Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4Q1D8_LEIMA

TriTrypDb:

LmjF.36.2820 , LMJLV39_360037200 , LMJSD75_360037100

Length:

591

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4Q1D8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4Q1D8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.669
CLV_C14_Caspase3-7	322	326	PF00656	0.721
CLV_C14_Caspase3-7	328	332	PF00656	0.688
CLV_C14_Caspase3-7	428	432	PF00656	0.773
CLV_C14_Caspase3-7	504	508	PF00656	0.784
CLV_NRD_NRD_1	12	14	PF00675	0.464
CLV_NRD_NRD_1	181	183	PF00675	0.667
CLV_NRD_NRD_1	473	475	PF00675	0.603
CLV_PCSK_FUR_1	467	471	PF00082	0.656
CLV_PCSK_KEX2_1	12	14	PF00082	0.534
CLV_PCSK_KEX2_1	320	322	PF00082	0.526
CLV_PCSK_KEX2_1	469	471	PF00082	0.557
CLV_PCSK_KEX2_1	472	474	PF00082	0.550
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.573
CLV_PCSK_PC7_1	467	473	PF00082	0.665
CLV_PCSK_SKI1_1	12	16	PF00082	0.468
CLV_PCSK_SKI1_1	167	171	PF00082	0.573
CLV_PCSK_SKI1_1	247	251	PF00082	0.467
CLV_PCSK_SKI1_1	255	259	PF00082	0.474
CLV_PCSK_SKI1_1	309	313	PF00082	0.468
DEG_APCC_DBOX_1	11	19	PF00400	0.646
DEG_Nend_Nbox_1	1	3	PF02207	0.728
DOC_CKS1_1	5	10	PF01111	0.666
DOC_CYCLIN_RxL_1	10	21	PF00134	0.716
DOC_CYCLIN_RxL_1	252	262	PF00134	0.665
DOC_MAPK_FxFP_2	3	6	PF00069	0.695
DOC_MAPK_gen_1	130	139	PF00069	0.644
DOC_MAPK_MEF2A_6	133	141	PF00069	0.647
DOC_PIKK_1	579	586	PF02985	0.760
DOC_PP1_RVXF_1	11	18	PF00149	0.723
DOC_PP4_FxxP_1	3	6	PF00568	0.695
DOC_PP4_FxxP_1	370	373	PF00568	0.724
DOC_USP7_MATH_1	243	247	PF00917	0.629
DOC_USP7_MATH_1	511	515	PF00917	0.713
DOC_USP7_UBL2_3	255	259	PF12436	0.667
DOC_USP7_UBL2_3	277	281	PF12436	0.734
DOC_WW_Pin1_4	4	9	PF00397	0.677
DOC_WW_Pin1_4	431	436	PF00397	0.780
LIG_14-3-3_CanoR_1	283	289	PF00244	0.660
LIG_14-3-3_CanoR_1	44	50	PF00244	0.382
LIG_AP2alpha_1	374	378	PF02296	0.732
LIG_APCC_ABBA_1	234	239	PF00400	0.636
LIG_BRCT_BRCA1_1	515	519	PF00533	0.763
LIG_Clathr_ClatBox_1	107	111	PF01394	0.389
LIG_Clathr_ClatBox_1	65	69	PF01394	0.454
LIG_CSL_BTD_1	432	435	PF09270	0.778
LIG_EH1_1	141	149	PF00400	0.546
LIG_eIF4E_1	53	59	PF01652	0.427
LIG_FHA_1	26	32	PF00498	0.413
LIG_FHA_1	72	78	PF00498	0.384
LIG_FHA_1	83	89	PF00498	0.443
LIG_FHA_2	182	188	PF00498	0.497
LIG_FHA_2	320	326	PF00498	0.701
LIG_FHA_2	442	448	PF00498	0.803
LIG_FHA_2	52	58	PF00498	0.444
LIG_GBD_Chelix_1	582	590	PF00786	0.587
LIG_Integrin_RGD_1	474	476	PF01839	0.602
LIG_Integrin_RGD_1	499	501	PF01839	0.509
LIG_LIR_Apic_2	367	373	PF02991	0.724
LIG_LIR_Apic_2	447	452	PF02991	0.806
LIG_LIR_Gen_1	111	120	PF02991	0.411
LIG_LIR_Gen_1	184	194	PF02991	0.453
LIG_LIR_Gen_1	195	205	PF02991	0.335
LIG_LIR_Gen_1	287	296	PF02991	0.613
LIG_LIR_Gen_1	313	323	PF02991	0.686
LIG_LIR_Gen_1	39	50	PF02991	0.451
LIG_LIR_LC3C_4	33	36	PF02991	0.436
LIG_LIR_Nem_3	111	115	PF02991	0.362
LIG_LIR_Nem_3	16	22	PF02991	0.631
LIG_LIR_Nem_3	184	189	PF02991	0.393
LIG_LIR_Nem_3	192	197	PF02991	0.342
LIG_LIR_Nem_3	202	208	PF02991	0.269
LIG_LIR_Nem_3	287	291	PF02991	0.627
LIG_LIR_Nem_3	293	299	PF02991	0.596
LIG_LIR_Nem_3	313	319	PF02991	0.656
LIG_LIR_Nem_3	367	372	PF02991	0.724
LIG_LIR_Nem_3	39	45	PF02991	0.430
LIG_MLH1_MIPbox_1	515	519	PF16413	0.763
LIG_NRBOX	109	115	PF00104	0.411
LIG_Pex14_2	108	112	PF04695	0.411
LIG_Pex14_2	119	123	PF04695	0.375
LIG_Pex14_2	224	228	PF04695	0.311
LIG_Pex14_2	370	374	PF04695	0.724
LIG_PTB_Apo_2	329	336	PF02174	0.690
LIG_PTB_Apo_2	368	375	PF02174	0.744
LIG_PTB_Apo_2	67	74	PF02174	0.382
LIG_PTB_Phospho_1	67	73	PF10480	0.379
LIG_SH2_CRK	288	292	PF00017	0.661
LIG_SH2_CRK	42	46	PF00017	0.365
LIG_SH2_CRK	449	453	PF00017	0.831
LIG_SH2_GRB2like	53	56	PF00017	0.452
LIG_SH2_NCK_1	449	453	PF00017	0.831
LIG_SH2_SRC	449	452	PF00017	0.859
LIG_SH2_STAP1	152	156	PF00017	0.411
LIG_SH2_STAP1	186	190	PF00017	0.487
LIG_SH2_STAT5	103	106	PF00017	0.411
LIG_SH2_STAT5	125	128	PF00017	0.708
LIG_SH2_STAT5	197	200	PF00017	0.357
LIG_SH2_STAT5	218	221	PF00017	0.398
LIG_SH2_STAT5	227	230	PF00017	0.646
LIG_SH2_STAT5	377	380	PF00017	0.737
LIG_SH2_STAT5	42	45	PF00017	0.449
LIG_SH2_STAT5	512	515	PF00017	0.852
LIG_SH2_STAT5	518	521	PF00017	0.772
LIG_SH2_STAT5	527	530	PF00017	0.671
LIG_SH2_STAT5	53	56	PF00017	0.358
LIG_SH2_STAT5	539	542	PF00017	0.703
LIG_SH2_STAT5	73	76	PF00017	0.303
LIG_SH3_1	5	11	PF00018	0.664
LIG_SH3_2	8	13	PF14604	0.655
LIG_SH3_3	134	140	PF00018	0.654
LIG_SH3_3	201	207	PF00018	0.385
LIG_SH3_3	385	391	PF00018	0.680
LIG_SH3_3	448	454	PF00018	0.806
LIG_SH3_3	488	494	PF00018	0.753
LIG_SH3_3	5	11	PF00018	0.664
LIG_SH3_4	255	262	PF00018	0.661
LIG_SH3_5	373	377	PF00018	0.728
LIG_Sin3_3	296	303	PF02671	0.654
LIG_SUMO_SIM_anti_2	111	117	PF11976	0.364
LIG_SUMO_SIM_anti_2	153	158	PF11976	0.513
LIG_SUMO_SIM_anti_2	33	40	PF11976	0.396
LIG_SUMO_SIM_anti_2	61	69	PF11976	0.383
LIG_SUMO_SIM_par_1	33	40	PF11976	0.396
LIG_SUMO_SIM_par_1	395	401	PF11976	0.778
LIG_SUMO_SIM_par_1	61	69	PF11976	0.456
LIG_SUMO_SIM_par_1	84	89	PF11976	0.476
LIG_TRAF2_1	398	401	PF00917	0.795
LIG_TRFH_1	418	422	PF08558	0.826
LIG_Vh1_VBS_1	17	35	PF01044	0.563
MOD_CDK_SPK_2	431	436	PF00069	0.706
MOD_CK1_1	48	54	PF00069	0.474
MOD_CK2_1	181	187	PF00069	0.491
MOD_CK2_1	226	232	PF00069	0.549
MOD_CK2_1	395	401	PF00069	0.857
MOD_CK2_1	431	437	PF00069	0.852
MOD_CK2_1	441	447	PF00069	0.620
MOD_CK2_1	556	562	PF00069	0.848
MOD_GlcNHglycan	219	222	PF01048	0.377
MOD_GlcNHglycan	347	352	PF01048	0.571
MOD_GlcNHglycan	534	537	PF01048	0.588
MOD_GlcNHglycan	540	543	PF01048	0.609
MOD_GSK3_1	142	149	PF00069	0.558
MOD_GSK3_1	195	202	PF00069	0.359
MOD_GSK3_1	36	43	PF00069	0.329
MOD_GSK3_1	455	462	PF00069	0.857
MOD_GSK3_1	556	563	PF00069	0.845
MOD_GSK3_1	82	89	PF00069	0.378
MOD_LATS_1	463	469	PF00433	0.725
MOD_N-GLC_1	123	128	PF02516	0.429
MOD_N-GLC_1	251	256	PF02516	0.533
MOD_N-GLC_1	325	330	PF02516	0.581
MOD_NEK2_1	123	128	PF00069	0.601
MOD_NEK2_1	181	186	PF00069	0.489
MOD_NEK2_1	208	213	PF00069	0.411
MOD_NEK2_1	25	30	PF00069	0.457
MOD_NEK2_1	250	255	PF00069	0.637
MOD_NEK2_1	319	324	PF00069	0.769
MOD_NEK2_1	341	346	PF00069	0.719
MOD_NEK2_1	357	362	PF00069	0.669
MOD_NEK2_1	441	446	PF00069	0.813
MOD_NEK2_1	45	50	PF00069	0.362
MOD_NEK2_1	532	537	PF00069	0.783
MOD_NEK2_1	549	554	PF00069	0.731
MOD_NEK2_1	97	102	PF00069	0.360
MOD_NEK2_2	73	78	PF00069	0.335
MOD_PIKK_1	146	152	PF00454	0.411
MOD_PIKK_1	325	331	PF00454	0.673
MOD_PIKK_1	455	461	PF00454	0.853
MOD_PIKK_1	492	498	PF00454	0.693
MOD_PKA_2	181	187	PF00069	0.491
MOD_PKA_2	43	49	PF00069	0.382
MOD_PKA_2	560	566	PF00069	0.840
MOD_PKB_1	564	572	PF00069	0.788
MOD_Plk_1	325	331	PF00069	0.766
MOD_Plk_2-3	395	401	PF00069	0.849
MOD_Plk_2-3	501	507	PF00069	0.699
MOD_Plk_2-3	584	590	PF00069	0.844
MOD_Plk_4	18	24	PF00069	0.526
MOD_Plk_4	195	201	PF00069	0.362
MOD_Plk_4	48	54	PF00069	0.474
MOD_ProDKin_1	4	10	PF00069	0.672
MOD_ProDKin_1	431	437	PF00069	0.780
MOD_SUMO_for_1	190	193	PF00179	0.410
MOD_SUMO_rev_2	495	504	PF00179	0.699
TRG_DiLeu_BaEn_1	111	116	PF01217	0.396
TRG_DiLeu_BaEn_1	245	250	PF01217	0.674
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.665
TRG_ENDOCYTIC_2	186	189	PF00928	0.447
TRG_ENDOCYTIC_2	197	200	PF00928	0.323
TRG_ENDOCYTIC_2	205	208	PF00928	0.267
TRG_ENDOCYTIC_2	288	291	PF00928	0.631
TRG_ENDOCYTIC_2	42	45	PF00928	0.356
TRG_ENDOCYTIC_2	95	98	PF00928	0.387
TRG_ER_diArg_1	11	13	PF00400	0.728
TRG_ER_diArg_1	467	470	PF00400	0.790
TRG_ER_diArg_1	471	474	PF00400	0.794
TRG_NLS_MonoExtC_3	181	187	PF00514	0.352
TRG_Pf-PMV_PEXEL_1	167	171	PF00026	0.631
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7M6	Leptomonas seymouri	59%	98%
A0A3Q8IW35	Leishmania donovani	93%	100%
A4HPE8	Leishmania braziliensis	74%	99%
A4ICI9	Leishmania infantum	93%	100%
E9AT59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%