Cyclin-e binding protein 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cyclin-e binding protein 1-like protein

Species:

Leishmania major

UniProt:

Q4Q1G1_LEIMA

TriTrypDb:

LmjF.36.2600 , LMJLV39_360034300 , LMJSD75_360034300

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1G1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1G1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	136	140	PF00656	0.666
CLV_C14_Caspase3-7	19	23	PF00656	0.612
CLV_C14_Caspase3-7	224	228	PF00656	0.687
CLV_C14_Caspase3-7	26	30	PF00656	0.522
CLV_C14_Caspase3-7	408	412	PF00656	0.715
CLV_C14_Caspase3-7	592	596	PF00656	0.633
CLV_NRD_NRD_1	162	164	PF00675	0.622
CLV_PCSK_KEX2_1	162	164	PF00082	0.507
CLV_PCSK_KEX2_1	333	335	PF00082	0.549
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.532
CLV_PCSK_SKI1_1	241	245	PF00082	0.404
CLV_PCSK_SKI1_1	278	282	PF00082	0.523
CLV_PCSK_SKI1_1	287	291	PF00082	0.454
CLV_PCSK_SKI1_1	32	36	PF00082	0.654
CLV_PCSK_SKI1_1	489	493	PF00082	0.699
CLV_PCSK_SKI1_1	615	619	PF00082	0.701
DEG_Nend_Nbox_1	1	3	PF02207	0.606
DEG_SCF_TRCP1_1	411	417	PF00400	0.680
DEG_SPOP_SBC_1	220	224	PF00917	0.795
DEG_SPOP_SBC_1	669	673	PF00917	0.684
DOC_CYCLIN_RxL_1	287	296	PF00134	0.461
DOC_MAPK_gen_1	194	202	PF00069	0.685
DOC_MAPK_MEF2A_6	194	202	PF00069	0.746
DOC_MAPK_MEF2A_6	66	74	PF00069	0.566
DOC_PP1_RVXF_1	288	294	PF00149	0.469
DOC_PP2B_LxvP_1	158	161	PF13499	0.543
DOC_PP2B_LxvP_1	376	379	PF13499	0.680
DOC_PP2B_LxvP_1	390	393	PF13499	0.663
DOC_PP2B_LxvP_1	524	527	PF13499	0.702
DOC_USP7_MATH_1	103	107	PF00917	0.441
DOC_USP7_MATH_1	189	193	PF00917	0.698
DOC_USP7_MATH_1	204	208	PF00917	0.738
DOC_USP7_MATH_1	219	223	PF00917	0.607
DOC_USP7_MATH_1	379	383	PF00917	0.567
DOC_USP7_MATH_1	41	45	PF00917	0.601
DOC_USP7_MATH_1	431	435	PF00917	0.618
DOC_USP7_MATH_1	540	544	PF00917	0.744
DOC_USP7_MATH_1	635	639	PF00917	0.680
DOC_USP7_MATH_1	669	673	PF00917	0.606
DOC_USP7_MATH_1	693	697	PF00917	0.781
DOC_USP7_MATH_1	712	716	PF00917	0.711
DOC_USP7_MATH_1	82	86	PF00917	0.596
DOC_USP7_UBL2_3	346	350	PF12436	0.544
DOC_USP7_UBL2_3	611	615	PF12436	0.686
DOC_WW_Pin1_4	185	190	PF00397	0.725
DOC_WW_Pin1_4	212	217	PF00397	0.674
DOC_WW_Pin1_4	35	40	PF00397	0.612
DOC_WW_Pin1_4	562	567	PF00397	0.665
DOC_WW_Pin1_4	576	581	PF00397	0.762
DOC_WW_Pin1_4	656	661	PF00397	0.688
DOC_WW_Pin1_4	678	683	PF00397	0.828
LIG_14-3-3_CanoR_1	334	338	PF00244	0.554
LIG_14-3-3_CanoR_1	597	606	PF00244	0.717
LIG_APCC_ABBA_1	31	36	PF00400	0.644
LIG_BIR_III_2	36	40	PF00653	0.524
LIG_CaM_NSCaTE_8	506	513	PF13499	0.509
LIG_Clathr_ClatBox_1	292	296	PF01394	0.493
LIG_eIF4E_1	628	634	PF01652	0.634
LIG_FHA_1	251	257	PF00498	0.366
LIG_FHA_1	330	336	PF00498	0.582
LIG_FHA_1	338	344	PF00498	0.584
LIG_FHA_1	40	46	PF00498	0.694
LIG_FHA_1	464	470	PF00498	0.739
LIG_FHA_1	519	525	PF00498	0.674
LIG_FHA_1	577	583	PF00498	0.782
LIG_FHA_1	628	634	PF00498	0.634
LIG_FHA_1	649	655	PF00498	0.685
LIG_FHA_1	696	702	PF00498	0.797
LIG_FHA_2	403	409	PF00498	0.734
LIG_FHA_2	446	452	PF00498	0.550
LIG_LIR_Apic_2	347	352	PF02991	0.545
LIG_LIR_Gen_1	307	316	PF02991	0.376
LIG_LIR_Gen_1	446	455	PF02991	0.564
LIG_LIR_Gen_1	715	720	PF02991	0.623
LIG_LIR_Nem_3	123	129	PF02991	0.399
LIG_LIR_Nem_3	231	235	PF02991	0.789
LIG_LIR_Nem_3	284	289	PF02991	0.442
LIG_LIR_Nem_3	307	311	PF02991	0.376
LIG_LIR_Nem_3	384	390	PF02991	0.562
LIG_LIR_Nem_3	446	450	PF02991	0.536
LIG_LIR_Nem_3	715	719	PF02991	0.618
LIG_SH2_CRK	110	114	PF00017	0.493
LIG_SH2_CRK	126	130	PF00017	0.354
LIG_SH2_CRK	349	353	PF00017	0.549
LIG_SH2_CRK	373	377	PF00017	0.738
LIG_SH2_CRK	442	446	PF00017	0.633
LIG_SH2_CRK	61	65	PF00017	0.485
LIG_SH2_GRB2like	122	125	PF00017	0.376
LIG_SH2_NCK_1	18	22	PF00017	0.480
LIG_SH2_PTP2	716	719	PF00017	0.689
LIG_SH2_STAP1	122	126	PF00017	0.430
LIG_SH2_STAP1	61	65	PF00017	0.485
LIG_SH2_STAT3	499	502	PF00017	0.743
LIG_SH2_STAT5	110	113	PF00017	0.430
LIG_SH2_STAT5	442	445	PF00017	0.555
LIG_SH2_STAT5	49	52	PF00017	0.531
LIG_SH2_STAT5	499	502	PF00017	0.743
LIG_SH2_STAT5	716	719	PF00017	0.689
LIG_SH3_3	150	156	PF00018	0.592
LIG_SH3_3	232	238	PF00018	0.653
LIG_SH3_3	332	338	PF00018	0.499
LIG_SH3_3	497	503	PF00018	0.751
LIG_SH3_3	551	557	PF00018	0.731
LIG_SUMO_SIM_anti_2	67	75	PF11976	0.509
LIG_SUMO_SIM_par_1	252	257	PF11976	0.376
LIG_SUMO_SIM_par_1	277	285	PF11976	0.507
LIG_SUMO_SIM_par_1	351	356	PF11976	0.548
LIG_SUMO_SIM_par_1	661	666	PF11976	0.686
LIG_SUMO_SIM_par_1	67	75	PF11976	0.499
LIG_TYR_ITIM	108	113	PF00017	0.424
LIG_UBA3_1	45	53	PF00899	0.540
MOD_CK1_1	116	122	PF00069	0.361
MOD_CK1_1	133	139	PF00069	0.565
MOD_CK1_1	183	189	PF00069	0.628
MOD_CK1_1	208	214	PF00069	0.660
MOD_CK1_1	222	228	PF00069	0.671
MOD_CK1_1	23	29	PF00069	0.444
MOD_CK1_1	336	342	PF00069	0.553
MOD_CK1_1	382	388	PF00069	0.577
MOD_CK1_1	432	438	PF00069	0.598
MOD_CK1_1	576	582	PF00069	0.716
MOD_CK1_1	596	602	PF00069	0.697
MOD_CK1_1	692	698	PF00069	0.697
MOD_CK2_1	445	451	PF00069	0.556
MOD_CK2_1	86	92	PF00069	0.505
MOD_GlcNHglycan	113	116	PF01048	0.385
MOD_GlcNHglycan	158	161	PF01048	0.614
MOD_GlcNHglycan	22	25	PF01048	0.640
MOD_GlcNHglycan	227	230	PF01048	0.746
MOD_GlcNHglycan	258	261	PF01048	0.478
MOD_GlcNHglycan	411	414	PF01048	0.760
MOD_GlcNHglycan	538	541	PF01048	0.698
MOD_GlcNHglycan	61	64	PF01048	0.436
MOD_GlcNHglycan	625	628	PF01048	0.720
MOD_GlcNHglycan	637	640	PF01048	0.708
MOD_GlcNHglycan	656	659	PF01048	0.675
MOD_GlcNHglycan	672	675	PF01048	0.739
MOD_GlcNHglycan	691	694	PF01048	0.751
MOD_GlcNHglycan	695	698	PF01048	0.718
MOD_GlcNHglycan	84	87	PF01048	0.628
MOD_GlcNHglycan	92	95	PF01048	0.524
MOD_GSK3_1	109	116	PF00069	0.304
MOD_GSK3_1	130	137	PF00069	0.517
MOD_GSK3_1	16	23	PF00069	0.581
MOD_GSK3_1	179	186	PF00069	0.731
MOD_GSK3_1	204	211	PF00069	0.658
MOD_GSK3_1	221	228	PF00069	0.637
MOD_GSK3_1	250	257	PF00069	0.353
MOD_GSK3_1	329	336	PF00069	0.559
MOD_GSK3_1	35	42	PF00069	0.553
MOD_GSK3_1	379	386	PF00069	0.603
MOD_GSK3_1	445	452	PF00069	0.489
MOD_GSK3_1	506	513	PF00069	0.685
MOD_GSK3_1	536	543	PF00069	0.714
MOD_GSK3_1	572	579	PF00069	0.644
MOD_GSK3_1	589	596	PF00069	0.667
MOD_GSK3_1	623	630	PF00069	0.650
MOD_GSK3_1	689	696	PF00069	0.700
MOD_GSK3_1	82	89	PF00069	0.598
MOD_LATS_1	331	337	PF00433	0.564
MOD_N-GLC_1	432	437	PF02516	0.619
MOD_N-GLC_1	703	708	PF02516	0.695
MOD_N-GLC_2	322	324	PF02516	0.376
MOD_NEK2_1	20	25	PF00069	0.543
MOD_NEK2_1	254	259	PF00069	0.376
MOD_NEK2_1	274	279	PF00069	0.303
MOD_NEK2_1	281	286	PF00069	0.430
MOD_NEK2_1	329	334	PF00069	0.569
MOD_NEK2_1	429	434	PF00069	0.707
MOD_NEK2_1	449	454	PF00069	0.406
MOD_NEK2_1	510	515	PF00069	0.520
MOD_NEK2_1	604	609	PF00069	0.668
MOD_NEK2_1	654	659	PF00069	0.637
MOD_NEK2_1	72	77	PF00069	0.478
MOD_NEK2_2	189	194	PF00069	0.706
MOD_NEK2_2	372	377	PF00069	0.695
MOD_NEK2_2	506	511	PF00069	0.639
MOD_OFUCOSY	571	578	PF10250	0.550
MOD_PIKK_1	254	260	PF00454	0.385
MOD_PKA_1	333	339	PF00069	0.500
MOD_PKA_2	333	339	PF00069	0.562
MOD_PKA_2	409	415	PF00069	0.769
MOD_PKA_2	596	602	PF00069	0.775
MOD_PKA_2	604	610	PF00069	0.630
MOD_PKA_2	620	626	PF00069	0.501
MOD_Plk_1	122	128	PF00069	0.417
MOD_Plk_1	383	389	PF00069	0.612
MOD_Plk_1	432	438	PF00069	0.604
MOD_Plk_4	113	119	PF00069	0.345
MOD_Plk_4	130	136	PF00069	0.506
MOD_Plk_4	250	256	PF00069	0.362
MOD_Plk_4	304	310	PF00069	0.423
MOD_Plk_4	383	389	PF00069	0.590
MOD_Plk_4	41	47	PF00069	0.650
MOD_Plk_4	506	512	PF00069	0.575
MOD_Plk_4	620	626	PF00069	0.768
MOD_Plk_4	628	634	PF00069	0.585
MOD_Plk_4	649	655	PF00069	0.706
MOD_Plk_4	696	702	PF00069	0.722
MOD_Plk_4	712	718	PF00069	0.702
MOD_Plk_4	86	92	PF00069	0.496
MOD_ProDKin_1	185	191	PF00069	0.723
MOD_ProDKin_1	212	218	PF00069	0.676
MOD_ProDKin_1	35	41	PF00069	0.618
MOD_ProDKin_1	562	568	PF00069	0.664
MOD_ProDKin_1	576	582	PF00069	0.763
MOD_ProDKin_1	656	662	PF00069	0.688
MOD_ProDKin_1	678	684	PF00069	0.828
MOD_SUMO_rev_2	347	352	PF00179	0.545
TRG_DiLeu_BaLyEn_6	487	492	PF01217	0.671
TRG_ENDOCYTIC_2	110	113	PF00928	0.493
TRG_ENDOCYTIC_2	126	129	PF00928	0.354
TRG_ENDOCYTIC_2	373	376	PF00928	0.657
TRG_ENDOCYTIC_2	387	390	PF00928	0.467
TRG_ENDOCYTIC_2	442	445	PF00928	0.560
TRG_ENDOCYTIC_2	61	64	PF00928	0.435
TRG_ENDOCYTIC_2	716	719	PF00928	0.618
TRG_ER_diArg_1	161	163	PF00400	0.619
TRG_ER_diArg_1	618	621	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB4	Leptomonas seymouri	44%	100%
A0A3S7XAY5	Leishmania donovani	92%	100%
A4HPC6	Leishmania braziliensis	72%	100%
A4ICG6	Leishmania infantum	92%	100%
E9AT37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BPT3	Trypanosoma cruzi	34%	100%