Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1E0_LEIMA

TriTrypDb:

LmjF.36.2800 , LMJLV39_360037000 , LMJSD75_360036900

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4Q1E0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1E0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.627
CLV_C14_Caspase3-7	182	186	PF00656	0.661
CLV_C14_Caspase3-7	284	288	PF00656	0.645
CLV_C14_Caspase3-7	594	598	PF00656	0.606
CLV_NRD_NRD_1	121	123	PF00675	0.528
CLV_NRD_NRD_1	132	134	PF00675	0.594
CLV_NRD_NRD_1	22	24	PF00675	0.623
CLV_NRD_NRD_1	289	291	PF00675	0.624
CLV_NRD_NRD_1	627	629	PF00675	0.443
CLV_NRD_NRD_1	69	71	PF00675	0.643
CLV_NRD_NRD_1	694	696	PF00675	0.464
CLV_NRD_NRD_1	78	80	PF00675	0.486
CLV_PCSK_KEX2_1	121	123	PF00082	0.528
CLV_PCSK_KEX2_1	132	134	PF00082	0.594
CLV_PCSK_KEX2_1	22	24	PF00082	0.623
CLV_PCSK_KEX2_1	241	243	PF00082	0.605
CLV_PCSK_KEX2_1	289	291	PF00082	0.624
CLV_PCSK_KEX2_1	299	301	PF00082	0.629
CLV_PCSK_KEX2_1	627	629	PF00082	0.443
CLV_PCSK_KEX2_1	69	71	PF00082	0.592
CLV_PCSK_KEX2_1	694	696	PF00082	0.464
CLV_PCSK_KEX2_1	78	80	PF00082	0.529
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.605
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.623
CLV_PCSK_SKI1_1	167	171	PF00082	0.535
CLV_PCSK_SKI1_1	22	26	PF00082	0.592
CLV_PCSK_SKI1_1	236	240	PF00082	0.537
CLV_PCSK_SKI1_1	389	393	PF00082	0.642
CLV_PCSK_SKI1_1	41	45	PF00082	0.445
CLV_PCSK_SKI1_1	628	632	PF00082	0.410
CLV_PCSK_SKI1_1	682	686	PF00082	0.364
CLV_PCSK_SKI1_1	69	73	PF00082	0.571
CLV_PCSK_SKI1_1	789	793	PF00082	0.416
CLV_PCSK_SKI1_1	79	83	PF00082	0.700
DEG_SCF_FBW7_1	1	8	PF00400	0.523
DEG_SPOP_SBC_1	398	402	PF00917	0.584
DOC_CKS1_1	348	353	PF01111	0.622
DOC_CKS1_1	64	69	PF01111	0.589
DOC_CYCLIN_RxL_1	386	396	PF00134	0.640
DOC_CYCLIN_yClb5_NLxxxL_5	833	842	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	656	662	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	799	805	PF00134	0.467
DOC_MAPK_DCC_7	347	356	PF00069	0.632
DOC_MAPK_gen_1	100	109	PF00069	0.592
DOC_MAPK_gen_1	129	138	PF00069	0.595
DOC_MAPK_gen_1	241	248	PF00069	0.642
DOC_MAPK_gen_1	627	635	PF00069	0.453
DOC_MAPK_MEF2A_6	100	109	PF00069	0.592
DOC_MAPK_MEF2A_6	347	356	PF00069	0.628
DOC_MAPK_MEF2A_6	627	635	PF00069	0.442
DOC_MAPK_NFAT4_5	628	636	PF00069	0.410
DOC_PP1_RVXF_1	312	318	PF00149	0.632
DOC_PP1_RVXF_1	479	486	PF00149	0.375
DOC_PP1_RVXF_1	754	761	PF00149	0.490
DOC_PP2B_LxvP_1	342	345	PF13499	0.702
DOC_PP2B_LxvP_1	635	638	PF13499	0.393
DOC_PP2B_LxvP_1	656	659	PF13499	0.434
DOC_USP7_MATH_1	201	205	PF00917	0.691
DOC_USP7_MATH_1	215	219	PF00917	0.663
DOC_USP7_MATH_1	232	236	PF00917	0.628
DOC_USP7_MATH_1	247	251	PF00917	0.781
DOC_USP7_MATH_1	398	402	PF00917	0.693
DOC_USP7_MATH_1	408	412	PF00917	0.589
DOC_USP7_MATH_1	415	419	PF00917	0.481
DOC_USP7_MATH_1	712	716	PF00917	0.464
DOC_USP7_MATH_1	81	85	PF00917	0.488
DOC_WW_Pin1_4	1	6	PF00397	0.525
DOC_WW_Pin1_4	347	352	PF00397	0.626
DOC_WW_Pin1_4	406	411	PF00397	0.653
DOC_WW_Pin1_4	41	46	PF00397	0.554
DOC_WW_Pin1_4	461	466	PF00397	0.486
DOC_WW_Pin1_4	503	508	PF00397	0.621
DOC_WW_Pin1_4	58	63	PF00397	0.619
DOC_WW_Pin1_4	778	783	PF00397	0.533
LIG_14-3-3_CanoR_1	137	144	PF00244	0.606
LIG_14-3-3_CanoR_1	153	158	PF00244	0.617
LIG_14-3-3_CanoR_1	22	27	PF00244	0.535
LIG_14-3-3_CanoR_1	242	248	PF00244	0.640
LIG_14-3-3_CanoR_1	270	275	PF00244	0.635
LIG_14-3-3_CanoR_1	289	295	PF00244	0.724
LIG_14-3-3_CanoR_1	347	351	PF00244	0.637
LIG_14-3-3_CanoR_1	405	412	PF00244	0.659
LIG_14-3-3_CanoR_1	496	500	PF00244	0.549
LIG_14-3-3_CanoR_1	675	681	PF00244	0.335
LIG_14-3-3_CanoR_1	694	698	PF00244	0.460
LIG_14-3-3_CanoR_1	79	89	PF00244	0.688
LIG_APCC_ABBA_1	220	225	PF00400	0.607
LIG_APCC_ABBA_1	760	765	PF00400	0.436
LIG_APCC_ABBA_1	795	800	PF00400	0.394
LIG_BIR_II_1	1	5	PF00653	0.523
LIG_BIR_III_4	285	289	PF00653	0.650
LIG_BIR_III_4	739	743	PF00653	0.493
LIG_Clathr_ClatBox_1	189	193	PF01394	0.663
LIG_CtBP_PxDLS_1	671	675	PF00389	0.397
LIG_deltaCOP1_diTrp_1	755	763	PF00928	0.464
LIG_EVH1_1	342	346	PF00568	0.665
LIG_FHA_1	16	22	PF00498	0.528
LIG_FHA_1	170	176	PF00498	0.633
LIG_FHA_1	386	392	PF00498	0.588
LIG_FHA_1	42	48	PF00498	0.650
LIG_FHA_1	462	468	PF00498	0.458
LIG_FHA_1	844	850	PF00498	0.403
LIG_FHA_2	168	174	PF00498	0.671
LIG_FHA_2	186	192	PF00498	0.482
LIG_FHA_2	23	29	PF00498	0.518
LIG_FHA_2	360	366	PF00498	0.628
LIG_FHA_2	457	463	PF00498	0.574
LIG_FHA_2	529	535	PF00498	0.650
LIG_FHA_2	572	578	PF00498	0.532
LIG_FHA_2	592	598	PF00498	0.583
LIG_FHA_2	842	848	PF00498	0.479
LIG_LIR_Apic_2	409	415	PF02991	0.539
LIG_LIR_Apic_2	61	67	PF02991	0.553
LIG_LIR_Gen_1	218	225	PF02991	0.604
LIG_LIR_Gen_1	490	500	PF02991	0.405
LIG_LIR_Gen_1	676	685	PF02991	0.342
LIG_LIR_Gen_1	755	764	PF02991	0.476
LIG_LIR_Gen_1	8	14	PF02991	0.581
LIG_LIR_Gen_1	809	820	PF02991	0.382
LIG_LIR_Nem_3	197	203	PF02991	0.660
LIG_LIR_Nem_3	218	223	PF02991	0.602
LIG_LIR_Nem_3	4	10	PF02991	0.588
LIG_LIR_Nem_3	477	483	PF02991	0.383
LIG_LIR_Nem_3	490	495	PF02991	0.355
LIG_LIR_Nem_3	606	612	PF02991	0.445
LIG_LIR_Nem_3	676	680	PF02991	0.372
LIG_LIR_Nem_3	755	760	PF02991	0.402
LIG_LIR_Nem_3	809	815	PF02991	0.377
LIG_LIR_Nem_3	93	98	PF02991	0.514
LIG_LYPXL_yS_3	200	203	PF13949	0.588
LIG_MYND_3	354	358	PF01753	0.571
LIG_Pex14_2	610	614	PF04695	0.361
LIG_Pex14_2	748	752	PF04695	0.352
LIG_REV1ctd_RIR_1	89	95	PF16727	0.615
LIG_SH2_CRK	10	14	PF00017	0.584
LIG_SH2_CRK	412	416	PF00017	0.594
LIG_SH2_CRK	480	484	PF00017	0.377
LIG_SH2_CRK	64	68	PF00017	0.552
LIG_SH2_CRK	662	666	PF00017	0.482
LIG_SH2_CRK	677	681	PF00017	0.250
LIG_SH2_CRK	98	102	PF00017	0.489
LIG_SH2_NCK_1	10	14	PF00017	0.584
LIG_SH2_NCK_1	64	68	PF00017	0.552
LIG_SH2_PTP2	492	495	PF00017	0.448
LIG_SH2_PTP2	812	815	PF00017	0.369
LIG_SH2_SRC	647	650	PF00017	0.425
LIG_SH2_STAP1	10	14	PF00017	0.584
LIG_SH2_STAP1	677	681	PF00017	0.353
LIG_SH2_STAT3	831	834	PF00017	0.468
LIG_SH2_STAT5	20	23	PF00017	0.565
LIG_SH2_STAT5	29	32	PF00017	0.495
LIG_SH2_STAT5	492	495	PF00017	0.448
LIG_SH2_STAT5	580	583	PF00017	0.635
LIG_SH2_STAT5	609	612	PF00017	0.418
LIG_SH2_STAT5	677	680	PF00017	0.334
LIG_SH2_STAT5	812	815	PF00017	0.369
LIG_SH2_STAT5	831	834	PF00017	0.396
LIG_SH3_3	175	181	PF00018	0.637
LIG_SH3_3	277	283	PF00018	0.658
LIG_SH3_3	340	346	PF00018	0.674
LIG_SH3_3	349	355	PF00018	0.659
LIG_SH3_3	40	46	PF00018	0.583
LIG_SH3_3	543	549	PF00018	0.687
LIG_SH3_3	566	572	PF00018	0.668
LIG_SUMO_SIM_par_1	187	193	PF11976	0.639
LIG_SUMO_SIM_par_1	670	676	PF11976	0.383
LIG_SUMO_SIM_par_1	817	824	PF11976	0.432
LIG_TRAF2_1	25	28	PF00917	0.514
LIG_TRAF2_1	252	255	PF00917	0.717
LIG_TRAF2_1	454	457	PF00917	0.491
LIG_TRAF2_1	605	608	PF00917	0.530
LIG_TYR_ITIM	660	665	PF00017	0.454
LIG_UBA3_1	832	836	PF00899	0.397
LIG_WW_3	344	348	PF00397	0.636
MOD_CDK_SPxK_1	63	69	PF00069	0.615
MOD_CDK_SPxxK_3	406	413	PF00069	0.641
MOD_CDK_SPxxK_3	41	48	PF00069	0.532
MOD_CDK_SPxxK_3	63	70	PF00069	0.611
MOD_CK1_1	131	137	PF00069	0.597
MOD_CK1_1	146	152	PF00069	0.605
MOD_CK1_1	160	166	PF00069	0.613
MOD_CK1_1	195	201	PF00069	0.589
MOD_CK1_1	218	224	PF00069	0.604
MOD_CK1_1	226	232	PF00069	0.600
MOD_CK1_1	273	279	PF00069	0.578
MOD_CK1_1	303	309	PF00069	0.658
MOD_CK1_1	379	385	PF00069	0.591
MOD_CK1_1	401	407	PF00069	0.706
MOD_CK1_1	595	601	PF00069	0.616
MOD_CK1_1	673	679	PF00069	0.404
MOD_CK1_1	715	721	PF00069	0.509
MOD_CK1_1	783	789	PF00069	0.543
MOD_CK1_1	841	847	PF00069	0.412
MOD_CK2_1	167	173	PF00069	0.732
MOD_CK2_1	22	28	PF00069	0.525
MOD_CK2_1	247	253	PF00069	0.602
MOD_CK2_1	359	365	PF00069	0.628
MOD_CK2_1	451	457	PF00069	0.529
MOD_CK2_1	460	466	PF00069	0.445
MOD_CK2_1	528	534	PF00069	0.615
MOD_CK2_1	550	556	PF00069	0.567
MOD_CK2_1	571	577	PF00069	0.563
MOD_CK2_1	602	608	PF00069	0.613
MOD_CK2_1	841	847	PF00069	0.480
MOD_CMANNOS	754	757	PF00535	0.402
MOD_Cter_Amidation	287	290	PF01082	0.607
MOD_GlcNHglycan	133	136	PF01048	0.595
MOD_GlcNHglycan	138	141	PF01048	0.600
MOD_GlcNHglycan	159	162	PF01048	0.618
MOD_GlcNHglycan	193	197	PF01048	0.591
MOD_GlcNHglycan	203	206	PF01048	0.623
MOD_GlcNHglycan	213	216	PF01048	0.682
MOD_GlcNHglycan	225	229	PF01048	0.542
MOD_GlcNHglycan	275	278	PF01048	0.601
MOD_GlcNHglycan	305	308	PF01048	0.758
MOD_GlcNHglycan	381	384	PF01048	0.590
MOD_GlcNHglycan	418	421	PF01048	0.464
MOD_GlcNHglycan	423	426	PF01048	0.661
MOD_GlcNHglycan	476	479	PF01048	0.425
MOD_GlcNHglycan	497	500	PF01048	0.467
MOD_GlcNHglycan	58	61	PF01048	0.610
MOD_GlcNHglycan	597	600	PF01048	0.585
MOD_GlcNHglycan	667	670	PF01048	0.408
MOD_GlcNHglycan	701	704	PF01048	0.569
MOD_GSK3_1	1	8	PF00069	0.523
MOD_GSK3_1	145	152	PF00069	0.614
MOD_GSK3_1	153	160	PF00069	0.630
MOD_GSK3_1	169	176	PF00069	0.657
MOD_GSK3_1	195	202	PF00069	0.614
MOD_GSK3_1	211	218	PF00069	0.554
MOD_GSK3_1	375	382	PF00069	0.626
MOD_GSK3_1	393	400	PF00069	0.632
MOD_GSK3_1	404	411	PF00069	0.598
MOD_GSK3_1	456	463	PF00069	0.523
MOD_GSK3_1	503	510	PF00069	0.780
MOD_GSK3_1	56	63	PF00069	0.595
MOD_GSK3_1	591	598	PF00069	0.668
MOD_GSK3_1	712	719	PF00069	0.426
MOD_GSK3_1	778	785	PF00069	0.455
MOD_N-GLC_1	398	403	PF02516	0.586
MOD_N-GLC_1	56	61	PF02516	0.547
MOD_N-GLC_1	699	704	PF02516	0.540
MOD_NEK2_1	223	228	PF00069	0.618
MOD_NEK2_1	391	396	PF00069	0.657
MOD_NEK2_1	423	428	PF00069	0.699
MOD_NEK2_1	631	636	PF00069	0.411
MOD_NEK2_1	791	796	PF00069	0.534
MOD_NEK2_1	80	85	PF00069	0.609
MOD_NEK2_1	838	843	PF00069	0.363
MOD_NEK2_2	693	698	PF00069	0.440
MOD_OFUCOSY	583	590	PF10250	0.639
MOD_PIKK_1	167	173	PF00454	0.679
MOD_PIKK_1	288	294	PF00454	0.798
MOD_PIKK_1	509	515	PF00454	0.554
MOD_PIKK_1	603	609	PF00454	0.520
MOD_PIKK_1	823	829	PF00454	0.514
MOD_PK_1	153	159	PF00069	0.689
MOD_PKA_1	22	28	PF00069	0.583
MOD_PKA_1	241	247	PF00069	0.604
MOD_PKA_1	69	75	PF00069	0.552
MOD_PKA_2	128	134	PF00069	0.596
MOD_PKA_2	136	142	PF00069	0.581
MOD_PKA_2	157	163	PF00069	0.668
MOD_PKA_2	179	185	PF00069	0.711
MOD_PKA_2	215	221	PF00069	0.600
MOD_PKA_2	22	28	PF00069	0.525
MOD_PKA_2	223	229	PF00069	0.622
MOD_PKA_2	241	247	PF00069	0.606
MOD_PKA_2	288	294	PF00069	0.641
MOD_PKA_2	303	309	PF00069	0.738
MOD_PKA_2	310	316	PF00069	0.681
MOD_PKA_2	346	352	PF00069	0.636
MOD_PKA_2	373	379	PF00069	0.588
MOD_PKA_2	385	391	PF00069	0.585
MOD_PKA_2	392	398	PF00069	0.615
MOD_PKA_2	404	410	PF00069	0.601
MOD_PKA_2	495	501	PF00069	0.566
MOD_PKA_2	69	75	PF00069	0.665
MOD_PKA_2	693	699	PF00069	0.462
MOD_PKB_1	300	308	PF00069	0.634
MOD_Plk_1	16	22	PF00069	0.563
MOD_Plk_1	173	179	PF00069	0.605
MOD_Plk_1	218	224	PF00069	0.604
MOD_Plk_1	359	365	PF00069	0.624
MOD_Plk_1	370	376	PF00069	0.612
MOD_Plk_1	537	543	PF00069	0.696
MOD_Plk_1	699	705	PF00069	0.534
MOD_Plk_1	758	764	PF00069	0.604
MOD_Plk_2-3	185	191	PF00069	0.636
MOD_Plk_2-3	456	462	PF00069	0.477
MOD_Plk_2-3	528	534	PF00069	0.653
MOD_Plk_4	16	22	PF00069	0.563
MOD_Plk_4	185	191	PF00069	0.748
MOD_Plk_4	423	429	PF00069	0.534
MOD_Plk_4	468	474	PF00069	0.432
MOD_Plk_4	676	682	PF00069	0.369
MOD_Plk_4	687	693	PF00069	0.401
MOD_ProDKin_1	1	7	PF00069	0.525
MOD_ProDKin_1	347	353	PF00069	0.624
MOD_ProDKin_1	406	412	PF00069	0.643
MOD_ProDKin_1	41	47	PF00069	0.561
MOD_ProDKin_1	461	467	PF00069	0.476
MOD_ProDKin_1	503	509	PF00069	0.626
MOD_ProDKin_1	58	64	PF00069	0.621
MOD_ProDKin_1	778	784	PF00069	0.531
MOD_SUMO_for_1	33	36	PF00179	0.569
TRG_DiLeu_BaEn_1	810	815	PF01217	0.355
TRG_DiLeu_BaLyEn_6	352	357	PF01217	0.563
TRG_ENDOCYTIC_2	10	13	PF00928	0.583
TRG_ENDOCYTIC_2	200	203	PF00928	0.629
TRG_ENDOCYTIC_2	480	483	PF00928	0.370
TRG_ENDOCYTIC_2	492	495	PF00928	0.382
TRG_ENDOCYTIC_2	662	665	PF00928	0.485
TRG_ENDOCYTIC_2	677	680	PF00928	0.250
TRG_ENDOCYTIC_2	812	815	PF00928	0.369
TRG_ENDOCYTIC_2	98	101	PF00928	0.499
TRG_ER_diArg_1	120	122	PF00400	0.525
TRG_ER_diArg_1	21	23	PF00400	0.636
TRG_ER_diArg_1	314	317	PF00400	0.742
TRG_ER_diArg_1	78	80	PF00400	0.513
TRG_NES_CRM1_1	99	113	PF08389	0.595
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	316	320	PF00026	0.610

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P794	Leptomonas seymouri	54%	99%
A0A3Q8INY8	Leishmania donovani	90%	99%
A4HPE6	Leishmania braziliensis	79%	99%
A4ICI7	Leishmania infantum	90%	99%
E9AT57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%