Nuclear pore protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP96

Species:

Leishmania major

UniProt:

Q4Q1H0_LEIMA

TriTrypDb:

LmjF.36.2510 , LMJLV39_360033100 , LMJSD75_360033100

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	12
GO:0016020	membrane	2	12
GO:0032991	protein-containing complex	1	12
GO:0044612	nuclear pore linkers	3	2
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12

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Expansion

Sequence features

Q4Q1H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1H0

Function

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Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	2
GO:0006406	mRNA export from nucleus	6	2
GO:0006606	protein import into nucleus	5	2
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0015931	nucleobase-containing compound transport	5	12

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Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12
GO:0017056	structural constituent of nuclear pore	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.441
CLV_C14_Caspase3-7	407	411	PF00656	0.437
CLV_C14_Caspase3-7	555	559	PF00656	0.294
CLV_C14_Caspase3-7	759	763	PF00656	0.205
CLV_C14_Caspase3-7	789	793	PF00656	0.482
CLV_MEL_PAP_1	386	392	PF00089	0.350
CLV_NRD_NRD_1	11	13	PF00675	0.724
CLV_NRD_NRD_1	266	268	PF00675	0.421
CLV_NRD_NRD_1	318	320	PF00675	0.417
CLV_NRD_NRD_1	333	335	PF00675	0.286

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C7	Leptomonas seymouri	73%	100%
A0A0S4JS37	Bodo saltans	31%	100%
A0A1X0P8L0	Trypanosomatidae	35%	100%
A0A3Q8IW16	Leishmania donovani	95%	100%
A0A422NCE5	Trypanosoma rangeli	36%	100%
A4HPB7	Leishmania braziliensis	90%	100%
A4ICF7	Leishmania infantum	95%	100%
D0A3C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AT28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BCK1	Trypanosoma cruzi	36%	100%

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