Centrosomal protein POC5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1F1_LEIMA

TriTrypDb:

LmjF.36.2690 , LMJLV39_360035800 , LMJSD75_360035700

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0005813	centrosome	3	2
GO:0005814	centriole	5	9
GO:0005815	microtubule organizing center	2	2
GO:0043226	organelle	2	9
GO:0043228	non-membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043232	intracellular non-membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4Q1F1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1F1

Function

Biological processes
Term	Name	Level	Count
GO:0007049	cell cycle	2	9
GO:0009987	cellular process	1	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.556
CLV_NRD_NRD_1	110	112	PF00675	0.424
CLV_NRD_NRD_1	120	122	PF00675	0.419
CLV_NRD_NRD_1	41	43	PF00675	0.473
CLV_NRD_NRD_1	62	64	PF00675	0.463
CLV_PCSK_FUR_1	150	154	PF00082	0.440
CLV_PCSK_KEX2_1	110	112	PF00082	0.438
CLV_PCSK_KEX2_1	119	121	PF00082	0.462
CLV_PCSK_KEX2_1	152	154	PF00082	0.459
CLV_PCSK_KEX2_1	161	163	PF00082	0.449
CLV_PCSK_KEX2_1	40	42	PF00082	0.488
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.545
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.486
CLV_PCSK_PC7_1	116	122	PF00082	0.596
CLV_PCSK_SKI1_1	195	199	PF00082	0.478
CLV_PCSK_SKI1_1	240	244	PF00082	0.622
DOC_MAPK_gen_1	78	86	PF00069	0.473
DOC_MAPK_MEF2A_6	26	35	PF00069	0.489
DOC_PP4_FxxP_1	272	275	PF00568	0.587
DOC_USP7_MATH_1	268	272	PF00917	0.428
DOC_USP7_MATH_1	293	297	PF00917	0.689
DOC_USP7_MATH_1	300	304	PF00917	0.591
DOC_USP7_UBL2_3	157	161	PF12436	0.506
DOC_WW_Pin1_4	240	245	PF00397	0.620
DOC_WW_Pin1_4	275	280	PF00397	0.563
DOC_WW_Pin1_4	318	323	PF00397	0.617
LIG_14-3-3_CanoR_1	104	110	PF00244	0.506
LIG_14-3-3_CanoR_1	132	136	PF00244	0.563
LIG_14-3-3_CanoR_1	238	243	PF00244	0.641
LIG_14-3-3_CanoR_1	291	300	PF00244	0.666
LIG_APCC_ABBA_1	57	62	PF00400	0.331
LIG_BIR_III_4	267	271	PF00653	0.498
LIG_BRCT_BRCA1_1	302	306	PF00533	0.633
LIG_eIF4E_1	139	145	PF01652	0.374
LIG_EVH1_2	322	326	PF00568	0.707
LIG_FHA_1	41	47	PF00498	0.439
LIG_LIR_Apic_2	271	275	PF02991	0.398
LIG_LIR_Nem_3	134	139	PF02991	0.399
LIG_LIR_Nem_3	278	284	PF02991	0.456
LIG_SH2_STAT3	176	179	PF00017	0.505
LIG_SH2_STAT5	281	284	PF00017	0.534
LIG_SH2_STAT5	38	41	PF00017	0.440
LIG_SH3_2	322	327	PF14604	0.649
LIG_SH3_3	319	325	PF00018	0.640
LIG_SUMO_SIM_anti_2	29	37	PF11976	0.482
LIG_TRAF2_1	73	76	PF00917	0.496
MOD_CK1_1	232	238	PF00069	0.693
MOD_CK1_1	250	256	PF00069	0.647
MOD_CK1_1	314	320	PF00069	0.731
MOD_CK1_1	330	336	PF00069	0.428
MOD_CK2_1	186	192	PF00069	0.457
MOD_DYRK1A_RPxSP_1	240	244	PF00069	0.622
MOD_GlcNHglycan	287	290	PF01048	0.651
MOD_GlcNHglycan	295	298	PF01048	0.755
MOD_GlcNHglycan	300	303	PF01048	0.681
MOD_GlcNHglycan	308	311	PF01048	0.485
MOD_GlcNHglycan	313	316	PF01048	0.476
MOD_GSK3_1	234	241	PF00069	0.580
MOD_GSK3_1	246	253	PF00069	0.560
MOD_GSK3_1	314	321	PF00069	0.664
MOD_GSK3_1	327	334	PF00069	0.630
MOD_LATS_1	236	242	PF00433	0.610
MOD_NEK2_1	105	110	PF00069	0.569
MOD_NEK2_1	247	252	PF00069	0.723
MOD_NEK2_1	329	334	PF00069	0.720
MOD_NEK2_2	131	136	PF00069	0.339
MOD_NEK2_2	268	273	PF00069	0.421
MOD_PIKK_1	40	46	PF00454	0.438
MOD_PK_1	238	244	PF00069	0.681
MOD_PKA_1	40	46	PF00069	0.438
MOD_PKA_2	131	137	PF00069	0.580
MOD_PKA_2	232	238	PF00069	0.596
MOD_PKA_2	285	291	PF00069	0.546
MOD_PKA_2	40	46	PF00069	0.513
MOD_Plk_1	186	192	PF00069	0.457
MOD_Plk_1	247	253	PF00069	0.666
MOD_Plk_1	8	14	PF00069	0.510
MOD_Plk_4	131	137	PF00069	0.338
MOD_Plk_4	268	274	PF00069	0.416
MOD_Plk_4	8	14	PF00069	0.552
MOD_ProDKin_1	240	246	PF00069	0.619
MOD_ProDKin_1	275	281	PF00069	0.570
MOD_ProDKin_1	318	324	PF00069	0.618
MOD_SUMO_for_1	4	7	PF00179	0.616
MOD_SUMO_for_1	50	53	PF00179	0.500
MOD_SUMO_rev_2	309	315	PF00179	0.412
TRG_ER_diArg_1	109	111	PF00400	0.471
TRG_ER_diArg_1	119	121	PF00400	0.425
TRG_ER_diArg_1	39	42	PF00400	0.506
TRG_NES_CRM1_1	92	103	PF08389	0.426
TRG_NLS_Bipartite_1	63	85	PF00514	0.492
TRG_NLS_MonoExtN_4	78	85	PF00514	0.437
TRG_Pf-PMV_PEXEL_1	120	124	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	178	183	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2V9	Leptomonas seymouri	49%	99%
A0A3Q8IKC6	Leishmania donovani	95%	100%
A4HPD7	Leishmania braziliensis	80%	100%
A4ICH6	Leishmania infantum	95%	100%
D0A3J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	93%
E9AT47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BK99	Trypanosoma cruzi	28%	90%