Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1E3_LEIMA

TriTrypDb:

LmjF.36.2770 , LMJLV39_360036700 , LMJSD75_360036600

Length:

746

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1E3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.741
CLV_C14_Caspase3-7	494	498	PF00656	0.616
CLV_C14_Caspase3-7	615	619	PF00656	0.473
CLV_NRD_NRD_1	119	121	PF00675	0.566
CLV_NRD_NRD_1	129	131	PF00675	0.645
CLV_NRD_NRD_1	136	138	PF00675	0.575
CLV_NRD_NRD_1	166	168	PF00675	0.749
CLV_NRD_NRD_1	178	180	PF00675	0.627
CLV_NRD_NRD_1	181	183	PF00675	0.597
CLV_NRD_NRD_1	20	22	PF00675	0.682
CLV_NRD_NRD_1	224	226	PF00675	0.710
CLV_NRD_NRD_1	250	252	PF00675	0.645
CLV_NRD_NRD_1	298	300	PF00675	0.742
CLV_NRD_NRD_1	317	319	PF00675	0.602
CLV_NRD_NRD_1	338	340	PF00675	0.701
CLV_NRD_NRD_1	356	358	PF00675	0.534
CLV_NRD_NRD_1	43	45	PF00675	0.640
CLV_NRD_NRD_1	430	432	PF00675	0.734
CLV_NRD_NRD_1	491	493	PF00675	0.654
CLV_NRD_NRD_1	516	518	PF00675	0.682
CLV_NRD_NRD_1	61	63	PF00675	0.628
CLV_NRD_NRD_1	700	702	PF00675	0.478
CLV_NRD_NRD_1	90	92	PF00675	0.753
CLV_NRD_NRD_1	99	101	PF00675	0.660
CLV_PCSK_FUR_1	179	183	PF00082	0.702
CLV_PCSK_FUR_1	296	300	PF00082	0.702
CLV_PCSK_KEX2_1	119	121	PF00082	0.748
CLV_PCSK_KEX2_1	128	130	PF00082	0.659
CLV_PCSK_KEX2_1	135	137	PF00082	0.595
CLV_PCSK_KEX2_1	161	163	PF00082	0.738
CLV_PCSK_KEX2_1	166	168	PF00082	0.710
CLV_PCSK_KEX2_1	178	180	PF00082	0.588
CLV_PCSK_KEX2_1	181	183	PF00082	0.558
CLV_PCSK_KEX2_1	19	21	PF00082	0.689
CLV_PCSK_KEX2_1	224	226	PF00082	0.710
CLV_PCSK_KEX2_1	250	252	PF00082	0.669
CLV_PCSK_KEX2_1	289	291	PF00082	0.733
CLV_PCSK_KEX2_1	298	300	PF00082	0.671
CLV_PCSK_KEX2_1	317	319	PF00082	0.602
CLV_PCSK_KEX2_1	337	339	PF00082	0.545
CLV_PCSK_KEX2_1	356	358	PF00082	0.530
CLV_PCSK_KEX2_1	43	45	PF00082	0.616
CLV_PCSK_KEX2_1	430	432	PF00082	0.734
CLV_PCSK_KEX2_1	516	518	PF00082	0.682
CLV_PCSK_KEX2_1	562	564	PF00082	0.762
CLV_PCSK_KEX2_1	700	702	PF00082	0.486
CLV_PCSK_KEX2_1	90	92	PF00082	0.753
CLV_PCSK_KEX2_1	98	100	PF00082	0.672
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.702
CLV_PCSK_PC1ET2_1	289	291	PF00082	0.700
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.723
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.731
CLV_PCSK_PC7_1	162	168	PF00082	0.693
CLV_PCSK_PC7_1	333	339	PF00082	0.671
CLV_PCSK_SKI1_1	290	294	PF00082	0.691
CLV_PCSK_SKI1_1	705	709	PF00082	0.504
CLV_PCSK_SKI1_1	711	715	PF00082	0.445
CLV_Separin_Metazoa	645	649	PF03568	0.366
DEG_APCC_DBOX_1	456	464	PF00400	0.540
DEG_APCC_DBOX_1	61	69	PF00400	0.684
DEG_SPOP_SBC_1	122	126	PF00917	0.617
DEG_SPOP_SBC_1	14	18	PF00917	0.707
DEG_SPOP_SBC_1	169	173	PF00917	0.740
DEG_SPOP_SBC_1	226	230	PF00917	0.691
DEG_SPOP_SBC_1	597	601	PF00917	0.541
DOC_ANK_TNKS_1	301	308	PF00023	0.592
DOC_CYCLIN_RxL_1	705	717	PF00134	0.417
DOC_MAPK_gen_1	277	286	PF00069	0.590
DOC_MAPK_gen_1	395	404	PF00069	0.677
DOC_PP4_FxxP_1	591	594	PF00568	0.588
DOC_USP7_MATH_1	121	125	PF00917	0.666
DOC_USP7_MATH_1	14	18	PF00917	0.707
DOC_USP7_MATH_1	165	169	PF00917	0.739
DOC_USP7_MATH_1	177	181	PF00917	0.616
DOC_USP7_MATH_1	209	213	PF00917	0.731
DOC_USP7_MATH_1	227	231	PF00917	0.555
DOC_USP7_MATH_1	294	298	PF00917	0.698
DOC_USP7_MATH_1	322	326	PF00917	0.666
DOC_USP7_MATH_1	387	391	PF00917	0.669
DOC_USP7_MATH_1	541	545	PF00917	0.724
DOC_USP7_MATH_1	597	601	PF00917	0.602
DOC_USP7_MATH_1	738	742	PF00917	0.600
DOC_USP7_UBL2_3	464	468	PF12436	0.601
DOC_WW_Pin1_4	123	128	PF00397	0.723
DOC_WW_Pin1_4	129	134	PF00397	0.692
DOC_WW_Pin1_4	161	166	PF00397	0.741
DOC_WW_Pin1_4	173	178	PF00397	0.611
DOC_WW_Pin1_4	194	199	PF00397	0.745
DOC_WW_Pin1_4	205	210	PF00397	0.626
DOC_WW_Pin1_4	215	220	PF00397	0.638
DOC_WW_Pin1_4	290	295	PF00397	0.710
DOC_WW_Pin1_4	312	317	PF00397	0.740
DOC_WW_Pin1_4	342	347	PF00397	0.721
DOC_WW_Pin1_4	425	430	PF00397	0.697
DOC_WW_Pin1_4	44	49	PF00397	0.686
DOC_WW_Pin1_4	440	445	PF00397	0.569
DOC_WW_Pin1_4	553	558	PF00397	0.726
DOC_WW_Pin1_4	582	587	PF00397	0.636
DOC_WW_Pin1_4	99	104	PF00397	0.698
LIG_14-3-3_CanoR_1	128	133	PF00244	0.730
LIG_14-3-3_CanoR_1	141	147	PF00244	0.605
LIG_14-3-3_CanoR_1	167	177	PF00244	0.739
LIG_14-3-3_CanoR_1	201	209	PF00244	0.739
LIG_14-3-3_CanoR_1	234	242	PF00244	0.702
LIG_14-3-3_CanoR_1	243	249	PF00244	0.618
LIG_14-3-3_CanoR_1	277	286	PF00244	0.735
LIG_14-3-3_CanoR_1	324	330	PF00244	0.658
LIG_14-3-3_CanoR_1	35	41	PF00244	0.707
LIG_14-3-3_CanoR_1	357	367	PF00244	0.600
LIG_14-3-3_CanoR_1	412	418	PF00244	0.624
LIG_14-3-3_CanoR_1	422	429	PF00244	0.651
LIG_14-3-3_CanoR_1	43	48	PF00244	0.681
LIG_14-3-3_CanoR_1	488	496	PF00244	0.674
LIG_14-3-3_CanoR_1	5	14	PF00244	0.720
LIG_14-3-3_CanoR_1	507	512	PF00244	0.635
LIG_14-3-3_CanoR_1	563	571	PF00244	0.611
LIG_14-3-3_CanoR_1	98	103	PF00244	0.689
LIG_Actin_WH2_2	632	650	PF00022	0.507
LIG_AP_GAE_1	656	662	PF02883	0.513
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_FHA_1	141	147	PF00498	0.673
LIG_FHA_1	150	156	PF00498	0.704
LIG_FHA_1	623	629	PF00498	0.598
LIG_FHA_2	169	175	PF00498	0.742
LIG_FHA_2	218	224	PF00498	0.640
LIG_FHA_2	517	523	PF00498	0.703
LIG_LIR_Apic_2	25	31	PF02991	0.717
LIG_LIR_Apic_2	369	375	PF02991	0.687
LIG_LIR_Apic_2	589	594	PF02991	0.621
LIG_LIR_Gen_1	612	617	PF02991	0.546
LIG_LIR_Gen_1	656	664	PF02991	0.515
LIG_LIR_LC3C_4	690	693	PF02991	0.475
LIG_LIR_Nem_3	145	150	PF02991	0.680
LIG_LIR_Nem_3	361	367	PF02991	0.666
LIG_LIR_Nem_3	612	616	PF02991	0.504
LIG_LIR_Nem_3	656	662	PF02991	0.513
LIG_LYPXL_S_1	146	150	PF13949	0.679
LIG_LYPXL_yS_3	147	150	PF13949	0.679
LIG_NRBOX	709	715	PF00104	0.487
LIG_PTAP_UEV_1	573	578	PF05743	0.650
LIG_SH2_CRK	191	195	PF00017	0.695
LIG_SH2_CRK	28	32	PF00017	0.697
LIG_SH2_GRB2like	433	436	PF00017	0.647
LIG_SH2_NCK_1	191	195	PF00017	0.671
LIG_SH2_PTP2	372	375	PF00017	0.562
LIG_SH2_SRC	433	436	PF00017	0.647
LIG_SH2_SRC	495	498	PF00017	0.593
LIG_SH2_STAP1	191	195	PF00017	0.659
LIG_SH2_STAP1	23	27	PF00017	0.584
LIG_SH2_STAT5	372	375	PF00017	0.635
LIG_SH2_STAT5	495	498	PF00017	0.617
LIG_SH2_STAT5	75	78	PF00017	0.675
LIG_SH3_1	216	222	PF00018	0.666
LIG_SH3_2	219	224	PF14604	0.733
LIG_SH3_2	557	562	PF14604	0.576
LIG_SH3_3	216	222	PF00018	0.738
LIG_SH3_3	370	376	PF00018	0.621
LIG_SH3_3	426	432	PF00018	0.700
LIG_SH3_3	436	442	PF00018	0.625
LIG_SH3_3	552	558	PF00018	0.684
LIG_SH3_3	571	577	PF00018	0.715
LIG_SH3_3	578	584	PF00018	0.646
LIG_SH3_3	740	746	PF00018	0.642
LIG_SH3_CIN85_PxpxPR_1	577	582	PF14604	0.688
LIG_SUMO_SIM_anti_2	400	406	PF11976	0.825
LIG_SUMO_SIM_anti_2	640	648	PF11976	0.439
LIG_SUMO_SIM_anti_2	690	695	PF11976	0.518
LIG_SUMO_SIM_par_1	152	159	PF11976	0.724
LIG_SUMO_SIM_par_1	403	409	PF11976	0.712
LIG_SUMO_SIM_par_1	437	443	PF11976	0.679
LIG_TRAF2_1	601	604	PF00917	0.635
LIG_WRC_WIRS_1	610	615	PF05994	0.623
LIG_WW_3	95	99	PF00397	0.739
MOD_CDC14_SPxK_1	126	129	PF00782	0.694
MOD_CDC14_SPxK_1	164	167	PF00782	0.737
MOD_CDC14_SPxK_1	208	211	PF00782	0.732
MOD_CDC14_SPxK_1	315	318	PF00782	0.738
MOD_CDC14_SPxK_1	428	431	PF00782	0.664
MOD_CDK_SPK_2	123	128	PF00069	0.689
MOD_CDK_SPK_2	161	166	PF00069	0.741
MOD_CDK_SPK_2	173	178	PF00069	0.611
MOD_CDK_SPK_2	194	199	PF00069	0.721
MOD_CDK_SPK_2	312	317	PF00069	0.740
MOD_CDK_SPK_2	425	430	PF00069	0.685
MOD_CDK_SPK_2	440	445	PF00069	0.569
MOD_CDK_SPxK_1	123	129	PF00069	0.724
MOD_CDK_SPxK_1	161	167	PF00069	0.743
MOD_CDK_SPxK_1	173	179	PF00069	0.614
MOD_CDK_SPxK_1	205	211	PF00069	0.741
MOD_CDK_SPxK_1	290	296	PF00069	0.744
MOD_CDK_SPxK_1	312	318	PF00069	0.741
MOD_CDK_SPxK_1	425	431	PF00069	0.666
MOD_CDK_SPxxK_3	123	130	PF00069	0.726
MOD_CDK_SPxxK_3	194	201	PF00069	0.675
MOD_CDK_SPxxK_3	44	51	PF00069	0.697
MOD_CK1_1	101	107	PF00069	0.741
MOD_CK1_1	140	146	PF00069	0.598
MOD_CK1_1	168	174	PF00069	0.742
MOD_CK1_1	205	211	PF00069	0.741
MOD_CK1_1	212	218	PF00069	0.671
MOD_CK1_1	230	236	PF00069	0.567
MOD_CK1_1	245	251	PF00069	0.644
MOD_CK1_1	255	261	PF00069	0.651
MOD_CK1_1	325	331	PF00069	0.746
MOD_CK1_1	37	43	PF00069	0.722
MOD_CK1_1	390	396	PF00069	0.702
MOD_CK1_1	406	412	PF00069	0.548
MOD_CK1_1	512	518	PF00069	0.730
MOD_CK1_1	545	551	PF00069	0.727
MOD_CK1_1	56	62	PF00069	0.572
MOD_CK1_1	612	618	PF00069	0.589
MOD_CK1_1	624	630	PF00069	0.425
MOD_CK2_1	217	223	PF00069	0.672
MOD_CK2_1	325	331	PF00069	0.746
MOD_CK2_1	347	353	PF00069	0.736
MOD_CK2_1	397	403	PF00069	0.851
MOD_CK2_1	516	522	PF00069	0.703
MOD_CK2_1	597	603	PF00069	0.693
MOD_CK2_1	726	732	PF00069	0.567
MOD_Cter_Amidation	159	162	PF01082	0.698
MOD_DYRK1A_RPxSP_1	582	586	PF00069	0.594
MOD_GlcNHglycan	1	4	PF01048	0.698
MOD_GlcNHglycan	110	114	PF01048	0.591
MOD_GlcNHglycan	167	170	PF01048	0.747
MOD_GlcNHglycan	205	208	PF01048	0.721
MOD_GlcNHglycan	229	232	PF01048	0.604
MOD_GlcNHglycan	306	310	PF01048	0.730
MOD_GlcNHglycan	320	323	PF01048	0.604
MOD_GlcNHglycan	385	388	PF01048	0.699
MOD_GlcNHglycan	397	400	PF01048	0.736
MOD_GlcNHglycan	408	411	PF01048	0.613
MOD_GlcNHglycan	413	416	PF01048	0.631
MOD_GlcNHglycan	489	492	PF01048	0.733
MOD_GlcNHglycan	503	506	PF01048	0.531
MOD_GlcNHglycan	56	59	PF01048	0.742
MOD_GlcNHglycan	714	717	PF01048	0.494
MOD_GSK3_1	136	143	PF00069	0.645
MOD_GSK3_1	161	168	PF00069	0.733
MOD_GSK3_1	169	176	PF00069	0.651
MOD_GSK3_1	190	197	PF00069	0.744
MOD_GSK3_1	205	212	PF00069	0.584
MOD_GSK3_1	226	233	PF00069	0.685
MOD_GSK3_1	241	248	PF00069	0.644
MOD_GSK3_1	252	259	PF00069	0.628
MOD_GSK3_1	290	297	PF00069	0.701
MOD_GSK3_1	318	325	PF00069	0.745
MOD_GSK3_1	329	336	PF00069	0.628
MOD_GSK3_1	33	40	PF00069	0.710
MOD_GSK3_1	379	386	PF00069	0.704
MOD_GSK3_1	387	394	PF00069	0.604
MOD_GSK3_1	416	423	PF00069	0.725
MOD_GSK3_1	497	504	PF00069	0.695
MOD_GSK3_1	512	519	PF00069	0.599
MOD_GSK3_1	541	548	PF00069	0.769
MOD_GSK3_1	618	625	PF00069	0.541
MOD_GSK3_1	679	686	PF00069	0.603
MOD_LATS_1	134	140	PF00433	0.728
MOD_LATS_1	420	426	PF00433	0.587
MOD_LATS_1	518	524	PF00433	0.729
MOD_NEK2_1	257	262	PF00069	0.599
MOD_NEK2_1	378	383	PF00069	0.691
MOD_NEK2_1	496	501	PF00069	0.722
MOD_NEK2_1	622	627	PF00069	0.550
MOD_NEK2_1	635	640	PF00069	0.379
MOD_PIKK_1	242	248	PF00454	0.720
MOD_PIKK_1	325	331	PF00454	0.640
MOD_PIKK_1	5	11	PF00454	0.698
MOD_PIKK_1	564	570	PF00454	0.682
MOD_PIKK_1	91	97	PF00454	0.738
MOD_PKA_1	128	134	PF00069	0.724
MOD_PKA_1	135	141	PF00069	0.693
MOD_PKA_1	298	304	PF00069	0.693
MOD_PKA_1	317	323	PF00069	0.548
MOD_PKA_1	43	49	PF00069	0.603
MOD_PKA_1	516	522	PF00069	0.703
MOD_PKA_1	90	96	PF00069	0.742
MOD_PKA_1	98	104	PF00069	0.664
MOD_PKA_2	128	134	PF00069	0.724
MOD_PKA_2	135	141	PF00069	0.693
MOD_PKA_2	165	171	PF00069	0.742
MOD_PKA_2	177	183	PF00069	0.619
MOD_PKA_2	202	208	PF00069	0.703
MOD_PKA_2	242	248	PF00069	0.688
MOD_PKA_2	252	258	PF00069	0.662
MOD_PKA_2	278	284	PF00069	0.729
MOD_PKA_2	298	304	PF00069	0.575
MOD_PKA_2	317	323	PF00069	0.577
MOD_PKA_2	325	331	PF00069	0.683
MOD_PKA_2	34	40	PF00069	0.704
MOD_PKA_2	358	364	PF00069	0.607
MOD_PKA_2	4	10	PF00069	0.745
MOD_PKA_2	411	417	PF00069	0.619
MOD_PKA_2	43	49	PF00069	0.663
MOD_PKA_2	484	490	PF00069	0.712
MOD_PKA_2	516	522	PF00069	0.680
MOD_PKA_2	53	59	PF00069	0.559
MOD_PKA_2	572	578	PF00069	0.674
MOD_PKA_2	90	96	PF00069	0.742
MOD_PKA_2	98	104	PF00069	0.664
MOD_PKB_1	11	19	PF00069	0.688
MOD_PKB_1	135	143	PF00069	0.698
MOD_PKB_1	201	209	PF00069	0.671
MOD_PKB_1	296	304	PF00069	0.695
MOD_PKB_1	357	365	PF00069	0.598
MOD_PKB_1	395	403	PF00069	0.656
MOD_PKB_1	507	515	PF00069	0.732
MOD_Plk_2-3	618	624	PF00069	0.510
MOD_Plk_2-3	637	643	PF00069	0.322
MOD_Plk_4	142	148	PF00069	0.686
MOD_Plk_4	359	365	PF00069	0.674
MOD_Plk_4	609	615	PF00069	0.514
MOD_Plk_4	738	744	PF00069	0.579
MOD_ProDKin_1	123	129	PF00069	0.724
MOD_ProDKin_1	161	167	PF00069	0.743
MOD_ProDKin_1	173	179	PF00069	0.614
MOD_ProDKin_1	194	200	PF00069	0.745
MOD_ProDKin_1	205	211	PF00069	0.628
MOD_ProDKin_1	215	221	PF00069	0.640
MOD_ProDKin_1	290	296	PF00069	0.713
MOD_ProDKin_1	312	318	PF00069	0.741
MOD_ProDKin_1	342	348	PF00069	0.714
MOD_ProDKin_1	425	431	PF00069	0.696
MOD_ProDKin_1	44	50	PF00069	0.686
MOD_ProDKin_1	440	446	PF00069	0.562
MOD_ProDKin_1	553	559	PF00069	0.724
MOD_ProDKin_1	582	588	PF00069	0.632
MOD_ProDKin_1	99	105	PF00069	0.697
MOD_SUMO_for_1	288	291	PF00179	0.719
MOD_SUMO_for_1	463	466	PF00179	0.583
TRG_ENDOCYTIC_2	147	150	PF00928	0.679
TRG_ENDOCYTIC_2	191	194	PF00928	0.696
TRG_ER_diArg_1	127	130	PF00400	0.696
TRG_ER_diArg_1	135	137	PF00400	0.648
TRG_ER_diArg_1	165	167	PF00400	0.737
TRG_ER_diArg_1	177	179	PF00400	0.608
TRG_ER_diArg_1	19	21	PF00400	0.743
TRG_ER_diArg_1	198	201	PF00400	0.699
TRG_ER_diArg_1	249	251	PF00400	0.667
TRG_ER_diArg_1	296	299	PF00400	0.747
TRG_ER_diArg_1	316	318	PF00400	0.586
TRG_ER_diArg_1	338	341	PF00400	0.699
TRG_ER_diArg_1	356	359	PF00400	0.534
TRG_ER_diArg_1	429	431	PF00400	0.723
TRG_ER_diArg_1	699	701	PF00400	0.599
TRG_ER_diArg_1	89	91	PF00400	0.751
TRG_ER_diArg_1	97	100	PF00400	0.665
TRG_NLS_MonoExtC_3	336	341	PF00514	0.673
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.674

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XB19	Leishmania donovani	89%	100%
A4HPE3	Leishmania braziliensis	65%	99%
A4ICI4	Leishmania infantum	89%	100%
E9AT54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%