Nuclear pore protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP96

Species:

Leishmania major

UniProt:

Q4Q1H0_LEIMA

TriTrypDb:

LmjF.36.2510 , LMJLV39_360033100 , LMJSD75_360033100

Length:

900

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	12
GO:0016020	membrane	2	12
GO:0032991	protein-containing complex	1	12
GO:0044612	nuclear pore linkers	3	2
GO:0110165	cellular anatomical entity	1	12
GO:0140513	nuclear protein-containing complex	2	12

Expansion

Sequence features

Q4Q1H0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1H0

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	2
GO:0006406	mRNA export from nucleus	6	2
GO:0006606	protein import into nucleus	5	2
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0015931	nucleobase-containing compound transport	5	12
GO:0016973	poly(A)+ mRNA export from nucleus	7	2
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	2
GO:0034504	protein localization to nucleus	6	2
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	2
GO:0050657	nucleic acid transport	6	12
GO:0050658	RNA transport	4	12
GO:0051028	mRNA transport	5	12
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051170	import into nucleus	6	2
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051236	establishment of RNA localization	3	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	2
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0072594	establishment of protein localization to organelle	4	2

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	12
GO:0017056	structural constituent of nuclear pore	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.441
CLV_C14_Caspase3-7	407	411	PF00656	0.437
CLV_C14_Caspase3-7	555	559	PF00656	0.294
CLV_C14_Caspase3-7	759	763	PF00656	0.205
CLV_C14_Caspase3-7	789	793	PF00656	0.482
CLV_MEL_PAP_1	386	392	PF00089	0.350
CLV_NRD_NRD_1	11	13	PF00675	0.724
CLV_NRD_NRD_1	266	268	PF00675	0.421
CLV_NRD_NRD_1	318	320	PF00675	0.417
CLV_NRD_NRD_1	333	335	PF00675	0.286
CLV_NRD_NRD_1	337	339	PF00675	0.262
CLV_NRD_NRD_1	603	605	PF00675	0.372
CLV_NRD_NRD_1	712	714	PF00675	0.420
CLV_NRD_NRD_1	73	75	PF00675	0.475
CLV_PCSK_KEX2_1	11	13	PF00082	0.744
CLV_PCSK_KEX2_1	266	268	PF00082	0.424
CLV_PCSK_KEX2_1	318	320	PF00082	0.417
CLV_PCSK_KEX2_1	333	335	PF00082	0.368
CLV_PCSK_KEX2_1	603	605	PF00082	0.308
CLV_PCSK_KEX2_1	712	714	PF00082	0.350
CLV_PCSK_KEX2_1	861	863	PF00082	0.353
CLV_PCSK_PC1ET2_1	861	863	PF00082	0.427
CLV_PCSK_SKI1_1	468	472	PF00082	0.417
CLV_PCSK_SKI1_1	512	516	PF00082	0.308
CLV_PCSK_SKI1_1	547	551	PF00082	0.343
CLV_PCSK_SKI1_1	849	853	PF00082	0.341
DEG_APCC_DBOX_1	337	345	PF00400	0.274
DEG_APCC_DBOX_1	39	47	PF00400	0.628
DEG_APCC_DBOX_1	511	519	PF00400	0.308
DEG_Nend_Nbox_1	1	3	PF02207	0.643
DEG_SCF_FBW7_1	501	506	PF00400	0.278
DEG_SCF_FBW7_2	415	422	PF00400	0.302
DOC_CKS1_1	500	505	PF01111	0.302
DOC_CYCLIN_yCln2_LP_2	580	586	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	795	801	PF00134	0.417
DOC_MAPK_gen_1	347	356	PF00069	0.383
DOC_MAPK_MEF2A_6	127	135	PF00069	0.551
DOC_MAPK_MEF2A_6	163	170	PF00069	0.593
DOC_MAPK_MEF2A_6	447	455	PF00069	0.289
DOC_MAPK_MEF2A_6	592	601	PF00069	0.417
DOC_MAPK_MEF2A_6	686	694	PF00069	0.318
DOC_MAPK_NFAT4_5	163	171	PF00069	0.592
DOC_PP2B_LxvP_1	580	583	PF13499	0.417
DOC_PP2B_LxvP_1	726	729	PF13499	0.417
DOC_PP2B_LxvP_1	795	798	PF13499	0.417
DOC_PP4_FxxP_1	799	802	PF00568	0.417
DOC_USP7_MATH_1	144	148	PF00917	0.572
DOC_USP7_MATH_1	220	224	PF00917	0.727
DOC_USP7_MATH_1	232	236	PF00917	0.739
DOC_USP7_MATH_1	246	250	PF00917	0.521
DOC_USP7_MATH_1	503	507	PF00917	0.349
DOC_USP7_MATH_1	729	733	PF00917	0.350
DOC_USP7_MATH_1	881	885	PF00917	0.350
DOC_WW_Pin1_4	415	420	PF00397	0.337
DOC_WW_Pin1_4	459	464	PF00397	0.302
DOC_WW_Pin1_4	499	504	PF00397	0.350
DOC_WW_Pin1_4	716	721	PF00397	0.440
LIG_14-3-3_CanoR_1	225	234	PF00244	0.637
LIG_14-3-3_CanoR_1	338	342	PF00244	0.409
LIG_14-3-3_CanoR_1	40	44	PF00244	0.519
LIG_14-3-3_CanoR_1	468	474	PF00244	0.431
LIG_14-3-3_CanoR_1	488	495	PF00244	0.278
LIG_14-3-3_CanoR_1	531	536	PF00244	0.289
LIG_14-3-3_CanoR_1	575	584	PF00244	0.414
LIG_14-3-3_CanoR_1	592	597	PF00244	0.249
LIG_14-3-3_CanoR_1	604	610	PF00244	0.293
LIG_14-3-3_CanoR_1	731	735	PF00244	0.472
LIG_14-3-3_CanoR_1	754	761	PF00244	0.260
LIG_14-3-3_CanoR_1	834	844	PF00244	0.467
LIG_14-3-3_CanoR_1	868	873	PF00244	0.360
LIG_14-3-3_CanoR_1	882	886	PF00244	0.230
LIG_Actin_WH2_2	474	490	PF00022	0.385
LIG_BIR_III_4	401	405	PF00653	0.350
LIG_Clathr_ClatBox_1	598	602	PF01394	0.315
LIG_CSL_BTD_1	193	196	PF09270	0.617
LIG_EH1_1	392	400	PF00400	0.323
LIG_EH1_1	534	542	PF00400	0.417
LIG_EH1_1	866	874	PF00400	0.205
LIG_eIF4E_1	393	399	PF01652	0.205
LIG_eIF4E_1	446	452	PF01652	0.308
LIG_eIF4E_1	593	599	PF01652	0.289
LIG_eIF4E_1	766	772	PF01652	0.388
LIG_FHA_1	105	111	PF00498	0.591
LIG_FHA_1	177	183	PF00498	0.550
LIG_FHA_1	286	292	PF00498	0.373
LIG_FHA_1	3	9	PF00498	0.638
LIG_FHA_1	34	40	PF00498	0.643
LIG_FHA_1	476	482	PF00498	0.313
LIG_FHA_1	658	664	PF00498	0.370
LIG_FHA_1	686	692	PF00498	0.350
LIG_FHA_1	766	772	PF00498	0.467
LIG_FHA_1	806	812	PF00498	0.476
LIG_FHA_2	292	298	PF00498	0.589
LIG_FHA_2	439	445	PF00498	0.289
LIG_FHA_2	553	559	PF00498	0.294
LIG_FHA_2	869	875	PF00498	0.350
LIG_GBD_Chelix_1	532	540	PF00786	0.267
LIG_LIR_Gen_1	203	212	PF02991	0.551
LIG_LIR_Gen_1	303	313	PF02991	0.459
LIG_LIR_Gen_1	483	492	PF02991	0.274
LIG_LIR_Gen_1	613	624	PF02991	0.398
LIG_LIR_Gen_1	765	772	PF02991	0.288
LIG_LIR_Gen_1	792	802	PF02991	0.383
LIG_LIR_Nem_3	147	152	PF02991	0.667
LIG_LIR_Nem_3	203	208	PF02991	0.513
LIG_LIR_Nem_3	285	290	PF02991	0.420
LIG_LIR_Nem_3	303	309	PF02991	0.466
LIG_LIR_Nem_3	483	489	PF02991	0.274
LIG_LIR_Nem_3	613	619	PF02991	0.336
LIG_LIR_Nem_3	765	769	PF02991	0.288
LIG_LIR_Nem_3	792	797	PF02991	0.383
LIG_LIR_Nem_3	884	890	PF02991	0.485
LIG_LYPXL_yS_3	887	890	PF13949	0.436
LIG_NRBOX	340	346	PF00104	0.368
LIG_NRBOX	450	456	PF00104	0.274
LIG_NRBOX	545	551	PF00104	0.372
LIG_PDZ_Class_2	895	900	PF00595	0.414
LIG_Pex14_1	194	198	PF04695	0.621
LIG_Pex14_1	283	287	PF04695	0.320
LIG_Pex14_1	381	385	PF04695	0.289
LIG_Pex14_2	190	194	PF04695	0.611
LIG_RPA_C_Fungi	69	81	PF08784	0.558
LIG_SH2_CRK	593	597	PF00017	0.289
LIG_SH2_NCK_1	278	282	PF00017	0.426
LIG_SH2_NCK_1	393	397	PF00017	0.308
LIG_SH2_NCK_1	94	98	PF00017	0.662
LIG_SH2_PTP2	198	201	PF00017	0.553
LIG_SH2_SRC	278	281	PF00017	0.423
LIG_SH2_SRC	436	439	PF00017	0.417
LIG_SH2_SRC	814	817	PF00017	0.417
LIG_SH2_SRC	94	97	PF00017	0.662
LIG_SH2_STAP1	779	783	PF00017	0.385
LIG_SH2_STAP1	847	851	PF00017	0.181
LIG_SH2_STAT5	198	201	PF00017	0.620
LIG_SH2_STAT5	290	293	PF00017	0.517
LIG_SH2_STAT5	328	331	PF00017	0.308
LIG_SH2_STAT5	593	596	PF00017	0.314
LIG_SH2_STAT5	618	621	PF00017	0.296
LIG_SH2_STAT5	814	817	PF00017	0.417
LIG_SH2_STAT5	818	821	PF00017	0.424
LIG_SH3_3	795	801	PF00018	0.289
LIG_SH3_3	882	888	PF00018	0.417
LIG_Sin3_3	829	836	PF02671	0.205
LIG_SUMO_SIM_anti_2	247	256	PF11976	0.554
LIG_SUMO_SIM_anti_2	301	306	PF11976	0.367
LIG_SUMO_SIM_anti_2	595	600	PF11976	0.290
LIG_TRAF2_1	76	79	PF00917	0.617
LIG_TYR_ITIM	885	890	PF00017	0.453
LIG_WRC_WIRS_1	532	537	PF05994	0.417
LIG_WRC_WIRS_1	766	771	PF05994	0.350
MOD_CK1_1	147	153	PF00069	0.668
MOD_CK1_1	228	234	PF00069	0.593
MOD_CK1_1	244	250	PF00069	0.651
MOD_CK1_1	256	262	PF00069	0.485
MOD_CK1_1	3	9	PF00069	0.698
MOD_CK1_1	42	48	PF00069	0.562
MOD_CK1_1	506	512	PF00069	0.417
MOD_CK1_1	567	573	PF00069	0.397
MOD_CK1_1	622	628	PF00069	0.417
MOD_CK1_1	679	685	PF00069	0.438
MOD_CK1_1	730	736	PF00069	0.332
MOD_CK2_1	575	581	PF00069	0.343
MOD_CK2_1	86	92	PF00069	0.679
MOD_CK2_1	868	874	PF00069	0.350
MOD_GlcNHglycan	14	17	PF01048	0.658
MOD_GlcNHglycan	145	149	PF01048	0.596
MOD_GlcNHglycan	21	26	PF01048	0.606
MOD_GlcNHglycan	222	225	PF01048	0.633
MOD_GlcNHglycan	234	237	PF01048	0.674
MOD_GlcNHglycan	243	246	PF01048	0.483
MOD_GlcNHglycan	255	258	PF01048	0.483
MOD_GlcNHglycan	30	33	PF01048	0.434
MOD_GlcNHglycan	362	365	PF01048	0.350
MOD_GlcNHglycan	496	500	PF01048	0.472
MOD_GlcNHglycan	566	569	PF01048	0.454
MOD_GlcNHglycan	577	580	PF01048	0.394
MOD_GlcNHglycan	621	624	PF01048	0.418
MOD_GlcNHglycan	678	681	PF01048	0.425
MOD_GlcNHglycan	783	786	PF01048	0.400
MOD_GlcNHglycan	829	832	PF01048	0.411
MOD_GlcNHglycan	837	840	PF01048	0.422
MOD_GSK3_1	220	227	PF00069	0.656
MOD_GSK3_1	228	235	PF00069	0.623
MOD_GSK3_1	241	248	PF00069	0.607
MOD_GSK3_1	255	262	PF00069	0.557
MOD_GSK3_1	285	292	PF00069	0.414
MOD_GSK3_1	324	331	PF00069	0.368
MOD_GSK3_1	371	378	PF00069	0.383
MOD_GSK3_1	495	502	PF00069	0.406
MOD_GSK3_1	657	664	PF00069	0.392
MOD_GSK3_1	729	736	PF00069	0.303
MOD_GSK3_1	781	788	PF00069	0.404
MOD_LATS_1	175	181	PF00433	0.613
MOD_N-GLC_1	360	365	PF02516	0.350
MOD_N-GLC_1	552	557	PF02516	0.313
MOD_N-GLC_1	781	786	PF02516	0.377
MOD_N-GLC_1	849	854	PF02516	0.278
MOD_N-GLC_2	528	530	PF02516	0.302
MOD_N-GLC_2	85	87	PF02516	0.663
MOD_NEK2_1	1	6	PF00069	0.664
MOD_NEK2_1	104	109	PF00069	0.476
MOD_NEK2_1	226	231	PF00069	0.552
MOD_NEK2_1	305	310	PF00069	0.350
MOD_NEK2_1	362	367	PF00069	0.319
MOD_NEK2_1	487	492	PF00069	0.366
MOD_NEK2_1	564	569	PF00069	0.309
MOD_NEK2_1	610	615	PF00069	0.318
MOD_NEK2_1	619	624	PF00069	0.318
MOD_NEK2_1	633	638	PF00069	0.329
MOD_NEK2_1	641	646	PF00069	0.350
MOD_NEK2_1	696	701	PF00069	0.416
MOD_NEK2_1	70	75	PF00069	0.614
MOD_NEK2_1	781	786	PF00069	0.432
MOD_NEK2_1	827	832	PF00069	0.342
MOD_NEK2_1	894	899	PF00069	0.545
MOD_NEK2_2	404	409	PF00069	0.350
MOD_NEK2_2	503	508	PF00069	0.350
MOD_PIKK_1	104	110	PF00454	0.494
MOD_PIKK_1	522	528	PF00454	0.417
MOD_PIKK_1	696	702	PF00454	0.364
MOD_PK_1	177	183	PF00069	0.551
MOD_PK_1	592	598	PF00069	0.417
MOD_PKA_1	318	324	PF00069	0.350
MOD_PKA_2	176	182	PF00069	0.546
MOD_PKA_2	224	230	PF00069	0.638
MOD_PKA_2	318	324	PF00069	0.417
MOD_PKA_2	337	343	PF00069	0.409
MOD_PKA_2	39	45	PF00069	0.523
MOD_PKA_2	475	481	PF00069	0.368
MOD_PKA_2	487	493	PF00069	0.337
MOD_PKA_2	605	611	PF00069	0.473
MOD_PKA_2	730	736	PF00069	0.420
MOD_PKA_2	881	887	PF00069	0.333
MOD_Plk_1	21	27	PF00069	0.670
MOD_Plk_1	292	298	PF00069	0.540
MOD_Plk_1	300	306	PF00069	0.384
MOD_Plk_1	552	558	PF00069	0.289
MOD_Plk_1	894	900	PF00069	0.512
MOD_Plk_4	177	183	PF00069	0.561
MOD_Plk_4	185	191	PF00069	0.504
MOD_Plk_4	246	252	PF00069	0.588
MOD_Plk_4	300	306	PF00069	0.474
MOD_Plk_4	324	330	PF00069	0.325
MOD_Plk_4	531	537	PF00069	0.274
MOD_Plk_4	567	573	PF00069	0.303
MOD_Plk_4	592	598	PF00069	0.338
MOD_Plk_4	605	611	PF00069	0.332
MOD_Plk_4	730	736	PF00069	0.419
MOD_Plk_4	868	874	PF00069	0.353
MOD_ProDKin_1	415	421	PF00069	0.337
MOD_ProDKin_1	459	465	PF00069	0.302
MOD_ProDKin_1	499	505	PF00069	0.350
MOD_ProDKin_1	716	722	PF00069	0.440
MOD_SUMO_rev_2	331	341	PF00179	0.275
MOD_SUMO_rev_2	857	863	PF00179	0.414
TRG_DiLeu_BaLyEn_6	116	121	PF01217	0.603
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.417
TRG_DiLeu_BaLyEn_6	544	549	PF01217	0.274
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.417
TRG_DiLeu_BaLyEn_6	861	866	PF01217	0.417
TRG_ENDOCYTIC_2	198	201	PF00928	0.620
TRG_ENDOCYTIC_2	205	208	PF00928	0.636
TRG_ENDOCYTIC_2	593	596	PF00928	0.294
TRG_ENDOCYTIC_2	766	769	PF00928	0.417
TRG_ENDOCYTIC_2	887	890	PF00928	0.436
TRG_ER_diArg_1	10	12	PF00400	0.734
TRG_ER_diArg_1	266	268	PF00400	0.454
TRG_ER_diArg_1	333	335	PF00400	0.368
TRG_ER_diArg_1	603	606	PF00400	0.368
TRG_ER_diArg_1	711	713	PF00400	0.350
TRG_ER_diArg_1	862	865	PF00400	0.378
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	347	352	PF00026	0.308
TRG_Pf-PMV_PEXEL_1	547	551	PF00026	0.274
TRG_Pf-PMV_PEXEL_1	754	758	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6C7	Leptomonas seymouri	73%	100%
A0A0S4JS37	Bodo saltans	31%	100%
A0A1X0P8L0	Trypanosomatidae	35%	100%
A0A3Q8IW16	Leishmania donovani	95%	100%
A0A422NCE5	Trypanosoma rangeli	36%	100%
A4HPB7	Leishmania braziliensis	90%	100%
A4ICF7	Leishmania infantum	95%	100%
D0A3C7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AT28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BCK1	Trypanosoma cruzi	36%	100%