MOD_CK1_1 3 9 PF00069 0.621
MOD_CK1_1 358 364 PF00069 0.690
MOD_CK1_1 472 478 PF00069 0.708
MOD_CK1_1 522 528 PF00069 0.412
MOD_CK1_1 59 65 PF00069 0.486
MOD_CK2_1 3 9 PF00069 0.621
MOD_CK2_1 57 63 PF00069 0.676
MOD_CMANNOS 247 250 PF00535 0.323
MOD_GlcNHglycan 136 139 PF01048 0.287
MOD_GlcNHglycan 154 157 PF01048 0.599
MOD_GlcNHglycan 168 171 PF01048 0.656
MOD_GlcNHglycan 174 177 PF01048 0.742
MOD_GlcNHglycan 203 206 PF01048 0.326
MOD_GlcNHglycan 211 214 PF01048 0.404
MOD_GlcNHglycan 464 467 PF01048 0.606
MOD_GlcNHglycan 469 472 PF01048 0.566
MOD_GlcNHglycan 574 577 PF01048 0.616
MOD_GlcNHglycan 606 609 PF01048 0.629
MOD_GlcNHglycan 620 624 PF01048 0.668
MOD_GlcNHglycan 647 650 PF01048 0.756
MOD_GSK3_1 122 129 PF00069 0.289
MOD_GSK3_1 159 166 PF00069 0.720
MOD_GSK3_1 189 196 PF00069 0.434
MOD_GSK3_1 232 239 PF00069 0.547
MOD_GSK3_1 292 299 PF00069 0.465
MOD_GSK3_1 343 350 PF00069 0.616
MOD_GSK3_1 354 361 PF00069 0.610
MOD_GSK3_1 438 445 PF00069 0.728
MOD_GSK3_1 457 464 PF00069 0.552
MOD_GSK3_1 514 521 PF00069 0.514
MOD_GSK3_1 538 545 PF00069 0.400
MOD_GSK3_1 59 66 PF00069 0.479
MOD_GSK3_1 600 607 PF00069 0.614
MOD_LATS_1 531 537 PF00433 0.374
MOD_NEK2_1 100 105 PF00069 0.355
MOD_NEK2_1 117 122 PF00069 0.417
MOD_NEK2_1 134 139 PF00069 0.191
MOD_NEK2_1 224 229 PF00069 0.436
MOD_NEK2_1 232 237 PF00069 0.381
MOD_NEK2_1 253 258 PF00069 0.360
MOD_NEK2_1 264 269 PF00069 0.346
MOD_NEK2_1 561 566 PF00069 0.482
MOD_NEK2_1 57 62 PF00069 0.496
MOD_NMyristoyl 1 7 PF02799 0.556
MOD_PIKK_1 438 444 PF00454 0.607
MOD_PIKK_1 478 484 PF00454 0.578
MOD_PKA_2 522 528 PF00069 0.393
MOD_PKA_2 600 606 PF00069 0.620
MOD_Plk_1 343 349 PF00069 0.518
MOD_Plk_1 542 548 PF00069 0.402
MOD_Plk_4 117 123 PF00069 0.498
MOD_Plk_4 215 221 PF00069 0.319
MOD_Plk_4 259 265 PF00069 0.391
MOD_Plk_4 652 658 PF00069 0.548
MOD_ProDKin_1 126 132 PF00069 0.286
MOD_ProDKin_1 303 309 PF00069 0.316
MOD_ProDKin_1 356 362 PF00069 0.733
MOD_ProDKin_1 574 580 PF00069 0.603
MOD_SUMO_for_1 270 273 PF00179 0.591
MOD_SUMO_rev_2 137 144 PF00179 0.289
MOD_SUMO_rev_2 178 187 PF00179 0.546
TRG_DiLeu_BaEn_1 50 55 PF01217 0.580
TRG_DiLeu_BaEn_4 50 56 PF01217 0.494
TRG_ENDOCYTIC_2 188 191 PF00928 0.271
TRG_ENDOCYTIC_2 300 303 PF00928 0.389
TRG_ENDOCYTIC_2 316 319 PF00928 0.493
TRG_ENDOCYTIC_2 555 558 PF00928 0.352
TRG_ER_diArg_1 277 279 PF00400 0.506
TRG_ER_diArg_1 300 302 PF00400 0.315
TRG_ER_diArg_1 34 37 PF00400 0.395
TRG_ER_diArg_1 490 493 PF00400 0.674
TRG_NLS_MonoCore_2 638 643 PF00514 0.561
TRG_NLS_MonoExtC_3 638 643 PF00514 0.561
TRG_NLS_MonoExtN_4 639 644 PF00514 0.568
TRG_Pf-PMV_PEXEL_1 413 417 PF00026 0.315
TRG_Pf-PMV_PEXEL_1 533 537 PF00026 0.340
TRG_PTS2 1 45 PF00400 0.544

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PBV3 Leptomonas seymouri 63% 99%
A0A1X0P8Z1 Trypanosomatidae 45% 100%
A0A3S7XAX4 Leishmania donovani 90% 100%
A0A422NCI3 Trypanosoma rangeli 47% 100%
A4HPB6 Leishmania braziliensis 81% 100%
A4ICF6 Leishmania infantum 90% 100%
D0A3C6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AT27 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
V5BH36 Trypanosoma cruzi 47% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS