LeishMANIAdb
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Membrane-bound acid phosphatase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Membrane-bound acid phosphatase
Gene product:
membrane-bound acid phosphatase precursor
Species:
Leishmania major
UniProt:
Q4Q1G4_LEIMA
TriTrypDb:
LmjF.36.2570 , LMJLV39_360034000 , LMJSD75_360034000
Length:
514

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 1
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 65
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 14
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 42, no: 5
NetGPI no yes: 0, no: 47
Cellular components
Term Name Level Count
GO:0016020 membrane 2 35
GO:0110165 cellular anatomical entity 1 35

Expansion

Sequence features

Q4Q1G4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1G4

Function

Biological processes
Term Name Level Count
GO:0006793 phosphorus metabolic process 3 6
GO:0006796 phosphate-containing compound metabolic process 4 6
GO:0008152 metabolic process 1 6
GO:0009987 cellular process 1 6
GO:0016311 dephosphorylation 5 6
GO:0044237 cellular metabolic process 2 6
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 9
GO:0016787 hydrolase activity 2 9
GO:0016788 hydrolase activity, acting on ester bonds 3 9
GO:0016791 phosphatase activity 5 9
GO:0042578 phosphoric ester hydrolase activity 4 9
GO:0003993 acid phosphatase activity 6 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 329 333 PF00656 0.426
CLV_C14_Caspase3-7 420 424 PF00656 0.422
CLV_NRD_NRD_1 168 170 PF00675 0.553
CLV_NRD_NRD_1 2 4 PF00675 0.683
CLV_NRD_NRD_1 434 436 PF00675 0.491
CLV_PCSK_KEX2_1 168 170 PF00082 0.518
CLV_PCSK_KEX2_1 2 4 PF00082 0.709
CLV_PCSK_KEX2_1 499 501 PF00082 0.384
CLV_PCSK_PC1ET2_1 499 501 PF00082 0.454
CLV_PCSK_SKI1_1 125 129 PF00082 0.547
CLV_PCSK_SKI1_1 369 373 PF00082 0.590
CLV_PCSK_SKI1_1 502 506 PF00082 0.382
DEG_Nend_UBRbox_1 1 4 PF02207 0.597
DOC_CDC14_PxL_1 224 232 PF14671 0.438
DOC_CKS1_1 91 96 PF01111 0.310
DOC_CYCLIN_RxL_1 122 132 PF00134 0.338
DOC_MAPK_FxFP_2 7 10 PF00069 0.388
DOC_PP1_RVXF_1 1 8 PF00149 0.709
DOC_PP2B_LxvP_1 25 28 PF13499 0.522
DOC_PP4_FxxP_1 7 10 PF00568 0.388
DOC_PP4_MxPP_1 315 318 PF00568 0.378
DOC_SPAK_OSR1_1 339 343 PF12202 0.232
DOC_USP7_MATH_1 129 133 PF00917 0.387
DOC_USP7_MATH_1 217 221 PF00917 0.298
DOC_USP7_MATH_1 242 246 PF00917 0.349
DOC_USP7_MATH_1 334 338 PF00917 0.463
DOC_USP7_MATH_1 461 465 PF00917 0.484
DOC_USP7_MATH_1 470 474 PF00917 0.492
DOC_USP7_UBL2_3 499 503 PF12436 0.594
DOC_WW_Pin1_4 298 303 PF00397 0.297
DOC_WW_Pin1_4 396 401 PF00397 0.330
DOC_WW_Pin1_4 42 47 PF00397 0.271
DOC_WW_Pin1_4 466 471 PF00397 0.550
DOC_WW_Pin1_4 90 95 PF00397 0.372
LIG_14-3-3_CanoR_1 109 117 PF00244 0.336
LIG_14-3-3_CanoR_1 178 183 PF00244 0.307
LIG_14-3-3_CanoR_1 425 434 PF00244 0.354
LIG_14-3-3_CanoR_1 81 91 PF00244 0.383
LIG_APCC_ABBA_1 382 387 PF00400 0.331
LIG_BIR_III_4 370 374 PF00653 0.444
LIG_BRCT_BRCA1_1 131 135 PF00533 0.330
LIG_BRCT_BRCA1_1 193 197 PF00533 0.359
LIG_BRCT_BRCA1_1 243 247 PF00533 0.314
LIG_BRCT_BRCA1_1 336 340 PF00533 0.398
LIG_Clathr_ClatBox_1 179 183 PF01394 0.234
LIG_Clathr_ClatBox_1 411 415 PF01394 0.259
LIG_deltaCOP1_diTrp_1 496 504 PF00928 0.485
LIG_DLG_GKlike_1 178 185 PF00625 0.219
LIG_eIF4E_1 266 272 PF01652 0.373
LIG_eIF4E_1 405 411 PF01652 0.232
LIG_FHA_1 109 115 PF00498 0.354
LIG_FHA_1 219 225 PF00498 0.393
LIG_FHA_1 319 325 PF00498 0.338
LIG_FHA_1 356 362 PF00498 0.375
LIG_FHA_1 377 383 PF00498 0.343
LIG_FHA_1 401 407 PF00498 0.371
LIG_FHA_2 384 390 PF00498 0.329
LIG_FHA_2 418 424 PF00498 0.434
LIG_GBD_Chelix_1 268 276 PF00786 0.483
LIG_LIR_Apic_2 403 408 PF02991 0.353
LIG_LIR_Gen_1 181 190 PF02991 0.392
LIG_LIR_Gen_1 338 345 PF02991 0.352
LIG_LIR_Gen_1 386 396 PF02991 0.290
LIG_LIR_Nem_3 132 138 PF02991 0.356
LIG_LIR_Nem_3 181 185 PF02991 0.391
LIG_LIR_Nem_3 338 344 PF02991 0.350
LIG_LIR_Nem_3 386 391 PF02991 0.302
LIG_LIR_Nem_3 496 501 PF02991 0.594
LIG_LIR_Nem_3 92 98 PF02991 0.379
LIG_LIR_Nem_3 99 103 PF02991 0.356
LIG_MLH1_MIPbox_1 131 135 PF16413 0.372
LIG_NRBOX 267 273 PF00104 0.370
LIG_PCNA_yPIPBox_3 115 128 PF02747 0.241
LIG_PDZ_Class_2 509 514 PF00595 0.554
LIG_Pex14_2 319 323 PF04695 0.294
LIG_Pex14_2 60 64 PF04695 0.234
LIG_Pex14_2 96 100 PF04695 0.421
LIG_SH2_PTP2 341 344 PF00017 0.399
LIG_SH2_SRC 291 294 PF00017 0.341
LIG_SH2_SRC 405 408 PF00017 0.313
LIG_SH2_SRC 448 451 PF00017 0.410
LIG_SH2_STAP1 291 295 PF00017 0.321
LIG_SH2_STAT3 163 166 PF00017 0.387
LIG_SH2_STAT3 67 70 PF00017 0.377
LIG_SH2_STAT5 107 110 PF00017 0.258
LIG_SH2_STAT5 201 204 PF00017 0.385
LIG_SH2_STAT5 341 344 PF00017 0.335
LIG_SH2_STAT5 376 379 PF00017 0.318
LIG_SH2_STAT5 405 408 PF00017 0.308
LIG_SH2_STAT5 448 451 PF00017 0.366
LIG_SH2_STAT5 79 82 PF00017 0.303
LIG_SH2_STAT5 84 87 PF00017 0.286
LIG_SH2_STAT5 95 98 PF00017 0.280
LIG_SH3_3 394 400 PF00018 0.294
LIG_SH3_3 464 470 PF00018 0.535
LIG_SH3_3 88 94 PF00018 0.395
LIG_Sin3_3 269 276 PF02671 0.219
LIG_SUMO_SIM_par_1 301 306 PF11976 0.372
LIG_SUMO_SIM_par_1 326 332 PF11976 0.353
LIG_TRAF2_1 164 167 PF00917 0.374
LIG_WRC_WIRS_1 179 184 PF05994 0.220
MOD_CK1_1 355 361 PF00069 0.377
MOD_CK1_1 439 445 PF00069 0.326
MOD_CK1_1 469 475 PF00069 0.474
MOD_CK1_1 89 95 PF00069 0.402
MOD_CK2_1 303 309 PF00069 0.359
MOD_CK2_1 383 389 PF00069 0.213
MOD_CK2_1 423 429 PF00069 0.462
MOD_GlcNHglycan 118 121 PF01048 0.530
MOD_GlcNHglycan 19 22 PF01048 0.630
MOD_GlcNHglycan 292 296 PF01048 0.542
MOD_GlcNHglycan 348 351 PF01048 0.541
MOD_GlcNHglycan 419 423 PF01048 0.574
MOD_GlcNHglycan 472 475 PF01048 0.689
MOD_GSK3_1 101 108 PF00069 0.303
MOD_GSK3_1 238 245 PF00069 0.317
MOD_GSK3_1 291 298 PF00069 0.319
MOD_GSK3_1 303 310 PF00069 0.303
MOD_GSK3_1 355 362 PF00069 0.376
MOD_GSK3_1 372 379 PF00069 0.249
MOD_GSK3_1 391 398 PF00069 0.270
MOD_GSK3_1 461 468 PF00069 0.478
MOD_GSK3_1 82 89 PF00069 0.373
MOD_N-GLC_1 101 106 PF02516 0.559
MOD_N-GLC_1 129 134 PF02516 0.571
MOD_N-GLC_1 199 204 PF02516 0.588
MOD_N-GLC_1 251 256 PF02516 0.566
MOD_N-GLC_1 355 360 PF02516 0.528
MOD_N-GLC_1 423 428 PF02516 0.558
MOD_N-GLC_1 439 444 PF02516 0.404
MOD_N-GLC_1 461 466 PF02516 0.715
MOD_N-GLC_1 50 55 PF02516 0.568
MOD_N-GLC_2 381 383 PF02516 0.546
MOD_NEK2_1 103 108 PF00069 0.331
MOD_NEK2_1 148 153 PF00069 0.377
MOD_NEK2_1 271 276 PF00069 0.346
MOD_NEK2_1 303 308 PF00069 0.300
MOD_NEK2_1 359 364 PF00069 0.394
MOD_NEK2_1 391 396 PF00069 0.253
MOD_NEK2_2 199 204 PF00069 0.404
MOD_NEK2_2 400 405 PF00069 0.355
MOD_OFUCOSY 438 443 PF10250 0.524
MOD_PIKK_1 191 197 PF00454 0.411
MOD_PKA_2 108 114 PF00069 0.345
MOD_PKA_2 281 287 PF00069 0.482
MOD_PKA_2 82 88 PF00069 0.363
MOD_PKB_1 367 375 PF00069 0.233
MOD_Plk_1 101 107 PF00069 0.318
MOD_Plk_1 199 205 PF00069 0.395
MOD_Plk_1 296 302 PF00069 0.317
MOD_Plk_1 308 314 PF00069 0.344
MOD_Plk_1 355 361 PF00069 0.339
MOD_Plk_1 423 429 PF00069 0.410
MOD_Plk_1 462 468 PF00069 0.489
MOD_Plk_1 50 56 PF00069 0.356
MOD_Plk_1 86 92 PF00069 0.386
MOD_Plk_2-3 326 332 PF00069 0.241
MOD_Plk_2-3 423 429 PF00069 0.269
MOD_Plk_4 149 155 PF00069 0.316
MOD_Plk_4 372 378 PF00069 0.341
MOD_Plk_4 477 483 PF00069 0.263
MOD_Plk_4 50 56 PF00069 0.357
MOD_Plk_4 96 102 PF00069 0.345
MOD_ProDKin_1 298 304 PF00069 0.298
MOD_ProDKin_1 396 402 PF00069 0.327
MOD_ProDKin_1 42 48 PF00069 0.271
MOD_ProDKin_1 466 472 PF00069 0.545
MOD_ProDKin_1 90 96 PF00069 0.368
MOD_SUMO_for_1 164 167 PF00179 0.247
MOD_SUMO_for_1 351 354 PF00179 0.336
TRG_DiLeu_BaEn_1 144 149 PF01217 0.326
TRG_DiLeu_BaLyEn_6 225 230 PF01217 0.361
TRG_DiLeu_BaLyEn_6 340 345 PF01217 0.408
TRG_ENDOCYTIC_2 341 344 PF00928 0.379
TRG_ENDOCYTIC_2 501 504 PF00928 0.657
TRG_ER_diArg_1 1 3 PF00400 0.628
TRG_ER_diArg_1 157 160 PF00400 0.356
TRG_ER_diArg_1 203 206 PF00400 0.382
TRG_ER_diArg_1 366 369 PF00400 0.206
TRG_ER_diArg_1 80 83 PF00400 0.377
TRG_NES_CRM1_1 313 326 PF08389 0.388
TRG_NLS_MonoExtC_3 498 503 PF00514 0.513
TRG_NLS_MonoExtN_4 499 506 PF00514 0.515
TRG_Pf-PMV_PEXEL_1 232 236 PF00026 0.582
TRG_Pf-PMV_PEXEL_1 425 429 PF00026 0.621

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5Y5 Leptomonas seymouri 35% 90%
A0A0N1I756 Leptomonas seymouri 66% 99%
A0A0N1PEH4 Leptomonas seymouri 39% 100%
A0A0S4IRF5 Bodo saltans 26% 77%
A0A0S4IUV8 Bodo saltans 25% 100%
A0A0S4IV77 Bodo saltans 34% 99%
A0A0S4JEA9 Bodo saltans 24% 100%
A0A0S4JJK3 Bodo saltans 31% 100%
A0A0S4JW09 Bodo saltans 27% 100%
A0A1X0NNY4 Trypanosomatidae 36% 93%
A0A1X0NQL4 Trypanosomatidae 29% 94%
A0A1X0NY34 Trypanosomatidae 27% 100%
A0A1X0P7V5 Trypanosomatidae 40% 98%
A0A3Q8IR23 Leishmania donovani 39% 90%
A0A3R7KSH4 Trypanosoma rangeli 25% 100%
A0A3R7MEN7 Trypanosoma rangeli 37% 99%
A0A3R7MHJ7 Trypanosoma rangeli 27% 100%
A0A3S5H827 Leishmania donovani 93% 100%
A0A3S7WXU0 Leishmania donovani 38% 97%
A0A3S7X1W4 Leishmania donovani 34% 94%
A4HCZ0 Leishmania braziliensis 38% 84%
A4HGW8 Leishmania braziliensis 37% 94%
A4HPC1 Leishmania braziliensis 71% 100%
A4HPC5 Leishmania braziliensis 39% 89%
A4HQG6 Leishmania braziliensis 39% 100%
A4HQG9 Leishmania braziliensis 39% 99%
A4I0H5 Leishmania infantum 38% 97%
A4I3Z8 Leishmania infantum 34% 94%
A4ICA5 Leishmania infantum 37% 77%
A4ICG3 Leishmania infantum 93% 100%
A4ICG5 Leishmania infantum 39% 90%
D0A3E0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 41% 97%
D0A947 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 100%
D0A948 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 24% 100%
D0A9J5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 40% 98%
E9AT34 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9AT36 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 90%
E9AWD7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 97%
E9B088 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 93%
Q4Q0A9 Leishmania major 29% 85%
Q4Q1G2 Leishmania major 36% 100%
Q4Q7Z7 Leishmania major 33% 94%
Q4QB35 Leishmania major 39% 95%
V5BCI2 Trypanosoma cruzi 27% 100%
V5BK91 Trypanosoma cruzi 39% 100%
V5BL75 Trypanosoma cruzi 28% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS