Meiosis recombination protein SPO11

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1E2_LEIMA

TriTrypDb:

LmjF.36.2780 , LMJLV39_360036800 , LMJSD75_360036700

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000228	nuclear chromosome	6	2
GO:0005694	chromosome	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4Q1E2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1E2

Function

Biological processes
Term	Name	Level	Count
GO:0000706	meiotic DNA double-strand break processing	3	2
GO:0000729	DNA double-strand break processing	5	2
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006310	DNA recombination	5	2
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0007131	reciprocal meiotic recombination	3	2
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	2
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0035825	homologous recombination	6	2
GO:0042138	meiotic DNA double-strand break formation	4	2
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0061982	meiosis I cell cycle process	3	2
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0140527	reciprocal homologous recombination	7	2
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1903046	meiotic cell cycle process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003824	catalytic activity	1	11
GO:0003916	DNA topoisomerase activity	3	11
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	3	11
GO:0005488	binding	1	11
GO:0008094	ATP-dependent activity, acting on DNA	2	11
GO:0016853	isomerase activity	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:0140097	catalytic activity, acting on DNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901363	heterocyclic compound binding	2	11
GO:0000166	nucleotide binding	3	5
GO:0005524	ATP binding	5	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	423	427	PF00656	0.604
CLV_NRD_NRD_1	287	289	PF00675	0.443
CLV_PCSK_KEX2_1	116	118	PF00082	0.504
CLV_PCSK_KEX2_1	287	289	PF00082	0.443
CLV_PCSK_KEX2_1	408	410	PF00082	0.456
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.504
CLV_PCSK_PC1ET2_1	408	410	PF00082	0.528
CLV_PCSK_PC7_1	283	289	PF00082	0.478
CLV_PCSK_SKI1_1	100	104	PF00082	0.348
CLV_PCSK_SKI1_1	148	152	PF00082	0.612
CLV_PCSK_SKI1_1	180	184	PF00082	0.392
CLV_PCSK_SKI1_1	241	245	PF00082	0.524
CLV_PCSK_SKI1_1	357	361	PF00082	0.525
CLV_PCSK_SKI1_1	408	412	PF00082	0.344
CLV_PCSK_SKI1_1	445	449	PF00082	0.520
DEG_APCC_DBOX_1	282	290	PF00400	0.367
DEG_APCC_DBOX_1	439	447	PF00400	0.411
DEG_SCF_FBW7_1	418	425	PF00400	0.446
DOC_CKS1_1	71	76	PF01111	0.684
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.579
DOC_MAPK_DCC_7	355	364	PF00069	0.551
DOC_MAPK_gen_1	116	124	PF00069	0.492
DOC_MAPK_gen_1	355	364	PF00069	0.551
DOC_MAPK_gen_1	455	464	PF00069	0.548
DOC_MAPK_JIP1_4	238	244	PF00069	0.516
DOC_MAPK_MEF2A_6	355	364	PF00069	0.551
DOC_MAPK_NFAT4_5	357	365	PF00069	0.533
DOC_PP2B_LxvP_1	102	105	PF13499	0.588
DOC_PP4_FxxP_1	144	147	PF00568	0.547
DOC_USP7_MATH_1	178	182	PF00917	0.488
DOC_USP7_MATH_1	202	206	PF00917	0.577
DOC_USP7_MATH_1	327	331	PF00917	0.741
DOC_USP7_MATH_1	38	42	PF00917	0.584
DOC_USP7_MATH_1	417	421	PF00917	0.580
DOC_USP7_MATH_1	422	426	PF00917	0.682
DOC_USP7_MATH_1	484	488	PF00917	0.520
DOC_WW_Pin1_4	1	6	PF00397	0.729
DOC_WW_Pin1_4	143	148	PF00397	0.602
DOC_WW_Pin1_4	162	167	PF00397	0.625
DOC_WW_Pin1_4	260	265	PF00397	0.620
DOC_WW_Pin1_4	323	328	PF00397	0.665
DOC_WW_Pin1_4	34	39	PF00397	0.645
DOC_WW_Pin1_4	344	349	PF00397	0.663
DOC_WW_Pin1_4	418	423	PF00397	0.493
DOC_WW_Pin1_4	70	75	PF00397	0.709
LIG_14-3-3_CanoR_1	109	115	PF00244	0.442
LIG_14-3-3_CanoR_1	231	240	PF00244	0.619
LIG_14-3-3_CanoR_1	265	270	PF00244	0.396
LIG_14-3-3_CanoR_1	44	51	PF00244	0.479
LIG_14-3-3_CanoR_1	440	444	PF00244	0.448
LIG_Actin_WH2_2	394	410	PF00022	0.497
LIG_BIR_II_1	1	5	PF00653	0.665
LIG_CaM_IQ_9	401	417	PF13499	0.555
LIG_Clathr_ClatBox_1	242	246	PF01394	0.411
LIG_EH1_1	54	62	PF00400	0.521
LIG_eIF4E_1	97	103	PF01652	0.434
LIG_FHA_1	186	192	PF00498	0.438
LIG_FHA_1	209	215	PF00498	0.434
LIG_FHA_1	351	357	PF00498	0.539
LIG_FHA_1	409	415	PF00498	0.441
LIG_FHA_1	434	440	PF00498	0.528
LIG_FHA_1	52	58	PF00498	0.418
LIG_FHA_1	82	88	PF00498	0.676
LIG_FHA_2	398	404	PF00498	0.422
LIG_FHA_2	471	477	PF00498	0.531
LIG_FHA_2	89	95	PF00498	0.418
LIG_GBD_Chelix_1	183	191	PF00786	0.484
LIG_LIR_Apic_2	141	147	PF02991	0.583
LIG_LIR_Apic_2	321	327	PF02991	0.619
LIG_LIR_Gen_1	266	277	PF02991	0.530
LIG_LIR_Gen_1	338	348	PF02991	0.571
LIG_LIR_Nem_3	237	243	PF02991	0.510
LIG_LIR_Nem_3	266	272	PF02991	0.536
LIG_LIR_Nem_3	274	280	PF02991	0.493
LIG_LIR_Nem_3	338	343	PF02991	0.733
LIG_LIR_Nem_3	54	58	PF02991	0.468
LIG_LIR_Nem_3	72	78	PF02991	0.734
LIG_LYPXL_yS_3	277	280	PF13949	0.457
LIG_PDZ_Class_3	485	490	PF00595	0.624
LIG_Pex14_2	27	31	PF04695	0.577
LIG_SH2_CRK	240	244	PF00017	0.514
LIG_SH2_CRK	75	79	PF00017	0.613
LIG_SH2_NCK_1	212	216	PF00017	0.490
LIG_SH2_PTP2	299	302	PF00017	0.502
LIG_SH2_STAP1	212	216	PF00017	0.342
LIG_SH2_STAP1	267	271	PF00017	0.448
LIG_SH2_STAT3	12	15	PF00017	0.629
LIG_SH2_STAT3	56	59	PF00017	0.502
LIG_SH2_STAT5	168	171	PF00017	0.417
LIG_SH2_STAT5	299	302	PF00017	0.502
LIG_SH2_STAT5	56	59	PF00017	0.419
LIG_SH3_3	465	471	PF00018	0.460
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.545
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.506
LIG_SUMO_SIM_par_1	187	193	PF11976	0.534
LIG_SUMO_SIM_par_1	196	201	PF11976	0.404
LIG_SUMO_SIM_par_1	241	246	PF11976	0.374
LIG_WRC_WIRS_1	337	342	PF05994	0.698
MOD_CDC14_SPxK_1	37	40	PF00782	0.685
MOD_CDK_SPK_2	143	148	PF00069	0.586
MOD_CDK_SPK_2	260	265	PF00069	0.386
MOD_CDK_SPxK_1	34	40	PF00069	0.663
MOD_CK1_1	338	344	PF00069	0.762
MOD_CK1_1	350	356	PF00069	0.451
MOD_CK1_1	376	382	PF00069	0.559
MOD_CK1_1	427	433	PF00069	0.663
MOD_CK2_1	15	21	PF00069	0.477
MOD_CK2_1	417	423	PF00069	0.515
MOD_CK2_1	427	433	PF00069	0.547
MOD_CK2_1	470	476	PF00069	0.524
MOD_GlcNHglycan	199	203	PF01048	0.498
MOD_GlcNHglycan	260	263	PF01048	0.553
MOD_GlcNHglycan	343	346	PF01048	0.719
MOD_GlcNHglycan	349	352	PF01048	0.622
MOD_GlcNHglycan	40	43	PF01048	0.581
MOD_GlcNHglycan	426	429	PF01048	0.628
MOD_GSK3_1	139	146	PF00069	0.600
MOD_GSK3_1	162	169	PF00069	0.647
MOD_GSK3_1	198	205	PF00069	0.483
MOD_GSK3_1	206	213	PF00069	0.464
MOD_GSK3_1	254	261	PF00069	0.473
MOD_GSK3_1	323	330	PF00069	0.716
MOD_GSK3_1	335	342	PF00069	0.575
MOD_GSK3_1	34	41	PF00069	0.566
MOD_GSK3_1	343	350	PF00069	0.414
MOD_GSK3_1	367	374	PF00069	0.511
MOD_GSK3_1	418	425	PF00069	0.605
MOD_GSK3_1	73	80	PF00069	0.724
MOD_NEK2_1	173	178	PF00069	0.535
MOD_NEK2_1	210	215	PF00069	0.396
MOD_NEK2_1	258	263	PF00069	0.539
MOD_NEK2_1	271	276	PF00069	0.338
MOD_NEK2_1	318	323	PF00069	0.571
MOD_NEK2_1	343	348	PF00069	0.644
MOD_NEK2_1	371	376	PF00069	0.604
MOD_NEK2_1	391	396	PF00069	0.601
MOD_NEK2_1	77	82	PF00069	0.634
MOD_OFUCOSY	368	375	PF10250	0.517
MOD_PIKK_1	155	161	PF00454	0.706
MOD_PIKK_1	328	334	PF00454	0.751
MOD_PIKK_1	391	397	PF00454	0.613
MOD_PK_1	409	415	PF00069	0.472
MOD_PKA_1	408	414	PF00069	0.316
MOD_PKA_2	108	114	PF00069	0.487
MOD_PKA_2	169	175	PF00069	0.468
MOD_PKA_2	221	227	PF00069	0.496
MOD_PKA_2	408	414	PF00069	0.456
MOD_PKA_2	43	49	PF00069	0.494
MOD_PKA_2	439	445	PF00069	0.399
MOD_Plk_2-3	88	94	PF00069	0.511
MOD_Plk_4	139	145	PF00069	0.599
MOD_Plk_4	178	184	PF00069	0.415
MOD_Plk_4	254	260	PF00069	0.568
MOD_Plk_4	265	271	PF00069	0.405
MOD_Plk_4	311	317	PF00069	0.391
MOD_Plk_4	367	373	PF00069	0.522
MOD_Plk_4	409	415	PF00069	0.501
MOD_Plk_4	470	476	PF00069	0.541
MOD_Plk_4	51	57	PF00069	0.481
MOD_Plk_4	73	79	PF00069	0.726
MOD_ProDKin_1	1	7	PF00069	0.727
MOD_ProDKin_1	143	149	PF00069	0.608
MOD_ProDKin_1	162	168	PF00069	0.608
MOD_ProDKin_1	260	266	PF00069	0.621
MOD_ProDKin_1	323	329	PF00069	0.672
MOD_ProDKin_1	34	40	PF00069	0.652
MOD_ProDKin_1	344	350	PF00069	0.655
MOD_ProDKin_1	418	424	PF00069	0.503
MOD_ProDKin_1	70	76	PF00069	0.715
MOD_SUMO_for_1	458	461	PF00179	0.499
TRG_ENDOCYTIC_2	240	243	PF00928	0.519
TRG_ENDOCYTIC_2	267	270	PF00928	0.519
TRG_ENDOCYTIC_2	277	280	PF00928	0.408
TRG_ENDOCYTIC_2	299	302	PF00928	0.502
TRG_ENDOCYTIC_2	75	78	PF00928	0.746
TRG_ER_diArg_1	286	288	PF00400	0.421
TRG_ER_diArg_1	455	458	PF00400	0.560
TRG_ER_diArg_1	97	100	PF00400	0.352
TRG_NES_CRM1_1	14	30	PF08389	0.554
TRG_Pf-PMV_PEXEL_1	445	449	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7M4	Leptomonas seymouri	40%	100%
A0A1X0NL58	Trypanosomatidae	30%	100%
A0A3R7LIJ3	Trypanosoma rangeli	31%	100%
A0A3S7XAZ9	Leishmania donovani	91%	99%
A4HPE4	Leishmania braziliensis	77%	93%
A4ICI5	Leishmania infantum	91%	92%
D0A3F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AT55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
V5BPV6	Trypanosoma cruzi	31%	100%