Excreted/secreted protein 20.2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

methyltransferase domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4Q1F6_LEIMA

TriTrypDb:

LmjF.36.2650 , LMJLV39_360035000 , LMJSD75_360034900

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1F6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1F6

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	11
GO:0002098	tRNA wobble uridine modification	8	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006399	tRNA metabolic process	7	11
GO:0006400	tRNA modification	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008033	tRNA processing	8	11
GO:0008152	metabolic process	1	11
GO:0009451	RNA modification	5	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034470	ncRNA processing	7	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034660	ncRNA metabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	2
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	2
GO:0008168	methyltransferase activity	4	11
GO:0008173	RNA methyltransferase activity	4	11
GO:0008175	tRNA methyltransferase activity	5	11
GO:0016300	tRNA (uracil) methyltransferase activity	6	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0097159	organic cyclic compound binding	2	2
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.681
CLV_C14_Caspase3-7	270	274	PF00656	0.501
CLV_NRD_NRD_1	171	173	PF00675	0.419
CLV_NRD_NRD_1	232	234	PF00675	0.448
CLV_NRD_NRD_1	292	294	PF00675	0.255
CLV_NRD_NRD_1	323	325	PF00675	0.509
CLV_PCSK_FUR_1	169	173	PF00082	0.392
CLV_PCSK_FUR_1	229	233	PF00082	0.305
CLV_PCSK_KEX2_1	169	171	PF00082	0.400
CLV_PCSK_KEX2_1	176	178	PF00082	0.339
CLV_PCSK_KEX2_1	231	233	PF00082	0.284
CLV_PCSK_KEX2_1	264	266	PF00082	0.443
CLV_PCSK_KEX2_1	292	294	PF00082	0.226
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.367
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.426
CLV_PCSK_PC7_1	172	178	PF00082	0.262
CLV_PCSK_PC7_1	260	266	PF00082	0.483
CLV_PCSK_SKI1_1	140	144	PF00082	0.362
CLV_PCSK_SKI1_1	176	180	PF00082	0.461
CLV_PCSK_SKI1_1	237	241	PF00082	0.269
CLV_PCSK_SKI1_1	99	103	PF00082	0.559
CLV_Separin_Metazoa	150	154	PF03568	0.374
CLV_Separin_Metazoa	193	197	PF03568	0.262
CLV_Separin_Metazoa	238	242	PF03568	0.255
DEG_APCC_KENBOX_2	329	333	PF00400	0.283
DEG_SPOP_SBC_1	108	112	PF00917	0.563
DOC_CKS1_1	185	190	PF01111	0.341
DOC_MAPK_gen_1	229	236	PF00069	0.305
DOC_PP2B_LxvP_1	102	105	PF13499	0.444
DOC_PP4_FxxP_1	33	36	PF00568	0.454
DOC_USP7_MATH_1	131	135	PF00917	0.528
DOC_USP7_MATH_1	208	212	PF00917	0.312
DOC_WW_Pin1_4	126	131	PF00397	0.496
DOC_WW_Pin1_4	184	189	PF00397	0.345
DOC_WW_Pin1_4	8	13	PF00397	0.707
LIG_14-3-3_CanoR_1	153	160	PF00244	0.429
LIG_14-3-3_CanoR_1	324	328	PF00244	0.397
LIG_14-3-3_CanoR_1	99	105	PF00244	0.560
LIG_Actin_WH2_2	138	155	PF00022	0.259
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_BRCT_BRCA1_1	210	214	PF00533	0.296
LIG_EVH1_1	33	37	PF00568	0.425
LIG_FHA_1	195	201	PF00498	0.259
LIG_FHA_1	261	267	PF00498	0.475
LIG_FHA_1	314	320	PF00498	0.414
LIG_FHA_2	23	29	PF00498	0.598
LIG_LIR_Gen_1	331	337	PF02991	0.266
LIG_PDZ_Class_3	335	340	PF00595	0.342
LIG_RPA_C_Fungi	166	178	PF08784	0.240
LIG_SH2_CRK	52	56	PF00017	0.347
LIG_SH2_NCK_1	52	56	PF00017	0.297
LIG_SH2_STAP1	147	151	PF00017	0.374
LIG_SH2_STAP1	52	56	PF00017	0.303
LIG_SH2_STAT5	141	144	PF00017	0.259
LIG_SH2_STAT5	253	256	PF00017	0.364
LIG_SH2_STAT5	93	96	PF00017	0.355
LIG_SH3_3	102	108	PF00018	0.596
LIG_SH3_3	125	131	PF00018	0.541
LIG_SH3_3	182	188	PF00018	0.310
LIG_SH3_3	28	34	PF00018	0.546
LIG_SUMO_SIM_anti_2	219	224	PF11976	0.286
LIG_TRAF2_1	190	193	PF00917	0.262
LIG_TRFH_1	33	37	PF08558	0.425
LIG_WRC_WIRS_1	132	137	PF05994	0.468
MOD_CDK_SPxxK_3	8	15	PF00069	0.580
MOD_CK1_1	112	118	PF00069	0.692
MOD_CK2_1	187	193	PF00069	0.249
MOD_Cter_Amidation	174	177	PF01082	0.262
MOD_GlcNHglycan	1	4	PF01048	0.669
MOD_GlcNHglycan	111	114	PF01048	0.556
MOD_GlcNHglycan	173	176	PF01048	0.461
MOD_GlcNHglycan	189	192	PF01048	0.119
MOD_GlcNHglycan	210	213	PF01048	0.296
MOD_GlcNHglycan	52	55	PF01048	0.418
MOD_GlcNHglycan	94	97	PF01048	0.486
MOD_GSK3_1	103	110	PF00069	0.675
MOD_GSK3_1	309	316	PF00069	0.424
MOD_N-GLC_2	332	334	PF02516	0.257
MOD_NEK2_1	100	105	PF00069	0.493
MOD_NEK2_1	109	114	PF00069	0.552
MOD_NEK2_1	151	156	PF00069	0.357
MOD_NEK2_1	59	64	PF00069	0.396
MOD_PIKK_1	152	158	PF00454	0.374
MOD_PKA_1	171	177	PF00069	0.412
MOD_PKA_2	152	158	PF00069	0.429
MOD_PKA_2	171	177	PF00069	0.284
MOD_PKA_2	323	329	PF00069	0.317
MOD_PKB_1	169	177	PF00069	0.412
MOD_Plk_2-3	22	28	PF00069	0.694
MOD_Plk_2-3	309	315	PF00069	0.401
MOD_Plk_4	323	329	PF00069	0.359
MOD_ProDKin_1	126	132	PF00069	0.494
MOD_ProDKin_1	184	190	PF00069	0.345
MOD_ProDKin_1	8	14	PF00069	0.706
MOD_SUMO_for_1	178	181	PF00179	0.262
MOD_SUMO_rev_2	10	17	PF00179	0.519
MOD_SUMO_rev_2	112	120	PF00179	0.554
TRG_ENDOCYTIC_2	294	297	PF00928	0.272
TRG_ENDOCYTIC_2	52	55	PF00928	0.333
TRG_ER_diArg_1	169	172	PF00400	0.305
TRG_ER_diArg_1	231	233	PF00400	0.287
TRG_ER_diArg_1	291	293	PF00400	0.263
TRG_NLS_MonoExtC_3	14	20	PF00514	0.662
TRG_NLS_MonoExtC_3	175	181	PF00514	0.354
TRG_NLS_MonoExtN_4	12	19	PF00514	0.653
TRG_Pf-PMV_PEXEL_1	157	161	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I4	Leptomonas seymouri	64%	100%
A0A1X0NKG3	Trypanosomatidae	44%	100%
A0A3S7XB23	Leishmania donovani	94%	100%
A0A422ND22	Trypanosoma rangeli	39%	100%
A4HPD1	Leishmania braziliensis	82%	100%
A4ICH1	Leishmania infantum	94%	100%
C4V9L5	Nosema ceranae (strain BRL01)	30%	100%
D0A3J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AT42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DGL8	Trypanosoma cruzi	44%	100%