Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1D9_LEIMA

TriTrypDb:

LmjF.36.2810 , LMJLV39_360037100 , LMJSD75_360037000

Length:

646

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0020016	ciliary pocket	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4Q1D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1D9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.496
CLV_C14_Caspase3-7	526	530	PF00656	0.664
CLV_NRD_NRD_1	306	308	PF00675	0.494
CLV_NRD_NRD_1	394	396	PF00675	0.661
CLV_NRD_NRD_1	562	564	PF00675	0.668
CLV_PCSK_KEX2_1	254	256	PF00082	0.388
CLV_PCSK_KEX2_1	306	308	PF00082	0.479
CLV_PCSK_KEX2_1	394	396	PF00082	0.661
CLV_PCSK_KEX2_1	562	564	PF00082	0.662
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.388
CLV_PCSK_SKI1_1	221	225	PF00082	0.354
CLV_PCSK_SKI1_1	255	259	PF00082	0.362
CLV_PCSK_SKI1_1	284	288	PF00082	0.461
CLV_PCSK_SKI1_1	310	314	PF00082	0.416
CLV_PCSK_SKI1_1	596	600	PF00082	0.628
CLV_Separin_Metazoa	327	331	PF03568	0.586
DEG_APCC_DBOX_1	254	262	PF00400	0.361
DEG_APCC_DBOX_1	283	291	PF00400	0.458
DEG_SCF_FBW7_1	74	79	PF00400	0.480
DEG_SPOP_SBC_1	109	113	PF00917	0.542
DEG_SPOP_SBC_1	246	250	PF00917	0.560
DEG_SPOP_SBC_1	347	351	PF00917	0.585
DOC_CYCLIN_RxL_1	218	228	PF00134	0.439
DOC_MAPK_DCC_7	194	203	PF00069	0.441
DOC_MAPK_gen_1	194	203	PF00069	0.441
DOC_MAPK_gen_1	254	260	PF00069	0.380
DOC_MAPK_gen_1	281	290	PF00069	0.451
DOC_MAPK_gen_1	306	314	PF00069	0.446
DOC_MAPK_gen_1	488	496	PF00069	0.584
DOC_MAPK_MEF2A_6	159	166	PF00069	0.460
DOC_MAPK_MEF2A_6	194	203	PF00069	0.382
DOC_MAPK_MEF2A_6	281	290	PF00069	0.451
DOC_MAPK_MEF2A_6	488	496	PF00069	0.527
DOC_PP1_RVXF_1	200	207	PF00149	0.339
DOC_PP1_RVXF_1	66	73	PF00149	0.502
DOC_PP2B_LxvP_1	321	324	PF13499	0.380
DOC_PP4_FxxP_1	9	12	PF00568	0.446
DOC_USP7_MATH_1	124	128	PF00917	0.711
DOC_USP7_MATH_1	170	174	PF00917	0.436
DOC_USP7_MATH_1	175	179	PF00917	0.422
DOC_USP7_MATH_1	18	22	PF00917	0.651
DOC_USP7_MATH_1	205	209	PF00917	0.366
DOC_USP7_MATH_1	234	238	PF00917	0.506
DOC_USP7_MATH_1	246	250	PF00917	0.543
DOC_USP7_MATH_1	33	37	PF00917	0.319
DOC_USP7_MATH_1	470	474	PF00917	0.721
DOC_USP7_MATH_1	579	583	PF00917	0.686
DOC_WW_Pin1_4	120	125	PF00397	0.625
DOC_WW_Pin1_4	134	139	PF00397	0.525
DOC_WW_Pin1_4	146	151	PF00397	0.767
DOC_WW_Pin1_4	296	301	PF00397	0.547
DOC_WW_Pin1_4	363	368	PF00397	0.784
DOC_WW_Pin1_4	370	375	PF00397	0.674
DOC_WW_Pin1_4	428	433	PF00397	0.445
DOC_WW_Pin1_4	618	623	PF00397	0.578
DOC_WW_Pin1_4	72	77	PF00397	0.499
LIG_14-3-3_CanoR_1	153	157	PF00244	0.684
LIG_14-3-3_CanoR_1	221	227	PF00244	0.411
LIG_14-3-3_CanoR_1	337	341	PF00244	0.683
LIG_14-3-3_CanoR_1	346	353	PF00244	0.634
LIG_14-3-3_CanoR_1	384	390	PF00244	0.725
LIG_14-3-3_CanoR_1	562	569	PF00244	0.662
LIG_14-3-3_CanoR_1	596	602	PF00244	0.622
LIG_14-3-3_CanoR_1	634	638	PF00244	0.462
LIG_BRCT_BRCA1_1	349	353	PF00533	0.600
LIG_Clathr_ClatBox_1	183	187	PF01394	0.453
LIG_deltaCOP1_diTrp_1	603	607	PF00928	0.605
LIG_eIF4E_1	282	288	PF01652	0.449
LIG_eIF4E_1	54	60	PF01652	0.464
LIG_FHA_1	198	204	PF00498	0.363
LIG_FHA_1	270	276	PF00498	0.401
LIG_FHA_1	278	284	PF00498	0.385
LIG_FHA_1	374	380	PF00498	0.555
LIG_FHA_1	42	48	PF00498	0.434
LIG_FHA_1	520	526	PF00498	0.634
LIG_FHA_1	55	61	PF00498	0.546
LIG_FHA_1	619	625	PF00498	0.555
LIG_FHA_2	111	117	PF00498	0.672
LIG_FHA_2	260	266	PF00498	0.551
LIG_FHA_2	349	355	PF00498	0.615
LIG_FHA_2	524	530	PF00498	0.560
LIG_FHA_2	76	82	PF00498	0.446
LIG_LIR_Gen_1	209	220	PF02991	0.423
LIG_LIR_Gen_1	424	432	PF02991	0.422
LIG_LIR_Gen_1	587	598	PF02991	0.655
LIG_LIR_Nem_3	126	132	PF02991	0.623
LIG_LIR_Nem_3	146	151	PF02991	0.737
LIG_LIR_Nem_3	209	215	PF02991	0.430
LIG_LIR_Nem_3	343	347	PF02991	0.666
LIG_LIR_Nem_3	424	428	PF02991	0.524
LIG_LIR_Nem_3	535	541	PF02991	0.593
LIG_LIR_Nem_3	587	593	PF02991	0.659
LIG_NRBOX	179	185	PF00104	0.434
LIG_NRBOX	282	288	PF00104	0.449
LIG_PCNA_yPIPBox_3	177	190	PF02747	0.449
LIG_Pex14_2	9	13	PF04695	0.480
LIG_PTB_Apo_2	250	257	PF02174	0.448
LIG_PTB_Apo_2	592	599	PF02174	0.595
LIG_SH2_CRK	212	216	PF00017	0.453
LIG_SH2_CRK	32	36	PF00017	0.397
LIG_SH2_CRK	344	348	PF00017	0.671
LIG_SH2_CRK	489	493	PF00017	0.545
LIG_SH2_GRB2like	538	541	PF00017	0.603
LIG_SH2_GRB2like	54	57	PF00017	0.474
LIG_SH2_NCK_1	32	36	PF00017	0.397
LIG_SH2_NCK_1	344	348	PF00017	0.611
LIG_SH2_STAP1	212	216	PF00017	0.453
LIG_SH2_STAT5	229	232	PF00017	0.450
LIG_SH2_STAT5	282	285	PF00017	0.400
LIG_SH2_STAT5	54	57	PF00017	0.611
LIG_SH2_STAT5	69	72	PF00017	0.414
LIG_SH3_3	193	199	PF00018	0.470
LIG_SH3_3	426	432	PF00018	0.426
LIG_SH3_3	61	67	PF00018	0.448
LIG_SUMO_SIM_anti_2	44	52	PF11976	0.462
LIG_SUMO_SIM_par_1	256	262	PF11976	0.478
LIG_SUMO_SIM_par_1	271	276	PF11976	0.348
LIG_SUMO_SIM_par_1	44	52	PF11976	0.405
LIG_SUMO_SIM_par_1	614	621	PF11976	0.617
LIG_TRAF2_1	113	116	PF00917	0.627
LIG_TRAF2_1	324	327	PF00917	0.537
LIG_TRAF2_1	455	458	PF00917	0.589
LIG_TYR_ITIM	624	629	PF00017	0.520
LIG_UBA3_1	59	68	PF00899	0.510
LIG_WRC_WIRS_1	422	427	PF05994	0.448
LIG_WRC_WIRS_1	83	88	PF05994	0.295
MOD_CDK_SPK_2	72	77	PF00069	0.499
MOD_CDK_SPxxK_3	146	153	PF00069	0.636
MOD_CDK_SPxxK_3	363	370	PF00069	0.777
MOD_CK1_1	120	126	PF00069	0.539
MOD_CK1_1	146	152	PF00069	0.775
MOD_CK1_1	345	351	PF00069	0.580
MOD_CK1_1	373	379	PF00069	0.677
MOD_CK1_1	388	394	PF00069	0.672
MOD_CK1_1	408	414	PF00069	0.523
MOD_CK1_1	461	467	PF00069	0.605
MOD_CK1_1	531	537	PF00069	0.638
MOD_CK1_1	547	553	PF00069	0.662
MOD_CK1_1	564	570	PF00069	0.488
MOD_CK2_1	109	115	PF00069	0.668
MOD_CK2_1	120	126	PF00069	0.530
MOD_CK2_1	265	271	PF00069	0.457
MOD_CK2_1	348	354	PF00069	0.606
MOD_CK2_1	472	478	PF00069	0.594
MOD_CK2_1	597	603	PF00069	0.578
MOD_CK2_1	75	81	PF00069	0.519
MOD_DYRK1A_RPxSP_1	370	374	PF00069	0.705
MOD_GlcNHglycan	101	104	PF01048	0.633
MOD_GlcNHglycan	139	142	PF01048	0.716
MOD_GlcNHglycan	171	175	PF01048	0.443
MOD_GlcNHglycan	177	180	PF01048	0.417
MOD_GlcNHglycan	236	239	PF01048	0.513
MOD_GlcNHglycan	275	278	PF01048	0.399
MOD_GlcNHglycan	358	361	PF01048	0.665
MOD_GlcNHglycan	412	415	PF01048	0.727
MOD_GlcNHglycan	418	421	PF01048	0.556
MOD_GlcNHglycan	460	463	PF01048	0.589
MOD_GlcNHglycan	472	475	PF01048	0.494
MOD_GlcNHglycan	51	54	PF01048	0.551
MOD_GlcNHglycan	534	537	PF01048	0.583
MOD_GlcNHglycan	640	643	PF01048	0.566
MOD_GSK3_1	111	118	PF00069	0.786
MOD_GSK3_1	120	127	PF00069	0.596
MOD_GSK3_1	132	139	PF00069	0.582
MOD_GSK3_1	18	25	PF00069	0.503
MOD_GSK3_1	224	231	PF00069	0.357
MOD_GSK3_1	240	247	PF00069	0.508
MOD_GSK3_1	261	268	PF00069	0.453
MOD_GSK3_1	269	276	PF00069	0.410
MOD_GSK3_1	336	343	PF00069	0.602
MOD_GSK3_1	345	352	PF00069	0.558
MOD_GSK3_1	366	373	PF00069	0.730
MOD_GSK3_1	397	404	PF00069	0.751
MOD_GSK3_1	458	465	PF00069	0.623
MOD_GSK3_1	519	526	PF00069	0.668
MOD_GSK3_1	527	534	PF00069	0.688
MOD_GSK3_1	54	61	PF00069	0.530
MOD_GSK3_1	540	547	PF00069	0.717
MOD_GSK3_1	72	79	PF00069	0.360
MOD_N-GLC_1	541	546	PF02516	0.661
MOD_NEK2_1	151	156	PF00069	0.749
MOD_NEK2_1	206	211	PF00069	0.551
MOD_NEK2_1	224	229	PF00069	0.303
MOD_NEK2_1	269	274	PF00069	0.417
MOD_NEK2_1	275	280	PF00069	0.441
MOD_NEK2_1	328	333	PF00069	0.596
MOD_NEK2_1	340	345	PF00069	0.502
MOD_NEK2_1	353	358	PF00069	0.674
MOD_NEK2_1	460	465	PF00069	0.581
MOD_NEK2_1	49	54	PF00069	0.568
MOD_NEK2_1	528	533	PF00069	0.672
MOD_NEK2_1	561	566	PF00069	0.763
MOD_NEK2_1	578	583	PF00069	0.525
MOD_NEK2_1	59	64	PF00069	0.517
MOD_NEK2_1	638	643	PF00069	0.493
MOD_NEK2_1	92	97	PF00069	0.514
MOD_NEK2_1	99	104	PF00069	0.585
MOD_NEK2_2	124	129	PF00069	0.739
MOD_NEK2_2	507	512	PF00069	0.659
MOD_NEK2_2	541	546	PF00069	0.644
MOD_PIKK_1	139	145	PF00454	0.773
MOD_PIKK_1	373	379	PF00454	0.769
MOD_PKA_2	1	7	PF00069	0.501
MOD_PKA_2	152	158	PF00069	0.697
MOD_PKA_2	290	296	PF00069	0.446
MOD_PKA_2	336	342	PF00069	0.596
MOD_PKA_2	345	351	PF00069	0.563
MOD_PKA_2	561	567	PF00069	0.655
MOD_PKA_2	633	639	PF00069	0.480
MOD_Plk_1	115	121	PF00069	0.626
MOD_Plk_1	353	359	PF00069	0.645
MOD_Plk_1	528	534	PF00069	0.683
MOD_Plk_1	541	547	PF00069	0.549
MOD_Plk_2-3	265	271	PF00069	0.457
MOD_Plk_4	1	7	PF00069	0.501
MOD_Plk_4	124	130	PF00069	0.551
MOD_Plk_4	225	231	PF00069	0.360
MOD_Plk_4	247	253	PF00069	0.625
MOD_Plk_4	265	271	PF00069	0.441
MOD_Plk_4	310	316	PF00069	0.377
MOD_Plk_4	336	342	PF00069	0.655
MOD_Plk_4	462	468	PF00069	0.636
MOD_Plk_4	472	478	PF00069	0.551
MOD_Plk_4	528	534	PF00069	0.606
MOD_Plk_4	633	639	PF00069	0.453
MOD_Plk_4	82	88	PF00069	0.511
MOD_ProDKin_1	120	126	PF00069	0.626
MOD_ProDKin_1	134	140	PF00069	0.527
MOD_ProDKin_1	146	152	PF00069	0.762
MOD_ProDKin_1	296	302	PF00069	0.549
MOD_ProDKin_1	363	369	PF00069	0.783
MOD_ProDKin_1	370	376	PF00069	0.672
MOD_ProDKin_1	428	434	PF00069	0.443
MOD_ProDKin_1	618	624	PF00069	0.566
MOD_ProDKin_1	72	78	PF00069	0.488
MOD_SUMO_rev_2	418	425	PF00179	0.517
TRG_ENDOCYTIC_2	129	132	PF00928	0.711
TRG_ENDOCYTIC_2	212	215	PF00928	0.464
TRG_ENDOCYTIC_2	32	35	PF00928	0.340
TRG_ENDOCYTIC_2	344	347	PF00928	0.672
TRG_ENDOCYTIC_2	480	483	PF00928	0.556
TRG_ENDOCYTIC_2	489	492	PF00928	0.612
TRG_ENDOCYTIC_2	626	629	PF00928	0.518
TRG_ENDOCYTIC_2	69	72	PF00928	0.483
TRG_ER_diArg_1	305	307	PF00400	0.502
TRG_ER_diArg_1	329	332	PF00400	0.582
TRG_ER_diArg_1	561	563	PF00400	0.663
TRG_NES_CRM1_1	421	434	PF08389	0.460

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9B6	Leptomonas seymouri	55%	98%
A0A1X0NKH5	Trypanosomatidae	39%	100%
A0A3Q8IJG0	Leishmania donovani	94%	100%
A4HPE7	Leishmania braziliensis	77%	100%
A4ICI8	Leishmania infantum	95%	100%
E9AT58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%