Putative membrane-bound acid phosphatase 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase 2, putative

Species:

Leishmania major

UniProt:

Q4Q1G2_LEIMA

TriTrypDb:

LmjF.36.2590 , LMJLV39_360034200 , LMJSD75_360034200

Length:

571

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 43, no: 4
NetGPI	no	yes: 0, no: 47

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	35
GO:0110165	cellular anatomical entity	1	35

Expansion

Sequence features

Q4Q1G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1G2

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016311	dephosphorylation	5	6
GO:0044237	cellular metabolic process	2	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9
GO:0003993	acid phosphatase activity	6	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.674
CLV_NRD_NRD_1	536	538	PF00675	0.476
CLV_PCSK_KEX2_1	251	253	PF00082	0.452
CLV_PCSK_KEX2_1	397	399	PF00082	0.619
CLV_PCSK_KEX2_1	535	537	PF00082	0.471
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.452
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.600
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.518
CLV_PCSK_SKI1_1	137	141	PF00082	0.564
CLV_PCSK_SKI1_1	177	181	PF00082	0.614
CLV_PCSK_SKI1_1	196	200	PF00082	0.475
CLV_PCSK_SKI1_1	222	226	PF00082	0.576
CLV_PCSK_SKI1_1	251	255	PF00082	0.574
CLV_PCSK_SKI1_1	398	402	PF00082	0.665
CLV_PCSK_SKI1_1	565	569	PF00082	0.606
DOC_CDC14_PxL_1	237	245	PF14671	0.446
DOC_CKS1_1	431	436	PF01111	0.392
DOC_CYCLIN_RxL_1	217	226	PF00134	0.417
DOC_PP1_RVXF_1	396	403	PF00149	0.466
DOC_PP1_RVXF_1	4	10	PF00149	0.726
DOC_PP4_FxxP_1	108	111	PF00568	0.351
DOC_PP4_MxPP_1	326	329	PF00568	0.413
DOC_USP7_MATH_1	141	145	PF00917	0.368
DOC_USP7_MATH_1	437	441	PF00917	0.396
DOC_USP7_MATH_1	510	514	PF00917	0.478
DOC_USP7_UBL2_3	196	200	PF12436	0.373
DOC_USP7_UBL2_3	397	401	PF12436	0.302
DOC_USP7_UBL2_3	40	44	PF12436	0.328
DOC_WW_Pin1_4	102	107	PF00397	0.389
DOC_WW_Pin1_4	319	324	PF00397	0.333
DOC_WW_Pin1_4	339	344	PF00397	0.354
DOC_WW_Pin1_4	356	361	PF00397	0.411
DOC_WW_Pin1_4	430	435	PF00397	0.517
DOC_WW_Pin1_4	69	74	PF00397	0.457
LIG_14-3-3_CanoR_1	121	129	PF00244	0.364
LIG_14-3-3_CanoR_1	252	260	PF00244	0.327
LIG_14-3-3_CanoR_1	536	544	PF00244	0.712
LIG_14-3-3_CanoR_1	545	551	PF00244	0.754
LIG_14-3-3_CanoR_1	95	100	PF00244	0.406
LIG_APCC_ABBA_1	390	395	PF00400	0.392
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BIR_III_4	378	382	PF00653	0.492
LIG_BIR_III_4	407	411	PF00653	0.419
LIG_BRCT_BRCA1_1	104	108	PF00533	0.400
LIG_deltaCOP1_diTrp_1	365	372	PF00928	0.365
LIG_FHA_1	121	127	PF00498	0.372
LIG_FHA_1	155	161	PF00498	0.334
LIG_FHA_1	186	192	PF00498	0.340
LIG_FHA_1	252	258	PF00498	0.396
LIG_FHA_1	434	440	PF00498	0.556
LIG_FHA_1	526	532	PF00498	0.540
LIG_FHA_1	63	69	PF00498	0.479
LIG_FHA_2	150	156	PF00498	0.381
LIG_FHA_2	214	220	PF00498	0.374
LIG_FHA_2	221	227	PF00498	0.357
LIG_FHA_2	285	291	PF00498	0.449
LIG_FHA_2	315	321	PF00498	0.371
LIG_FHA_2	360	366	PF00498	0.522
LIG_FHA_2	478	484	PF00498	0.606
LIG_FHA_2	495	501	PF00498	0.469
LIG_FHA_2	547	553	PF00498	0.591
LIG_LIR_Apic_2	105	111	PF02991	0.354
LIG_LIR_Gen_1	144	154	PF02991	0.391
LIG_LIR_Gen_1	165	173	PF02991	0.420
LIG_LIR_Gen_1	244	253	PF02991	0.371
LIG_LIR_Nem_3	144	150	PF02991	0.347
LIG_LIR_Nem_3	165	171	PF02991	0.358
LIG_LIR_Nem_3	244	250	PF02991	0.381
LIG_LIR_Nem_3	395	399	PF02991	0.360
LIG_LIR_Nem_3	78	82	PF02991	0.449
LIG_LYPXL_yS_3	240	243	PF13949	0.452
LIG_PDZ_Class_3	566	571	PF00595	0.816
LIG_Pex14_1	168	172	PF04695	0.434
LIG_Pex14_2	135	139	PF04695	0.431
LIG_Pex14_2	364	368	PF04695	0.493
LIG_Rb_pABgroove_1	219	227	PF01858	0.431
LIG_SH2_CRK	147	151	PF00017	0.403
LIG_SH2_CRK	431	435	PF00017	0.526
LIG_SH2_GRB2like	173	176	PF00017	0.415
LIG_SH2_PTP2	348	351	PF00017	0.425
LIG_SH2_SRC	206	209	PF00017	0.261
LIG_SH2_SRC	260	263	PF00017	0.416
LIG_SH2_STAP1	113	117	PF00017	0.351
LIG_SH2_STAP1	260	264	PF00017	0.393
LIG_SH2_STAT3	413	416	PF00017	0.302
LIG_SH2_STAT5	210	213	PF00017	0.394
LIG_SH2_STAT5	348	351	PF00017	0.363
LIG_SH2_STAT5	411	414	PF00017	0.360
LIG_SH2_STAT5	76	79	PF00017	0.368
LIG_SH3_3	100	106	PF00018	0.402
LIG_SH3_3	180	186	PF00018	0.379
LIG_SH3_3	422	428	PF00018	0.437
LIG_TRAF2_1	480	483	PF00917	0.444
LIG_TRAF2_1	549	552	PF00917	0.725
LIG_TRAF2_2	356	361	PF00917	0.457
LIG_UBA3_1	224	232	PF00899	0.442
LIG_WRC_WIRS_1	514	519	PF05994	0.460
LIG_WRC_WIRS_1	88	93	PF05994	0.372
MOD_CDK_SPxxK_3	356	363	PF00069	0.450
MOD_CK1_1	101	107	PF00069	0.420
MOD_CK1_1	120	126	PF00069	0.384
MOD_CK1_1	359	365	PF00069	0.479
MOD_CK1_1	471	477	PF00069	0.491
MOD_CK1_1	513	519	PF00069	0.549
MOD_CK2_1	149	155	PF00069	0.407
MOD_CK2_1	209	215	PF00069	0.457
MOD_CK2_1	284	290	PF00069	0.407
MOD_CK2_1	359	365	PF00069	0.476
MOD_CK2_1	367	373	PF00069	0.472
MOD_CK2_1	477	483	PF00069	0.581
MOD_CK2_1	494	500	PF00069	0.452
MOD_CK2_1	545	551	PF00069	0.737
MOD_GlcNHglycan	130	133	PF01048	0.556
MOD_GlcNHglycan	304	307	PF01048	0.574
MOD_GlcNHglycan	447	450	PF01048	0.627
MOD_GlcNHglycan	482	487	PF01048	0.757
MOD_GlcNHglycan	504	507	PF01048	0.789
MOD_GlcNHglycan	57	60	PF01048	0.643
MOD_GSK3_1	149	156	PF00069	0.365
MOD_GSK3_1	209	216	PF00069	0.389
MOD_GSK3_1	302	309	PF00069	0.350
MOD_GSK3_1	433	440	PF00069	0.484
MOD_GSK3_1	477	484	PF00069	0.552
MOD_GSK3_1	494	501	PF00069	0.658
MOD_GSK3_1	63	70	PF00069	0.462
MOD_GSK3_1	87	94	PF00069	0.413
MOD_GSK3_1	98	105	PF00069	0.372
MOD_LATS_1	543	549	PF00433	0.584
MOD_N-GLC_1	141	146	PF02516	0.563
MOD_N-GLC_1	264	269	PF02516	0.561
MOD_N-GLC_1	63	68	PF02516	0.653
MOD_N-GLC_2	389	391	PF02516	0.602
MOD_NEK2_1	160	165	PF00069	0.395
MOD_NEK2_1	171	176	PF00069	0.444
MOD_NEK2_1	302	307	PF00069	0.392
MOD_NEK2_1	438	443	PF00069	0.477
MOD_NEK2_1	445	450	PF00069	0.442
MOD_NEK2_1	498	503	PF00069	0.649
MOD_NEK2_1	91	96	PF00069	0.373
MOD_NEK2_2	220	225	PF00069	0.412
MOD_OFUCOSY	468	475	PF10250	0.692
MOD_PIKK_1	162	168	PF00454	0.447
MOD_PIKK_1	535	541	PF00454	0.692
MOD_PKA_1	251	257	PF00069	0.252
MOD_PKA_1	494	500	PF00069	0.464
MOD_PKA_1	535	541	PF00069	0.642
MOD_PKA_2	120	126	PF00069	0.372
MOD_PKA_2	251	257	PF00069	0.391
MOD_PKA_2	498	504	PF00069	0.610
MOD_PKA_2	535	541	PF00069	0.662
MOD_PKA_2	544	550	PF00069	0.693
MOD_PKB_1	93	101	PF00069	0.446
MOD_Plk_1	141	147	PF00069	0.417
MOD_Plk_1	307	313	PF00069	0.360
MOD_Plk_2-3	415	421	PF00069	0.310
MOD_Plk_4	142	148	PF00069	0.381
MOD_Plk_4	87	93	PF00069	0.373
MOD_Plk_4	98	104	PF00069	0.383
MOD_ProDKin_1	102	108	PF00069	0.389
MOD_ProDKin_1	319	325	PF00069	0.333
MOD_ProDKin_1	339	345	PF00069	0.354
MOD_ProDKin_1	356	362	PF00069	0.414
MOD_ProDKin_1	430	436	PF00069	0.519
MOD_ProDKin_1	69	75	PF00069	0.451
MOD_SUMO_rev_2	34	42	PF00179	0.378
MOD_SUMO_rev_2	359	364	PF00179	0.333
MOD_SUMO_rev_2	487	497	PF00179	0.469
TRG_DiLeu_BaEn_4	551	557	PF01217	0.592
TRG_DiLeu_BaLyEn_6	238	243	PF01217	0.355
TRG_ENDOCYTIC_2	147	150	PF00928	0.378
TRG_ENDOCYTIC_2	240	243	PF00928	0.411
TRG_ENDOCYTIC_2	299	302	PF00928	0.412
TRG_ENDOCYTIC_2	348	351	PF00928	0.404
TRG_ENDOCYTIC_2	411	414	PF00928	0.395
TRG_ER_diArg_1	92	95	PF00400	0.403
TRG_NES_CRM1_1	324	337	PF08389	0.431
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.591

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	62%	100%
A0A0N1I756	Leptomonas seymouri	40%	100%
A0A0N1PEH4	Leptomonas seymouri	39%	100%
A0A0S4IRF5	Bodo saltans	23%	85%
A0A0S4IV77	Bodo saltans	35%	100%
A0A0S4JEA9	Bodo saltans	27%	100%
A0A0S4JJK3	Bodo saltans	26%	100%
A0A0S4JW09	Bodo saltans	30%	100%
A0A1X0NNY4	Trypanosomatidae	34%	100%
A0A1X0NQL4	Trypanosomatidae	30%	100%
A0A1X0NY34	Trypanosomatidae	25%	100%
A0A1X0P7V5	Trypanosomatidae	45%	100%
A0A3Q8IR23	Leishmania donovani	94%	100%
A0A3R7KSH4	Trypanosoma rangeli	25%	100%
A0A3R7MEN7	Trypanosoma rangeli	42%	100%
A0A3R7MHJ7	Trypanosoma rangeli	30%	100%
A0A3S5H827	Leishmania donovani	38%	100%
A0A3S7WXU0	Leishmania donovani	51%	100%
A0A3S7X1W4	Leishmania donovani	45%	100%
A4HCZ0	Leishmania braziliensis	49%	93%
A4HGW8	Leishmania braziliensis	46%	100%
A4HPC1	Leishmania braziliensis	37%	100%
A4HPC5	Leishmania braziliensis	80%	99%
A4HQG6	Leishmania braziliensis	38%	100%
A4HQG9	Leishmania braziliensis	37%	100%
A4I0H5	Leishmania infantum	51%	100%
A4I3Z8	Leishmania infantum	45%	100%
A4ICA5	Leishmania infantum	39%	86%
A4ICG3	Leishmania infantum	38%	100%
A4ICG5	Leishmania infantum	94%	100%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9B088	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q0A9	Leishmania major	27%	92%
Q4Q1G4	Leishmania major	36%	100%
Q4Q7Z7	Leishmania major	45%	100%
Q4QB35	Leishmania major	49%	100%
V5BCI2	Trypanosoma cruzi	27%	100%
V5BIM1	Trypanosoma cruzi	25%	100%
V5BK91	Trypanosoma cruzi	41%	100%
V5BL75	Trypanosoma cruzi	30%	100%