Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1G6_LEIMA

TriTrypDb:

LmjF.36.2550 , LMJLV39_360033500 , LMJSD75_360033500

Length:

373

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1G6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	174	176	PF00675	0.673
CLV_NRD_NRD_1	218	220	PF00675	0.636
CLV_NRD_NRD_1	258	260	PF00675	0.666
CLV_NRD_NRD_1	311	313	PF00675	0.595
CLV_NRD_NRD_1	348	350	PF00675	0.654
CLV_NRD_NRD_1	42	44	PF00675	0.611
CLV_NRD_NRD_1	79	81	PF00675	0.665
CLV_PCSK_KEX2_1	174	176	PF00082	0.673
CLV_PCSK_KEX2_1	258	260	PF00082	0.666
CLV_PCSK_KEX2_1	311	313	PF00082	0.595
CLV_PCSK_KEX2_1	321	323	PF00082	0.620
CLV_PCSK_KEX2_1	348	350	PF00082	0.677
CLV_PCSK_KEX2_1	42	44	PF00082	0.611
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.667
CLV_PCSK_SKI1_1	175	179	PF00082	0.691
CLV_PCSK_SKI1_1	20	24	PF00082	0.691
CLV_PCSK_SKI1_1	259	263	PF00082	0.599
CLV_PCSK_SKI1_1	312	316	PF00082	0.702
DEG_APCC_DBOX_1	300	308	PF00400	0.732
DEG_SPOP_SBC_1	34	38	PF00917	0.672
DOC_CKS1_1	270	275	PF01111	0.737
DOC_CYCLIN_RxL_1	257	266	PF00134	0.662
DOC_MAPK_gen_1	112	120	PF00069	0.644
DOC_MAPK_gen_1	308	317	PF00069	0.677
DOC_MAPK_gen_1	40	49	PF00069	0.601
DOC_MAPK_MEF2A_6	190	197	PF00069	0.562
DOC_MAPK_MEF2A_6	40	49	PF00069	0.692
DOC_PP1_RVXF_1	257	264	PF00149	0.738
DOC_PP4_FxxP_1	146	149	PF00568	0.677
DOC_USP7_MATH_1	205	209	PF00917	0.669
DOC_USP7_MATH_1	283	287	PF00917	0.662
DOC_USP7_MATH_1	320	324	PF00917	0.636
DOC_USP7_MATH_1	34	38	PF00917	0.748
DOC_WW_Pin1_4	145	150	PF00397	0.755
DOC_WW_Pin1_4	269	274	PF00397	0.669
DOC_WW_Pin1_4	279	284	PF00397	0.564
DOC_WW_Pin1_4	4	9	PF00397	0.687
LIG_14-3-3_CanoR_1	154	158	PF00244	0.585
LIG_14-3-3_CanoR_1	232	237	PF00244	0.652
LIG_14-3-3_CanoR_1	284	288	PF00244	0.722
LIG_14-3-3_CanoR_1	306	311	PF00244	0.648
LIG_14-3-3_CanoR_1	80	86	PF00244	0.747
LIG_BIR_II_1	1	5	PF00653	0.777
LIG_BRCT_BRCA1_1	147	151	PF00533	0.666
LIG_FHA_1	201	207	PF00498	0.653
LIG_FHA_1	332	338	PF00498	0.728
LIG_FHA_2	184	190	PF00498	0.545
LIG_FHA_2	21	27	PF00498	0.690
LIG_FHA_2	225	231	PF00498	0.674
LIG_FHA_2	236	242	PF00498	0.659
LIG_LIR_Apic_2	144	149	PF02991	0.675
LIG_LIR_Gen_1	355	365	PF02991	0.588
LIG_LIR_Gen_1	70	79	PF02991	0.708
LIG_LIR_Nem_3	230	234	PF02991	0.578
LIG_LIR_Nem_3	246	252	PF02991	0.604
LIG_LIR_Nem_3	345	350	PF02991	0.632
LIG_LIR_Nem_3	355	360	PF02991	0.575
LIG_LIR_Nem_3	50	55	PF02991	0.612
LIG_LIR_Nem_3	70	74	PF02991	0.425
LIG_LYPXL_yS_3	52	55	PF13949	0.674
LIG_PDZ_Class_3	368	373	PF00595	0.735
LIG_SH2_CRK	231	235	PF00017	0.568
LIG_SH2_CRK	347	351	PF00017	0.713
LIG_SH2_PTP2	357	360	PF00017	0.595
LIG_SH2_SRC	247	250	PF00017	0.696
LIG_SH2_STAP1	247	251	PF00017	0.651
LIG_SH2_STAT5	161	164	PF00017	0.589
LIG_SH2_STAT5	201	204	PF00017	0.651
LIG_SH2_STAT5	357	360	PF00017	0.590
LIG_SH3_3	2	8	PF00018	0.675
LIG_SH3_3	334	340	PF00018	0.714
LIG_TRAF2_1	300	303	PF00917	0.616
LIG_UBA3_1	21	25	PF00899	0.613
MOD_CDK_SPK_2	279	284	PF00069	0.624
MOD_CK1_1	133	139	PF00069	0.619
MOD_CK1_1	235	241	PF00069	0.600
MOD_CK1_1	250	256	PF00069	0.517
MOD_CK1_1	291	297	PF00069	0.736
MOD_CK2_1	147	153	PF00069	0.707
MOD_CK2_1	183	189	PF00069	0.553
MOD_CK2_1	20	26	PF00069	0.695
MOD_CK2_1	235	241	PF00069	0.679
MOD_CK2_1	272	278	PF00069	0.728
MOD_CK2_1	283	289	PF00069	0.607
MOD_CK2_1	296	302	PF00069	0.544
MOD_CK2_1	320	326	PF00069	0.626
MOD_CK2_1	89	95	PF00069	0.748
MOD_GlcNHglycan	249	252	PF01048	0.608
MOD_GlcNHglycan	298	301	PF01048	0.661
MOD_GlcNHglycan	317	320	PF01048	0.440
MOD_GlcNHglycan	322	325	PF01048	0.645
MOD_GlcNHglycan	344	347	PF01048	0.745
MOD_GSK3_1	103	110	PF00069	0.619
MOD_GSK3_1	141	148	PF00069	0.656
MOD_GSK3_1	200	207	PF00069	0.569
MOD_GSK3_1	243	250	PF00069	0.575
MOD_GSK3_1	279	286	PF00069	0.599
MOD_GSK3_1	291	298	PF00069	0.585
MOD_GSK3_1	320	327	PF00069	0.595
MOD_GSK3_1	329	336	PF00069	0.673
MOD_N-GLC_1	353	358	PF02516	0.739
MOD_N-GLC_2	107	109	PF02516	0.640
MOD_NEK2_1	103	108	PF00069	0.668
MOD_NEK2_1	169	174	PF00069	0.685
MOD_NEK2_1	243	248	PF00069	0.573
MOD_NEK2_1	263	268	PF00069	0.402
MOD_NEK2_1	277	282	PF00069	0.505
MOD_NEK2_1	288	293	PF00069	0.635
MOD_NEK2_1	315	320	PF00069	0.644
MOD_PIKK_1	224	230	PF00454	0.715
MOD_PKA_2	111	117	PF00069	0.674
MOD_PKA_2	153	159	PF00069	0.588
MOD_PKA_2	283	289	PF00069	0.610
MOD_Plk_1	152	158	PF00069	0.631
MOD_Plk_1	193	199	PF00069	0.656
MOD_Plk_1	263	269	PF00069	0.733
MOD_Plk_1	277	283	PF00069	0.497
MOD_Plk_1	288	294	PF00069	0.578
MOD_Plk_1	353	359	PF00069	0.699
MOD_Plk_1	69	75	PF00069	0.732
MOD_Plk_2-3	183	189	PF00069	0.644
MOD_Plk_2-3	70	76	PF00069	0.713
MOD_Plk_4	213	219	PF00069	0.622
MOD_Plk_4	272	278	PF00069	0.682
MOD_Plk_4	283	289	PF00069	0.648
MOD_Plk_4	333	339	PF00069	0.673
MOD_Plk_4	353	359	PF00069	0.486
MOD_ProDKin_1	145	151	PF00069	0.750
MOD_ProDKin_1	269	275	PF00069	0.665
MOD_ProDKin_1	279	285	PF00069	0.561
MOD_ProDKin_1	4	10	PF00069	0.686
MOD_SUMO_rev_2	183	191	PF00179	0.637
TRG_DiLeu_BaEn_4	302	308	PF01217	0.583
TRG_ENDOCYTIC_2	201	204	PF00928	0.579
TRG_ENDOCYTIC_2	231	234	PF00928	0.568
TRG_ENDOCYTIC_2	347	350	PF00928	0.628
TRG_ENDOCYTIC_2	357	360	PF00928	0.570
TRG_ENDOCYTIC_2	367	370	PF00928	0.515
TRG_ENDOCYTIC_2	52	55	PF00928	0.674
TRG_ER_diArg_1	142	145	PF00400	0.714
TRG_ER_diArg_1	173	175	PF00400	0.593
TRG_ER_diArg_1	257	259	PF00400	0.659
TRG_ER_diArg_1	310	312	PF00400	0.593
TRG_ER_diArg_1	347	349	PF00400	0.676
TRG_ER_diArg_1	42	44	PF00400	0.611
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.596

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYX6	Leptomonas seymouri	60%	97%
A0A1X0P7K9	Trypanosomatidae	39%	100%
A0A3Q8IKB1	Leishmania donovani	98%	100%
A0A3R7K7R7	Trypanosoma rangeli	41%	100%
A4HPC3	Leishmania braziliensis	81%	100%
A4ICG1	Leishmania infantum	97%	100%
D0A3D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AT32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5BH32	Trypanosoma cruzi	38%	100%