Glycerophosphocholine phosphodiesterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

related to multifunctional cyclin-dependent kinase pho85-like protein

Species:

Leishmania major

UniProt:

Q4Q1G3_LEIMA

TriTrypDb:

LmjF.36.2580 , LMJLV39_360034100 , LMJSD75_360034100

Length:

991

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q1G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1G3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	7
GO:0009395	phospholipid catabolic process	5	7
GO:0009987	cellular process	1	7
GO:0016042	lipid catabolic process	4	7
GO:0016310	phosphorylation	5	5
GO:0019637	organophosphate metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044242	cellular lipid catabolic process	4	7
GO:0044248	cellular catabolic process	3	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0046434	organophosphate catabolic process	4	7
GO:0046475	glycerophospholipid catabolic process	6	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046503	glycerolipid catabolic process	5	7
GO:0071704	organic substance metabolic process	2	7
GO:1901575	organic substance catabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0008081	phosphoric diester hydrolase activity	5	7
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0047389	glycerophosphocholine phosphodiesterase activity	6	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.610
CLV_C14_Caspase3-7	269	273	PF00656	0.530
CLV_C14_Caspase3-7	333	337	PF00656	0.602
CLV_C14_Caspase3-7	817	821	PF00656	0.329
CLV_NRD_NRD_1	194	196	PF00675	0.566
CLV_NRD_NRD_1	211	213	PF00675	0.534
CLV_NRD_NRD_1	329	331	PF00675	0.472
CLV_NRD_NRD_1	380	382	PF00675	0.517
CLV_NRD_NRD_1	427	429	PF00675	0.664
CLV_NRD_NRD_1	629	631	PF00675	0.415
CLV_NRD_NRD_1	721	723	PF00675	0.239
CLV_NRD_NRD_1	822	824	PF00675	0.329
CLV_NRD_NRD_1	950	952	PF00675	0.320
CLV_PCSK_FUR_1	209	213	PF00082	0.538
CLV_PCSK_FUR_1	378	382	PF00082	0.543
CLV_PCSK_KEX2_1	194	196	PF00082	0.566
CLV_PCSK_KEX2_1	211	213	PF00082	0.534
CLV_PCSK_KEX2_1	328	330	PF00082	0.487
CLV_PCSK_KEX2_1	380	382	PF00082	0.570
CLV_PCSK_KEX2_1	427	429	PF00082	0.663
CLV_PCSK_KEX2_1	661	663	PF00082	0.307
CLV_PCSK_KEX2_1	950	952	PF00082	0.321
CLV_PCSK_PC1ET2_1	661	663	PF00082	0.307
CLV_PCSK_SKI1_1	173	177	PF00082	0.581
CLV_PCSK_SKI1_1	455	459	PF00082	0.461
CLV_PCSK_SKI1_1	707	711	PF00082	0.310
CLV_PCSK_SKI1_1	767	771	PF00082	0.352
CLV_PCSK_SKI1_1	813	817	PF00082	0.329
CLV_PCSK_SKI1_1	823	827	PF00082	0.380
CLV_PCSK_SKI1_1	857	861	PF00082	0.342
CLV_PCSK_SKI1_1	950	954	PF00082	0.342
CLV_Separin_Metazoa	325	329	PF03568	0.518
CLV_Separin_Metazoa	574	578	PF03568	0.426
DEG_SPOP_SBC_1	401	405	PF00917	0.636
DEG_SPOP_SBC_1	986	990	PF00917	0.532
DOC_ANK_TNKS_1	331	338	PF00023	0.541
DOC_CDC14_PxL_1	232	240	PF14671	0.633
DOC_CDC14_PxL_1	77	85	PF14671	0.494
DOC_CKS1_1	136	141	PF01111	0.589
DOC_CKS1_1	67	72	PF01111	0.481
DOC_CYCLIN_yCln2_LP_2	364	370	PF00134	0.495
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.484
DOC_MAPK_DCC_7	241	250	PF00069	0.618
DOC_MAPK_gen_1	194	202	PF00069	0.565
DOC_MAPK_gen_1	630	637	PF00069	0.415
DOC_MAPK_gen_1	643	650	PF00069	0.346
DOC_MAPK_gen_1	841	850	PF00069	0.307
DOC_MAPK_MEF2A_6	241	250	PF00069	0.618
DOC_MAPK_MEF2A_6	643	650	PF00069	0.425
DOC_PP1_RVXF_1	811	817	PF00149	0.307
DOC_PP1_RVXF_1	821	828	PF00149	0.307
DOC_PP2B_LxvP_1	364	367	PF13499	0.510
DOC_PP2B_LxvP_1	585	588	PF13499	0.396
DOC_PP4_FxxP_1	133	136	PF00568	0.643
DOC_USP7_MATH_1	216	220	PF00917	0.581
DOC_USP7_MATH_1	263	267	PF00917	0.604
DOC_USP7_MATH_1	270	274	PF00917	0.633
DOC_USP7_MATH_1	314	318	PF00917	0.542
DOC_USP7_MATH_1	33	37	PF00917	0.669
DOC_USP7_MATH_1	400	404	PF00917	0.586
DOC_USP7_MATH_1	46	50	PF00917	0.507
DOC_USP7_MATH_1	604	608	PF00917	0.329
DOC_USP7_MATH_1	880	884	PF00917	0.307
DOC_USP7_UBL2_3	723	727	PF12436	0.239
DOC_WW_Pin1_4	135	140	PF00397	0.586
DOC_WW_Pin1_4	143	148	PF00397	0.540
DOC_WW_Pin1_4	164	169	PF00397	0.545
DOC_WW_Pin1_4	331	336	PF00397	0.544
DOC_WW_Pin1_4	600	605	PF00397	0.370
DOC_WW_Pin1_4	66	71	PF00397	0.556
DOC_WW_Pin1_4	672	677	PF00397	0.327
DOC_WW_Pin1_4	75	80	PF00397	0.537
DOC_WW_Pin1_4	770	775	PF00397	0.315
DOC_WW_Pin1_4	888	893	PF00397	0.375
LIG_14-3-3_CanoR_1	100	109	PF00244	0.535
LIG_14-3-3_CanoR_1	110	116	PF00244	0.500
LIG_14-3-3_CanoR_1	157	161	PF00244	0.614
LIG_14-3-3_CanoR_1	431	437	PF00244	0.651
LIG_14-3-3_CanoR_1	524	533	PF00244	0.443
LIG_14-3-3_CanoR_1	577	585	PF00244	0.378
LIG_14-3-3_CanoR_1	602	612	PF00244	0.284
LIG_14-3-3_CanoR_1	730	740	PF00244	0.352
LIG_14-3-3_CanoR_1	823	828	PF00244	0.329
LIG_14-3-3_CanoR_1	912	920	PF00244	0.329
LIG_APCC_ABBA_1	274	279	PF00400	0.634
LIG_BIR_II_1	1	5	PF00653	0.476
LIG_BRCT_BRCA1_1	218	222	PF00533	0.589
LIG_BRCT_BRCA1_1	297	301	PF00533	0.455
LIG_BRCT_BRCA1_1	437	441	PF00533	0.642
LIG_BRCT_BRCA1_1	578	582	PF00533	0.389
LIG_BRCT_BRCA1_1	775	779	PF00533	0.307
LIG_BRCT_BRCA1_1	792	796	PF00533	0.307
LIG_BRCT_BRCA1_1	798	802	PF00533	0.307
LIG_Clathr_ClatBox_1	125	129	PF01394	0.511
LIG_Clathr_ClatBox_1	753	757	PF01394	0.329
LIG_eIF4E_1	555	561	PF01652	0.327
LIG_eIF4E_1	785	791	PF01652	0.375
LIG_FHA_1	215	221	PF00498	0.588
LIG_FHA_1	403	409	PF00498	0.670
LIG_FHA_1	459	465	PF00498	0.483
LIG_FHA_1	475	481	PF00498	0.448
LIG_FHA_1	496	502	PF00498	0.494
LIG_FHA_1	528	534	PF00498	0.520
LIG_FHA_1	67	73	PF00498	0.487
LIG_FHA_1	704	710	PF00498	0.375
LIG_FHA_1	914	920	PF00498	0.329
LIG_FHA_2	100	106	PF00498	0.556
LIG_FHA_2	165	171	PF00498	0.584
LIG_FHA_2	419	425	PF00498	0.714
LIG_FHA_2	954	960	PF00498	0.375
LIG_Integrin_isoDGR_2	821	823	PF01839	0.329
LIG_Integrin_RGD_1	212	214	PF01839	0.532
LIG_LIR_Apic_2	130	136	PF02991	0.613
LIG_LIR_Apic_2	155	161	PF02991	0.613
LIG_LIR_Gen_1	227	237	PF02991	0.547
LIG_LIR_Gen_1	548	559	PF02991	0.383
LIG_LIR_Gen_1	579	590	PF02991	0.382
LIG_LIR_Gen_1	636	641	PF02991	0.375
LIG_LIR_Gen_1	826	834	PF02991	0.317
LIG_LIR_Gen_1	843	850	PF02991	0.251
LIG_LIR_Gen_1	962	971	PF02991	0.375
LIG_LIR_Nem_3	129	135	PF02991	0.497
LIG_LIR_Nem_3	227	232	PF02991	0.536
LIG_LIR_Nem_3	38	44	PF02991	0.540
LIG_LIR_Nem_3	548	554	PF02991	0.409
LIG_LIR_Nem_3	579	585	PF02991	0.391
LIG_LIR_Nem_3	673	677	PF02991	0.476
LIG_LIR_Nem_3	826	830	PF02991	0.317
LIG_LIR_Nem_3	843	848	PF02991	0.251
LIG_LIR_Nem_3	861	865	PF02991	0.318
LIG_LIR_Nem_3	934	939	PF02991	0.338
LIG_LIR_Nem_3	962	968	PF02991	0.307
LIG_MYND_1	236	240	PF01753	0.592
LIG_MYND_1	75	79	PF01753	0.550
LIG_Pex14_1	551	555	PF04695	0.391
LIG_REV1ctd_RIR_1	130	135	PF16727	0.580
LIG_REV1ctd_RIR_1	17	26	PF16727	0.574
LIG_RPA_C_Fungi	376	388	PF08784	0.496
LIG_SH2_CRK	158	162	PF00017	0.600
LIG_SH2_CRK	233	237	PF00017	0.628
LIG_SH2_CRK	674	678	PF00017	0.375
LIG_SH2_CRK	686	690	PF00017	0.259
LIG_SH2_CRK	845	849	PF00017	0.329
LIG_SH2_GRB2like	302	305	PF00017	0.425
LIG_SH2_NCK_1	158	162	PF00017	0.600
LIG_SH2_NCK_1	233	237	PF00017	0.628
LIG_SH2_NCK_1	968	972	PF00017	0.307
LIG_SH2_SRC	866	869	PF00017	0.375
LIG_SH2_STAP1	845	849	PF00017	0.307
LIG_SH2_STAP1	968	972	PF00017	0.284
LIG_SH2_STAT3	785	788	PF00017	0.307
LIG_SH2_STAT3	95	98	PF00017	0.500
LIG_SH2_STAT5	503	506	PF00017	0.405
LIG_SH2_STAT5	536	539	PF00017	0.551
LIG_SH2_STAT5	555	558	PF00017	0.387
LIG_SH2_STAT5	674	677	PF00017	0.375
LIG_SH2_STAT5	686	689	PF00017	0.259
LIG_SH2_STAT5	76	79	PF00017	0.624
LIG_SH2_STAT5	866	869	PF00017	0.375
LIG_SH2_STAT5	95	98	PF00017	0.567
LIG_SH2_STAT5	963	966	PF00017	0.315
LIG_SH3_1	233	239	PF00018	0.632
LIG_SH3_1	241	247	PF00018	0.587
LIG_SH3_2	236	241	PF14604	0.641
LIG_SH3_3	112	118	PF00018	0.461
LIG_SH3_3	133	139	PF00018	0.588
LIG_SH3_3	233	239	PF00018	0.577
LIG_SH3_3	241	247	PF00018	0.579
LIG_SH3_3	287	293	PF00018	0.665
LIG_SH3_3	303	309	PF00018	0.391
LIG_SH3_3	453	459	PF00018	0.475
LIG_SH3_3	496	502	PF00018	0.436
LIG_SH3_3	528	534	PF00018	0.422
LIG_SH3_3	69	75	PF00018	0.474
LIG_SH3_3	780	786	PF00018	0.307
LIG_SH3_3	896	902	PF00018	0.317
LIG_SH3_3	927	933	PF00018	0.375
LIG_SUMO_SIM_par_1	124	130	PF11976	0.519
LIG_SUMO_SIM_par_1	246	252	PF11976	0.618
LIG_SUMO_SIM_par_1	295	300	PF11976	0.402
LIG_SUMO_SIM_par_1	57	62	PF11976	0.505
LIG_SUMO_SIM_par_1	646	652	PF11976	0.437
LIG_TRAF2_1	102	105	PF00917	0.495
LIG_TRAF2_2	306	311	PF00917	0.510
LIG_TYR_ITIM	556	561	PF00017	0.325
LIG_TYR_ITIM	684	689	PF00017	0.375
LIG_UBA3_1	654	661	PF00899	0.325
LIG_WRC_WIRS_1	621	626	PF05994	0.375
LIG_WRC_WIRS_1	827	832	PF05994	0.307
LIG_WRC_WIRS_1	862	867	PF05994	0.307
LIG_WW_3	238	242	PF00397	0.607
MOD_CDK_SPxK_1	672	678	PF00069	0.329
MOD_CDK_SPxxK_3	66	73	PF00069	0.435
MOD_CK1_1	159	165	PF00069	0.516
MOD_CK1_1	266	272	PF00069	0.605
MOD_CK1_1	317	323	PF00069	0.523
MOD_CK1_1	34	40	PF00069	0.615
MOD_CK1_1	403	409	PF00069	0.638
MOD_CK1_1	413	419	PF00069	0.573
MOD_CK1_1	426	432	PF00069	0.590
MOD_CK1_1	525	531	PF00069	0.416
MOD_CK1_1	578	584	PF00069	0.404
MOD_CK1_1	603	609	PF00069	0.368
MOD_CK1_1	617	623	PF00069	0.422
MOD_CK1_1	716	722	PF00069	0.339
MOD_CK1_1	732	738	PF00069	0.284
MOD_CK1_1	745	751	PF00069	0.365
MOD_CK2_1	111	117	PF00069	0.535
MOD_CK2_1	164	170	PF00069	0.571
MOD_CK2_1	221	227	PF00069	0.559
MOD_CK2_1	418	424	PF00069	0.646
MOD_CK2_1	762	768	PF00069	0.375
MOD_CK2_1	87	93	PF00069	0.616
MOD_CK2_1	99	105	PF00069	0.429
MOD_Cter_Amidation	821	824	PF01082	0.329
MOD_GlcNHglycan	178	182	PF01048	0.583
MOD_GlcNHglycan	251	254	PF01048	0.599
MOD_GlcNHglycan	268	271	PF01048	0.612
MOD_GlcNHglycan	33	36	PF01048	0.568
MOD_GlcNHglycan	382	385	PF01048	0.598
MOD_GlcNHglycan	415	418	PF01048	0.689
MOD_GlcNHglycan	428	431	PF01048	0.572
MOD_GlcNHglycan	437	440	PF01048	0.561
MOD_GlcNHglycan	519	522	PF01048	0.427
MOD_GlcNHglycan	527	530	PF01048	0.395
MOD_GlcNHglycan	744	747	PF01048	0.329
MOD_GlcNHglycan	874	877	PF01048	0.420
MOD_GlcNHglycan	908	911	PF01048	0.409
MOD_GSK3_1	156	163	PF00069	0.733
MOD_GSK3_1	262	269	PF00069	0.626
MOD_GSK3_1	317	324	PF00069	0.505
MOD_GSK3_1	400	407	PF00069	0.675
MOD_GSK3_1	418	425	PF00069	0.547
MOD_GSK3_1	513	520	PF00069	0.411
MOD_GSK3_1	523	530	PF00069	0.424
MOD_GSK3_1	596	603	PF00069	0.327
MOD_GSK3_1	729	736	PF00069	0.421
MOD_GSK3_1	741	748	PF00069	0.276
MOD_GSK3_1	928	935	PF00069	0.331
MOD_N-GLC_1	411	416	PF02516	0.639
MOD_N-GLC_1	684	689	PF02516	0.375
MOD_N-GLC_2	142	144	PF02516	0.529
MOD_N-GLC_2	5	7	PF02516	0.476
MOD_N-GLC_2	833	835	PF02516	0.307
MOD_NEK2_1	207	212	PF00069	0.695
MOD_NEK2_1	297	302	PF00069	0.390
MOD_NEK2_1	31	36	PF00069	0.551
MOD_NEK2_1	379	384	PF00069	0.590
MOD_NEK2_1	402	407	PF00069	0.616
MOD_NEK2_1	411	416	PF00069	0.569
MOD_NEK2_1	522	527	PF00069	0.512
MOD_NEK2_1	596	601	PF00069	0.363
MOD_NEK2_1	684	689	PF00069	0.307
MOD_NEK2_1	729	734	PF00069	0.375
MOD_NEK2_1	790	795	PF00069	0.375
MOD_NEK2_1	840	845	PF00069	0.307
MOD_NEK2_2	450	455	PF00069	0.523
MOD_PIKK_1	10	16	PF00454	0.612
MOD_PIKK_1	100	106	PF00454	0.556
MOD_PIKK_1	156	162	PF00454	0.608
MOD_PIKK_1	304	310	PF00454	0.497
MOD_PIKK_1	432	438	PF00454	0.606
MOD_PIKK_1	474	480	PF00454	0.411
MOD_PIKK_1	733	739	PF00454	0.420
MOD_PKA_1	380	386	PF00069	0.550
MOD_PKA_1	823	829	PF00069	0.329
MOD_PKA_2	156	162	PF00069	0.608
MOD_PKA_2	379	385	PF00069	0.548
MOD_PKA_2	395	401	PF00069	0.578
MOD_PKA_2	426	432	PF00069	0.788
MOD_PKA_2	523	529	PF00069	0.446
MOD_PKA_2	576	582	PF00069	0.397
MOD_PKA_2	729	735	PF00069	0.329
MOD_PKA_2	99	105	PF00069	0.531
MOD_PKB_1	378	386	PF00069	0.519
MOD_Plk_1	196	202	PF00069	0.604
MOD_Plk_1	263	269	PF00069	0.608
MOD_Plk_1	317	323	PF00069	0.392
MOD_Plk_1	495	501	PF00069	0.373
MOD_Plk_1	508	514	PF00069	0.486
MOD_Plk_1	617	623	PF00069	0.317
MOD_Plk_1	684	690	PF00069	0.347
MOD_Plk_1	749	755	PF00069	0.354
MOD_Plk_1	88	94	PF00069	0.457
MOD_Plk_4	117	123	PF00069	0.418
MOD_Plk_4	146	152	PF00069	0.578
MOD_Plk_4	297	303	PF00069	0.396
MOD_Plk_4	513	519	PF00069	0.385
MOD_Plk_4	527	533	PF00069	0.398
MOD_Plk_4	546	552	PF00069	0.439
MOD_Plk_4	586	592	PF00069	0.362
MOD_Plk_4	713	719	PF00069	0.483
MOD_Plk_4	749	755	PF00069	0.375
MOD_Plk_4	885	891	PF00069	0.307
MOD_Plk_4	959	965	PF00069	0.375
MOD_ProDKin_1	135	141	PF00069	0.585
MOD_ProDKin_1	143	149	PF00069	0.539
MOD_ProDKin_1	164	170	PF00069	0.554
MOD_ProDKin_1	331	337	PF00069	0.547
MOD_ProDKin_1	600	606	PF00069	0.370
MOD_ProDKin_1	66	72	PF00069	0.559
MOD_ProDKin_1	672	678	PF00069	0.327
MOD_ProDKin_1	75	81	PF00069	0.537
MOD_ProDKin_1	770	776	PF00069	0.315
MOD_ProDKin_1	888	894	PF00069	0.375
MOD_SUMO_for_1	660	663	PF00179	0.375
MOD_SUMO_rev_2	776	786	PF00179	0.307
MOD_SUMO_rev_2	846	856	PF00179	0.340
TRG_DiLeu_BaEn_2	226	232	PF01217	0.493
TRG_DiLeu_BaEn_2	802	808	PF01217	0.307
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.437
TRG_DiLeu_BaLyEn_6	650	655	PF01217	0.375
TRG_DiLeu_BaLyEn_6	786	791	PF01217	0.307
TRG_ENDOCYTIC_2	558	561	PF00928	0.323
TRG_ENDOCYTIC_2	674	677	PF00928	0.375
TRG_ENDOCYTIC_2	686	689	PF00928	0.259
TRG_ENDOCYTIC_2	845	848	PF00928	0.307
TRG_ENDOCYTIC_2	862	865	PF00928	0.344
TRG_ENDOCYTIC_2	963	966	PF00928	0.375
TRG_ER_diArg_1	209	212	PF00400	0.544
TRG_ER_diArg_1	327	330	PF00400	0.470
TRG_ER_diArg_1	377	380	PF00400	0.528
TRG_ER_diArg_1	950	952	PF00400	0.399
TRG_NES_CRM1_1	117	130	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	690	695	PF00026	0.307
TRG_Pf-PMV_PEXEL_1	857	861	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL19	Leptomonas seymouri	54%	96%
A0A3S7XAZ7	Leishmania donovani	94%	100%
A4HPC4	Leishmania braziliensis	80%	97%
A4ICG4	Leishmania infantum	94%	100%
E9AT35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%