Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1F4_LEIMA

TriTrypDb:

LmjF.36.2670 , LMJLV39_360035500 , LMJSD75_360035400

Length:

481

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1F4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1F4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	282	284	PF00675	0.574
CLV_NRD_NRD_1	404	406	PF00675	0.373
CLV_NRD_NRD_1	427	429	PF00675	0.499
CLV_NRD_NRD_1	66	68	PF00675	0.452
CLV_PCSK_KEX2_1	282	284	PF00082	0.574
CLV_PCSK_KEX2_1	330	332	PF00082	0.515
CLV_PCSK_KEX2_1	404	406	PF00082	0.373
CLV_PCSK_KEX2_1	66	68	PF00082	0.452
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.395
CLV_PCSK_SKI1_1	16	20	PF00082	0.396
CLV_PCSK_SKI1_1	238	242	PF00082	0.472
CLV_PCSK_SKI1_1	282	286	PF00082	0.367
CLV_PCSK_SKI1_1	331	335	PF00082	0.410
CLV_PCSK_SKI1_1	404	408	PF00082	0.365
CLV_PCSK_SKI1_1	432	436	PF00082	0.607
CLV_PCSK_SKI1_1	71	75	PF00082	0.491
DOC_CDC14_PxL_1	127	135	PF14671	0.409
DOC_CDC14_PxL_1	448	456	PF14671	0.496
DOC_CYCLIN_yCln2_LP_2	182	188	PF00134	0.403
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.353
DOC_CYCLIN_yCln2_LP_2	471	474	PF00134	0.405
DOC_MAPK_gen_1	238	247	PF00069	0.309
DOC_MAPK_MEF2A_6	11	19	PF00069	0.385
DOC_MAPK_MEF2A_6	196	205	PF00069	0.367
DOC_MAPK_MEF2A_6	238	247	PF00069	0.309
DOC_MAPK_MEF2A_6	282	291	PF00069	0.352
DOC_PP2B_LxvP_1	284	287	PF13499	0.337
DOC_PP2B_LxvP_1	42	45	PF13499	0.421
DOC_PP2B_LxvP_1	421	424	PF13499	0.445
DOC_PP2B_LxvP_1	471	474	PF13499	0.405
DOC_PP4_FxxP_1	174	177	PF00568	0.533
DOC_USP7_MATH_1	168	172	PF00917	0.572
DOC_USP7_MATH_1	197	201	PF00917	0.550
DOC_USP7_MATH_1	24	28	PF00917	0.413
DOC_USP7_MATH_1	274	278	PF00917	0.399
DOC_USP7_MATH_1	357	361	PF00917	0.522
DOC_USP7_MATH_1	385	389	PF00917	0.511
DOC_USP7_MATH_1	78	82	PF00917	0.403
DOC_USP7_UBL2_3	326	330	PF12436	0.541
DOC_WW_Pin1_4	163	168	PF00397	0.654
DOC_WW_Pin1_4	25	30	PF00397	0.409
DOC_WW_Pin1_4	305	310	PF00397	0.357
DOC_WW_Pin1_4	315	320	PF00397	0.492
DOC_WW_Pin1_4	363	368	PF00397	0.483
DOC_WW_Pin1_4	376	381	PF00397	0.355
LIG_14-3-3_CanoR_1	101	107	PF00244	0.395
LIG_14-3-3_CanoR_1	144	148	PF00244	0.599
LIG_14-3-3_CanoR_1	351	358	PF00244	0.576
LIG_14-3-3_CanoR_1	384	390	PF00244	0.529
LIG_14-3-3_CanoR_1	428	432	PF00244	0.469
LIG_14-3-3_CanoR_1	71	79	PF00244	0.479
LIG_Actin_WH2_2	1	18	PF00022	0.385
LIG_Actin_WH2_2	186	204	PF00022	0.382
LIG_BRCT_BRCA1_1	104	108	PF00533	0.390
LIG_BRCT_BRCA1_1	170	174	PF00533	0.539
LIG_BRCT_BRCA1_1	247	251	PF00533	0.376
LIG_Clathr_ClatBox_1	83	87	PF01394	0.390
LIG_EH1_1	258	266	PF00400	0.357
LIG_FHA_1	135	141	PF00498	0.610
LIG_FHA_1	177	183	PF00498	0.513
LIG_FHA_1	276	282	PF00498	0.447
LIG_LIR_Apic_2	171	177	PF02991	0.552
LIG_LIR_Gen_1	102	111	PF02991	0.389
LIG_LIR_Gen_1	2	10	PF02991	0.384
LIG_LIR_Gen_1	39	49	PF02991	0.418
LIG_LIR_LC3C_4	372	376	PF02991	0.402
LIG_LIR_Nem_3	102	106	PF02991	0.384
LIG_LIR_Nem_3	125	130	PF02991	0.347
LIG_LIR_Nem_3	2	6	PF02991	0.395
LIG_PDZ_Class_2	476	481	PF00595	0.358
LIG_Pex14_2	108	112	PF04695	0.398
LIG_Pex14_2	247	251	PF04695	0.398
LIG_SH2_CRK	103	107	PF00017	0.384
LIG_SH2_CRK	127	131	PF00017	0.369
LIG_SH2_CRK	306	310	PF00017	0.360
LIG_SH2_NCK_1	188	192	PF00017	0.396
LIG_SH2_SRC	188	191	PF00017	0.417
LIG_SH2_STAP1	188	192	PF00017	0.329
LIG_SH2_STAP1	397	401	PF00017	0.457
LIG_SH2_STAT3	397	400	PF00017	0.401
LIG_SH2_STAT5	129	132	PF00017	0.402
LIG_SH2_STAT5	290	293	PF00017	0.339
LIG_SH2_STAT5	91	94	PF00017	0.384
LIG_SH3_2	165	170	PF14604	0.597
LIG_SH3_3	162	168	PF00018	0.605
LIG_SH3_3	191	197	PF00018	0.427
LIG_SH3_3	294	300	PF00018	0.405
LIG_SH3_3	364	370	PF00018	0.388
LIG_SH3_3	377	383	PF00018	0.507
LIG_SH3_3	449	455	PF00018	0.473
LIG_SH3_3	467	473	PF00018	0.450
LIG_SUMO_SIM_anti_2	30	35	PF11976	0.396
LIG_SUMO_SIM_anti_2	372	377	PF11976	0.434
LIG_SUMO_SIM_anti_2	4	9	PF11976	0.378
LIG_SUMO_SIM_par_1	202	209	PF11976	0.353
LIG_SUMO_SIM_par_1	475	480	PF11976	0.346
LIG_SUMO_SIM_par_1	80	87	PF11976	0.392
LIG_WRC_WIRS_1	38	43	PF05994	0.397
MOD_CDK_SPK_2	305	310	PF00069	0.357
MOD_CDK_SPxxK_3	163	170	PF00069	0.597
MOD_CK1_1	102	108	PF00069	0.386
MOD_CK1_1	142	148	PF00069	0.616
MOD_CK1_1	178	184	PF00069	0.509
MOD_CK1_1	27	33	PF00069	0.404
MOD_CK1_1	308	314	PF00069	0.434
MOD_CK1_1	315	321	PF00069	0.525
MOD_CK1_1	347	353	PF00069	0.611
MOD_CK1_1	37	43	PF00069	0.390
MOD_CK2_1	156	162	PF00069	0.595
MOD_CK2_1	17	23	PF00069	0.405
MOD_CK2_1	357	363	PF00069	0.454
MOD_CK2_1	385	391	PF00069	0.530
MOD_Cter_Amidation	324	327	PF01082	0.417
MOD_GlcNHglycan	170	173	PF01048	0.587
MOD_GlcNHglycan	246	250	PF01048	0.346
MOD_GlcNHglycan	253	256	PF01048	0.411
MOD_GlcNHglycan	335	338	PF01048	0.517
MOD_GSK3_1	139	146	PF00069	0.725
MOD_GSK3_1	147	154	PF00069	0.644
MOD_GSK3_1	245	252	PF00069	0.417
MOD_GSK3_1	308	315	PF00069	0.451
MOD_GSK3_1	347	354	PF00069	0.628
MOD_GSK3_1	36	43	PF00069	0.397
MOD_NEK2_1	151	156	PF00069	0.615
MOD_NEK2_1	251	256	PF00069	0.522
MOD_NEK2_1	36	41	PF00069	0.392
MOD_NEK2_1	90	95	PF00069	0.426
MOD_NEK2_2	197	202	PF00069	0.367
MOD_OFUCOSY	70	75	PF10250	0.449
MOD_PK_1	214	220	PF00069	0.435
MOD_PKA_2	134	140	PF00069	0.559
MOD_PKA_2	143	149	PF00069	0.636
MOD_PKA_2	350	356	PF00069	0.598
MOD_PKA_2	427	433	PF00069	0.464
MOD_PKB_1	212	220	PF00069	0.427
MOD_Plk_1	214	220	PF00069	0.466
MOD_Plk_1	245	251	PF00069	0.395
MOD_Plk_1	292	298	PF00069	0.334
MOD_Plk_4	151	157	PF00069	0.571
MOD_Plk_4	292	298	PF00069	0.476
MOD_Plk_4	37	43	PF00069	0.396
MOD_Plk_4	472	478	PF00069	0.471
MOD_Plk_4	78	84	PF00069	0.401
MOD_ProDKin_1	163	169	PF00069	0.655
MOD_ProDKin_1	25	31	PF00069	0.409
MOD_ProDKin_1	305	311	PF00069	0.360
MOD_ProDKin_1	315	321	PF00069	0.488
MOD_ProDKin_1	363	369	PF00069	0.479
MOD_ProDKin_1	376	382	PF00069	0.362
TRG_DiLeu_BaEn_2	231	237	PF01217	0.505
TRG_ENDOCYTIC_2	103	106	PF00928	0.384
TRG_ENDOCYTIC_2	127	130	PF00928	0.352
TRG_ER_diArg_1	281	283	PF00400	0.442
TRG_ER_diArg_1	358	361	PF00400	0.419
TRG_ER_diArg_1	403	405	PF00400	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I7	Leptomonas seymouri	59%	100%
A0A3Q8IW24	Leishmania donovani	93%	100%
A4HPD3	Leishmania braziliensis	80%	100%
A4ICH3	Leishmania infantum	93%	100%
E9AT44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%