Putative membrane-bound acid phosphatase 2

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase 2, putative

Species:

Leishmania major

UniProt:

Q4Q1G2_LEIMA

TriTrypDb:

LmjF.36.2590 , LMJLV39_360034200 , LMJSD75_360034200

Length:

571

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 65

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 43, no: 4
NetGPI	no	yes: 0, no: 47

Show entries

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	35
GO:0110165	cellular anatomical entity	1	35

Previous1Next

Expansion

Sequence features

Q4Q1G2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1G2

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016311	dephosphorylation	5	6
GO:0044237	cellular metabolic process	2	6

Previous1Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0003993	acid phosphatase activity	6	3
GO:0016787	hydrolase activity	2	9
GO:0016788	hydrolase activity, acting on ester bonds	3	9
GO:0016791	phosphatase activity	5	9
GO:0042578	phosphoric ester hydrolase activity	4	9

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	484	488	PF00656	0.674
CLV_NRD_NRD_1	536	538	PF00675	0.476
CLV_PCSK_KEX2_1	251	253	PF00082	0.452
CLV_PCSK_KEX2_1	397	399	PF00082	0.619
CLV_PCSK_KEX2_1	535	537	PF00082	0.471
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.452
CLV_PCSK_PC1ET2_1	397	399	PF00082	0.600
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.518
CLV_PCSK_SKI1_1	137	141	PF00082	0.564
CLV_PCSK_SKI1_1	177	181	PF00082	0.614

Previous1 2 3 4 5…18Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	62%	100%
A0A0N1I756	Leptomonas seymouri	40%	100%
A0A0N1PEH4	Leptomonas seymouri	39%	100%
A0A0S4IRF5	Bodo saltans	23%	85%
A0A0S4IV77	Bodo saltans	35%	100%
A0A0S4JEA9	Bodo saltans	27%	100%
A0A0S4JJK3	Bodo saltans	26%	100%
A0A0S4JW09	Bodo saltans	30%	100%
A0A1X0NNY4	Trypanosomatidae	34%	100%
A0A1X0NQL4	Trypanosomatidae	30%	100%

Previous1 2 3 4 5Next